KEGG   Ailuropoda melanoleuca (giant panda): 100472811
Entry
100472811         CDS       T01329                                 
Symbol
PAK1
Name
(RefSeq) serine/threonine-protein kinase PAK 1
  KO
K04409  p21-activated kinase 1 [EC:2.7.11.1]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
aml04010  MAPK signaling pathway
aml04012  ErbB signaling pathway
aml04014  Ras signaling pathway
aml04024  cAMP signaling pathway
aml04062  Chemokine signaling pathway
aml04360  Axon guidance
aml04392  Hippo signaling pathway - multiple species
aml04510  Focal adhesion
aml04625  C-type lectin receptor signaling pathway
aml04650  Natural killer cell mediated cytotoxicity
aml04660  T cell receptor signaling pathway
aml04666  Fc gamma R-mediated phagocytosis
aml04810  Regulation of actin cytoskeleton
aml05132  Salmonella infection
aml05170  Human immunodeficiency virus 1 infection
aml05205  Proteoglycans in cancer
aml05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:aml00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100472811 (PAK1)
   04012 ErbB signaling pathway
    100472811 (PAK1)
   04014 Ras signaling pathway
    100472811 (PAK1)
   04392 Hippo signaling pathway - multiple species
    100472811 (PAK1)
   04024 cAMP signaling pathway
    100472811 (PAK1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100472811 (PAK1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100472811 (PAK1)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    100472811 (PAK1)
   04650 Natural killer cell mediated cytotoxicity
    100472811 (PAK1)
   04660 T cell receptor signaling pathway
    100472811 (PAK1)
   04666 Fc gamma R-mediated phagocytosis
    100472811 (PAK1)
   04062 Chemokine signaling pathway
    100472811 (PAK1)
  09158 Development and regeneration
   04360 Axon guidance
    100472811 (PAK1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    100472811 (PAK1)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    100472811 (PAK1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100472811 (PAK1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100472811 (PAK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:aml01001]
    100472811 (PAK1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:aml04131]
    100472811 (PAK1)
   03036 Chromosome and associated proteins [BR:aml03036]
    100472811 (PAK1)
Enzymes [BR:aml01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100472811 (PAK1)
Protein kinases [BR:aml01001]
 Serine/threonine kinases: STE group
  STE20 family
   100472811 (PAK1)
Membrane trafficking [BR:aml04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    100472811 (PAK1)
 Endocytosis
  Macropinocytosis
   Kinases
    100472811 (PAK1)
Chromosome and associated proteins [BR:aml03036]
 Eukaryotic type
  Sister chromatid separation proteins
   Aurora kinases
    Regulators of Aurora kinases
     100472811 (PAK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PBD ABC1 Kinase-like Pkinase_fungal APH DSHCT Kdo YrbL-PhoP_reg
Other DBs
NCBI-GeneID: 100472811
NCBI-ProteinID: XP_002929110
Ensembl: ENSAMEG00000005584
UniProt: G1LGB3
LinkDB
Position
8:51692073..51839127
AA seq 544 aa
MSNNGLDIQDKPPAPPMRNTSTMIGAGSKDAGTLNHGSKPLPPNPEEKKKKDRFYRSILP
GDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKN
PQAVLDVLEFYNSKKTSNSQKYMSFTDKSAEDYNSSNTLNVKTVSETPAVPPVSEDEDDD
DDATPPPVIAPRPEHTKSVYTRSVIEPLPVTPTRDAATSPISPTENNTPPPDALTRSTEK
QKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQM
NLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCM
DEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR
STMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT
PELQNPEKLSAFFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEAT
KNNH
NT seq 1635 nt   +upstreamnt  +downstreamnt
atgtcaaataacggcctagacattcaagacaaacccccagcccctccgatgagaaacacc
agcactatgattggagccggcagcaaagatgctggaaccctaaaccacggttccaaacct
ctgcctccaaacccagaggagaagaaaaagaaggaccgattttacagatccatcttacct
ggagataaaacaaataaaaagaaggagaaagaacggccagagatctctcttccttcagat
tttgagcacacgattcatgttggttttgatgctgtcacaggggagtttacagggatgcca
gagcagtgggctcgcctgcttcagacatcaaatatcactaagtcagagcagaagaaaaac
ccacaggctgttctggatgtattggaattttataactcaaagaagacctccaacagccag
aagtacatgagctttacagataaatcagctgaggattataattcttctaacactttgaat
gtgaagacggtgtctgagacccctgctgtgccacccgtttcagaagacgaagatgatgat
gatgatgctaccccccctccagtgattgctccacgcccagagcacacaaagtctgtatac
acacggtctgtgatagaacctcttcctgttactccaactcgggatgcagctacgtctcct
atctcacctacggagaataatacccctccaccagatgctctgacccggagtaccgagaag
cagaagaagaagcccaaaatgtctgatgaggagatcttagagaaattacggagcatagtg
agtgtgggcgatcctaagaagaaatatacacggtttgagaagattggacaaggtgcttca
ggcactgtgtacactgcaatggatgtggccacaggacaggaggtggccattaagcagatg
aacctgcagcagcagccgaagaaagagctgattattaatgagatcctggtcatgagggaa
aacaagaacccaaatattgtgaactacttggacagttacctcgtgggagatgagctgtgg
gttgtcatggaatacttggctggaggttctttgacagatgtggtgacagaaacttgcatg
gatgaaggccagattgcagctgtctgccgtgagtgcctgcaggctttggagtttctgcat
tcgaaccaggtcattcacagagacatcaagagcgacaacatcctgttgggaatggatggc
tctgtcaagctaaccgattttggattctgtgcccagatcaccccagagcagagcaaacgg
agcaccatggtgggaactccatactggatggccccagaggttgtgacgcggaaggcctat
ggacccaaggttgacatctggtccctgggtatcatggccatcgaaatgattgaaggagag
cccccatacctcaatgaaaatcctctgagagctttgtacctcattgccaccaatgggacc
ccagagcttcagaacccagagaagctgtcagctttcttccgggactttctgaaccgctgt
cttgagatggatgtggagaagagaggttcagctaaagagctgctgcagcatcagttcctg
aagattgccaagcccctctccagcctcactccactgattgctgcagcaaaggaggcaacc
aagaacaatcactaa

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