KEGG   Bos indicus (zebu cattle): 109556202
Entry
109556202         CDS       T04792                                 

Gene name
JAK1
Definition
(RefSeq) LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1
  KO
K11217  Janus kinase 1 [EC:2.7.10.2]
Organism
biu  Bos indicus (zebu cattle)
Pathway
biu01521  EGFR tyrosine kinase inhibitor resistance
biu04151  PI3K-Akt signaling pathway
biu04217  Necroptosis
biu04380  Osteoclast differentiation
biu04550  Signaling pathways regulating pluripotency of stem cells
biu04621  NOD-like receptor signaling pathway
biu04630  JAK-STAT signaling pathway
biu04658  Th1 and Th2 cell differentiation
biu04659  Th17 cell differentiation
biu05140  Leishmaniasis
biu05145  Toxoplasmosis
biu05152  Tuberculosis
biu05160  Hepatitis C
biu05161  Hepatitis B
biu05162  Measles
biu05163  Human cytomegalovirus infection
biu05164  Influenza A
biu05165  Human papillomavirus infection
biu05166  Human T-cell leukemia virus 1 infection
biu05167  Kaposi sarcoma-associated herpesvirus infection
biu05168  Herpes simplex virus 1 infection
biu05169  Epstein-Barr virus infection
biu05171  Coronavirus disease - COVID-19
biu05200  Pathways in cancer
biu05203  Viral carcinogenesis
biu05212  Pancreatic cancer
biu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:biu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    109556202 (JAK1)
   04151 PI3K-Akt signaling pathway
    109556202 (JAK1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    109556202 (JAK1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    109556202 (JAK1)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    109556202 (JAK1)
   04658 Th1 and Th2 cell differentiation
    109556202 (JAK1)
   04659 Th17 cell differentiation
    109556202 (JAK1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    109556202 (JAK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109556202 (JAK1)
   05203 Viral carcinogenesis
    109556202 (JAK1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109556202 (JAK1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    109556202 (JAK1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    109556202 (JAK1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109556202 (JAK1)
   05161 Hepatitis B
    109556202 (JAK1)
   05160 Hepatitis C
    109556202 (JAK1)
   05171 Coronavirus disease - COVID-19
    109556202 (JAK1)
   05164 Influenza A
    109556202 (JAK1)
   05162 Measles
    109556202 (JAK1)
   05168 Herpes simplex virus 1 infection
    109556202 (JAK1)
   05163 Human cytomegalovirus infection
    109556202 (JAK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109556202 (JAK1)
   05169 Epstein-Barr virus infection
    109556202 (JAK1)
   05165 Human papillomavirus infection
    109556202 (JAK1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    109556202 (JAK1)
   05140 Leishmaniasis
    109556202 (JAK1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109556202 (JAK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:biu01001]
    109556202 (JAK1)
Enzymes [BR:biu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     109556202 (JAK1)
Protein kinases [BR:biu01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   109556202 (JAK1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 Jak1_Phl FERM_F1 SH2
Other DBs
NCBI-GeneID: 109556202
NCBI-ProteinID: XP_019812878
UniProt: A0A6P5B2T5
LinkDB
Position
3
AA seq 1158 aa
MQYLNIKEDCSAMAFCAKMRSSKKAEMNLEAPEPGVEVLFYLSDREPLRLGGGEYTAEEL
CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTVTVDDKTSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKXPDATPLLDAXSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
