Bos indicus (zebu cattle): 109576053
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Entry
109576053 CDS
T04792
Gene name
RAF1
Definition
(RefSeq) LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase
KO
K04366
RAF proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
biu
Bos indicus (zebu cattle)
Pathway
biu01521
EGFR tyrosine kinase inhibitor resistance
biu01522
Endocrine resistance
biu04010
MAPK signaling pathway
biu04012
ErbB signaling pathway
biu04014
Ras signaling pathway
biu04015
Rap1 signaling pathway
biu04022
cGMP-PKG signaling pathway
biu04024
cAMP signaling pathway
biu04062
Chemokine signaling pathway
biu04068
FoxO signaling pathway
biu04071
Sphingolipid signaling pathway
biu04072
Phospholipase D signaling pathway
biu04140
Autophagy - animal
biu04150
mTOR signaling pathway
biu04151
PI3K-Akt signaling pathway
biu04210
Apoptosis
biu04218
Cellular senescence
biu04270
Vascular smooth muscle contraction
biu04360
Axon guidance
biu04370
VEGF signaling pathway
biu04371
Apelin signaling pathway
biu04510
Focal adhesion
biu04540
Gap junction
biu04550
Signaling pathways regulating pluripotency of stem cells
biu04613
Neutrophil extracellular trap formation
biu04625
C-type lectin receptor signaling pathway
biu04630
JAK-STAT signaling pathway
biu04650
Natural killer cell mediated cytotoxicity
biu04660
T cell receptor signaling pathway
biu04662
B cell receptor signaling pathway
biu04664
Fc epsilon RI signaling pathway
biu04666
Fc gamma R-mediated phagocytosis
biu04720
Long-term potentiation
biu04722
Neurotrophin signaling pathway
biu04726
Serotonergic synapse
biu04730
Long-term depression
biu04810
Regulation of actin cytoskeleton
biu04910
Insulin signaling pathway
biu04912
GnRH signaling pathway
biu04914
Progesterone-mediated oocyte maturation
biu04915
Estrogen signaling pathway
biu04916
Melanogenesis
biu04917
Prolactin signaling pathway
biu04919
Thyroid hormone signaling pathway
biu04921
Oxytocin signaling pathway
biu04926
Relaxin signaling pathway
biu04928
Parathyroid hormone synthesis, secretion and action
biu04929
GnRH secretion
biu04935
Growth hormone synthesis, secretion and action
biu05010
Alzheimer disease
biu05022
Pathways of neurodegeneration - multiple diseases
biu05034
Alcoholism
biu05132
Salmonella infection
biu05152
Tuberculosis
biu05160
Hepatitis C
biu05161
Hepatitis B
biu05163
Human cytomegalovirus infection
biu05164
Influenza A
biu05165
Human papillomavirus infection
biu05167
Kaposi sarcoma-associated herpesvirus infection
biu05170
Human immunodeficiency virus 1 infection
biu05200
Pathways in cancer
biu05205
Proteoglycans in cancer
biu05206
MicroRNAs in cancer
biu05210
Colorectal cancer
biu05211
Renal cell carcinoma
biu05212
Pancreatic cancer
biu05213
Endometrial cancer
biu05214
Glioma
biu05215
Prostate cancer
biu05218
Melanoma
biu05219
Bladder cancer
biu05220
Chronic myeloid leukemia
biu05221
Acute myeloid leukemia
biu05223
Non-small cell lung cancer
biu05224
Breast cancer
biu05225
Hepatocellular carcinoma
biu05226
Gastric cancer
biu05230
Central carbon metabolism in cancer
biu05231
Choline metabolism in cancer
biu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
biu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
109576053 (RAF1)
04012 ErbB signaling pathway
109576053 (RAF1)
04014 Ras signaling pathway
109576053 (RAF1)
04015 Rap1 signaling pathway
109576053 (RAF1)
04370 VEGF signaling pathway
109576053 (RAF1)
04371 Apelin signaling pathway
109576053 (RAF1)
