KEGG   Ailuropoda melanoleuca (giant panda): 100471164
Entry
100471164         CDS       T01329                                 

Gene name
ADCY3
Definition
(RefSeq) adenylate cyclase type 3 isoform X2
  KO
K08043  adenylate cyclase 3 [EC:4.6.1.1]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
aml00230  Purine metabolism
aml01100  Metabolic pathways
aml01522  Endocrine resistance
aml04015  Rap1 signaling pathway
aml04020  Calcium signaling pathway
aml04022  cGMP-PKG signaling pathway
aml04024  cAMP signaling pathway
aml04062  Chemokine signaling pathway
aml04072  Phospholipase D signaling pathway
aml04114  Oocyte meiosis
aml04211  Longevity regulating pathway
aml04213  Longevity regulating pathway - multiple species
aml04261  Adrenergic signaling in cardiomyocytes
aml04270  Vascular smooth muscle contraction
aml04371  Apelin signaling pathway
aml04540  Gap junction
aml04611  Platelet activation
aml04713  Circadian entrainment
aml04714  Thermogenesis
aml04723  Retrograde endocannabinoid signaling
aml04724  Glutamatergic synapse
aml04725  Cholinergic synapse
aml04727  GABAergic synapse
aml04740  Olfactory transduction
aml04750  Inflammatory mediator regulation of TRP channels
aml04911  Insulin secretion
aml04912  GnRH signaling pathway
aml04913  Ovarian steroidogenesis
aml04914  Progesterone-mediated oocyte maturation
aml04915  Estrogen signaling pathway
aml04916  Melanogenesis
aml04918  Thyroid hormone synthesis
aml04921  Oxytocin signaling pathway
aml04923  Regulation of lipolysis in adipocytes
aml04925  Aldosterone synthesis and secretion
aml04926  Relaxin signaling pathway
aml04927  Cortisol synthesis and secretion
aml04928  Parathyroid hormone synthesis, secretion and action
aml04934  Cushing syndrome
aml04935  Growth hormone synthesis, secretion and action
aml04962  Vasopressin-regulated water reabsorption
aml04970  Salivary secretion
aml04971  Gastric acid secretion
aml04972  Pancreatic secretion
aml04976  Bile secretion
aml05032  Morphine addiction
aml05163  Human cytomegalovirus infection
aml05166  Human T-cell leukemia virus 1 infection
aml05200  Pathways in cancer
aml05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:aml00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    100471164 (ADCY3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    100471164 (ADCY3)
   04371 Apelin signaling pathway
    100471164 (ADCY3)
   04020 Calcium signaling pathway
    100471164 (ADCY3)
   04072 Phospholipase D signaling pathway
    100471164 (ADCY3)
   04024 cAMP signaling pathway
    100471164 (ADCY3)
   04022 cGMP-PKG signaling pathway
    100471164 (ADCY3)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    100471164 (ADCY3)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    100471164 (ADCY3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    100471164 (ADCY3)
   04062 Chemokine signaling pathway
    100471164 (ADCY3)
  09152 Endocrine system
   04911 Insulin secretion
    100471164 (ADCY3)
   04923 Regulation of lipolysis in adipocytes
    100471164 (ADCY3)
   04912 GnRH signaling pathway
    100471164 (ADCY3)
   04913 Ovarian steroidogenesis
    100471164 (ADCY3)
   04915 Estrogen signaling pathway
    100471164 (ADCY3)
   04914 Progesterone-mediated oocyte maturation
    100471164 (ADCY3)
   04921 Oxytocin signaling pathway
    100471164 (ADCY3)
   04926 Relaxin signaling pathway
    100471164 (ADCY3)
   04935 Growth hormone synthesis, secretion and action
    100471164 (ADCY3)
   04918 Thyroid hormone synthesis
