Bos mutus (wild yak): 102278692 Help Entry 102278692         CDS       T02919                                  Gene name JAK2 Definition (RefSeq) Janus kinase 2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism bom  Bos mutus (wild yak) Pathway bom01521   EGFR tyrosine kinase inhibitor resistance bom04062   Chemokine signaling pathway bom04151   PI3K-Akt signaling pathway bom04217   Necroptosis bom04550   Signaling pathways regulating pluripotency of stem cells bom04630   JAK-STAT signaling pathway bom04658   Th1 and Th2 cell differentiation bom04659   Th17 cell differentiation bom04725   Cholinergic synapse bom04917   Prolactin signaling pathway bom04920   Adipocytokine signaling pathway bom04933   AGE-RAGE signaling pathway in diabetic complications bom04935   Growth hormone synthesis, secretion and action bom05140   Leishmaniasis bom05145   Toxoplasmosis bom05152   Tuberculosis bom05161   Hepatitis B bom05164   Influenza A bom05167   Kaposi sarcoma-associated herpesvirus infection bom05168   Herpes simplex virus 1 infection bom05200   Pathways in cancer bom05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:bom00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102278692 (JAK2)    04151 PI3K-Akt signaling pathway     102278692 (JAK2)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     102278692 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     102278692 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     102278692 (JAK2)    04659 Th17 cell differentiation     102278692 (JAK2)    04062 Chemokine signaling pathway     102278692 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     102278692 (JAK2)    04917 Prolactin signaling pathway     102278692 (JAK2)    04935 Growth hormone synthesis, secretion and action     102278692 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     102278692 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102278692 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102278692 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     102278692 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     102278692 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     102278692 (JAK2)    05164 Influenza A     102278692 (JAK2)    05168 Herpes simplex virus 1 infection     102278692 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     102278692 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102278692 (JAK2)    05140 Leishmaniasis     102278692 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102278692 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bom01001]     102278692 (JAK2) Enzymes [BR:bom01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102278692 (JAK2) Protein kinases [BR:bom01001]  Non-receptor tyrosine kinases   JAK family [OT]    102278692 (JAK2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl SH2 RIO1 Kinase-like APH Motif Other DBs NCBI-GeneID:  102278692 NCBI-ProteinID:  XP_005891424 UniProt:  L8IT24 LinkDB All DBs Position Un AA seq 1132 aa AA seqDB search MGMACLTMTEMEGTSTSPVHQNGDISGNANSVKQIDPVLQVYLYHSLGNAEGDYLQFLTG EYVAEEICIAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRQNVLYRIRFYF PYWYCNGSNRTYRHGIARGAEAPLLDDFVMSYLFAQWRHDFLHGWIKVPVTHETQEECLG MAVLDMMRIAKEKNQTPLDIYSSISYKTFLPKCVRAKIQEYHILTRKRIRYRFRRFIEQF SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPDIIDISIKQANQEGANESRIVTIHKQDGKSLEIELKSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPISMDFAISKLKKTGNQT GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVPTSPTLQRHNNVNQMVFHKI RNEDLVFNESLGQGTFTKIFKGIRREIGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSQLSHKHLILNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA MHFLEEKTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRHNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIDKSKSPPAEFMRMIGNDKQGQMIVFHLIE LLKNNGRLPRPDGCPDEIYVIMTECWNNNVNQRPSFRDLAVRVDQIRDNMTG NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcttgccttacaatgacagaaatggaaggaacatccacatcccctgtacat cagaatggtgatatttctggaaatgctaactctgtgaagcaaatagatccagtcctacag gtctatctttatcattcccttgggaacgctgagggggattatctgcagtttctaactgga gagtatgttgctgaagagatctgtattgctgcttctaaagcttgtggaatcacacctgta tatcacagtatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat gtcttccatatagatgaatcaaccaggcaaaacgtactctacagaatcagattttacttc ccttactggtattgtaatggcagcaacagaacctatcgacatggaatagctcgaggtgct gaagctcctcttcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat tttttacatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg atggcagtgttagatatgatgagaatagccaaagaaaagaatcaaaccccactggacatc tatagctctatcagctacaagacatttttgccaaaatgtgttcgagcaaagatccaagag tatcatattttgacaaggaagagaataaggtacagatttcgcagatttattgagcaattc agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggaaacataaagaaagtgagacactgacagaacaggatttacagttgtattgtgatttt cctgatattattgatatcagtattaaacaagcaaatcaagaaggcgcaaatgaaagcaga attgtaactattcataagcaagatggtaaaagtctagaaattgagcttaagtcattaaga gaagctttgtcttttgtgtcattaattgatggatattatagattaactgcagatgcacat cattatctttgtaaagaagtagcacctccaatggtgcttgaaaatatacaaagcaactgt catggcccaatttcaatggattttgctatcagtaaactgaagaaaacaggtaatcagact ggactctatgtacttcgatgcagtcctaaggactttaataaatattttctgacttttgct gttgagcgagaaaatgttattgaatataagcactgtttgattaccaaaaatgagaatgga gaatacaacctcagtggtactaagaagaacttcagtaatcttaaagatcttctgaattgc taccagatggaaactgttcgctcagacagtataattttccagtttactaaatgctgtccc ccaaagccaaaagacaaatcaaaccttctagtcttcagaaccaatggtatttctgatgta ccaacctcaccaactttacaaaggcataataatgtgaaccaaatggtgttccacaaaatt agaaatgaagatttggtatttaatgaaagccttggccaaggaacttttacaaaaattttt aaaggtataagaagagaaataggagactatggtcagcttcatgaaacagaagttctttta aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg atgagccagctttctcacaaacatctgattttaaattatggagtatgtgtctgtggagag gagaatattctggttcaggaatttgtaaaatttggatcactagatacgtatctgaaaaag aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc atgcattttctagaagaaaaaacccttattcatgggaatgtgtgcgccaaaaatattctt cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct ggcattagtattacagttttgccaaaagacatcctgcaggagagaataccatgggtacca cctgaatgcattgaaaatcctaaaaatctaaacctggcaacagacaaatggagttttggt accacattgtgggaaatctgcagtggaggagataagcctctgagtgctttggattctcaa agaaaactacagttttatgaagataggcaccagcttcctgcgccaaagtggacagaatta gcaaatcttattaataattgcatggattatgaaccagattttaggccttctttcagagcc attataagagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac atgttaccaaatatgagaataggtgctctaggattttctggtgcttttgaagaccgagac cctacacaatttgaagaaagacacttgaaatttctacagcaacttggcaagggtaatttt gggagtgtggagatgtgtcggtatgaccctctacaagacaatactggggaggtggtggct gtgaaaaagctccagcacagtactgaagagcacctcagagacttcgaaagagaaattgaa atccttaaatccttgcagcatgacaacattgtaaagtacaaaggagtctgctacagtgct ggccggcataatctaagattaattatggagtatttaccatatggaagtttacgagactat ctccaaaaacataaagaacggatagatcataaaaaacttctgcaatacacatctcagata tgcaaggggatggaatatcttggtacaaaaagatatatccacagggatctggcaacaagg aatatattagtggagaatgaaaacagagttaaaataggagattttggattaaccaaagtc ttgccacaagacaaagagtactacaaagtgaaagagcctggtgaaagtcccatattctgg tatgcaccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagcttt ggagtggttctgtatgaacttttcacatatattgacaagagtaaaagcccaccagcggaa tttatgcgtatgattggcaatgacaaacaaggacagatgattgtgttccatttgatagaa ctcctgaagaataacggaagattaccaagaccagatggatgcccagatgagatatatgtg attatgacagaatgctggaacaataatgtaaaccagcgcccctctttcagagacctagca gttcgagttgatcaaataagggacaacatgactggatga