04630 JAK-STAT signaling pathway
109576053 (RAF1)
04068 FoxO signaling pathway
109576053 (RAF1)
04072 Phospholipase D signaling pathway
109576053 (RAF1)
04071 Sphingolipid signaling pathway
109576053 (RAF1)
04024 cAMP signaling pathway
109576053 (RAF1)
04022 cGMP-PKG signaling pathway
109576053 (RAF1)
04151 PI3K-Akt signaling pathway
109576053 (RAF1)
04150 mTOR signaling pathway
109576053 (RAF1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
109576053 (RAF1)
09143 Cell growth and death
04210 Apoptosis
109576053 (RAF1)
04218 Cellular senescence
109576053 (RAF1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
109576053 (RAF1)
04540 Gap junction
109576053 (RAF1)
04550 Signaling pathways regulating pluripotency of stem cells
109576053 (RAF1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
109576053 (RAF1)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
109576053 (RAF1)
04625 C-type lectin receptor signaling pathway
109576053 (RAF1)
04650 Natural killer cell mediated cytotoxicity
109576053 (RAF1)
04660 T cell receptor signaling pathway
109576053 (RAF1)
04662 B cell receptor signaling pathway
109576053 (RAF1)
04664 Fc epsilon RI signaling pathway
109576053 (RAF1)
04666 Fc gamma R-mediated phagocytosis
109576053 (RAF1)
04062 Chemokine signaling pathway
109576053 (RAF1)
09152 Endocrine system
04910 Insulin signaling pathway
109576053 (RAF1)
04929 GnRH secretion
109576053 (RAF1)
04912 GnRH signaling pathway
109576053 (RAF1)
04915 Estrogen signaling pathway
109576053 (RAF1)
04914 Progesterone-mediated oocyte maturation
109576053 (RAF1)
04917 Prolactin signaling pathway
109576053 (RAF1)
04921 Oxytocin signaling pathway
109576053 (RAF1)
04926 Relaxin signaling pathway
109576053 (RAF1)
04935 Growth hormone synthesis, secretion and action
109576053 (RAF1)
04919 Thyroid hormone signaling pathway
109576053 (RAF1)
04928 Parathyroid hormone synthesis, secretion and action
109576053 (RAF1)
04916 Melanogenesis
109576053 (RAF1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
109576053 (RAF1)
09156 Nervous system
04726 Serotonergic synapse
109576053 (RAF1)
04720 Long-term potentiation
109576053 (RAF1)
04730 Long-term depression
109576053 (RAF1)
04722 Neurotrophin signaling pathway
109576053 (RAF1)
09158 Development and regeneration
04360 Axon guidance
109576053 (RAF1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
109576053 (RAF1)
05206 MicroRNAs in cancer
109576053 (RAF1)
05205 Proteoglycans in cancer
109576053 (RAF1)
05230 Central carbon metabolism in cancer
109576053 (RAF1)
05231 Choline metabolism in cancer
109576053 (RAF1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
109576053 (RAF1)
09162 Cancer: specific types
05210 Colorectal cancer
109576053 (RAF1)
05212 Pancreatic cancer
109576053 (RAF1)
05225 Hepatocellular carcinoma
109576053 (RAF1)
05226 Gastric cancer
109576053 (RAF1)
05214 Glioma
109576053 (RAF1)
05221 Acute myeloid leukemia
109576053 (RAF1)
05220 Chronic myeloid leukemia
109576053 (RAF1)
05218 Melanoma
109576053 (RAF1)
05211 Renal cell carcinoma
109576053 (RAF1)
05219 Bladder cancer
109576053 (RAF1)
05215 Prostate cancer
109576053 (RAF1)
05213 Endometrial cancer
109576053 (RAF1)
05224 Breast cancer
109576053 (RAF1)
05223 Non-small cell lung cancer
109576053 (RAF1)
09164 Neurodegenerative disease
05010 Alzheimer disease
109576053 (RAF1)
05022 Pathways of neurodegeneration - multiple diseases
109576053 (RAF1)
09165 Substance dependence
05034 Alcoholism
