KEGG   Ailuropoda melanoleuca (giant panda): 100468916
Entry
100468916         CDS       T01329                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor-bound protein 2 isoform X1
  KO
K04364  growth factor receptor-bound protein 2
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
aml01521  EGFR tyrosine kinase inhibitor resistance
aml01522  Endocrine resistance
aml04010  MAPK signaling pathway
aml04012  ErbB signaling pathway
aml04014  Ras signaling pathway
aml04062  Chemokine signaling pathway
aml04068  FoxO signaling pathway
aml04072  Phospholipase D signaling pathway
aml04150  mTOR signaling pathway
aml04151  PI3K-Akt signaling pathway
aml04380  Osteoclast differentiation
aml04510  Focal adhesion
aml04540  Gap junction
aml04550  Signaling pathways regulating pluripotency of stem cells
aml04630  JAK-STAT signaling pathway
aml04650  Natural killer cell mediated cytotoxicity
aml04660  T cell receptor signaling pathway
aml04662  B cell receptor signaling pathway
aml04664  Fc epsilon RI signaling pathway
aml04714  Thermogenesis
aml04722  Neurotrophin signaling pathway
aml04910  Insulin signaling pathway
aml04912  GnRH signaling pathway
aml04915  Estrogen signaling pathway
aml04917  Prolactin signaling pathway
aml04926  Relaxin signaling pathway
aml04935  Growth hormone synthesis, secretion and action
aml05034  Alcoholism
aml05160  Hepatitis C
aml05161  Hepatitis B
aml05163  Human cytomegalovirus infection
aml05165  Human papillomavirus infection
aml05200  Pathways in cancer
aml05203  Viral carcinogenesis
aml05205  Proteoglycans in cancer
aml05206  MicroRNAs in cancer
aml05210  Colorectal cancer
aml05211  Renal cell carcinoma
aml05213  Endometrial cancer
aml05214  Glioma
aml05215  Prostate cancer
aml05220  Chronic myeloid leukemia
aml05221  Acute myeloid leukemia
aml05223  Non-small cell lung cancer
aml05224  Breast cancer
aml05225  Hepatocellular carcinoma
aml05226  Gastric cancer
aml05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:aml00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100468916 (GRB2)
   04012 ErbB signaling pathway
    100468916 (GRB2)
   04014 Ras signaling pathway
    100468916 (GRB2)
   04630 JAK-STAT signaling pathway
    100468916 (GRB2)
   04068 FoxO signaling pathway
    100468916 (GRB2)
   04072 Phospholipase D signaling pathway
    100468916 (GRB2)
   04151 PI3K-Akt signaling pathway
    100468916 (GRB2)
   04150 mTOR signaling pathway
    100468916 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100468916 (GRB2)
   04540 Gap junction
    100468916 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100468916 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100468916 (GRB2)
   04660 T cell receptor signaling pathway
    100468916 (GRB2)
   04662 B cell receptor signaling pathway
    100468916 (GRB2)
   04664 Fc epsilon RI signaling pathway
    100468916 (GRB2)
   04062 Chemokine signaling pathway
    100468916 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100468916 (GRB2)
   04912 GnRH signaling pathway
    100468916 (GRB2)
   04915 Estrogen signaling pathway
    100468916 (GRB2)
   04917 Prolactin signaling pathway
    100468916 (GRB2)
   04926 Relaxin signaling pathway
    100468916 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    100468916 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100468916 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100468916 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    100468916 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100468916 (GRB2)
   05206 MicroRNAs in cancer
    100468916 (GRB2)
   05205 Proteoglycans in cancer
    100468916 (GRB2)
   05203 Viral carcinogenesis
    100468916 (GRB2)
   05231 Choline metabolism in cancer
    100468916 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100468916 (GRB2)
   05225 Hepatocellular carcinoma
    100468916 (GRB2)
   05226 Gastric cancer
    100468916 (GRB2)
   05214 Glioma
    100468916 (GRB2)
   05221 Acute myeloid leukemia
    100468916 (GRB2)
   05220 Chronic myeloid leukemia
    100468916 (GRB2)
   05211 Renal cell carcinoma
    100468916 (GRB2)
   05215 Prostate cancer
    100468916 (GRB2)
   05213 Endometrial cancer
    100468916 (GRB2)
   05224 Breast cancer
    100468916 (GRB2)
   05223 Non-small cell lung cancer
    100468916 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    100468916 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100468916 (GRB2)
   05160 Hepatitis C
    100468916 (GRB2)
   05163 Human cytomegalovirus infection
    100468916 (GRB2)
   05165 Human papillomavirus infection
    100468916 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100468916 (GRB2)
   01522 Endocrine resistance
    100468916 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:aml04131]
    100468916 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:aml04990]
    100468916 (GRB2)
Membrane trafficking [BR:aml04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    100468916 (GRB2)
Domain-containing proteins not elsewhere classified [BR:aml04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   100468916 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 100468916
NCBI-ProteinID: XP_019655876
Ensembl: ENSAMEG00000009339
UniProt: D2HD44
LinkDB
Position
13
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagctactgctgacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaatgaagaatgtgatcagaactggtacaaggcagaa
ctcaatgggaaagatggcttcattcccaagaattatatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcatgac
ggggcctttcttatccgagagagtgagagtgcccctggggacttctccctctctgtcaag
tttggaaatgatgtacagcacttcaaggtgctccgagatggagctgggaagtatttcctc
tgggtggtgaaattcaattctctgaacgagctggtagattatcacaggtctacatccgtc
tccagaaaccagcagatattcctccgggacatagaacaggtgccacagcaaccaacgtac
gtccaggccctctttgactttgatccccaggaggatggagagctgggattccgtcgggga
gactttatccacgtcatggataactcagaccccaactggtggaaaggggcctgccacggg
cagaccggcatgtttccccgcaattacgtcacccccgtgaaccggaacgtctaa

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