KEGG   Ailuropoda melanoleuca (giant panda): 100472842
Entry
100472842         CDS       T01329                                 

Gene name
CASP8
Definition
(RefSeq) caspase-8 isoform X1
  KO
K04398  caspase 8 [EC:3.4.22.61]
Organism
aml  Ailuropoda melanoleuca (giant panda)
Pathway
aml01524  Platinum drug resistance
aml04115  p53 signaling pathway
aml04210  Apoptosis
aml04215  Apoptosis - multiple species
aml04217  Necroptosis
aml04620  Toll-like receptor signaling pathway
aml04621  NOD-like receptor signaling pathway
aml04622  RIG-I-like receptor signaling pathway
aml04625  C-type lectin receptor signaling pathway
aml04657  IL-17 signaling pathway
aml04668  TNF signaling pathway
aml04932  Non-alcoholic fatty liver disease
aml05010  Alzheimer disease
aml05016  Huntington disease
aml05022  Pathways of neurodegeneration - multiple diseases
aml05132  Salmonella infection
aml05134  Legionellosis
aml05142  Chagas disease
aml05145  Toxoplasmosis
aml05152  Tuberculosis
aml05160  Hepatitis C
aml05161  Hepatitis B
aml05162  Measles
aml05163  Human cytomegalovirus infection
aml05164  Influenza A
aml05165  Human papillomavirus infection
aml05167  Kaposi sarcoma-associated herpesvirus infection
aml05168  Herpes simplex virus 1 infection
aml05169  Epstein-Barr virus infection
aml05170  Human immunodeficiency virus 1 infection
aml05200  Pathways in cancer
aml05203  Viral carcinogenesis
aml05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:aml00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    100472842 (CASP8)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    100472842 (CASP8)
   04215 Apoptosis - multiple species
    100472842 (CASP8)
   04217 Necroptosis
    100472842 (CASP8)
   04115 p53 signaling pathway
    100472842 (CASP8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100472842 (CASP8)
   04621 NOD-like receptor signaling pathway
    100472842 (CASP8)
   04622 RIG-I-like receptor signaling pathway
    100472842 (CASP8)
   04625 C-type lectin receptor signaling pathway
    100472842 (CASP8)
   04657 IL-17 signaling pathway
    100472842 (CASP8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100472842 (CASP8)
   05203 Viral carcinogenesis
    100472842 (CASP8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100472842 (CASP8)
   05016 Huntington disease
    100472842 (CASP8)
   05022 Pathways of neurodegeneration - multiple diseases
    100472842 (CASP8)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    100472842 (CASP8)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    100472842 (CASP8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100472842 (CASP8)
   05134 Legionellosis
    100472842 (CASP8)
   05152 Tuberculosis
    100472842 (CASP8)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100472842 (CASP8)
   05161 Hepatitis B
    100472842 (CASP8)
   05160 Hepatitis C
    100472842 (CASP8)
   05164 Influenza A
    100472842 (CASP8)
   05162 Measles
    100472842 (CASP8)
   05168 Herpes simplex virus 1 infection
    100472842 (CASP8)
   05163 Human cytomegalovirus infection
    100472842 (CASP8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100472842 (CASP8)
   05169 Epstein-Barr virus infection
    100472842 (CASP8)
   05165 Human papillomavirus infection
    100472842 (CASP8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100472842 (CASP8)
   05142 Chagas disease
    100472842 (CASP8)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    100472842 (CASP8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:aml01002]
    100472842 (CASP8)
Enzymes [BR:aml01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.61  caspase-8
     100472842 (CASP8)
Peptidases and inhibitors [BR:aml01002]
 Cysteine peptidases
  Family C14: caspase family
   100472842 (CASP8)
SSDB
Motif
Pfam: Peptidase_C14 DED
Other DBs
NCBI-GeneID: 100472842
NCBI-ProteinID: XP_002915893
Ensembl: ENSAMEG00000006066
UniProt: G1LHK8
LinkDB
Position
Unknown
AA seq 486 aa
MNFSKCLYNIGEQLDSDELASLKFLSMDYIPQKKQEPIKDPLMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLVTYLDTSKEEMEQELQIPGRAQISAYRVMLFQISEDVSKLELRSF
KFFLSQEISRCKLHDDLNLFDIFIEMEKRVILGERNLDTLKRICDQINKSLLKKITDYEE
LSREQTLSPQRSLDEISNDMSQLLVGEESLRVLPMSDSPGEQDCEPETSDKVYRMESKPR
GYCLIFNNYDFSIARKEVPKLQSIKDRNGTDLDADALCQTFSELHFEIVPFKDCTAKKIC
EVLKSYQCMDHSSRDCFICCILSHGDKGIIYGSDGQEVPIYELTSYFTGSKCPSLAGKPK
IFFIQACQGDNYQKGIAVETDSEQKEAYLEMDSSYQKRYIPEDADFLLGMATVNNCVSYR
NPMEGTWYIQSLCQSLRERCPRGEDILTILTEVNFEVSNKDDRKNMGKQMPQPTFTLRKK
LFFPLN
NT seq 1461 nt   +upstreamnt  +downstreamnt
atgaatttcagcaaatgcctctataatattggagaacagctggacagtgatgagctggcc
tccctcaagttcctgagcatggactacatcccacagaagaagcaggaacccatcaaggat
cccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaacctgtcc
ttcttgaaggagctgcttttccgaattaatagactggacctgctggttacctacctggac
accagcaaggaggagatggagcaggagcttcaaataccaggcagagcccagatctctgcc
tacagggtcatgctttttcagatttcagaagatgtaagcaaattggaattgaggtccttt
aagttttttttgagccaggagatctccagatgtaaactgcatgatgacttgaacttgttt
gatattttcatagagatggagaagagggtcatcctcggggaaagaaatttggataccctg
aaaagaatctgtgaccaaattaacaagagcctgctgaagaaaatcacggattatgaagaa
ttaagcagagagcaaacactgagccctcaaagaagtctagatgaaatttcaaatgatatg
tctcagttgcttgtaggggaggaatccctgagggtactgccaatgtcggactctccagga
gaacaggactgtgaaccagagacatcggacaaagtttaccgaatggaaagcaaacctcga
ggatattgtttgatctttaacaattacgactttagcatagcacggaaggaagtgcccaaa
cttcagagcattaaggataggaatgggacagacttggatgcagatgctttgtgtcagacc
tttagtgagcttcattttgagatcgtgcctttcaaagactgtacagccaagaaaatctgt
gaggttctgaaatcctaccaatgcatggaccactctagcagggattgctttatctgctgc
atcctctcccatggagacaagggcatcatctatggctctgatgggcaagaagtccccatc
tatgagctgacttcttacttcactggttcaaagtgcccttcccttgcaggcaagcccaaa
atcttttttattcaggcttgtcaaggggataactaccagaaaggtatagctgttgagact
gactctgaacagaaggaagcctatttagaaatggactcatcctatcagaagagatatatc
ccagaagacgctgactttctgctggggatggccactgtgaataattgtgtttcctaccga
aaccccatggaaggaacctggtatatccagtcactttgccagagcctgagagaaagatgt
cctaggggcgaagatattctcaccatccttaccgaggtgaactttgaagtgagcaataag
gatgacaggaaaaacatggggaaacaaatgccacaacctactttcacactgaggaaaaaa
ctctttttccctcttaattga

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