109576053 (RAF1)
09171 Infectious disease: bacterial
05132 Salmonella infection
109576053 (RAF1)
05152 Tuberculosis
109576053 (RAF1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
109576053 (RAF1)
05161 Hepatitis B
109576053 (RAF1)
05160 Hepatitis C
109576053 (RAF1)
05164 Influenza A
109576053 (RAF1)
05163 Human cytomegalovirus infection
109576053 (RAF1)
05167 Kaposi sarcoma-associated herpesvirus infection
109576053 (RAF1)
05165 Human papillomavirus infection
109576053 (RAF1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
109576053 (RAF1)
01522 Endocrine resistance
109576053 (RAF1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
biu01001
]
109576053 (RAF1)
Enzymes [BR:
biu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
109576053 (RAF1)
Protein kinases [BR:
biu01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
109576053 (RAF1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
C1_2
Motif
Other DBs
NCBI-GeneID:
109576053
NCBI-ProteinID:
XP_019839917
UniProt:
A0A6P5DSH8
LinkDB
All DBs
Position
22
AA seq
648 aa
AA seq
DB search
MEHIQGAWKTISNGFGFKDTVFDGTSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDGGVPALPSLTMRRMRESVSRIPPGSQHRYSTPHAFTF
SASSPSSEGSLSQRQRSTSTPNVHMVSATLPVDSRMIEDAIRSHSESGSPSALSSSPNNL
SPTGWSQPKTPAPAQRERAPGSSTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQXQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq
1947 nt
NT seq
+upstream
nt +downstream
nt
atggagcacatacagggcgcctggaagacgatcagcaacggtttcggattcaaagacacg
gtgtttgacggcaccagctgcatctcccctacaatagttcagcaatttggctatcagcgt
cgggcgtcagatgatggcaaacttacggacccttctaagacaagcaacactatccgtgtg
tttttgccmaacaagcaragaacagtggtcaatgtgcggaatggaatgagcttgcatgac
tgcctcatgaaagctctcaaggtgaggggcctgcaaccagagtgctgtgcagtgttcaga
cttctccacgaacacaagggtaaaaaagcacggttagattggaatactgatgctgcctcg
ttgatcggagaggaacttcaagtggatttcctggatcatgttcccctcacaacacacaac
tttgctcggaaaaccttcctgaagcttgccttctgtgacatctgtcagaagttcttgcta
aatggatttagatgtcagacttgtggctacaagtttcacgagcattgtagcaccaaagta
cccactatgtgtgtggactggagtaatatcagacagctcttattgttcccaaattccact
gttggtgatggcggggtcccagcgctgccttctttgacgatgcgtcggatgcgagagtct
gtttcccggatacctcctggttcccagcacagatattccacaccccatgctttcacattc
agcgcctccagcccctcctctgaaggctccctctcccagaggcagaggtcgacgtccacg
cccaacgtgcacatggtcagcgccaccctgcctgtggacagcaggatgatcgaggatgca
attcgaagtcacagtgaatcaggctccccttcagccttgtccagcagtcccaacaatttg
agcccaacaggctggtcacagcccaaaacccctgcgcctgcacagagagagcgggcgcca
ggctccagcacccaggagaagaacaaaattaggcctcgtggacagagagattcgagctat
tactgggaaatagaagccagtgaagtgatgctgtccactcggattggatcaggctccttt
gggactgtttataagggcaagtggcatggagacgttgcagtaaagattctgaaggtcgtt
gaccccaccccagagcagtsccaggccttcaggaatgaggtggctgtcctccgcaaaacc
cggcacgtgaacatcctgctcttcatggggtacatgacgaaggacaacctggcgatagtg
acccagtggtgcgagggcagcagcctctacaaacacctgcacgtccaggagaccaagttc
cagatgttccagctgattgacattgcccggcagacggctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaataatatatttctccatgaaggcctg
acggtgaaaatcggtgattttggattggccacggtgaagtcacgctggagtggttctcag
caggtcgagcagcccaccggctccatcctgtggatggccccagaggtgatccggatgcag
gataataacccgttcagcttccagtccgacgtctactcctacggcatcgtgctgtatgag
ctcatgacgggggagctcccttactcccacatcaacaaccgcgaccagatcatcttcatg
gtgggccgcgggtatgcctccccagacctcagcaagctatacaagaactgccccaaagcc
atgaagaggctggtagctgactgcgtgaagaaagtgaaggaagaaaggcctctttttccc
cagatcctgtcttccatcgagctgctccagcattctctgcccaagatcaaccggagtgcc
tcggagccctccctgcaccgggcggcccacaccgaggacatcaacgcctgcacgctgacc
acgtcccctcggctscctgtcttctag
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