KEGG   Addendum: AAG02357
Entry
AAG02357          CDS       T10000                                 
Symbol
blmVIII
Name
(KEGG) nonribosomal peptide synthetase protein BlmVIII
  KO
K16110  nonribosomal peptide synthetase protein BlmVIII
Taxonomy
TAX:29309
  Lineage
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces
Organism
Streptomyces verticillus
SSDB
Motif
Pfam: ketoacyl-synt Acyl_transf_1 KR Ketoacyl-synt_C KAsynt_C_assoc PP-binding Methyltransf_12 Methyltransf_23 Methyltransf_31 Methyltransf_25 adh_short Methyltransf_11 adh_short_C2 Thiolase_N Epimerase
Other DBs
NCBI-ProteinID: AAG02357
GB: AF210249
UniProt: Q9FB25
LinkDB
AA seq 1841 aa
MSHADAGDGLDAADTTDAADGIAVISLGGRFPGADRVDRLWTNLLDREDAISHFTADERL
ARGRDPELVRHPRFVGAEGVLGDVSLFDAEFFGCSPREAEVMDPQHRLCLEEAWHVFDTA
GYDPAATGTAVGVFLSASLSSYLIRNVLPGGAAQRLLGGFPLLIHNDKDFLATTVSHKLG
LTGPSYAVGSACSSSLVAVHLACQSLLTEECDMALAGGVSLQVPQGQGYVHADDGIYSPD
GRCAPFDAGAAGTVGGSGVGLVLLKRLADAVRDGDRVHAVILGSAVNNDGADKVGYTAPG
VTGQSAVVAEALAVAGISAATVGVLEAHGTGTRLGDPVEVAALTRAFRAHTDRSGFCALG
SVKANVGHLDAAAGVTGLIKAVLAVREGVIPGTPHYRSPNPAIDFATTPFYVTADTLAWP
EADHPRRAGVSSFGIGGTNAHVILEQAPPAAPRADRTAGVPMPLVVSARTREALAEAVRD
LAAWSAPEPGTRLADLAATLAGRRAFPYRAAVVCHDLPEAARLLGGARGETALPGREAVF
LFPGQGTLPPDTGRGLYADVPAFRAHFDACAEGFAPLGTDLHAALGAPADDTRAAQPALF
AVEYALARTLMDWGVRPAAMLGHSLGEYVAATLAGVLSLPDALTLVRARAEAQHTMPPGR
MLAVPLTPDDLRPLLPPEVEFSAFNAPGRCVVGGPPEPVAELRARLARRGVPAAELATAH
AFHSAAVEPLLDGFRGVLEGVRLRPPRLRYVSSLTGDWADAAVTTPAYWLAHLRRPVRFA
DGLRRCLDLGPVALVETGPRAGLTGLARRAAGPGEPPYTVRCLAAPDEAASLTHAVAVLW
RSGCAVDWTAFHRPGRPRRTTVPGYPFQRVRHWIDAPDESEPTDLATALRAELRTDGDPP
LAVDQRPGLRTGLNRLCAALARDYLATGVEASGVLPGFHRFLDYLRTLAASAPAADDAGT
IAAEITAAHPSFSGLVDLLRHCAQGYPRALSTPGAALDVLYPAGSGDLLRRTLGEGTADH
RATGRLTRLAGSLLDRLAADREPGRPLRVLEAGAGAGSLTQALVTRAPGRLDYHATDISR
HFVTALGREAARRGLDFVRARVLDIARDPGEQGFAGERFDVVCGLDVVHATPDLRTTLGH
LRSLMAPDGTLALIETTADDPWLTMIWGLTDGWWHHTDRRTHGPLLDAAGWRALLAGEDF
ATADVIVPPDGPQDAALLLARQTPRPAAAAPSVGKRDVGTWCYARGWRHAAPADPAPLTG
GCLLLGDGDTAKAVASRLEALGVPVTTVGGGRPPGPERYRELVGPATRLAVDLWPLRDAS
HRGRAAGAAGVRTAQDAALHNLLHLARAFGALEERHPARVVTVTTGAHDVLGDDLAHPEH
ATVPAAAKVIPREYPWIACTALDVEPGLDAERLADLIVRELGAARETTVTACRGRRRFTP
CPVRQPLPAAPERPAVRPGGVYLVCGGLGGIGLHLAEYLGRARTTVVLTHRRPFPAPGAW
DGLPAGHPEAAVVRRLRSLAATGATVVVRRADLTDHDAMRALADEVEQAHGPVRGVVHAA
GVPDTAGMIQRRDRAGTDAALAAKLTGTLVLDEVFAHRDLDFLVLCSSIGTVLHKLKFGE
VGYVAGNEFLDAYAAHRAARRPGRTLSIAWTDWRESGMWAAAQRRLTERYGTGADLPVPP
GGDLLGAISPEEGVDVFARLLAADTGPNVIVSAQDLDELLARHAAYTTDDHLAALGDLRI
AAARDRSAPAAPYAAPHTPAQRRIAGWYRDLLGVEHVGLDDDFFALGGDSLLALRLLSQL
RDAYGVEISVARMFDEPTVAALAAATGPPPEETPGQEEVVL
Reference
PMID:11048953
  Authors
Du L, Sanchez C, Chen M, Edwards DJ, Shen B.
  Title
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase.
  Journal
Chem Biol 7:623-42 (2000)
DOI:10.1016/S1074-5521(00)00011-9
Reference
PMID:10930733
  Authors
Du L, Chen M, Sanchez C, Shen B
  Title
An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003.
  Journal
FEMS Microbiol Lett 189:171-5 (2000)
DOI:10.1111/j.1574-6968.2000.tb09225.x

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