KEGG   PATHWAY: bcig03430
bcig03430                   Pathway                                

Mismatch repair - Candidatus Baumannia cicadellinicola B-GSS
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Genetic Information Processing; Replication and repair
Pathway map
bcig03430  Mismatch repair

Other DBs
GO: 0006298
Candidatus Baumannia cicadellinicola B-GSS [GN:bcig]
AB162_182  mutS; DNA mismatch repair protein MutS [KO:K03555]
AB162_529  mutL; DNA mismatch repair protein [KO:K03572]
AB162_489  mutH; DNA mismatch repair endonuclease [KO:K03573]
AB162_105  uvrD; ATP-dependent DNA helicase UvrD/PcrA [KO:K03657] [EC:]
AB162_129  recJ; Single-stranded-DNA-specific exonuclease RecJ [KO:K07462] [EC:3.1.-.-]
AB162_086  ssB; Single-stranded DNA-binding protein [KO:K03111]
AB162_487  dnaE; DNA polymerase III alpha subunit [KO:K02337] [EC:]
AB162_110  dnaN; DNA polymerase III beta subunit [KO:K02338] [EC:]
AB162_093  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:]
AB162_195  holA; DNA polymerase III delta subunit [KO:K02340] [EC:]
AB162_379  holB; DNA polymerase III delta prime subunit [KO:K02341] [EC:]
AB162_421  dnaQ; DNA polymerase III epsilon subunit [KO:K02342] [EC:]
AB162_233  holC; DNA polymerase III chi subunit [KO:K02339] [EC:]
AB162_570  holD; DNA polymerase III psi subunit [KO:K02344] [EC:]
AB162_048  ligA; DNA ligase [KO:K01972] [EC:]
Jiricny J.
The multifaceted mismatch-repair system.
Nat Rev Mol Cell Biol 7:335-46 (2006)
Li GM.
Mechanisms and functions of DNA mismatch repair.
Cell Res 18:85-98 (2008)
Marti TM, Kunz C, Fleck O.
DNA mismatch repair and mutation avoidance pathways.
J Cell Physiol 191:28-41 (2002)
Ikejima M, Shimada T.
[Molecular mechanism of mismatch repair] Japanese
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway

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