    100471164 (ADCY3)
   04928 Parathyroid hormone synthesis, secretion and action
    100471164 (ADCY3)
   04916 Melanogenesis
    100471164 (ADCY3)
   04925 Aldosterone synthesis and secretion
    100471164 (ADCY3)
   04927 Cortisol synthesis and secretion
    100471164 (ADCY3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    100471164 (ADCY3)
   04270 Vascular smooth muscle contraction
    100471164 (ADCY3)
  09154 Digestive system
   04970 Salivary secretion
    100471164 (ADCY3)
   04971 Gastric acid secretion
    100471164 (ADCY3)
   04972 Pancreatic secretion
    100471164 (ADCY3)
   04976 Bile secretion
    100471164 (ADCY3)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    100471164 (ADCY3)
  09156 Nervous system
   04724 Glutamatergic synapse
    100471164 (ADCY3)
   04727 GABAergic synapse
    100471164 (ADCY3)
   04725 Cholinergic synapse
    100471164 (ADCY3)
   04723 Retrograde endocannabinoid signaling
    100471164 (ADCY3)
  09157 Sensory system
   04740 Olfactory transduction
    100471164 (ADCY3)
   04750 Inflammatory mediator regulation of TRP channels
    100471164 (ADCY3)
  09149 Aging
   04211 Longevity regulating pathway
    100471164 (ADCY3)
   04213 Longevity regulating pathway - multiple species
    100471164 (ADCY3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    100471164 (ADCY3)
   04714 Thermogenesis
    100471164 (ADCY3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100471164 (ADCY3)
  09165 Substance dependence
   05032 Morphine addiction
    100471164 (ADCY3)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    100471164 (ADCY3)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100471164 (ADCY3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100471164 (ADCY3)
   05163 Human cytomegalovirus infection
    100471164 (ADCY3)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    100471164 (ADCY3)
Enzymes [BR:aml01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     100471164 (ADCY3)
SSDB
Motif
Pfam: Guanylate_cyc AC_N HNOBA Peptidase_S49_N
Other DBs
NCBI-GeneID: 100471164
NCBI-ProteinID: XP_002913837
Ensembl: ENSAMEG00000002572
UniProt: D2GXP9
LinkDB
Position
4
AA seq 1145 aa
MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPE
SLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLAPLLVAGMGLLLDIL
LFVLCKKGLLPDRVTRKVVPYLLWLLITAQIFSYLGLNFARAHAASDTVGWQAFFVFSFF
ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDGLKGMHLLREILANVFLYLCAIVVG
IMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDES
QKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ
LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV
LGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTLDCLKGEFDVEPGDGGSRCE
YLEEKGIETYLIIASKPEVKKTATQHGLGGPALLNGAPASSKPSSPALIETKEPNGSIHT
GGSTSEEPEEQEAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESA
QVVKKRNTFLLSMRFMDPDMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTN
YMTFVVGEVLLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN
VVDMLSCLQYYTGPTNSTAGLEMEDGCVENPKYYNYVAVLSLIATIMLVQVSHMVKLTLM
LLVTGAVVVINIYAWRPIFDEYDRKRFQEHDFPAVALEKTQGFSTPGLNGTGRLPPVPSK
YSMTAMIFVMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEH
VARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDF
DSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEEKSDKERWQHLADLADF
ALAMKDTLTNINHQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGV
MGNIQVVEETQAILREYGFRFVRRGTIFVKGKGELLTFFLKGRDKPAAFPNGSSVTLPHQ
VVDNS
NT seq 3438 nt   +upstreamnt  +downstreamnt
atgcctaggaaccagggcttctctgagcctgagtactcggccgagtactccgccgagtac
