KEGG   Bos indicus (zebu cattle): 109574040
Entry
109574040         CDS       T04792                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor-bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
biu  Bos indicus (zebu cattle)
Pathway
biu01521  EGFR tyrosine kinase inhibitor resistance
biu01522  Endocrine resistance
biu04010  MAPK signaling pathway
biu04012  ErbB signaling pathway
biu04014  Ras signaling pathway
biu04062  Chemokine signaling pathway
biu04068  FoxO signaling pathway
biu04072  Phospholipase D signaling pathway
biu04150  mTOR signaling pathway
biu04151  PI3K-Akt signaling pathway
biu04380  Osteoclast differentiation
biu04510  Focal adhesion
biu04540  Gap junction
biu04550  Signaling pathways regulating pluripotency of stem cells
biu04630  JAK-STAT signaling pathway
biu04650  Natural killer cell mediated cytotoxicity
biu04660  T cell receptor signaling pathway
biu04662  B cell receptor signaling pathway
biu04664  Fc epsilon RI signaling pathway
biu04714  Thermogenesis
biu04722  Neurotrophin signaling pathway
biu04910  Insulin signaling pathway
biu04912  GnRH signaling pathway
biu04915  Estrogen signaling pathway
biu04917  Prolactin signaling pathway
biu04926  Relaxin signaling pathway
biu04935  Growth hormone synthesis, secretion and action
biu05034  Alcoholism
biu05160  Hepatitis C
biu05161  Hepatitis B
biu05163  Human cytomegalovirus infection
biu05165  Human papillomavirus infection
biu05200  Pathways in cancer
biu05203  Viral carcinogenesis
biu05205  Proteoglycans in cancer
biu05206  MicroRNAs in cancer
biu05210  Colorectal cancer
biu05211  Renal cell carcinoma
biu05213  Endometrial cancer
biu05214  Glioma
biu05215  Prostate cancer
biu05220  Chronic myeloid leukemia
biu05221  Acute myeloid leukemia
biu05223  Non-small cell lung cancer
biu05224  Breast cancer
biu05225  Hepatocellular carcinoma
biu05226  Gastric cancer
biu05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:biu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    109574040 (GRB2)
   04012 ErbB signaling pathway
    109574040 (GRB2)
   04014 Ras signaling pathway
    109574040 (GRB2)
   04630 JAK-STAT signaling pathway
    109574040 (GRB2)
   04068 FoxO signaling pathway
    109574040 (GRB2)
   04072 Phospholipase D signaling pathway
    109574040 (GRB2)
   04151 PI3K-Akt signaling pathway
    109574040 (GRB2)
   04150 mTOR signaling pathway
    109574040 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109574040 (GRB2)
   04540 Gap junction
    109574040 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    109574040 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    109574040 (GRB2)
   04660 T cell receptor signaling pathway
    109574040 (GRB2)
   04662 B cell receptor signaling pathway
    109574040 (GRB2)
   04664 Fc epsilon RI signaling pathway
    109574040 (GRB2)
   04062 Chemokine signaling pathway
    109574040 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109574040 (GRB2)
   04912 GnRH signaling pathway
    109574040 (GRB2)
   04915 Estrogen signaling pathway
    109574040 (GRB2)
   04917 Prolactin signaling pathway
    109574040 (GRB2)
   04926 Relaxin signaling pathway
    109574040 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    109574040 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    109574040 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    109574040 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    109574040 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109574040 (GRB2)
   05206 MicroRNAs in cancer
    109574040 (GRB2)
   05205 Proteoglycans in cancer
    109574040 (GRB2)
   05203 Viral carcinogenesis
    109574040 (GRB2)
   05231 Choline metabolism in cancer
    109574040 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109574040 (GRB2)
   05225 Hepatocellular carcinoma
    109574040 (GRB2)
   05226 Gastric cancer
    109574040 (GRB2)
   05214 Glioma
    109574040 (GRB2)
   05221 Acute myeloid leukemia
    109574040 (GRB2)
   05220 Chronic myeloid leukemia
    109574040 (GRB2)
   05211 Renal cell carcinoma
    109574040 (GRB2)
   05215 Prostate cancer
    109574040 (GRB2)
   05213 Endometrial cancer
    109574040 (GRB2)
   05224 Breast cancer
    109574040 (GRB2)
   05223 Non-small cell lung cancer
    109574040 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    109574040 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    109574040 (GRB2)
   05160 Hepatitis C
    109574040 (GRB2)
   05163 Human cytomegalovirus infection
    109574040 (GRB2)
   05165 Human papillomavirus infection
    109574040 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109574040 (GRB2)
   01522 Endocrine resistance
    109574040 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:biu04131]
    109574040 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:biu04990]
    109574040 (GRB2)
Membrane trafficking [BR:biu04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    109574040 (GRB2)
Domain-containing proteins not elsewhere classified [BR:biu04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   109574040 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 109574040
NCBI-ProteinID: XP_019837306
UniProt: A0A6P5DGF5
LinkDB
Position
19
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagccaccgcagacgacgagctgagcttcaaa
agaggggacatcctcaaggttttgaatgaggaatgtgatcagaactggtacaaggcagag
ctcaatgggaaagacggcttcatccccaagaactacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgctcagcaaacagcggcatgac
ggggcctttcttatccgagagagcgagagtgctcctggggatttctccctctccgtcaag
tttggaaatgatgtacagcacttcaaggtgctccgagatggggctggaaagtatttcctc
tgggtggtcaagttcaactctttgaatgagctggtagattatcacagatctacatccgtc
tccagaaaccagcagatatttctccgggacatagagcaggtgccacagcagccaacatac
gtccaagccctctttgactttgacccccaagaggatggagagctgggattccgtcgggga
gactttatccacgtcatggataactcagaccccaactggtggaaaggggcttgccacggg
cagaccggcatgttcccacgcaattacgtcacccccgtgaaccggaacgtctaa

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