RFHPNDSGNVLCYEVMVTGNLGIQWRQKPHIVPVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEVLGIQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK
RCCQPKPREISNLLVATKKAQEWQPVYTMSQLSFDRILKKDITQGEHLGRGTRTHIYSGT
LTDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV
ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL
LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT
TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI
MRDINKLEEQNPDIVSEKKPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT
GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS
GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD
FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD
SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQHMRKCWEFQPSNRTT
FQNLIEGFEALLRSMSNI
NT seq 3477 nt   +upstreamnt  +downstreamnt
atgcagtatctaaatataaaagaggactgcagtgccatggctttctgtgctaaaatgagg
agctccaagaaggcggagatgaatctggaggcccctgagccgggggtggaggtgctcttc
tacctgtcggatagggagcctctccggctgggcggtggagagtacacggcggaggagctg
tgcatccgggcggcgcaggagtgctgtatctctcctctgtgtcacaacctctttgccctg
tatgacgagaacaccaagctctggtatgctccgaatcgcaccgtcaccgtcgacgacaaa
acgtcactccggcttcactaccggatgaggttctatttcaccaactggcatgggaccaac
gacaatgaacaatcagtatggcgacattctccaaagaagcagaaaaacggctatgagaaa
aaaaagnttccagatgcaacacctctccttgacgccmgctcgctggagtatctgtttgct
cagggacagtatgatttggtcaaatgcctggctcccattcgagaccccaagacggagcag
gatgggcacgacattgagaacgagtgtcttgggatggccgtgctggccatctcccactac
gccatgatgaagaagatgcaattgccagaactccccaaggacatcagctacaagcgatat
attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata
aataatgttttcaaggattttctaaaggagtttaacaacaagaccatttgtgacagcagc
gtgtccacgcacgacctgaaggtgaaatacctggctaccttggaaactttgacaaaacat
tatggtgctgaaatatttgagacttccatgctactgatttcatcagaaaatgagatgaat
cggttccatccaaatgatagtggaaatgttctctgctatgaagtgatggtsactggaaat
cttggaatccagtggagacagaaaccacatattgttcctgttgaaaaggaaaaaaacaaa
ctgaaacggaaaaaactggaaaataaacacaagaaggatgaggaaaaaaacaaaatccga
gaagagtggaacaatttttcttacttccctgagatcactcacattgtaatcaaggagtct
gtggtcagcattaataagcaggacaacaaaaaaatggaactgaagctctcttcccacgag
gaggccttgtccttcgtgtccctggtcgatggctacttccggctcacggcagacgcccat
cactacctctgcactgacgtggctcccccattgatcgtccacaacatacagaatggctgt
catggtccaatctgcacggagtatgccatcaataagctgcggcaggaggggagcgaggag
gggatgtacgtgctgcggtggagctgcaccgactttgacaacatcctcatgaccgtcacc
tgcttcgaaaagtctgaggtgctgggtatccagaaacagttcaagaactttcagattgag
gtgcagaagggccgctacagcctgcatggctcggaccgcagcttcccgagccttggggac
ctcatgagccacctaaagaagcagatcctgcgcacggacaacatcagctttgtgctgaag
cgctgctgccagcccaagccccgagaaatctccaatctgctggtggccaccaagaaagcc
caggagtggcagcctgtctacaccatgagccagctgagtttcgatcgaatcctcaagaaa
gatattacgcaaggcgagcaccttgggagaggcacgcggacacacatctactctgggacc
ctcacggattacaaggatgacgaagggacttctgaagagaagagaataaaagtcatcctg
aaggtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatg
atgaggcaggtctcccacaaacacatcgtgtacctctatggggtttgcgtccgagatgtg
gagaatatcatggtggaagagtttgtggaggggggacccctggacctcttcatgcatcgg
aaaagtgacgtcctcaccacaccctggaagtttaaagttgccaaacagctggccagcgcc
ctgagttacttggaggataaagacctggtccacggaaatgtgtgcactaaaaacctccty
ctggcccgcgagggcatcgacagtgagtgcggccccttcatcaagctcagtgaccctggc
atccccatcactgtgctctccaggcaagagtgcatagaacgaatcccctggattgctccc
gagtgtgttgaagactccaagaatctgagtgtggctgctgacaagtggagctttggaacc
acactctgggaaatctgctacaatggcgagatccccttgaaagacaagacgctgattgag
aaagagagattctatgaaagccggtgcaggccagtgaccccgtcttgtaaggagctagct
gacttgatgacccgctgcatgaactacgaccccaaccagagacccttcttccgagccatc
atgagagacatcaataagctggaggagcagaatccagacattgtatcagaaaaaaagcca
acaactgaagtggatcccacacattttgaaaagcggttcttaaagaggatccgtgacttg
ggagagggccactttgggaaggtcgagctctgcaggtatgaccctgagggggacaataca
ggggagcaagtggctgtcaaatccctgaagcccgagagtggagggaaccacatcgctgat
ctgaagaaggagattgaaatcttaagaaatctttatcatgagaacattgtgaagtataaa
ggcatctgcacagaagatggtggaaatggtattaagctcatcatggagtttctgccttca
gggagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcaatta
aaatacgccgttcagatttgtaaggggatggactatctgggttctcggcagtacgttcac
cgggacttagcagcaagaaacgtcctcgtggagagtgagcaccaggtgaaaatcggggac
ttcggtctcaccaaagccatcgaaaccgataaggagtactacacagtcaaggacgaccgg
gacagccctgtgttttggtatgctccagaatgtttaattcagtgtaagttctatatcgcc
tctgatgtctggtctttcggagtgactctgcatgagctgcttacttactgtgattcagat
tccagtcccatggccttgttcctgaaaatgataggcccaactcatggtcagatgacggta
acaagactcgtgaatacattaaaagaaggaaaacgcttgccatgtccaccgaactgtcca
gatgaggtttatcaacatatgcgaaagtgttgggaatttcaaccatctaatcggacaacc
tttcagaaccttattgaaggatttgaagcacttctaagaagcatgagtaacatttaa

KEGG   Bos indicus (zebu cattle): 109561426
Entry
109561426         CDS       T04792                                 

Gene name
JAK3
Definition
(RefSeq) tyrosine-protein kinase JAK3
  KO
K11218  Janus kinase 3 [EC:2.7.10.2]
Organism
biu  Bos indicus (zebu cattle)
Pathway
biu04062  Chemokine signaling pathway
biu04151  PI3K-Akt signaling pathway
biu04217  Necroptosis
biu04550  Signaling pathways regulating pluripotency of stem cells
biu04630  JAK-STAT signaling pathway
biu04658  Th1 and Th2 cell differentiation
biu04659  Th17 cell differentiation
biu05161  Hepatitis B
biu05162  Measles
biu05166  Human T-cell leukemia virus 1 infection
biu05169  Epstein-Barr virus infection
biu05200  Pathways in cancer
biu05203  Viral carcinogenesis
biu05223  Non-small cell lung cancer
biu05340  Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:biu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    109561426 (JAK3)
   04151 PI3K-Akt signaling pathway
    109561426 (JAK3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    109561426 (JAK3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    109561426 (JAK3)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    109561426 (JAK3)
   04659 Th17 cell differentiation
    109561426 (JAK3)
   04062 Chemokine signaling pathway
    109561426 (JAK3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109561426 (JAK3)
   05203 Viral carcinogenesis
    109561426 (JAK3)
  09162 Cancer: specific types
   05223 Non-small cell lung cancer
    109561426 (JAK3)
  09163 Immune disease
   05340 Primary immunodeficiency
    109561426 (JAK3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109561426 (JAK3)
   05161 Hepatitis B
    109561426 (JAK3)
   05162 Measles
    109561426 (JAK3)
   05169 Epstein-Barr virus infection
    109561426 (JAK3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:biu01001]
    109561426 (JAK3)
Enzymes [BR:biu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     109561426 (JAK3)
Protein kinases [BR:biu01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   109561426 (JAK3)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl Kdo APH
Other DBs
NCBI-GeneID: 109561426
NCBI-ProteinID: XP_019819423
UniProt: A0A6P5C1T5
LinkDB
Position
7
AA seq 1104 aa
MAPPSEETPLISQRSCSLSSSEAGALHVLLPPRGPGPPQCLSFSFGDHSAEDLCVCAAKA
SGILPVYHSLFALALEDLSCWFPPSHIFSVEDTGTQVLVYRLRFYFPNWFGLEKCHRFGL
RKDLTSAILDLPVLEHLFAQHRHDLVSGRLRVGLSLKEQGECLSLAVLDLARMALEQAQR
PEELLKTVSYKVCLPPGLRDLIQGLSFVTRRRIRRTVCRALRGVATCQADRHSLMVKYIM
DLERLDPDRAAETFRVGLPGAAGGQDTPGLLRVAGGSGIAWSPGEHEVLQPFCDFPEIVD
ISIKQAPCIGPAAEHRLVTITRTDNQILEAEFPGLPAALSFVALVDGYFRLTTDSRHYFC
REVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSLPGSYVLRRSPQDFDSYLLTVCVLTP
LGPDYKGCLIRCDPTGTFSLAGLGRSHSSLRELLAACWNGGLHVDGVELYLTFCCNPRPK
EKSNLIVVRRGCNPPTSSPVQPQFQCQLSQMTFHKIPADSLQWHENLGHGSFTKIYRGCH
HEIVDGEARETEVLLKVMDAKHKNCMESFLEAASLMSQVSYQHLVLLHGVCMAGDSIMVQ
EFVRLGALDTYLRKCGHLVPASWKLQVIKQLAYALNYLEDKGLPHGNVSARKVLLAREGT
DGNLPFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEARTLGLEADKWGFGATVWEVFS
GVTVPISTLEPAKKLQFYQERQQLPAPKWMELALLIQQCMAYEPGQRPSFRAVIRDLNSL
