KEGG   Bubalus bubalis (water buffalo): 102394713
Entry
102394713         CDS       T05912                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor-bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
bbub  Bubalus bubalis (water buffalo)
Pathway
bbub01521  EGFR tyrosine kinase inhibitor resistance
bbub01522  Endocrine resistance
bbub04010  MAPK signaling pathway
bbub04012  ErbB signaling pathway
bbub04014  Ras signaling pathway
bbub04062  Chemokine signaling pathway
bbub04068  FoxO signaling pathway
bbub04072  Phospholipase D signaling pathway
bbub04150  mTOR signaling pathway
bbub04151  PI3K-Akt signaling pathway
bbub04380  Osteoclast differentiation
bbub04510  Focal adhesion
bbub04540  Gap junction
bbub04550  Signaling pathways regulating pluripotency of stem cells
bbub04630  JAK-STAT signaling pathway
bbub04650  Natural killer cell mediated cytotoxicity
bbub04660  T cell receptor signaling pathway
bbub04662  B cell receptor signaling pathway
bbub04664  Fc epsilon RI signaling pathway
bbub04714  Thermogenesis
bbub04722  Neurotrophin signaling pathway
bbub04910  Insulin signaling pathway
bbub04912  GnRH signaling pathway
bbub04915  Estrogen signaling pathway
bbub04917  Prolactin signaling pathway
bbub04926  Relaxin signaling pathway
bbub04935  Growth hormone synthesis, secretion and action
bbub05034  Alcoholism
bbub05160  Hepatitis C
bbub05161  Hepatitis B
bbub05163  Human cytomegalovirus infection
bbub05165  Human papillomavirus infection
bbub05200  Pathways in cancer
bbub05203  Viral carcinogenesis
bbub05205  Proteoglycans in cancer
bbub05206  MicroRNAs in cancer
bbub05210  Colorectal cancer
bbub05211  Renal cell carcinoma
bbub05213  Endometrial cancer
bbub05214  Glioma
bbub05215  Prostate cancer
bbub05220  Chronic myeloid leukemia
bbub05221  Acute myeloid leukemia
bbub05223  Non-small cell lung cancer
bbub05224  Breast cancer
bbub05225  Hepatocellular carcinoma
bbub05226  Gastric cancer
bbub05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:bbub00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102394713 (GRB2)
   04012 ErbB signaling pathway
    102394713 (GRB2)
   04014 Ras signaling pathway
    102394713 (GRB2)
   04630 JAK-STAT signaling pathway
    102394713 (GRB2)
   04068 FoxO signaling pathway
    102394713 (GRB2)
   04072 Phospholipase D signaling pathway
    102394713 (GRB2)
   04151 PI3K-Akt signaling pathway
    102394713 (GRB2)
   04150 mTOR signaling pathway
    102394713 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102394713 (GRB2)
   04540 Gap junction
    102394713 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    102394713 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    102394713 (GRB2)
   04660 T cell receptor signaling pathway
    102394713 (GRB2)
   04662 B cell receptor signaling pathway
    102394713 (GRB2)
   04664 Fc epsilon RI signaling pathway
    102394713 (GRB2)
   04062 Chemokine signaling pathway
    102394713 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102394713 (GRB2)
   04912 GnRH signaling pathway
    102394713 (GRB2)
   04915 Estrogen signaling pathway
    102394713 (GRB2)
   04917 Prolactin signaling pathway
    102394713 (GRB2)
   04926 Relaxin signaling pathway
    102394713 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    102394713 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    102394713 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102394713 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    102394713 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102394713 (GRB2)
   05206 MicroRNAs in cancer
    102394713 (GRB2)
   05205 Proteoglycans in cancer
    102394713 (GRB2)
   05203 Viral carcinogenesis
    102394713 (GRB2)
   05231 Choline metabolism in cancer
    102394713 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102394713 (GRB2)
   05225 Hepatocellular carcinoma
    102394713 (GRB2)
   05226 Gastric cancer
    102394713 (GRB2)
   05214 Glioma
    102394713 (GRB2)
   05221 Acute myeloid leukemia
    102394713 (GRB2)
   05220 Chronic myeloid leukemia
    102394713 (GRB2)
   05211 Renal cell carcinoma
    102394713 (GRB2)
   05215 Prostate cancer
    102394713 (GRB2)
   05213 Endometrial cancer
    102394713 (GRB2)
   05224 Breast cancer
    102394713 (GRB2)
   05223 Non-small cell lung cancer
    102394713 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    102394713 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    102394713 (GRB2)
   05160 Hepatitis C
    102394713 (GRB2)
   05163 Human cytomegalovirus infection
    102394713 (GRB2)
   05165 Human papillomavirus infection
    102394713 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102394713 (GRB2)
   01522 Endocrine resistance
    102394713 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bbub04131]
    102394713 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:bbub04990]
    102394713 (GRB2)
Membrane trafficking [BR:bbub04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    102394713 (GRB2)
Domain-containing proteins not elsewhere classified [BR:bbub04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   102394713 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 102394713
NCBI-ProteinID: XP_006045307
LinkDB
Position
3
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagccaccgcagacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaatgaggaatgtgatcagaactggtacaaggcagag
ctcaatgggaaagacggcttcatccccaagaactacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgctcagcaaacagcggcatgac
ggggcctttcttatccgagagagcgagagtgctcctggggatttctccctctccgtcaag
tttggaaatgatgtacagcacttcaaggtgctccgagatggggctggaaagtatttcctc
tgggtggtcaagttcaactctttgaatgagctggtagattatcacagatctacatccgtc
tccagaaaccagcagatatttctccgggacatagagcaggtgccacagcagccgacatac
gtccaagccctctttgactttgacccccaagaggatggagagctgggattccgtcgggga
gactttatccacgtcatggataactcagaccccaactggtggaaaggggcctgccacggg
cagaccggcatgttcccacgcaattacgtcacccccgtgaaccggaacgtctaa

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