tcggtcagcctgccctctgaccctgaccgcggggtgggccggacccatgaaatctcggtc
cggaactcgggatcctgcctctgcctgcctcggttcatgcggctgaccttcgtgcccgag
tccttggagaacctgtaccagacctacttcaaacggcagcgccacgagaccctgctggtg
ctggtggtgttcgcggcgctcttcgactgctatgtggtggtcatgtgtgcggtggtcttc
tccagcgacaagctggctcccctcctcgtggcggggatgggactgctgttggacatcctc
ctcttcgtactctgcaaaaaggggctgctcccggaccgggtcacgcggaaagtggtgccc
tacctgctgtggctgctgataactgcccagattttctcttacctgggcctgaactttgcc
cgagcccatgcggccagtgacacggtgggctggcaggccttctttgtcttctccttcttc
atcacgctgccgctcagcctcagccccatcgtcatcatctctgtggtctcctgcgtcgtg
cacacactcgtcttgggggtcaccgtggcccagcagcagcaggacgggctgaagggcatg
cacttgctgagggagatcctggcaaacgtcttcctctacctgtgcgccatcgtcgtgggc
atcatgtcctactacatggcggaccgcaagcaccgcaaggccttcctggaggcccgccag
tcgctggaggtgaagatgaatctggaggagcagagccagcagcaggagaaccttatgctc
tccatcctgcccaagcacgtggctgacgagatgctgaaggacatgaagaaggacgagagc
cagaaggaccagcagcagttcaacaccatgtacatgtaccggcacgagaacgtcagcatc
ctctttgcggacatcgtgggcttcacccagctgtcttctgcctgcagtgcccaggagctc
gtgaagctgctcaacgagctctttgcccgcttcgacaagctggcagctaaataccaccag
ctgcggattaagatcctaggcgactgttactactgcatctgcggcctgcccgactaccgg
gaggaccacgccgtctgctccatcctcatggggctcgccatggtggaggccatctcgtac
gtgcgggagaagacgaagactggggtggacatgcgcgtgggggtgcacacgggcaccgtg
ctggggggcgtcctgggccagaaacgctggcagtacgacgtgtggtctaccgacgtcact
gtggccaacaagatggaggccggaggcatccccgggcgtgtgcacatctcccagagcacc
ctggactgcctgaagggcgagttcgatgtggagccgggcgacgggggcagccgctgtgag
tacctggaggagaagggcatcgagacctacctcattatcgcgtccaagccagaggtgaag
aaaacagccacccagcacggcctcggtggcccggccctgctgaacggagccccggcttcc
tccaagcccagctcgcccgccctcatcgagaccaaggagcccaacgggagcatccacacc
ggcggctccacgtcggaggagcccgaggagcaggaggcccaggccgacaacccctcgttc
cccaacccgcgccggaggctgcgccttcaggacctggctgaccgagtggtggacgcctcc
gaggacgagcacgagctcaaccagctactcaacgaggccctgctggagcgagagtccgcc
caggtggtgaagaagagaaacaccttcctcctttccatgcggttcatggaccccgacatg
gaaacccgctactcagtggagaaggaaaagcagagcggggctgccttcagctgctcctgt
gtcgtcctgctctgtacggccctggtcgagatactcatcgacccctggctaatgacaaac
tacatgacctttgtggttggggaggttctgcttctgatcctgacaatctgctcgctggcc
gccatctttccccgggcctttcctaagaagctcgtggccttctccacttggattgaccgg
acccgctgggccaggaacacctgggccatgttagccatcttcattctggttatggcaaat
gtcgtggacatgctcagctgtctccagtactacacaggcccgaccaacagcaccgcaggg
ctggagatggaggacggctgcgttgagaaccccaagtattacaactatgtggccgtgctg
tccctcatcgccaccatcatgctggtgcaggtcagccacatggtgaagctcacactcatg
ctgctcgtcacgggggccgtggtcgtcatcaacatctatgcctggcgccccatctttgat
gaatatgaccgcaaacgttttcaggaacatgacttccctgcagtcgccttagagaagacg
cagggattttccacccctgggctcaatggcactggcaggctgcccccggtgccttctaag
tactccatgaccgcgatgatcttcgtcatgatgctgagcttctactacttctcgcgccac
gtggaaaaattggcaaggacactgttcttgtggaagattgaggtccacgaccagaaggaa
cgggtctacgagatgcggcgctggaatgaggcattggtcaccaacatgttgcctgagcac
gtggcacgccatttcttggggtccaagaagagagatgaggagctgtacagccagtcttac
gatgagatcggagtcatgtttgcctccctgcccaactttgccgacttctacacggaggag
agcatcaacaatggtggcattgagtgtctgcgcttcctcaacgagatcatctcagatttt
gattctctcctggacaatcccaagttccgggtcatcaccaagatcaaaaccattggcagc
acctacatggccgcttccggagtcaccccggatgtcaacaccaacggctttgccagctcc
aacaaggaggagaagtcagacaaggagcgctggcagcacctggctgacctggccgacttc
gctctggccatgaaggatacgctcacgaacatcaaccaccagtccttcaacaacttcatg
ctgcgcatcggcatgaacaaaggaggggtcctcgctggggtcattggagcccggaaacca
cactatgacatctggggcaacacagtcaatgtggccagcaggatggagtccacaggggtc
atgggcaacattcaggtggtggaagaaacacaagccatccttcgagagtacggcttccgc
tttgtgaggcgagggacaatctttgtgaaagggaaaggggagctgctaacctttttctta
aaggggcgtgataagccagctgccttcccgaatggctcctcggtcaccctgccccaccag
gtggtggacaactcctga

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