Bos indicus (zebu cattle): 109564697
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Entry
109564697 CDS
T04792
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
KO
K04368
mitogen-activated protein kinase kinase 1 [EC:
2.7.12.2
]
Organism
biu
Bos indicus (zebu cattle)
Pathway
biu01521
EGFR tyrosine kinase inhibitor resistance
biu01522
Endocrine resistance
biu04010
MAPK signaling pathway
biu04012
ErbB signaling pathway
biu04014
Ras signaling pathway
biu04015
Rap1 signaling pathway
biu04022
cGMP-PKG signaling pathway
biu04024
cAMP signaling pathway
biu04062
Chemokine signaling pathway
biu04066
HIF-1 signaling pathway
biu04068
FoxO signaling pathway
biu04071
Sphingolipid signaling pathway
biu04072
Phospholipase D signaling pathway
biu04114
Oocyte meiosis
biu04140
Autophagy - animal
biu04148
Efferocytosis
biu04150
mTOR signaling pathway
biu04151
PI3K-Akt signaling pathway
biu04210
Apoptosis
biu04218
Cellular senescence
biu04270
Vascular smooth muscle contraction
biu04370
VEGF signaling pathway
biu04371
Apelin signaling pathway
biu04380
Osteoclast differentiation
biu04510
Focal adhesion
biu04540
Gap junction
biu04550
Signaling pathways regulating pluripotency of stem cells
biu04613
Neutrophil extracellular trap formation
biu04620
Toll-like receptor signaling pathway
biu04650
Natural killer cell mediated cytotoxicity
biu04660
T cell receptor signaling pathway
biu04662
B cell receptor signaling pathway
biu04664
Fc epsilon RI signaling pathway
biu04666
Fc gamma R-mediated phagocytosis
biu04668
TNF signaling pathway
biu04720
Long-term potentiation
biu04722
Neurotrophin signaling pathway
biu04725
Cholinergic synapse
biu04726
Serotonergic synapse
biu04730
Long-term depression
biu04810
Regulation of actin cytoskeleton
biu04910
Insulin signaling pathway
biu04912
GnRH signaling pathway
biu04914
Progesterone-mediated oocyte maturation
biu04915
Estrogen signaling pathway
biu04916
Melanogenesis
biu04917
Prolactin signaling pathway
biu04919
Thyroid hormone signaling pathway
biu04921
Oxytocin signaling pathway
biu04926
Relaxin signaling pathway
biu04928
Parathyroid hormone synthesis, secretion and action
biu04929
GnRH secretion
biu04934
Cushing syndrome
biu04935
Growth hormone synthesis, secretion and action
biu05010
Alzheimer disease
biu05022
Pathways of neurodegeneration - multiple diseases
biu05034
Alcoholism
biu05132
Salmonella infection
biu05135
Yersinia infection
biu05160
Hepatitis C
biu05161
Hepatitis B
biu05163
Human cytomegalovirus infection
biu05164
Influenza A
biu05165
Human papillomavirus infection
biu05166
Human T-cell leukemia virus 1 infection
biu05167
Kaposi sarcoma-associated herpesvirus infection
biu05170
Human immunodeficiency virus 1 infection
biu05200
Pathways in cancer
biu05205
Proteoglycans in cancer
biu05206
MicroRNAs in cancer
biu05207
Chemical carcinogenesis - receptor activation
biu05208
Chemical carcinogenesis - reactive oxygen species
biu05210
Colorectal cancer
biu05211
Renal cell carcinoma
biu05212
Pancreatic cancer
biu05213
Endometrial cancer
biu05214
Glioma
biu05215
Prostate cancer
biu05216
Thyroid cancer
biu05218
Melanoma
biu05219
Bladder cancer
biu05220
Chronic myeloid leukemia
biu05221
Acute myeloid leukemia
biu05223
Non-small cell lung cancer
biu05224
Breast cancer
biu05225
Hepatocellular carcinoma
biu05226
Gastric cancer
biu05230
Central carbon metabolism in cancer
biu05231
Choline metabolism in cancer
