Bubalus bubalis (water buffalo): 102401079
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Entry
102401079 CDS
T05912
Gene name
BRAF
Definition
(RefSeq) serine/threonine-protein kinase B-raf isoform X4
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
bbub
Bubalus bubalis (water buffalo)
Pathway
bbub01521
EGFR tyrosine kinase inhibitor resistance
bbub01522
Endocrine resistance
bbub04010
MAPK signaling pathway
bbub04012
ErbB signaling pathway
bbub04015
Rap1 signaling pathway
bbub04024
cAMP signaling pathway
bbub04062
Chemokine signaling pathway
bbub04068
FoxO signaling pathway
bbub04150
mTOR signaling pathway
bbub04270
Vascular smooth muscle contraction
bbub04510
Focal adhesion
bbub04650
Natural killer cell mediated cytotoxicity
bbub04720
Long-term potentiation
bbub04722
Neurotrophin signaling pathway
bbub04726
Serotonergic synapse
bbub04730
Long-term depression
bbub04810
Regulation of actin cytoskeleton
bbub04910
Insulin signaling pathway
bbub04914
Progesterone-mediated oocyte maturation
bbub04928
Parathyroid hormone synthesis, secretion and action
bbub04934
Cushing syndrome
bbub05010
Alzheimer disease
bbub05022
Pathways of neurodegeneration - multiple diseases
bbub05034
Alcoholism
bbub05160
Hepatitis C
bbub05161
Hepatitis B
bbub05200
Pathways in cancer
bbub05205
Proteoglycans in cancer
bbub05210
Colorectal cancer
bbub05211
Renal cell carcinoma
bbub05212
Pancreatic cancer
bbub05213
Endometrial cancer
bbub05214
Glioma
bbub05215
Prostate cancer
bbub05216
Thyroid cancer
bbub05218
Melanoma
bbub05219
Bladder cancer
bbub05220
Chronic myeloid leukemia
bbub05221
Acute myeloid leukemia
bbub05223
Non-small cell lung cancer
bbub05224
Breast cancer
bbub05225
Hepatocellular carcinoma
bbub05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
bbub00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
102401079 (BRAF)
04012 ErbB signaling pathway
102401079 (BRAF)
04015 Rap1 signaling pathway
102401079 (BRAF)
04068 FoxO signaling pathway
102401079 (BRAF)
04024 cAMP signaling pathway
102401079 (BRAF)
04150 mTOR signaling pathway
102401079 (BRAF)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
102401079 (BRAF)
09142 Cell motility
04810 Regulation of actin cytoskeleton
102401079 (BRAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
102401079 (BRAF)
04062 Chemokine signaling pathway
102401079 (BRAF)
09152 Endocrine system
04910 Insulin signaling pathway
102401079 (BRAF)
04914 Progesterone-mediated oocyte maturation
102401079 (BRAF)
04928 Parathyroid hormone synthesis, secretion and action
102401079 (BRAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
102401079 (BRAF)
09156 Nervous system
04726 Serotonergic synapse
102401079 (BRAF)
04720 Long-term potentiation
102401079 (BRAF)
04730 Long-term depression
102401079 (BRAF)
04722 Neurotrophin signaling pathway
102401079 (BRAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
102401079 (BRAF)
05205 Proteoglycans in cancer
102401079 (BRAF)
09162 Cancer: specific types
05210 Colorectal cancer
102401079 (BRAF)
05212 Pancreatic cancer
102401079 (BRAF)
05225 Hepatocellular carcinoma
102401079 (BRAF)
05226 Gastric cancer
102401079 (BRAF)
05214 Glioma
102401079 (BRAF)
05216 Thyroid cancer
102401079 (BRAF)
05221 Acute myeloid leukemia
102401079 (BRAF)
05220 Chronic myeloid leukemia
102401079 (BRAF)
05218 Melanoma
102401079 (BRAF)
05211 Renal cell carcinoma
102401079 (BRAF)
05219 Bladder cancer
102401079 (BRAF)
05215 Prostate cancer
102401079 (BRAF)
05213 Endometrial cancer
102401079 (BRAF)
05224 Breast cancer
102401079 (BRAF)
05223 Non-small cell lung cancer
102401079 (BRAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
102401079 (BRAF)
05022 Pathways of neurodegeneration - multiple diseases
102401079 (BRAF)
09165 Substance dependence
05034 Alcoholism
102401079 (BRAF)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
102401079 (BRAF)
09172 Infectious disease: viral