ITSDYELLSDPTPGTLAPRDGLWNGTQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR
YDPLGDNTGALVAVKQLQHSGPEQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL
VMEYLPSGCLRDFLQRHRARLDAGRLLLYASQICKGMEYLGSCRCLHRDLAARNILVESE
THVKIADFGLAKLLPLDKEYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL
FTYSDKNCSPSAEFLRMMGCERDVPALCRLLELLAEGQRLPAPPACPSEVHELMKLCWAP
NPQDRPSFSALGPQLDALWSGSRG
NT seq 3315 nt   +upstreamnt  +downstreamnt
atggcacctccaagtgaggagacacccctgatttctcagcgctcctgcagcctctcctct
tcagaggctggtgccctgcatgtgctgctgccccctcggggccctggacccccacagtgc
ctgtccttctcctttggggaccactcagctgaagacctgtgtgtttgcgctgctaaggcc
agtggcatcctgcccgtgtaccactccctctttgctctggctttggaagacctgtcctgc
tggttccccccaagccacatcttctccgtggaggacacgggtacccaggtcctcgtctac
aggctccgcttttacttccctaactggtttggactagagaagtgccaccgatttgggcta
cgaaaggacttgaccagcgccatcttggatctgccagtcctggagcacctctttgctcag
caccgccatgacctggtgagcggccgcctccgggtaggcctcagcctcaaggaacagggt
gagtgtctcagcttggctgttctggacctggcccggatggccctcgagcaggctcagcgg
cccgaggaattgctgaagacggtcagctacaaggtctgcctgccccctggcctacgcgac
ctgatccagggtttgagcttcgtgactcggaggcgcatccgaaggacagtgtgccgggcc
ttgcgcggggtggcgacctgccaggctgacaggcactcgctcatggtcaagtacatcatg
gacctcgagaggctggatccagacagggctgccgagaccttccgcgtgggtctccccggc
gctgctggtggtcaggatacgccggggctgctccgtgtggctggtggcagtggcatcgcc
tggagcccaggagaacacgaggtcctccagcccttctgcgactttccagaaatcgtggat
atcagcatcaagcaggcgccgtgcattggcccggctgccgagcaccgcctggtcaccatc
accaggacagacaatcagatcctggaggccgagttcccggggcttcccgcagcgttgtcc
ttcgtggcgctcgtggatggctacttccggctgaccacggactcgaggcactacttctgc
agggaggtggcgccgccgcggctgctggaggaggtggctgagcagtgccatggccctatc
accctggattttgccatcaacaaactcaagactgggggctcacttcccggctcctacgtc
ctccgccgcagtccccaggatttcgacagctacctcctaactgtttgtgtcctgaccccc
ctggggccggattataagggctgcctcatccggtgcgaccccacaggaaccttctccctg
gctggccttggccgttcccacagcagtcttcgagagctcctggcagcctgttggaatggt
gggttgcacgtggatggggttgagctgtacctcaccttctgctgcaaccccagacctaaa
gaaaagtccaatctgattgtggtccggagaggctgcaacccacccacatcatcccctgtt
cagccccaattccagtgccagctgagtcagatgacgtttcacaagatccctgctgacagc
ctgcagtggcatgagaacctaggtcacgggtccttcaccaagatttatcggggctgtcac
catgagattgtggatggggaggcccgcgagacagaggtactgctcaaagtgatggatgcc
aagcacaagaattgcatggagtcattcctggaagcagcgagcttgatgagccaagtgtca
taccagcatctcgtattgctccacggcgtgtgcatggctggagacagtatcatggttcag
gaatttgtacgcctgggagcactggacacatatctacgcaagtgtggccacctagtgcca
gccagctggaagctacaggtgatcaaacagctggcctatgccctcaactatctggaagac
aaaggtctccctcatggcaatgtctcagcccggaaggtgctcttggctcgtgaggggact
gatgggaacctgcctttcatcaagctgagtgacccgggtgtcagccccactgtgctaagc
ctggagatgctcactgacaggatcccctgggtggcccctgaatgtctccaggaggcccga
acacttggcttggaagctgacaagtggggctttggagccacagtctgggaggtgttcagt
ggtgtcacagtgcccatcagcaccctggagcctgccaagaagctccagttttaccaggaa
cggcagcagttgcctgcccctaagtggatggagctggccctgctgatccaacagtgcatg
gcctatgagccaggccagaggccctctttccgtgctgtcatccgtgacctgaacagcctc
atcacttcagattatgagctcctctcagaccccacacctggcaccctggcgccccgtgat
gggctctggaatggtacccagctctacgcctgccaggaccctaccatctttgaagagaga
cacctcaaatacatctcacagctgggcaagggcaactttggcagcgtggaactgtgccgc
tacgacccgctgggcgacaacacaggggccctggtggccgtgaagcagttgcagcatagt
gggccagaacagcagagggacttccagcgggagatccagatcctcaaagccctccacagt
gacttcattgtcaagtaccggggtgtcagctatggcccaggccgccagagcctgcggttg
gtcatggagtatctgcccagtggctgcctgcgcgacttcctgcagcggcaccgcgcccgc
ctcgacgctggccgcctgctcctctaygcctcacagatctgcaagggcatggagtacctg
ggctcctgccgctgcctgcaccgcgacctggcagcccggaacatcctggtggaaagcgag
acgcacgtcaagatcgccgacttcggcctcgccaagctgctgcctctcgacaaagagtac
tacgtggtccgcgagccaggccagagccccatcttctggtatgccccagagtccctctcg
gacaacatcttctcgcgccagtcggatgtctggagcttcggggtcgtcctgtacgagctc
ttcacctacagtgacaagaactgtagcccctcagccgagttcctgcggatgatgggatgt
gagagagatgttccagccctctgccgcctcctggagctgctggctgagggccagaggctg