biu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
biu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
109564697 (MAP2K1)
04012 ErbB signaling pathway
109564697 (MAP2K1)
04014 Ras signaling pathway
109564697 (MAP2K1)
04015 Rap1 signaling pathway
109564697 (MAP2K1)
04370 VEGF signaling pathway
109564697 (MAP2K1)
04371 Apelin signaling pathway
109564697 (MAP2K1)
04668 TNF signaling pathway
109564697 (MAP2K1)
04066 HIF-1 signaling pathway
109564697 (MAP2K1)
04068 FoxO signaling pathway
109564697 (MAP2K1)
04072 Phospholipase D signaling pathway
109564697 (MAP2K1)
04071 Sphingolipid signaling pathway
109564697 (MAP2K1)
04024 cAMP signaling pathway
109564697 (MAP2K1)
04022 cGMP-PKG signaling pathway
109564697 (MAP2K1)
04151 PI3K-Akt signaling pathway
109564697 (MAP2K1)
04150 mTOR signaling pathway
109564697 (MAP2K1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
109564697 (MAP2K1)
04148 Efferocytosis
109564697 (MAP2K1)
09143 Cell growth and death
04114 Oocyte meiosis
109564697 (MAP2K1)
04210 Apoptosis
109564697 (MAP2K1)
04218 Cellular senescence
109564697 (MAP2K1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
109564697 (MAP2K1)
04540 Gap junction
109564697 (MAP2K1)
04550 Signaling pathways regulating pluripotency of stem cells
109564697 (MAP2K1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
109564697 (MAP2K1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
109564697 (MAP2K1)
04620 Toll-like receptor signaling pathway
109564697 (MAP2K1)
04650 Natural killer cell mediated cytotoxicity
109564697 (MAP2K1)
04660 T cell receptor signaling pathway
109564697 (MAP2K1)
04662 B cell receptor signaling pathway
109564697 (MAP2K1)
04664 Fc epsilon RI signaling pathway
109564697 (MAP2K1)
04666 Fc gamma R-mediated phagocytosis
109564697 (MAP2K1)
04062 Chemokine signaling pathway
109564697 (MAP2K1)
09152 Endocrine system
04910 Insulin signaling pathway
109564697 (MAP2K1)
04929 GnRH secretion
109564697 (MAP2K1)
04912 GnRH signaling pathway
109564697 (MAP2K1)
04915 Estrogen signaling pathway
109564697 (MAP2K1)
04914 Progesterone-mediated oocyte maturation
109564697 (MAP2K1)
04917 Prolactin signaling pathway
109564697 (MAP2K1)
04921 Oxytocin signaling pathway
109564697 (MAP2K1)
04926 Relaxin signaling pathway
109564697 (MAP2K1)
04935 Growth hormone synthesis, secretion and action
109564697 (MAP2K1)
04919 Thyroid hormone signaling pathway
109564697 (MAP2K1)
04928 Parathyroid hormone synthesis, secretion and action
109564697 (MAP2K1)
04916 Melanogenesis
109564697 (MAP2K1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
109564697 (MAP2K1)
09156 Nervous system
04725 Cholinergic synapse
109564697 (MAP2K1)
04726 Serotonergic synapse
109564697 (MAP2K1)
04720 Long-term potentiation
109564697 (MAP2K1)
04730 Long-term depression
109564697 (MAP2K1)
04722 Neurotrophin signaling pathway
109564697 (MAP2K1)
09158 Development and regeneration
04380 Osteoclast differentiation
109564697 (MAP2K1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
109564697 (MAP2K1)
05206 MicroRNAs in cancer
109564697 (MAP2K1)
05205 Proteoglycans in cancer
109564697 (MAP2K1)
05207 Chemical carcinogenesis - receptor activation
109564697 (MAP2K1)
05208 Chemical carcinogenesis - reactive oxygen species
109564697 (MAP2K1)
05230 Central carbon metabolism in cancer
109564697 (MAP2K1)
05231 Choline metabolism in cancer
