KEGG   PATHWAY: bcig03030
bcig03030                   Pathway                                

DNA replication - Candidatus Baumannia cicadellinicola B-GSS
A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA.
Genetic Information Processing; Replication and repair
Pathway map
bcig03030  DNA replication

Candidatus Baumannia cicadellinicola B-GSS [GN:bcig]
AB162_421  dnaQ; DNA polymerase III epsilon subunit [KO:K02342] [EC:]
AB162_487  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:]
AB162_093  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:]
AB162_379  holB; DNA polymerase III delta prime subunit [KO:K02341] [EC:]
AB162_195  holA; DNA polymerase III delta subunit [KO:K02340] [EC:]
AB162_570  holD; DNA polymerase III psi subunit [KO:K02344] [EC:]
AB162_233  holC; DNA polymerase III chi subunit [KO:K02339] [EC:]
AB162_110  dnaN; DNA polymerase III beta subunit [KO:K02338] [EC:]
AB162_497  dnaB; Replicative DNA helicase [KO:K02314] [EC:]
AB162_560  dnaG; DNA primase [KO:K02316] [EC:]
AB162_086  ssB; Single-stranded DNA-binding protein [KO:K03111]
AB162_422  rnhA; Ribonuclease HI [KO:K03469] [EC:]
AB162_092  polA; DNA polymerase I [KO:K02335] [EC:]
AB162_048  ligA; DNA ligase [KO:K01972] [EC:]
Stillman B.
Smart machines at the DNA replication fork.
Cell 78:725-8 (1994)
Waga S, Stillman B.
The DNA replication fork in eukaryotic cells.
Annu Rev Biochem 67:721-51 (1998)
KO pathway

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