KEGG   Bos indicus (zebu cattle): 109564697
Entry
109564697         CDS       T04792                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
biu  Bos indicus (zebu cattle)
Pathway
biu01521  EGFR tyrosine kinase inhibitor resistance
biu01522  Endocrine resistance
biu04010  MAPK signaling pathway
biu04012  ErbB signaling pathway
biu04014  Ras signaling pathway
biu04015  Rap1 signaling pathway
biu04022  cGMP-PKG signaling pathway
biu04024  cAMP signaling pathway
biu04062  Chemokine signaling pathway
biu04066  HIF-1 signaling pathway
biu04068  FoxO signaling pathway
biu04071  Sphingolipid signaling pathway
biu04072  Phospholipase D signaling pathway
biu04114  Oocyte meiosis
biu04140  Autophagy - animal
biu04148  Efferocytosis
biu04150  mTOR signaling pathway
biu04151  PI3K-Akt signaling pathway
biu04210  Apoptosis
biu04218  Cellular senescence
biu04270  Vascular smooth muscle contraction
biu04370  VEGF signaling pathway
biu04371  Apelin signaling pathway
biu04380  Osteoclast differentiation
biu04510  Focal adhesion
biu04540  Gap junction
biu04550  Signaling pathways regulating pluripotency of stem cells
biu04613  Neutrophil extracellular trap formation
biu04620  Toll-like receptor signaling pathway
biu04650  Natural killer cell mediated cytotoxicity
biu04660  T cell receptor signaling pathway
biu04662  B cell receptor signaling pathway
biu04664  Fc epsilon RI signaling pathway
biu04666  Fc gamma R-mediated phagocytosis
biu04668  TNF signaling pathway
biu04720  Long-term potentiation
biu04722  Neurotrophin signaling pathway
biu04725  Cholinergic synapse
biu04726  Serotonergic synapse
biu04730  Long-term depression
biu04810  Regulation of actin cytoskeleton
biu04910  Insulin signaling pathway
biu04912  GnRH signaling pathway
biu04914  Progesterone-mediated oocyte maturation
biu04915  Estrogen signaling pathway
biu04916  Melanogenesis
biu04917  Prolactin signaling pathway
biu04919  Thyroid hormone signaling pathway
biu04921  Oxytocin signaling pathway
biu04926  Relaxin signaling pathway
biu04928  Parathyroid hormone synthesis, secretion and action
biu04929  GnRH secretion
biu04934  Cushing syndrome
biu04935  Growth hormone synthesis, secretion and action
biu05010  Alzheimer disease
biu05022  Pathways of neurodegeneration - multiple diseases
biu05034  Alcoholism
biu05132  Salmonella infection
biu05135  Yersinia infection
biu05160  Hepatitis C
biu05161  Hepatitis B
biu05163  Human cytomegalovirus infection
biu05164  Influenza A
biu05165  Human papillomavirus infection
biu05166  Human T-cell leukemia virus 1 infection
biu05167  Kaposi sarcoma-associated herpesvirus infection
biu05170  Human immunodeficiency virus 1 infection
biu05200  Pathways in cancer
biu05205  Proteoglycans in cancer
biu05206  MicroRNAs in cancer
biu05207  Chemical carcinogenesis - receptor activation
biu05208  Chemical carcinogenesis - reactive oxygen species
biu05210  Colorectal cancer
biu05211  Renal cell carcinoma
biu05212  Pancreatic cancer
biu05213  Endometrial cancer
biu05214  Glioma
biu05215  Prostate cancer
biu05216  Thyroid cancer
biu05218  Melanoma
biu05219  Bladder cancer
biu05220  Chronic myeloid leukemia
biu05221  Acute myeloid leukemia
biu05223  Non-small cell lung cancer
biu05224  Breast cancer
biu05225  Hepatocellular carcinoma
biu05226  Gastric cancer
biu05230  Central carbon metabolism in cancer
biu05231  Choline metabolism in cancer
biu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:biu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109564697 (MAP2K1)
   04012 ErbB signaling pathway
    109564697 (MAP2K1)
   04014 Ras signaling pathway
    109564697 (MAP2K1)
   04015 Rap1 signaling pathway
    109564697 (MAP2K1)
   04370 VEGF signaling pathway
    109564697 (MAP2K1)
   04371 Apelin signaling pathway
    109564697 (MAP2K1)
   04668 TNF signaling pathway
    109564697 (MAP2K1)
   04066 HIF-1 signaling pathway
    109564697 (MAP2K1)
   04068 FoxO signaling pathway
    109564697 (MAP2K1)
   04072 Phospholipase D signaling pathway
    109564697 (MAP2K1)
   04071 Sphingolipid signaling pathway
    109564697 (MAP2K1)
   04024 cAMP signaling pathway
    109564697 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    109564697 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    109564697 (MAP2K1)
   04150 mTOR signaling pathway
    109564697 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109564697 (MAP2K1)
   04148 Efferocytosis
    109564697 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    109564697 (MAP2K1)
   04210 Apoptosis
    109564697 (MAP2K1)
   04218 Cellular senescence
    109564697 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109564697 (MAP2K1)
   04540 Gap junction
    109564697 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    109564697 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109564697 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    109564697 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    109564697 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    109564697 (MAP2K1)