Bos mutus (wild yak): 102286011 Help Entry 102286011         CDS       T02919                                  Gene name JAK3 Definition (RefSeq) Janus kinase 3   KO K11218   Janus kinase 3 [EC:2.7.10.2] Organism bom  Bos mutus (wild yak) Pathway bom04062   Chemokine signaling pathway bom04151   PI3K-Akt signaling pathway bom04217   Necroptosis bom04550   Signaling pathways regulating pluripotency of stem cells bom04630   JAK-STAT signaling pathway bom04658   Th1 and Th2 cell differentiation bom04659   Th17 cell differentiation bom05161   Hepatitis B bom05162   Measles bom05166   Human T-cell leukemia virus 1 infection bom05169   Epstein-Barr virus infection bom05200   Pathways in cancer bom05203   Viral carcinogenesis bom05223   Non-small cell lung cancer bom05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:bom00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102286011 (JAK3)    04151 PI3K-Akt signaling pathway     102286011 (JAK3)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     102286011 (JAK3)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     102286011 (JAK3)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     102286011 (JAK3)    04659 Th17 cell differentiation     102286011 (JAK3)    04062 Chemokine signaling pathway     102286011 (JAK3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102286011 (JAK3)    05203 Viral carcinogenesis     102286011 (JAK3)   09162 Cancer: specific types    05223 Non-small cell lung cancer     102286011 (JAK3)   09163 Immune disease    05340 Primary immunodeficiency     102286011 (JAK3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102286011 (JAK3)    05161 Hepatitis B     102286011 (JAK3)    05162 Measles     102286011 (JAK3)    05169 Epstein-Barr virus infection     102286011 (JAK3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bom01001]     102286011 (JAK3) Enzymes [BR:bom01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102286011 (JAK3) Protein kinases [BR:bom01001]  Non-receptor tyrosine kinases   JAK family [OT]    102286011 (JAK3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl Kdo APH Motif Other DBs NCBI-GeneID:  102286011 NCBI-ProteinID:  XP_014334338 LinkDB All DBs Position Un AA seq 1104 aa AA seqDB search MAPPSEETPLISQRSCSLSSSEAGALHVLLPPRGPGPPQCLSFSFGDHSAEDLCVCAAKA SGILPVYHSLFALALEDLSCWFPPSHIFSVEDTGTQVLVYRLRFYFPNWFGLEKCHRFGL RKDLTSAILDLPVLEHLFAQHRHDLVSGRLRVGLSLKEQGECLSLAVLDLARMALEQAQR PEELLKTVSYKVCLPPGLRDLIQGLSFVTRRRIRRTVCRALRGVATCQADRHSLMVKYIM DLERLDPDRAAETFRVGLPGAAGGQDTPGLLRVAGGSGIAWSPGEHEVLQPFCDFPEIVD ISIKQAPCIGPAAEHRLVTITRTDNQILEAEFPGLPAALSFVALVDGYFRLTTDSRHYFC KEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSLPGSYVLRRSPQDFDSYLLTVCVLTP LGPDYKGCLIRCDPTGTFSLAGLGRSHSSLRELLAACWNGGLHVDGVELYLTFCCNPRPK EKSNLIVVRRGCNPPTSSPVQPQFQCQLSQMTFHKIPADSLQWHENLGHGSFTKIYRGCH HEIVDGEARETEVLLKVMDAKHKNCMESFLEAASLMSQVSYQHLVLLHGVCMAGDSIMVQ EFVRLGALDTYLRKCGHLVPASWKLQVIKQLAYALNYLEDKGLPHGNVSARKVLLAREGT DGNLPFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEARTLGLEADKWGFGATVWEVFS GVTVPISTLEPAKKLQFYQERQQLPAPKWMELALLIQQCMAYEPGQRPSFRAVIRDLNSL ITSDYELLSDPTPGTLAPRDGLWNGTQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR YDPLGDNTGALVAVKQLQHSGPEQQRDFQREIQILKALHSDFIVKYRGVRYGPGRQSLRL VMEYLPSGCLRDFLQRHRARLDAGRLLLYASQICKGMEYLGSCRCLHRDLAARNILVESE THVKIADFGLAKLLPLDKEYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL FTYSDKNCSPSAEFLRMMGCERDVPALCRLLELLAEGQRLPAPPACPSEVHELMKLCWAP NPQDRPSFSALGPQLDALWSGSRG