KEGG T04657: 106969949

KEGG Orthology (KO) [BR:aju00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    106969949 (CDK6)
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    106969949 (CDK6)
   04115 p53 signaling pathway
    106969949 (CDK6)
   04218 Cellular senescence
    106969949 (CDK6)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    106969949 (CDK6)
   05206 MicroRNAs in cancer
    106969949 (CDK6)
   05203 Viral carcinogenesis
    106969949 (CDK6)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    106969949 (CDK6)
   05225 Hepatocellular carcinoma
    106969949 (CDK6)
   05214 Glioma
    106969949 (CDK6)
   05220 Chronic myeloid leukemia
    106969949 (CDK6)
   05218 Melanoma
    106969949 (CDK6)
   05224 Breast cancer
    106969949 (CDK6)
   05222 Small cell lung cancer
    106969949 (CDK6)
   05223 Non-small cell lung cancer
    106969949 (CDK6)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    106969949 (CDK6)
  09172 Infectious disease: viral
   05160 Hepatitis C
    106969949 (CDK6)
   05164 Influenza A
    106969949 (CDK6)
   05162 Measles
    106969949 (CDK6)
   05163 Human cytomegalovirus infection
    106969949 (CDK6)
   05167 Kaposi sarcoma-associated herpesvirus infection
    106969949 (CDK6)
   05169 Epstein-Barr virus infection
    106969949 (CDK6)
   05165 Human papillomavirus infection
    106969949 (CDK6)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:aju01001]
    106969949 (CDK6)
Enzymes [BR:aju01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     106969949 (CDK6)
Protein kinases [BR:aju01001]
Serine/threonine kinases: CMGC group
  CDK family
   106969949 (CDK6)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr APH Kdo Kinase-like RIO1 FTA2

Other DBs

NCBI-GeneID:

106969949

NCBI-ProteinID:

XP_026927685

UniProt:

A0A6J2AGZ7

LinkDB

Position

Unknown

AA seq 326 aa
MEKDGLSRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSPQPIEKFVTDIDEQGKDLLLKCLTFNPAKRISAYSALSHPYF
HDLERCKENLDSRLPPNQNSSEMNTA

NT seq 981 nt +upstreamnt +downstreamnt
atggagaaggacggcctgagccgcgcggaccagcagtacgagtgcgtggcggagatcggg
gagggcgcctatggaaaggtgttcaaggcccgggacctgaagaacggaggccggttcgtg
gcgctgaagcgcgtgcgggtgcagacaggcgaggagggcatgccgctctccaccatccgc
gaggtggcggtgctgaggcacctggagaccttcgagcaccccaacgtggtcaggttgttt
gatgtatgcacagtgtcacgaacagacagagaaaccaaactaacattagtgtttgaacat
gttgatcaagacctgaccacttatttggataaagtcccggagcctggagtgcccactgaa
accataaaggatatgatgtttcagcttctccgaggtctggactttcttcattctcaccga
gtagtgcatcgtgatctaaaaccgcagaacattctggtgaccagcagcggacaaataaaa
ctggctgactttggccttgcccgcatctacagttttcagatggctctcacctcagtggtc
gtcacgctgtggtacagagctccagaagtcttgcttcagtccagctacgccacccccgtg
gacctctggagtgttggctgcatatttgcagaaatgtttcgtagaaagcctctttttcgt
ggaagttcagacgttgatcaacttggaaaaatcttggatgtaattggactcccaggagaa
gaagactggcccagagatgtcgcccttcccagacaggcttttcactcaaaatctcctcaa
ccaattgagaagttcgtaacagatattgatgaacaaggcaaagacctactcctgaagtgc
ctaacctttaatccggccaaaagaatatctgcctacagtgccctgtctcacccctacttc
catgatctggagaggtgcaaggagaatctggattcccgtctgcctcccaaccagaacagc
tcagagatgaatacagcctga

Acinonyx jubatus (cheetah): 106975871

Entry

106975871 CDS T04657

Gene name

CDK4

Definition

(RefSeq) cyclin-dependent kinase 4 isoform X1

K02089

cyclin-dependent kinase 4 [EC:2.7.11.22]

Organism

aju Acinonyx jubatus (cheetah)