   04660 T cell receptor signaling pathway
    109564697 (MAP2K1)
   04662 B cell receptor signaling pathway
    109564697 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    109564697 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    109564697 (MAP2K1)
   04062 Chemokine signaling pathway
    109564697 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109564697 (MAP2K1)
   04929 GnRH secretion
    109564697 (MAP2K1)
   04912 GnRH signaling pathway
    109564697 (MAP2K1)
   04915 Estrogen signaling pathway
    109564697 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    109564697 (MAP2K1)
   04917 Prolactin signaling pathway
    109564697 (MAP2K1)
   04921 Oxytocin signaling pathway
    109564697 (MAP2K1)
   04926 Relaxin signaling pathway
    109564697 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    109564697 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    109564697 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    109564697 (MAP2K1)
   04916 Melanogenesis
    109564697 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    109564697 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    109564697 (MAP2K1)
   04726 Serotonergic synapse
    109564697 (MAP2K1)
   04720 Long-term potentiation
    109564697 (MAP2K1)
   04730 Long-term depression
    109564697 (MAP2K1)
   04722 Neurotrophin signaling pathway
    109564697 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    109564697 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109564697 (MAP2K1)
   05206 MicroRNAs in cancer
    109564697 (MAP2K1)
   05205 Proteoglycans in cancer
    109564697 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    109564697 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    109564697 (MAP2K1)
   05230 Central carbon metabolism in cancer
    109564697 (MAP2K1)
   05231 Choline metabolism in cancer
    109564697 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109564697 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109564697 (MAP2K1)
   05212 Pancreatic cancer
    109564697 (MAP2K1)
   05225 Hepatocellular carcinoma
    109564697 (MAP2K1)
   05226 Gastric cancer
    109564697 (MAP2K1)
   05214 Glioma
    109564697 (MAP2K1)
   05216 Thyroid cancer
    109564697 (MAP2K1)
   05221 Acute myeloid leukemia
    109564697 (MAP2K1)
   05220 Chronic myeloid leukemia
    109564697 (MAP2K1)
   05218 Melanoma
    109564697 (MAP2K1)
   05211 Renal cell carcinoma
    109564697 (MAP2K1)
   05219 Bladder cancer
    109564697 (MAP2K1)
   05215 Prostate cancer
    109564697 (MAP2K1)
   05213 Endometrial cancer
    109564697 (MAP2K1)
   05224 Breast cancer
    109564697 (MAP2K1)
   05223 Non-small cell lung cancer
    109564697 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109564697 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    109564697 (MAP2K1)
   05161 Hepatitis B
    109564697 (MAP2K1)
   05160 Hepatitis C
    109564697 (MAP2K1)
   05164 Influenza A
    109564697 (MAP2K1)
   05163 Human cytomegalovirus infection
    109564697 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109564697 (MAP2K1)
   05165 Human papillomavirus infection
    109564697 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    109564697 (MAP2K1)
   05135 Yersinia infection
    109564697 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109564697 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    109564697 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    109564697 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    109564697 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109564697 (MAP2K1)
   01522 Endocrine resistance
    109564697 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:biu01001]
    109564697 (MAP2K1)
Enzymes [BR:biu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     109564697 (MAP2K1)
Protein kinases [BR:biu01001]
 Serine/threonine kinases: STE group
  STE7 family
   109564697 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Seadorna_VP7 Haspin_kinase
Other DBs
NCBI-GeneID: 109564697
NCBI-ProteinID: XP_019823715
UniProt: A0A6P5CDE2
LinkDB
Position
10:13145754..13220303
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggccccggacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgcctcgaggcctttctgacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgccggcaatggaggt
gtggtgttcaaggtctcccacaagccgtccggacttgttatggccagaaagctaattcac
ctggagatcaaacctgccatccggaaccagatcataagggagctgcaggttctccatgag
tgcaactcgccttatatcgtgggcttctacggggcrttctacagcgacggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagttctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccgtccaacatcctagtgaacagc
cgtggagagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcaccaggtcctacatgtcgccagagcgactccaggggacccattac
tccgtgcagtcggacatctggagcatggggctctctctggttgagatggctgtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccgcccaggccaaggacccccgggaggcccctcagctcttat
ggaatggacagccgacctccaatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccaacccagcacacccacccatgcggctggcgtctaa

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