KEGG   PATHWAY: ahp03440
Entry
ahp03440                    Pathway                                

Name
Homologous recombination - Aeromonas hydrophila pc104A
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ahp03440  Homologous recombination
ahp03440

Other DBs
GO: 0000724
Organism
Aeromonas hydrophila pc104A [GN:ahp]
Gene
V429_18185  ssDNA exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
V429_21855  single-stranded DNA-binding protein [KO:K03111]
V429_00015  recF; recombination protein F [KO:K03629]
V429_04275  DNA recombination protein RecO [KO:K03584]
V429_13695  recR; recombination protein RecR [KO:K06187]
V429_20625  recombinase RecA [KO:K03553]
V429_01075  DNA polymerase I [KO:K02335] [EC:2.7.7.7]
V429_20030  ruvA; ATP-dependent DNA helicase RuvA [KO:K03550] [EC:3.6.4.12]
V429_20025  ruvB; ATP-dependent DNA helicase RuvB [KO:K03551] [EC:3.6.4.12]
V429_07065  crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.22.4]
V429_01510  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
V429_00315  ATP-dependent DNA helicase RecG [KO:K03655] [EC:3.6.4.12]
V429_21950  exodeoxyribonuclease V subunit beta [KO:K03582] [EC:3.1.11.5]
V429_21955  exodeoxyribonuclease V subunit gamma [KO:K03583] [EC:3.1.11.5]
V429_21945  exodeoxyribonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
V429_06550  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
V429_00010  DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
V429_12245  DNA polymerase III subunit gamma/tau [KO:K02343] [EC:2.7.7.7]
V429_18085  DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
V429_12015  ATPase AAA [KO:K02341] [EC:2.7.7.7]
V429_13260  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
V429_08920  DNA polymerase III subunit epsilon [KO:K02342] [EC:2.7.7.7]
V429_20550  DNA polymerase III subunit chi [KO:K02339] [EC:2.7.7.7]
V429_03870  hypothetical protein [KO:K02344] [EC:2.7.7.7]
V429_22895  primosomal protein N' [KO:K04066] [EC:3.6.4.-]
V429_19320  hypothetical protein [KO:K02317]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators] Japanese
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
LinkDB

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