Pathway

aju01522

Endocrine resistance

aju04110

Cell cycle

aju04115

p53 signaling pathway

aju04151

PI3K-Akt signaling pathway

aju04218

Cellular senescence

aju04530

Tight junction

aju04660

T cell receptor signaling pathway

aju04933

AGE-RAGE signaling pathway in diabetic complications

aju04934

Cushing syndrome

aju05160

Hepatitis C

aju05162

Measles

aju05163

Human cytomegalovirus infection

aju05164

Influenza A

aju05165

Human papillomavirus infection

aju05166

Human T-cell leukemia virus 1 infection

aju05167

Kaposi sarcoma-associated herpesvirus infection

aju05169

Epstein-Barr virus infection

aju05200

Pathways in cancer

aju05203

Viral carcinogenesis

aju05212

Pancreatic cancer

aju05214

Glioma

aju05218

Melanoma

aju05219

Bladder cancer

aju05220

Chronic myeloid leukemia

aju05222

Small cell lung cancer

aju05223

Non-small cell lung cancer

aju05224

Breast cancer

aju05225

Hepatocellular carcinoma

Brite

KEGG Orthology (KO) [BR:aju00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    106975871 (CDK4)
09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    106975871 (CDK4)
   04115 p53 signaling pathway
    106975871 (CDK4)
   04218 Cellular senescence
    106975871 (CDK4)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    106975871 (CDK4)
09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    106975871 (CDK4)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    106975871 (CDK4)
   05203 Viral carcinogenesis
    106975871 (CDK4)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    106975871 (CDK4)
   05225 Hepatocellular carcinoma
    106975871 (CDK4)
   05214 Glioma
    106975871 (CDK4)
   05220 Chronic myeloid leukemia
    106975871 (CDK4)
   05218 Melanoma
    106975871 (CDK4)
   05219 Bladder cancer
    106975871 (CDK4)
   05224 Breast cancer
    106975871 (CDK4)
   05222 Small cell lung cancer
    106975871 (CDK4)
   05223 Non-small cell lung cancer
    106975871 (CDK4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    106975871 (CDK4)
   04934 Cushing syndrome
    106975871 (CDK4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    106975871 (CDK4)
   05160 Hepatitis C
    106975871 (CDK4)
   05164 Influenza A
    106975871 (CDK4)
   05162 Measles
    106975871 (CDK4)
   05163 Human cytomegalovirus infection
    106975871 (CDK4)
   05167 Kaposi sarcoma-associated herpesvirus infection
    106975871 (CDK4)
   05169 Epstein-Barr virus infection
    106975871 (CDK4)
   05165 Human papillomavirus infection
    106975871 (CDK4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    106975871 (CDK4)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:aju01001]
    106975871 (CDK4)
Enzymes [BR:aju01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     106975871 (CDK4)
Protein kinases [BR:aju01001]
Serine/threonine kinases: CMGC group
  CDK family
   106975871 (CDK4)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr APH Kdo Kinase-like

Other DBs

NCBI-GeneID:

106975871

NCBI-ProteinID:

XP_014928729

UniProt:

A0A6I9ZQG2

LinkDB

Position

Unknown

AA seq 307 aa
MATPRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGASGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATARTDRETKVTLVFEHVDQDLRTYLDKAPPPGLPVETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVSRKVV
TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED
DWPRDVSLPRGAFSPRGPRPVQSVVPELEESGAQLLLEMLTFNPHKRISAFRALQHSYLQ
KAEGNPE

NT seq 924 nt +upstreamnt +downstreamnt
atggctactcctcgatatgagccagtggccgagattggtgttggtgcttatggaaccgtg
tacaaggcccgtgatccccacagtggccactttgtggccctcaagagtgtgagagtccct
aacggaggaggtgctagcgggggccttcccatcagcacagttcgtgaggtggccttactg
aggcggctggaggcttttgaacatcccaatgttgtccggctgatggatgtctgtgccact
gcccgaactgaccgagagaccaaagtgaccctggtgtttgagcatgtggaccaagaccta
aggacatatctggacaaggcacccccaccaggcttgccagtggagactatcaaggatctg
atgcgccagtttctaagaggcctagatttcctccatgccaactgcattgttcatcgagat
ctgaagccagagaacattctggtgacaagtggtgggacagtcaagctggctgactttggc
ctggccagaatctacagctatcagatggcacttacacctgtggtcagtagaaaggttgtt
acactctggtaccgtgctccggaagttcttctgcagtctacgtacgcaacacctgtggac
atgtggagcgttggctgtatcttcgcagagatgtttcgtcgcaagcctctcttctgtgga
aactctgaagctgaccagttaggcaaaatctttgacctgatcgggctgcccccagaggat
gactggccccgagatgtgtctctgccccgaggagccttttcccccagaggaccccgtcca
gtgcagtcagtggtacctgagttggaggagtctggagcacagctgctgctggagatgctg
acttttaacccacacaagcgaatctctgccttccgagccctgcagcactcttatctacaa
aaggcagaaggtaacccagagtga

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