NT seq 3315 nt NT seq  +upstreamnt  +downstreamnt atggcacctccaagtgaggagacacccctgatttctcagcgctcctgcagcctctcctct tcagaggctggtgccctgcatgtgctgctgccccctcggggccctggacccccacagtgc ctgtccttctcctttggggaccactcagctgaagacctgtgtgtttgcgctgctaaggcc agtggcatcctgcccgtgtaccactccctctttgctctggctttggaagacctgtcctgc tggttccccccgagccacatcttctccgtggaggacacgggtacccaggtcctcgtctac aggctccgcttttacttccctaactggtttggactagagaagtgccaccgatttgggcta cgaaaggacttgaccagcgccatcttggatctgccagtcctggagcacctctttgctcag caccgccatgacctggtgagcggccgcctccgggtaggcctcagcctcaaggaacagggt gagtgtctcagcttggctgttctggacctggcccggatggccctcgagcaggctcagcgg cccgaggagttgctgaagacggtcagctacaaggtctgcctgccccctggcctacgcgac ctgatccagggtttgagcttcgtgactcggaggcgcatccgaaggacagtgtgccgggcc ttgcgcggcgtggcgacctgccaggctgacaggcactcgctcatggtcaagtacatcatg gacctcgagaggctggatccagacagggctgccgagaccttccgcgtgggtctccccggc gctgctggtggtcaggatacgccggggctgctccgtgtggctggtggcagtggcatcgcc tggagcccaggagaacacgaggtcctccagcccttctgcgactttccagaaatcgtggat atcagcatcaagcaggcgccgtgcattggcccggctgccgagcaccgcctggtcaccatc accaggacagacaatcagatcctggaggccgagttcccggggcttcccgcagcgttgtcc ttcgtggcgctcgtggatggctacttccggctgaccacggactcgaggcactacttctgc aaggaggtggcgccaccgcggctgctggaggaggtggctgagcagtgccatggccctatc accctggattttgccatcaacaaactcaagactgggggctcacttcccggctcctacgtc ctccgccgcagtccccaggatttcgacagctacctcctaactgtttgtgtcctgaccccc ctggggccggattataagggctgcctcatccggtgcgaccccacaggaaccttctccctg gctggccttggccgttcccacagcagtcttcgagagctcctggcagcctgttggaatggt gggttgcacgtggatggggttgagctgtacctcaccttctgctgcaaccccagacctaaa gaaaagtccaatctgattgtggtccggagaggctgcaacccacccacatcatcccctgtt cagccccaattccagtgccagctgagtcagatgacgtttcacaagatccctgctgacagc ctgcagtggcatgagaacctaggtcatgggtccttcaccaagatttatcggggctgtcac catgagattgtggatggggaggcccgagagacagaggtactgctcaaagtgatggatgcc aagcacaagaattgcatggagtcattcctggaagcagcgagcttgatgagccaagtgtca taccagcatctcgtattgctccacggcgtgtgcatggctggagacagtatcatggttcag gaatttgtacgcctgggagcactggacacatatctacgcaagtgtggccacctagtgcca gccagctggaagctacaggtgatcaaacagctggcctatgccctcaactatctggaagac aaaggtctccctcatggcaatgtctcagcccggaaggtgctcttggctcgtgaggggact gatgggaacctgcctttcatcaagctgagtgacccgggtgtcagccccactgtgctaagc ctggagatgctcactgacaggatcccctgggtggcccctgaatgtctccaggaggcccga acacttggcttggaagctgacaagtggggctttggagccacagtctgggaggtgttcagt ggtgtcacagtgcccatcagcaccctggagcctgccaagaagctccagttttaccaggaa cggcagcagttgcctgcccctaagtggatggagctggccctgctgatccaacagtgcatg gcctatgagccaggccagaggccctctttccgtgctgtcatccgtgacctgaacagcctc atcacttcagattatgagctcctctcagaccccacacctggcaccctggcgccccgtgat gggctctggaatggtacccagctctacgcctgccaggaccctaccatctttgaagagaga cacctcaaatacatctcacagctgggcaagggcaactttggcagcgtggaactgtgccgc tacgacccgctgggcgacaacacaggggccctggtggccgtgaagcagttgcagcatagt gggccagaacagcagagggacttccagcgggagatccagatcctcaaagccctccacagt gacttcattgtcaagtaccggggtgtacgctatggcccaggccgccagagcctgcggttg gtcatggagtatctgcccagtggctgcctgcgcgacttcctgcagcggcaccgcgcccgc ctcgacgctggccgcctgctcctctacgcctcacagatctgcaagggcatggagtacctg ggctcctgccgctgcctgcaccgcgacctggcagcccggaacatcctggtggaaagcgag acgcacgtcaagatcgccgacttcggcctcgccaagctgctgcctctcgacaaagagtac tacgtggtccgcgagccaggccagagccccatcttctggtatgccccagagtccctctcg gacaacatcttctcgcgccagtcggatgtctggagcttcggggtcgtcctgtacgagctc ttcacctacagtgacaagaactgtagcccctcagccgagttcctgcggatgatgggatgt gagagagatgttccagccctctgccgcctcctggagctgctggctgagggccagaggctg cccgcacctcccgcctgtcctagtgaggttcatgagctcatgaagctgtgctgggcccct aaccctcaagaccgaccatcattcagtgccctgggcccccagctagatgcgctgtggagt ggaagccggggatag