cccgcacctcccgcctgtcctagtgaggttcatgagctcatgaagctgtgctgggcccct
aaccctcaagaccggccatcattcagtgccctgggcccccagctagatgcgctgtggagt
ggaagccggggatag

KEGG   Bos indicus (zebu cattle): 109561587
Entry
109561587         CDS       T04792                                 

Gene name
TYK2
Definition
(RefSeq) non-receptor tyrosine-protein kinase TYK2
  KO
K11219  non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
Organism
biu  Bos indicus (zebu cattle)
Pathway
biu04217  Necroptosis
biu04380  Osteoclast differentiation
biu04621  NOD-like receptor signaling pathway
biu04630  JAK-STAT signaling pathway
biu04658  Th1 and Th2 cell differentiation
biu04659  Th17 cell differentiation
biu05145  Toxoplasmosis
biu05160  Hepatitis C
biu05161  Hepatitis B
biu05162  Measles
biu05164  Influenza A
biu05165  Human papillomavirus infection
biu05167  Kaposi sarcoma-associated herpesvirus infection
biu05168  Herpes simplex virus 1 infection
biu05169  Epstein-Barr virus infection
biu05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:biu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    109561587 (TYK2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    109561587 (TYK2)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    109561587 (TYK2)
   04658 Th1 and Th2 cell differentiation
    109561587 (TYK2)
   04659 Th17 cell differentiation
    109561587 (TYK2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    109561587 (TYK2)
 09160 Human Diseases
  09172 Infectious disease: viral
   05161 Hepatitis B
    109561587 (TYK2)
   05160 Hepatitis C
    109561587 (TYK2)
   05171 Coronavirus disease - COVID-19
    109561587 (TYK2)
   05164 Influenza A
    109561587 (TYK2)
   05162 Measles
    109561587 (TYK2)
   05168 Herpes simplex virus 1 infection
    109561587 (TYK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109561587 (TYK2)
   05169 Epstein-Barr virus infection
    109561587 (TYK2)
   05165 Human papillomavirus infection
    109561587 (TYK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    109561587 (TYK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:biu01001]
    109561587 (TYK2)
Enzymes [BR:biu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     109561587 (TYK2)
Protein kinases [BR:biu01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   109561587 (TYK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 Kinase-like Kdo APH
Other DBs
NCBI-GeneID: 109561587
NCBI-ProteinID: XP_019819701
UniProt: A0A6P5C255
LinkDB
Position
7
AA seq 1187 aa
MPLCQWRATTRGRKPSGDGAQPMATREGLKVLLHWAGPSGGEPWVTFTEPTLTAEDVCIH
VXHKVGITPPCFNLFALFDAQAQVWLPPNHILDTSRDSSLTLYFRMRFYFRNWHGTNPQE
PAVYRCGPPGAETSSEQAEQGVQLLDPASFEYLFEQGKHEFVNDVASLWELSSEEEIHHF
QNESLGMALLHLCHLALRNGVPLEKVAKKTSFKDCIPRSFRRQMRQHNALTRLRQRSIFR
KFLRAFQPGCLSQQVVMVKYLATLERLAPRFGTERVPVCHLELLSQADGEPCYIREGGQA
PPDPGSESAAGPPTHEVLVSGTEGIRWRLVPAEGPADGGAGGGSRMPDADPSGKKMKAEE
VGSEPVDRPRESPWSYFCDFQDITHMVLKERHVSIHCQDNKCLELTLPXXXXALSLVSLV
DGYFRLTADSNHYLCHEVAPPRLVMSIQDGIHGPLLEPFVLAKLKPEAGLYLIHWSTSHL
HRLILTVAQRDQLQAPGTKGLRLRKFPIELQAGTVMLEGWGRSFPSVRDLRAALQDCSLR
AGNDCFSLRRCCLPRPGEISNLIVTRGPQASTRPLNLSHLSFYRVRQEDITQLSHLGQGT
RTNVYEGLLRVGGGGPEEDKADGEEPPTPXGDRGQELRVVLKVLDPSHHDIALAFYETAS
LMSQVSHVHLAFVHGVFVHGSENIMVTEYVEHGPLDVWLRRERGRVPLAWKLAVAQQLAS
ALSYLEDKSLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLSALSREERVERIPWTA
PECLSGGANSLSTAADKWGFGATLLEICFDGEAPLQGRSPSEKERFYQKQHKLPEPSCPE
LATLTSQCLTYEPAQRPSFRTILRDFTQLQPQNLADVLSVSPDSLASDPTVFHKRYLKKI
RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAGCGPQLRTGWRREIDILRKLYHKHIV
KYKGCCEDQGEKSIQLVMEYMPLGSLRDYLPRHNVGLVQLLLFSLQICEGMAYLHSQHYV
HRDLAARNVLLDNNRLVKIGDFGLTKAVPEGHEYYCVREDGDSPVFWYAPECLKECKFYY
ASDVWSFGVLMYELLTYCDSSQSPPSKFIELIGLTQGQMTVLRLTELLERGERLPQPEKC
