KEGG   PATHWAY: biu04640
biu04640                    Pathway                                

Hematopoietic cell lineage - Bos indicus (zebu cattle)
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Organismal Systems; Immune system
Pathway map
biu04640  Hematopoietic cell lineage

Bos indicus (zebu cattle) [GN:biu]
109558333  KITLG; kit ligand [KO:K05461]
109568650  IL7; interleukin-7 [KO:K05431]
109561213  IL4; interleukin-4 [KO:K05430]
109561218  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
109572992  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
109561216  IL5; interleukin-5 [KO:K05428]
109573417  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
109561219  interleukin-3 [KO:K04736]
109558077  IL6; interleukin-6 [KO:K05405]
109566132  IL1A; interleukin-1 alpha [KO:K04383]
109566133  IL1B; interleukin-1 beta [KO:K04519]
109577428  TNF; tumor necrosis factor [KO:K03156]
109555962  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
109578290  EPO; erythropoietin [KO:K05437]
109557333  THPO; thrombopoietin isoform X1 [KO:K06854]
109570522  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
109567013  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:]
109579068  DNTT; DNA nucleotidylexotransferase isoform X1 [KO:K00977] [EC:]
109576545  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109576596  HLA class II histocompatibility antigen, DO alpha chain-like isoform X1 [KO:K06752]
109577038  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109577039  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
109577041  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109577042  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
109576666  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109577307  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
109577316  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
109576780  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109569730  CD44; CD44 antigen isoform X1 [KO:K06256]
109560477  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:]
109567961  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
109575020  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
109556162  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
109560687  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1 [KO:K01242] [EC:]
109574499  CD7; T-cell antigen CD7 isoform X1 [KO:K06457]
109555873  CD2; T-cell surface antigen CD2 [KO:K06449]
109554664  CD5; T-cell surface glycoprotein CD5 [KO:K06455]
109578976  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
109578994  T-cell surface glycoprotein CD1e, membrane-associated-like [KO:K06448]
109579006  antigen-presenting glycoprotein CD1d-like [KO:K06448]
109579016  antigen-presenting glycoprotein CD1d-like [KO:K06448]
109579024  antigen-presenting glycoprotein CD1d-like [KO:K06448]
109556982  T-cell surface glycoprotein CD1b-3 [KO:K06448]
109556631  T-cell surface glycoprotein CD1b-2-like [KO:K06448]
109556709  T-cell surface glycoprotein CD1b-2-like [KO:K06448]
109556712  T-cell surface glycoprotein CD1a-like [KO:K06448]
109558922  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
109566151  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
109566150  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
109569960  CD3D; T-cell surface glycoprotein CD3 delta chain [KO:K06450]
109569940  CD3E; T-cell surface glycoprotein CD3 epsilon chain [KO:K06451]
109569992  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
109559100  MME; neprilysin [KO:K01389] [EC:]
109559732  CD9; CD9 antigen [KO:K06460]
109578140  CD19; B-lymphocyte antigen CD19 [KO:K06465]
109572327  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
109571527  CD24; signal transducer CD24 [KO:K06469]
109569985  MS4A1; B-lymphocyte antigen CD20 [KO:K06466]
109572704  CD37; leukocyte antigen CD37 [KO:K06475]
109561648  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X1 [KO:K06468]
109568669  LOW QUALITY PROTEIN: granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
109571796  myeloid cell surface antigen CD33-like [KO:K06473]
109571913  myeloid cell surface antigen CD33-like [KO:K06473]
109578521  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
109554138  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
109555819  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
109562194  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:]
109575620  ANPEP; aminopeptidase N [KO:K11140] [EC:]
109562104  CD14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391]
109578826  interleukin-9 receptor-like [KO:K05073]
109565502  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
109565866  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
109556495  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
109575848  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
109561621  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
109557879  LOW QUALITY PROTEIN: platelet glycoprotein 4-like [KO:K06259]
109557335  platelet glycoprotein 4-like [KO:K06259]
109569753  CD59; CD59 glycoprotein [KO:K04008]
109563195  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
109574140  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
109573568  ITGA2B; integrin alpha-IIb [KO:K06476]
109576426  GP9; platelet glycoprotein IX [KO:K06263]
109574196  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
109556472  GP5; platelet glycoprotein V [KO:K06260]
109574799  ITGA1; integrin alpha-1 [KO:K06480]
109574862  ITGA2; integrin alpha-2 [KO:K06481]
109574210  ITGA3; integrin alpha-3 [KO:K06482]
109565881  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
109558343  ITGA5; integrin alpha-5 [KO:K06484]
109566462  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
Immunobiology - International editon: The immune system in health and disease
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Abe T
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (Japanese)
Nihonijishinhousya (2000)
Rothenberg EV, Taghon T.
Molecular genetics of T cell development.
Annu Rev Immunol 23:601-49 (2005)
Ceredig R, Rolink T.
A positive look at double-negative thymocytes.
Nat Rev Immunol 2:888-97 (2002)
de Bruijn MF, Speck NA.
Core-binding factors in hematopoiesis and immune function.
Oncogene 23:4238-48 (2004)
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
Notch regulation of lymphocyte development and function.
Nat Immunol 5:247-53 (2004)
Spits H.
Development of alphabeta T cells in the human thymus.
Nat Rev Immunol 2:760-72 (2002)
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
J Exp Med 189:563-74 (1999)
Mak TW, Penninger JM, Ohashi PS.
Knockout mice: a paradigm shift in modern immunology.
Nat Rev Immunol 1:11-9 (2001)
Shapiro-Shelef M, Calame K.
Regulation of plasma-cell development.
Nat Rev Immunol 5:230-42 (2005)
Maillard I, Adler SH, Pear WS.
Notch and the immune system.
Immunity 19:781-91 (2003)
Alpdogan O, van den Brink MR.
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
Trends Immunol 26:56-64 (2005)
KO pathway

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