Bos mutus (wild yak): 102286137 Help Entry 102286137         CDS       T02919                                  Gene name JAK1 Definition (RefSeq) Janus kinase 1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism bom  Bos mutus (wild yak) Pathway bom01521   EGFR tyrosine kinase inhibitor resistance bom04151   PI3K-Akt signaling pathway bom04217   Necroptosis bom04380   Osteoclast differentiation bom04550   Signaling pathways regulating pluripotency of stem cells bom04621   NOD-like receptor signaling pathway bom04630   JAK-STAT signaling pathway bom04658   Th1 and Th2 cell differentiation bom04659   Th17 cell differentiation bom05140   Leishmaniasis bom05145   Toxoplasmosis bom05152   Tuberculosis bom05160   Hepatitis C bom05161   Hepatitis B bom05162   Measles bom05163   Human cytomegalovirus infection bom05164   Influenza A bom05165   Human papillomavirus infection bom05166   Human T-cell leukemia virus 1 infection bom05167   Kaposi sarcoma-associated herpesvirus infection bom05168   Herpes simplex virus 1 infection bom05169   Epstein-Barr virus infection bom05171   Coronavirus disease - COVID-19 bom05200   Pathways in cancer bom05203   Viral carcinogenesis bom05212   Pancreatic cancer bom05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:bom00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102286137 (JAK1)    04151 PI3K-Akt signaling pathway     102286137 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     102286137 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     102286137 (JAK1)  09150 Organismal Systems   09151 Immune system    04621 NOD-like receptor signaling pathway     102286137 (JAK1)    04658 Th1 and Th2 cell differentiation     102286137 (JAK1)    04659 Th17 cell differentiation     102286137 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     102286137 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102286137 (JAK1)    05203 Viral carcinogenesis     102286137 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102286137 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     102286137 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     102286137 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102286137 (JAK1)    05161 Hepatitis B     102286137 (JAK1)    05160 Hepatitis C     102286137 (JAK1)    05171 Coronavirus disease - COVID-19     102286137 (JAK1)    05164 Influenza A     102286137 (JAK1)    05162 Measles     102286137 (JAK1)    05168 Herpes simplex virus 1 infection     102286137 (JAK1)    05163 Human cytomegalovirus infection     102286137 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     102286137 (JAK1)    05169 Epstein-Barr virus infection     102286137 (JAK1)    05165 Human papillomavirus infection     102286137 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102286137 (JAK1)    05140 Leishmaniasis     102286137 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102286137 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bom01001]     102286137 (JAK1) Enzymes [BR:bom01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102286137 (JAK1) Protein kinases [BR:bom01001]  Non-receptor tyrosine kinases   JAK family [OT]    102286137 (JAK1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 Jak1_Phl FERM_F1 SH2 Motif Other DBs NCBI-GeneID:  102286137 NCBI-ProteinID:  XP_005886754 LinkDB All DBs Position Un AA seq 1158 aa AA seqDB search MQYLNIKEDCSAMAFCAKMRSSKKAEMNLEAPEPGVEVLFYLSDREPLRLGGGEYTAEEL CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTVTVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN RFHPNDSGNVLCYEVMVTGNLGIQWRQKPHIVPVEKEKNKLKRKKLENKHKKDEEKNKIR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEVLGIQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYTMSQLSFDRILKKDITQGEHLGRGTRTHIYSGT LTDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSEKKPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQHMRKCWEFQPSNRTT FQNLIEGFEALLRSMSNI NT seq 3477 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcagtgccatggctttctgtgctaaaatgagg agctccaagaaggcagagatgaatctggaggcccctgagccgggggtggaggtgctcttc tacctgtcggatagggagcctctccggctgggcggtggagagtacacggcggaggagctg tgcattcgggcggcgcaggagtgctgtatctctcctctgtgtcacaacctctttgccctg tatgacgagaacaccaagctctggtatgctccgaatcgcaccgtcaccgtcgacgacaaa acgtcactccggcttcactaccggatgaggttctatttcaccaactggcatgggaccaac gacaatgaacaatcagtatggcgacattctccaaagaagcagaaaaacggctacgagaaa aaaaaagttccagatgcaacacctctccttgacgccagctcgctggagtatctgtttgct cagggacagtatgatttggtcaaatgcctggctcccattcgagaccccaagacggagcag gatgggcacgacattgagaacgagtgtcttgggatggccgtgctggccatctcccactac gccatgatgaagaagatgcaattgccagaactccccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata aataatgttttcaaggattttctaaaggagtttaacaacaagaccatttgtgacagcagc gtgtccacgcacgacctgaaggtgaaatacctggctaccttggaaactttgacaaaacat tatggtgctgaaatatttgagacttccatgctactgatttcatcagaaaatgagatgaat cggttccatccaaatgatagtggaaatgttctctgctatgaagtgatggtgactggaaat cttggaatccagtggagacagaaaccacatattgttcctgttgaaaaggaaaaaaacaaa ctgaaacggaaaaaactggaaaataaacacaagaaggatgaggaaaaaaacaaaatccga gaagagtggaacaatttttcttacttccctgagatcactcacattgtaatcaaggagtct gtggtcagcattaataagcaggacaacaaaaaaatggaactgaagctctcttcccacgag gaggccttgtccttcgtgtccctggtcgatggctacttccggctcacggcagacgcccat cactacctctgcactgacgtggctcccccattgatcgtccacaacatacagaatggctgt catggtccaatctgcacggagtatgccatcaataagctgcggcaggaggggagcgaggag gggatgtacgtgctgcggtggagctgcaccgactttgacaacatcctcatgaccgtcacc tgcttcgaaaagtctgaggtgctgggtatccagaaacagttcaagaactttcagatcgag gtgcagaagggccgctacagcctgcatggctcggaccgcagcttcccgagccttggggac ctcatgagccacctaaagaagcagatcctgcgcacggacaacatcagcttcgtgctgaag cgctgctgccagcccaagccccgagaaatctccaatctgctggtggccaccaagaaagcc caggagtggcagcctgtctacaccatgagccagctgagtttcgatcgaatcctcaagaaa gatattacgcaaggcgagcaccttgggagaggcacgcggacacacatctactctgggacc ctcacggattacaaggatgacgaagggacttctgaagagaagagaataaaagtcatcctg aaggtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatg atgaggcaggtctcccacaaacacatcgtgtacctctatggggtttgcgtccgagatgtg gagaatatcatggtggaagagtttgtggaggggggacccctggacctcttcatgcaccgg aaaagtgacgtcctcaccacaccctggaagtttaaagttgccaaacagctggccagcgcc ctgagttacttggaggataaagacctggtccacggaaatgtgtgcactaaaaacctcctt ctggcccgcgagggcatcgacagtgagtgcggccccttcatcaagctcagtgaccctggc atccccatcactgtgctctccaggcaagagtgcatagaacgaatcccctggattgctccc gagtgtgttgaagactccaagaatctgagtgtggctgctgacaagtggagctttggaacc acactctgggaaatctgctacaatggcgagatccccttgaaagacaagacgctgattgag aaagagagattctatgaaagccggtgcaggccagtgaccccatcttgtaaggagctagct gacttgatgacccgctgcatgaactacgaccccaaccagagacccttcttccgagccatc atgagagacatcaataagctggaggagcagaatccagacattgtatcagaaaaaaagcca acaactgaagtggatcccacacattttgaaaagcggttcttaaagaggatccgtgacttg ggagagggccactttgggaaggtcgagctctgcaggtatgaccctgagggggacaataca ggggagcaagtggctgtcaaatccctgaagcccgagagtggagggaaccacatcgctgat ctgaagaaggagattgaaatcttaagaaatctttatcatgagaacattgtgaagtataaa ggcatctgcacagaagatggtggaaatggtattaagctcatcatggagtttctgccttca gggagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcaatta aaatatgccgttcagatttgtaaggggatggactatctgggttctcggcagtacgttcac cgggacttagcagcaagaaacgtcctcgtggagagtgagcaccaggtgaaaatcggggac ttcggtctcaccaaagccatcgaaactgataaggagtactacacagtcaaggacgaccgc gacagccctgtgttttggtatgctccagaatgtttaattcagtgtaagttctatatcgcc tctgatgtctggtctttcggagtgactctgcatgagctgcttacttactgtgattcagat tccagtcccatggccttgttcctgaaaatgataggcccaactcatggtcagatgacggta acaagactcgtgaatacattaaaagaaggaaaacgcttgccatgtccaccgaactgtcca gatgaggtttatcaacatatgcgaaagtgttgggaatttcaaccatctaatcggacaacc tttcagaaccttattgaaggatttgaagcacttctaagaagcatgagtaacatttaa

