KEGG   PATHWAY: ahp03430
Entry
ahp03430                    Pathway                                

Name
Mismatch repair - Aeromonas hydrophila pc104A
Description
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Class
Genetic Information Processing; Replication and repair
Pathway map
ahp03430  Mismatch repair
ahp03430

Other DBs
GO: 0006298
Organism
Aeromonas hydrophila pc104A [GN:ahp]
Gene
V429_20650  DNA mismatch repair protein MutS [KO:K03555]
V429_04885  DNA mismatch repair protein MutL [KO:K03572]
V429_03595  DNA mismatch repair protein MutH [KO:K03573]
V429_01205  uvrD; DNA-dependent helicase II [KO:K03657] [EC:3.6.4.12]
V429_10575  exonuclease I [KO:K01141] [EC:3.1.11.1]
V429_13505  xseA; exodeoxyribonuclease VII large subunit [KO:K03601] [EC:3.1.11.6]
V429_18430  exodeoxyribonuclease VII small subunit [KO:K03602] [EC:3.1.11.6]
V429_18185  ssDNA exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
V429_21855  single-stranded DNA-binding protein [KO:K03111]
V429_06550  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
V429_00010  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
V429_12245  DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
V429_18085  DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
V429_12015  ATPase AAA [KO:K02341] [EC:2.7.7.7]
V429_13260  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
V429_08920  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
V429_20550  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
V429_03870  hypothetical protein [KO:K02344] [EC:2.7.7.7]
V429_06735  ligA; NAD-dependent DNA ligase LigA [KO:K01972] [EC:6.5.1.2]
V429_17770  DNA adenine methylase [KO:K06223] [EC:2.1.1.72]
Reference
  Authors
Jiricny J.
  Title
The multifaceted mismatch-repair system.
  Journal
Nat Rev Mol Cell Biol 7:335-46 (2006)
DOI:10.1038/nrm1907
Reference
  Authors
Li GM.
  Title
Mechanisms and functions of DNA mismatch repair.
  Journal
Cell Res 18:85-98 (2008)
DOI:10.1038/cr.2007.115
Reference
  Authors
Marti TM, Kunz C, Fleck O.
  Title
DNA mismatch repair and mutation avoidance pathways.
  Journal
J Cell Physiol 191:28-41 (2002)
DOI:10.1002/jcp.10077
Reference
  Authors
Ikejima M, Shimada T.
  Title
[Molecular mechanism of mismatch repair] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway
ko03430   
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