PSEIYCLMKDCWKAEASFRPTFQNLVPILRSYHEKYQGQAPSVFSVC
NT seq 3564 nt   +upstreamnt  +downstreamnt
atgcctctgtgccaatggagggccaccaccaggggcaggaagcccagtggggacggagct
cagcccatggccaccagagaaggcctgaaagtgcttctgcactgggctggccccagtggt
ggggagccctgggtcaccttcactgagcccacactgaccgcggaggatgtctgcatccac
gtcgyacacaaagtcggcatcactccaccctgcttcaatctttttgccctcttcgatgcc
caggcccaggtctggctgcctccaaatcacattctggatacctccagggactccagcctg
acgctgtacttccgcatgaggttttatttccgaaactggcatggcacgaatcctcaggag
ccagctgtgtaccgctgcgggcccccaggggccgagacttcctcagaacaggcagagcag
ggggtgcaactcctggaccctgcctcctttgagtacctctttgagcagggcaagcatgaa
tttgtaaatgacgtggcatcactatgggagctatccagcgaggaggagatccaccacttt
cagaatgagagcctgggcatggcccttttgcacctctgccacctcgctctccgcaatggt
gtcccccttgaaaaggtggcgaagaaaaccagcttcaaggattgcatcccacgctccttc
cggcggcagatgcggcagcacaacgctctgacacggctgcgccaacggagcatcttccgc
aagttcctgcgggccttccagccgggctgcctctcccagcaggtcgtcatggtgaagtac
ctggccacgctcgagcgactggcaccccgctttggcacagagcgtgtgcccgtgtgccac
ctggagctgctgtcccaagctgacggggagccctgctacatccgggagggtgggcaggcc
cctcctgaccccgggtctgagtctgctgccggaccccccacccacgaggtgctggtgtca
ggcacggaaggcatccggtggcggctggtaccggcggaggggcctgctgatggcggtgct
ggtggcggcagcaggatgcctgatgctgacccatctgggaagaaaatgaaggccgaggag
gtgggcagcgagccagtggacaggcctcgggagagcccctggtcctacttctgtgacttc
caggacatcacccacatggtgctgaaggaacgccacgtcagcatccattgtcaggacaac
aagtgcctggagctgaccctgccttnnnnnnnnnnggccctgtccttggtgtcgctggtg
gatggctacttccgcctgaccgccgactcaaaccactacctgtgccacgaggtggctcct
ccacggctggtgatgagtatccaggatggcatccacggccccctgctggagccatttgtg
ctggccaagctgaagcccgaggctggcctctaccttatccactggagcaccagccacctc
caccgcctcatcctcacagtggcccagcgcgaccagctgcaggctccaggcactaagggc
ttgcgcctgcggaagttccctatcgagctccaggccgggacagtcatgctggagggctgg
ggccggtctttccccagcgtgcgggacctgagggctgccctgcaggactgctcgctgcgg
gccggcaacgactgcttttccctgcgtcgctgctgcctgccccggcccggagagatctcc
aacctcatcgtcacacgggggcctcaggccagcaccagaccgctcaacctcagtcatctc
agcttctaccgagtccgccaggaagacatcacccagctgtcccacttgggccagggcaca
aggaccaacgtgtatgagggcctcttgcgagtggggggcggaggccccgaggaggacaag
gcagatggcgaggaaccccccacgcccgytggggaccgtgggcaggagctgcgtgtggtg
ctcaaggtgctagaccccagtcaccacgacatcgccctggccttctacgagacagccagc
ctcatgagccaggtctcccacgtgcacctggccttcgtgcacggcgtcttcgtgcacggc
tccgagaacatcatggtgaccgagtacgtggagcacgggcccctggacgtatggctgcgg
cgggagaggggccgcgtgcccctggcctggaagttggcagtggcccagcagctggccagc
gccctcagttacctggaagacaaaagcctggttcatggcaacgtgtgtggccggaacatc
ctgctggcacggctggggctggcggagggcaccagccccttcatcaagctgagtgacccc
ggcgtgggcctgagtgccctctccagggaggagcgggtggagcggatcccctggacagcc
cccgagtgcctgtctggtggagccaacagcctgagcaccgcagccgacaagtggggcttt
ggtgccaccctcctggagatctgcttcgacggcgaggcccccctgcagggccgtagtccc
tctgagaaagagcgcttctaccagaagcagcacaaactgcctgagccctcgtgcccagag
ctggccacactcaccagccagtgcctgacctacgagccagcccagcggccatccttccgc
accatcctgcgtgacttcactcagctacagccccagaatctcgctgatgtcttgtctgtg
agcccggattcactggcttcagatcccacggttttccacaagcgatacttgaaaaagatc
cgggatctgggtgagggtcacttcggaaaggtcagcctgtattgctacgaccccaccaac
gacggcactggtgagatggtagccgtgaaggccctcaaggcaggctgcggtccccagctc
cggacgggctggaggcgagaaatcgacatcctacgcaagctctaccacaagcacatcgtc
aagtacaagggctgctgcgaggaccaaggcgagaagtcgatacagctggtcatggaatac
atgcccctgggcagcctccgagactacttgccccggcacaatgtcgggctggtccagctg
ctgctcttctccctgcagatctgcgagggtatggcctacctgcactcacagcactacgtg
catcgagacctggctgcgcgcaacgtgctgctggacaacaacaggctagtcaagatcggg
gacttcggcctcaccaaggccgtgcccgaaggccacgagtattactgtgtgcgcgaggat
ggggacagtcctgtgttctggtatgccccggagtgcctgaaggagtgtaagttctactat
gcatcagacgtctggtcctttggggtcctcatgtatgagctgctgacctactgtgactcc
agccagagccctccctcgaaattcatcgagctcataggcctcacccaagggcagatgact
gtgctgaggctcacagagctgctggaacgaggggagaggctgccacaaccagagaaatgc
ccctctgagatctattgcctcatgaaggactgctggaaggcagaggcctcattccgcccg
accttccagaacctcgtacccatcctcagatcataccacgagaaataccaaggccaggcc
ccctcggtgttcagtgtctgctga