05161 Hepatitis B
102401079 (BRAF)
05160 Hepatitis C
102401079 (BRAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
102401079 (BRAF)
01522 Endocrine resistance
102401079 (BRAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
bbub01001
]
102401079 (BRAF)
Enzymes [BR:
bbub01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
102401079 (BRAF)
Protein kinases [BR:
bbub01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
102401079 (BRAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
C1_2
Pkinase_fungal
APH
Kdo
Motif
Other DBs
NCBI-GeneID:
102401079
NCBI-ProteinID:
XP_006078854
LinkDB
All DBs
Position
8
AA seq
765 aa
AA seq
DB search
MAALSGGGGGGGGAEQGQALFNGDMEPEAGAAASSAADPAIPEEVWNIKQMIKLTQEHIE
ALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASTDTVTS
SSSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLK
KALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTF
FTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQ
EEASLAETTLPCGSSPSAPPSDSIGPPILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDR
SSSAPNVHINTIEPVNIDDLIRDQGFRSDGGSTTGLSATPPASLPGSLSNVKALQKSPGP
QRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAV
KMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLH
IIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKS
RWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNR
DQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP
KIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
NT seq
2298 nt
NT seq
+upstream
nt +downstream
nt
atggcggcgctgagcggcggtggcggcggcggcggcggcgcggagcagggccaggctctg
ttcaatggggacatggagcccgaggccggcgccgcggcctcttcggctgcggaccccgcc
attcccgaggaggtgtggaatatcaaacaaatgattaagttgacacaggaacatatagag
gccctattggacaaatttggtggggagcataatccaccatcaatatatctggaggcctat
gaagaatacaccagcaagctagatgccctccaacaaagagaacaacagttattggaatcc
ctggggaatggaactgatttttctgtttctagctctgcatcaacggacaccgttacatct
tcttcctcttctagcctttcagtgctgccttcatctctttcagtttttcaaaatcccaca
gatgtgtcacggagcaaccccaagtcaccacaaaaacctatcgttagagtcttcctgccc
aataaacagaggacagtggtacctgcacggtgtggagtcacagtccgggacagcctgaag
aaggcactgatgatgagaggtctaatcccagagtgctgtgctgtttacagaattcaggat
ggggagaagaaaccaattggctgggacactgatatttcctggcttactggagaggagttg
catgtagaagtgttggagaatgttccacttacaacacacaactttgtacggaaaactttt
ttcaccttagcattttgtgacttctgtagaaagctgcttttccaggggttccgctgtcaa
acatgtggttataaatttcaccagcgttgtagtacagaggttccactgatgtgtgttaat
tatgaccaactagatttgctgtttgtctccaagttctttgaacaccacccaataccacag
gaggaggcctccttagcagagactacccttccatgtggctcatctccttctgcacccccc
tccgattctattgggcccccaattctcaccagtccatctccttcaaaatccattccaatt
ccacagcctttccgaccagcagatgaagatcatcgaaatcagtttggacaacgagaccgg
tcctcatcagctccaaatgtgcatataaacacaatagaacccgtcaatattgatgacttg
attagagaccaagggtttcgtagtgatggaggatcaaccacaggtttatccgccacaccc
cctgcctcattacctggctcactctctaatgtgaaagcattgcagaaatctccaggacct
cagcgagaaagaaagtcctcttcatcctcagaagataggaatcgaatgaaaacgcttggt
agacgggattcaagtgacgattgggagattcctgatggacagatcacagtgggacaaaga
attggatcagggtcatttgggacggtctacaagggaaagtggcatggtgatgtggcagtg
aaaatgttgaatgtgacagcacccacacctcagcagttacaggccttcaaaaatgaagta
ggagtactcaggaaaacgcgacatgtgaatatcctcctcttcatgggttattcaacaaag
ccacaactggctattgttacccagtggtgtgagggctccagtttatatcatcatctccac
atcattgagaccaaattcgagatgatcaaacttatagatattgcacggcagactgcacag
ggcatggattacttacacgccaagtcaatcatccacagagacctcaagagtaataatatt
tttcttcatgaagacctcacagtaaaaataggtgattttggtctagccacagtgaaatct
cgatggagtgggtcccatcagtttgaacagttgtctggatccattttgtggatggcacca
gaagtaatcagaatgcaagataaaaacccatatagctttcagtcagatgtatatgcattt
gggattgttctgtatgaattgatgaccggacagttaccttattcaaatatcaacaacagg
gaccagataatttttatggtgggacgaggatatctgtctccagatctcagtaaggtacgg
agtaactgtccaaaagccatgaagagattaatggcagagtgcctaaaaaagaaaagagat
gaaagaccactctttccccaaattctcgcctctattgagctgctggcccgctcattgcca
aaaattcaccgcagtgcatcagaaccctccttgaatcgggctggcttccaaacagaggat
tttagtctatatgcttgtgcttctccaaaaacacccattcaggcagggggatatggagaa
tttgcagccttcaagtag
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