109564697 (MAP2K1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
109564697 (MAP2K1)
09162 Cancer: specific types
05210 Colorectal cancer
109564697 (MAP2K1)
05212 Pancreatic cancer
109564697 (MAP2K1)
05225 Hepatocellular carcinoma
109564697 (MAP2K1)
05226 Gastric cancer
109564697 (MAP2K1)
05214 Glioma
109564697 (MAP2K1)
05216 Thyroid cancer
109564697 (MAP2K1)
05221 Acute myeloid leukemia
109564697 (MAP2K1)
05220 Chronic myeloid leukemia
109564697 (MAP2K1)
05218 Melanoma
109564697 (MAP2K1)
05211 Renal cell carcinoma
109564697 (MAP2K1)
05219 Bladder cancer
109564697 (MAP2K1)
05215 Prostate cancer
109564697 (MAP2K1)
05213 Endometrial cancer
109564697 (MAP2K1)
05224 Breast cancer
109564697 (MAP2K1)
05223 Non-small cell lung cancer
109564697 (MAP2K1)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
109564697 (MAP2K1)
05170 Human immunodeficiency virus 1 infection
109564697 (MAP2K1)
05161 Hepatitis B
109564697 (MAP2K1)
05160 Hepatitis C
109564697 (MAP2K1)
05164 Influenza A
109564697 (MAP2K1)
05163 Human cytomegalovirus infection
109564697 (MAP2K1)
05167 Kaposi sarcoma-associated herpesvirus infection
109564697 (MAP2K1)
05165 Human papillomavirus infection
109564697 (MAP2K1)
09171 Infectious disease: bacterial
05132 Salmonella infection
109564697 (MAP2K1)
05135 Yersinia infection
109564697 (MAP2K1)
09164 Neurodegenerative disease
05010 Alzheimer disease
109564697 (MAP2K1)
05022 Pathways of neurodegeneration - multiple diseases
109564697 (MAP2K1)
09165 Substance dependence
05034 Alcoholism
109564697 (MAP2K1)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
109564697 (MAP2K1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
109564697 (MAP2K1)
01522 Endocrine resistance
109564697 (MAP2K1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
biu01001
]
109564697 (MAP2K1)
Enzymes [BR:
biu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
109564697 (MAP2K1)
Protein kinases [BR:
biu01001
]
Serine/threonine kinases: STE group
STE7 family
109564697 (MAP2K1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
ABC1
Pkinase_fungal
Kinase-like
Seadorna_VP7
Haspin_kinase
Motif
Other DBs
NCBI-GeneID:
109564697
NCBI-ProteinID:
XP_019823715
UniProt:
A0A6P5CDE2
LinkDB
All DBs
Position
10:13145754..13220303
Genome browser
AA seq
393 aa
AA seq
DB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq
1182 nt
NT seq
+upstream
nt +downstream
nt
atgcccaagaagaagccgacgcccatccagctgaacccggccccggacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagctcgatgaacagcagcggaagcgcctcgaggcctttctgacccagaagcagaaggtg
ggggaactgaaggatgatgactttgagaagatcagtgagctgggtgccggcaatggaggt
gtggtgttcaaggtctcccacaagccgtccggacttgttatggccagaaagctaattcac
ctggagatcaaacctgccatccggaaccagatcataagggagctgcaggttctccatgag
tgcaactcgccttatatcgtgggcttctacggggcrttctacagcgacggcgagatcagc
atctgcatggagcacatggatgggggttccttggatcaagttctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatacctg
agggagaagcacaagattatgcacagagatgtcaagccgtccaacatcctagtgaacagc
cgtggagagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcaccaggtcctacatgtcgccagagcgactccaggggacccattac
tccgtgcagtcggacatctggagcatggggctctctctggttgagatggctgtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggag
ggagatgcggctgagaccccgcccaggccaaggacccccgggaggcccctcagctcttat
ggaatggacagccgacctccaatggcaatttttgagttgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccaacccagcacacccacccatgcggctggcgtctaa
DBGET
integrated database retrieval system