KEGG   Bos indicus (zebu cattle): 109562906
Entry
109562906         CDS       T04792                                 

Gene name
JAK2
Definition
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
  KO
K04447  Janus kinase 2 [EC:2.7.10.2]
Organism
biu  Bos indicus (zebu cattle)
Pathway
biu01521  EGFR tyrosine kinase inhibitor resistance
biu04062  Chemokine signaling pathway
biu04151  PI3K-Akt signaling pathway
biu04217  Necroptosis
biu04550  Signaling pathways regulating pluripotency of stem cells
biu04630  JAK-STAT signaling pathway
biu04658  Th1 and Th2 cell differentiation
biu04659  Th17 cell differentiation
biu04725  Cholinergic synapse
biu04917  Prolactin signaling pathway
biu04920  Adipocytokine signaling pathway
biu04933  AGE-RAGE signaling pathway in diabetic complications
biu04935  Growth hormone synthesis, secretion and action
biu05140  Leishmaniasis
biu05145  Toxoplasmosis
biu05152  Tuberculosis
biu05161  Hepatitis B
biu05164  Influenza A
biu05167  Kaposi sarcoma-associated herpesvirus infection
biu05168  Herpes simplex virus 1 infection
biu05200  Pathways in cancer
biu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:biu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    109562906 (JAK2)
   04151 PI3K-Akt signaling pathway
    109562906 (JAK2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    109562906 (JAK2)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    109562906 (JAK2)
 09150 Organismal Systems
  09151 Immune system
   04658 Th1 and Th2 cell differentiation
    109562906 (JAK2)
   04659 Th17 cell differentiation
    109562906 (JAK2)
   04062 Chemokine signaling pathway
    109562906 (JAK2)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    109562906 (JAK2)
   04917 Prolactin signaling pathway
    109562906 (JAK2)
   04935 Growth hormone synthesis, secretion and action
    109562906 (JAK2)
  09156 Nervous system
   04725 Cholinergic synapse
    109562906 (JAK2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109562906 (JAK2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109562906 (JAK2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    109562906 (JAK2)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    109562906 (JAK2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    109562906 (JAK2)
   05164 Influenza A
    109562906 (JAK2)
   05168 Herpes simplex virus 1 infection
    109562906 (JAK2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109562906 (JAK2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    109562906 (JAK2)
   05140 Leishmaniasis
    109562906 (JAK2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109562906 (JAK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:biu01001]
    109562906 (JAK2)
Enzymes [BR:biu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     109562906 (JAK2)
Protein kinases [BR:biu01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   109562906 (JAK2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl SH2 RIO1 Kinase-like APH
Other DBs
NCBI-GeneID: 109562906
NCBI-ProteinID: XP_019821552
UniProt: A0A6P5C7W4
LinkDB
Position
8
AA seq 1132 aa
MGMACLTMTEMEGTSTSPVHQNGDISGNANSVKQIDPVLQVYLYHSLGNAEGDYLQFLTG
EYVAEEICIAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRQNVLYRIRFYF
PYWYCNGSNRTYRHGIARGAEAPLLDDFVMSYLFAQWRHDFLHGWIKVPVTHETQEECLG
MAVLDMMRIAKEKNQTPLDIYSSISYKTFLPKCVRAKIQEYHILTRKRIRYRFRRFIEQF
SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDISIKQANQEGANESRIVTIHKQDGKSLEIELKSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPISMDFAISKLKKTGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVPTSPTLQRHNNVNQMVFHKI
RNEDLVFNESLGQGTFTKIFKGIRREIGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLILNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA
MHFLEEKTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRHNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIDKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYVIMTECWNNNVNQRPSFRDLAVRVDQIRDNMTG
NT seq 3399 nt   +upstreamnt  +downstreamnt
atgggaatggcttgccttacaatgacagaaatggaaggaacatccacatcccctgtacat
cagaatggtgatatttctggaaatgctaactctgtgaagcaaatagatccagtcctacag
gtctatctttatcattcccttgggaacgctgagggggattatctgcagtttctaactgga
gagtatgttgctgaagagatctgtattgctgcttctaaagcttgtggaatcacacctgta
tatcacagtatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat
gtcttccatatagatgaatcaaccaggcaaaacgtactctacagaatcagattttacttc
ccttactggtattgtaatggcagcaacagaacctatcgacatggaatagctcgaggtgct
gaagctcctcttcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat
tttttacatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg
atggcagtgttagatatgatgagaatagccaaagaaaaaaatcaaaccccactggacatc
tatagctctatcagctacaagacatttttgccaaaatgtgttcgagcaaagatccaagag
tatcatattttgacaaggaagagaataaggtacagatttcgcagatttattgagcaattc
agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact
cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttgtattgtgatttt
cctgatattattgatatcagtattaaacaagcaaatcaagaaggcgcaaatgaaagcaga
attgtaactattcataagcaagatggtaaaagtctagaaattgagcttaagtcattaaga
gaagctttgtcttttgtgtcattaattgatggatattatagattaactgcagatgcacat
cattatctttgtaaagaagtagcacctccaatggtgcttgaaaatatacaaagcaactgt
catggcccaatttcaatggattttgctatcagtaaactgaagaaaacaggtaatcagact
ggactctatgtacttcgatgcagtcctaaggactttaataaatattttctgacttttgct
gttgagcgagaaaatgttattgaatataagcactgtttgattaccaaaaatgagaatgga
gaatacaacctcagtggtactaagaagaacttcagtaatcttaaagatcttctgaattgc
taccagatggaaactgttcgctcagacagtataattttccagtttactaaatgctgtccc
ccaaagccaaaagacaaatcaaaccttctagtcttcagaaccaatggtatttctgatgta
ccaacctcaccaactttacaaaggcataataatgtgaaccaaatggtgttccacaaaatt
agaaatgaagatttggtatttaatgaaagccttggccaaggaacttttacaaaaattttt
aaaggtataagaagagaaataggagactatggtcagctgcatgaaacagaagttctttta
aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg
atgagccagctttctcacaaacatctgattttaaattatggagtatgtgtctgtggagag
gagaatattctggttcaggaatttgtaaaatttggatcactagatacgtatctgaaaaag
aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc
atgcattttctagaagaaaaaacccttattcatgggaatgtgtgcgccaaaaatattctt
cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaagacatcctgcaggagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaaatctaaacctggcaacagacaaatggagttttggt
accacattgtgggaaatctgcagtggaggagataagcctctgagtgctttggattctcaa
agaaaactacagttttatgaagataggcaccagcttcctgcgccaaagtggacagaatta
gcaaatcttattaataattgcatggattatgaaccagattttaggccttctttcagagcc
attataagagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac
atgttaccaaatatgagaataggtgccctaggattttctggtgcttttgaagaccgagac
cctacacaatttgaagaaagacacttgaaatttctacagcaacttggcaagggtaatttt
gggagtgtggagatgtgccggtatgaccctctacaagacaatactggggaggtggtggct
gtgaaaaagctccagcacagtactgaagagcacctcagagacttcgaaagagaaattgaa
atccttaaatccttgcagcatgacaacattgtaaagtacaaaggagtctgctacagtgct
ggccggcataatctaagattaattatggagtatttaccatatggaagtttacgagactat
ctccaaaaacataaagaacggatagatcataaaaaacttctgcaatacacatctcagata
tgcaaggggatggaatatcttggtacaaaaagatatatccacagggatctggcaacaagg
aatatattagtggagaatgaaaacagagttaaaataggagattttggattaaccaaagtc
ttgccacaagacaaagagtactacaaagtgaaagagcctggtgaaagtcccatattctgg
tatgcaccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagcttt
ggagtggttctgtatgaacttttcacatatattgacaagagtaaaagcccaccagcggaa
tttatgcgtatgattggcaatgacaaacaaggacagatgattgtgttccatttgatagaa
ctcctgaagaataatggaagattaccaagaccagatggatgcccagatgagatatatgtg
attatgacagaatgctggaacaataatgtaaaccagcgcccctctttcagagacctagca
gttcgagttgatcaaataagggacaacatgactggatga

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