Bos mutus (wild yak): 102287266 Help Entry 102287266         CDS       T02919                                  Gene name TYK2 Definition (RefSeq) tyrosine kinase 2   KO K11219   non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2] Organism bom  Bos mutus (wild yak) Pathway bom04217   Necroptosis bom04380   Osteoclast differentiation bom04621   NOD-like receptor signaling pathway bom04630   JAK-STAT signaling pathway bom04658   Th1 and Th2 cell differentiation bom04659   Th17 cell differentiation bom05145   Toxoplasmosis bom05160   Hepatitis C bom05161   Hepatitis B bom05162   Measles bom05164   Influenza A bom05165   Human papillomavirus infection bom05167   Kaposi sarcoma-associated herpesvirus infection bom05168   Herpes simplex virus 1 infection bom05169   Epstein-Barr virus infection bom05171   Coronavirus disease - COVID-19 Brite KEGG Orthology (KO) [BR:bom00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102287266 (TYK2)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     102287266 (TYK2)  09150 Organismal Systems   09151 Immune system    04621 NOD-like receptor signaling pathway     102287266 (TYK2)    04658 Th1 and Th2 cell differentiation     102287266 (TYK2)    04659 Th17 cell differentiation     102287266 (TYK2)   09158 Development and regeneration    04380 Osteoclast differentiation     102287266 (TYK2)  09160 Human Diseases   09172 Infectious disease: viral    05161 Hepatitis B     102287266 (TYK2)    05160 Hepatitis C     102287266 (TYK2)    05171 Coronavirus disease - COVID-19     102287266 (TYK2)    05164 Influenza A     102287266 (TYK2)    05162 Measles     102287266 (TYK2)    05168 Herpes simplex virus 1 infection     102287266 (TYK2)    05167 Kaposi sarcoma-associated herpesvirus infection     102287266 (TYK2)    05169 Epstein-Barr virus infection     102287266 (TYK2)    05165 Human papillomavirus infection     102287266 (TYK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102287266 (TYK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bom01001]     102287266 (TYK2) Enzymes [BR:bom01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102287266 (TYK2) Protein kinases [BR:bom01001]  Non-receptor tyrosine kinases   JAK family [OT]    102287266 (TYK2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 Kinase-like Kdo Motif Other DBs NCBI-GeneID:  102287266 NCBI-ProteinID:  XP_005902973 LinkDB All DBs Position Un AA seq 1185 aa AA seqDB search MPLCQWRATTRGRKPSGDGAQPMATREGLKVLLHWAGPSGGEPWVTFTEPTLTAEDVCIH VAHKVGITPPCFNLFALFDAQAQVWLPPNHILDTSRDSSLTLYFRMRFYFRNWHGTNPQE PAVYRCGPPGAETSSEQAEQGVQLLDPASFEYLFEQGKHEFVNDVASLWELSSEEEIHHF QNESLGMALLHLCHLALRNGVPLEKVAKKTSFKDCIPRSFRRQMRQHNALTRLRQRSIFR KFLRAFQPGCLSQQVVMVKYLATLERLAPCFGTERVPVCHLELLSQADGEPCYIRDGGQA PPDPGSESAVGPPTHEVLVSGTEGIRWRLVPAEGPADGGAGGGSRMPDADPSGKKMKAEE VGSEPVDRPRESPWSYFCDFQDITHMVLKERHVSIHCQDNKCLELTLPSRAAALSLVSLV DGYFRLTADSNHYLCHEVAPPRLLMSIQDGIHGPLLEPFVLAKLKPEAGLYLIHWSTSHL HRLILTVAQRDQAPGTKGLRLRKFPIELQAGTVMLEGWGRSFPSVRDLRAALQDCSLRAG NDCFSLRRCCLPRPGEISNLIVTRGPQASTRPLNLSHLSFYRVRQEDITQLSHLGQGTRT NVYEGLLRVGGGGPEEDKADGEEPPTPAGDRGQELRVVLKVLDPSHHDIALAFYETASLM SQVSHVHLAFVHGVFVHGSENIMVTEYVEHGPLDVWLRRERGRVPLAWKLAVAQQLASAL SYLEDKSLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLSALSREERVERIPWTAPE CLSGGANSLSTAADKWGFGATLLEICFDGEAPLQGRSPSEKERFYQKQHKLPEPSCPELA TLTSQCLTYEPAQRPSFRTILRDFTQLQPQNLADVLSVSPDSLASDPTVFHKRYLKKIRD LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKAGCGPQLRTGWRREIDILRTLYHKHIVKY KGCCEDQGEKSIQLVMEYMPLGSLRDYLPRHNVGLVQLLLFSLQICEGMAYLHTQHYVHR DLAARNVLLDNNRLVKIGDFGLTKAVPEGHEYYCVREDGDSPVFWYAPECLKECKFYYAS DVWSFGVLMYELLTYCDSSQSPPSKFIELIGLTQGQMTVLRLTELLERGERLPQPEKCPS EIYCLMKDCWKAEASFRPTFQNLVPILRSYHEKYQGQAPSVFSVC NT seq 3558 nt NT seq  +upstreamnt  +downstreamnt atgcctctgtgccaatggagggccaccaccaggggcaggaagcccagtggggacggagct cagcccatggccaccagagaaggcctgaaagtgcttctgcactgggctggccccagtggt ggggagccctgggtcaccttcactgagcccacactgaccgcggaggatgtctgcatccac gtcgcacacaaagtcggcatcactccaccctgcttcaatctttttgccctcttcgatgcc caggcccaggtctggctgcctccaaatcacattctggatacctccagggactccagcctg acgctgtacttccgcatgaggttttatttccgaaactggcatggcacgaatcctcaggag ccagctgtgtaccgctgcgggcccccaggggccgagacttcctcagaacaggcagagcag ggggtgcaactcctggaccctgcctcctttgagtacctctttgagcagggcaagcatgaa tttgtaaatgacgtggcatcactatgggagctatccagcgaggaggagatccaccacttt cagaatgagagcctgggcatggcccttttgcacctctgccacctcgctctccgcaatggt gtcccccttgaaaaggtggccaagaagaccagcttcaaggattgcatcccacgctccttc cggcggcagatgcggcagcacaacgctctgacacggctgcgccaacggagcatcttccgc aagttcctgcgggccttccagccgggctgcctctcccagcaggtcgtcatggtgaagtac ctggccacgctcgagcgactggcaccctgctttggcacagagcgtgtgcccgtgtgccac ctggagctgctgtcccaagccgatggggagccctgctacatccgggacggtgggcaggcc cctcctgaccccgggtctgagtctgctgtcggaccccccacccacgaggtgctggtgtca ggcacggaaggcatccggtggcggctggtaccggcggaggggcctgctgatggtggtgct ggtggcggcagcaggatgcctgatgctgacccatctgggaagaaaatgaaggccgaggag gtgggcagcgagccagtggacaggcctcgggagagcccctggtcctacttctgtgacttc caggacatcacccacatggtgctgaaggaacgccacgtcagcatccattgtcaggacaac aagtgcctggagctgaccctgccttcccgggctgcggccctgtccttggtgtcgctggtg gatggctacttccgcctgactgccgactcaaaccactacctgtgccacgaggtggctcct ccacggctgctgatgagtatccaggatggtatccacggccccctgctggagccatttgtg ctggccaagctgaagcccgaggctggcctctaccttatccactggagcaccagccacctc caccgcctcatcctcacagtggcccagcgcgaccaggctccaggcactaagggcttgcgc ctgcggaagttccctatcgagctccaggccgggacagtcatgctggagggctggggccgg tctttccccagcgtgcgggacctgagggctgccctgcaggactgctcgctgcgggccggc aacgactgcttttccctgcgtcgctgctgcctgccccggcccggagagatctccaacctc atcgtcacacgggggcctcaggccagcaccagaccgctcaacctcagtcatctcagcttc taccgagtccgccaggaagacatcacccagctgtcccacttaggccagggcacaaggacc aacgtgtatgagggcctcttgcgagtggggggcggaggccccgaggaggacaaggcagat ggcgaggaaccccccacgcccgctggggaccgtgggcaggagcttcgtgtggtgctcaag gtgctagaccccagtcaccacgacatcgccctggccttctacgagacagccagcctcatg agccaggtctcccacgtgcacctggccttcgtgcacggcgtcttcgtgcacggctccgag aacatcatggtgaccgagtacgtggagcacgggcccctggacgtatggctgcggcgggag aggggccgcgtgcccctggcctggaagttggcagtggcccagcagctggccagcgccctc agttacctggaagacaaaagcctggttcatggcaacgtgtgtggccggaacatcctgctg gcacggctggggctggcggagggcaccagccccttcatcaagctgagtgaccccggcgtg ggcctgagtgccctctccagggaggagcgggtggagcggatcccctggacagcccccgag tgcctgtctggtggagccaacagcctgagcaccgcagccgacaagtggggctttggtgcc accctcctggagatctgcttcgacggcgaggcccccctgcagggccgtagtccctctgag aaagagcgcttctaccagaagcagcacaaactgcctgagccctcatgcccagagctggcc acactcaccagccagtgcctgacctacgagccagcccagcggccatccttccgcaccatc ctgcgtgacttcactcagctacagccccagaatctcgctgatgtcttgtctgtgagcccg gattcactggcttcagatcccacggttttccacaagcgatacttgaaaaagatccgggat ctgggtgagggtcacttcggaaaggtcagcctgtattgctacgaccccaccaacgacggc actggtgagatggtagccgtgaaggccctcaaggcaggctgcggtccccagctccggacg ggctggaggcgagaaatcgacatcctacgcacgctctaccacaagcacatcgtcaagtac aagggctgctgcgaggaccaaggcgagaagtcgatacagctggtcatggaatacatgccc ctgggcagcctccgagactacttgccccggcacaatgtcgggctggtccagctgctgctc ttctccctgcagatctgcgagggtatggcctacctgcacacacagcactacgtgcatcga gacctggccgcgcgcaacgtgctgctggacaacaacaggctagtcaagatcggggacttc ggcctcaccaaggccgtgcccgaaggccacgagtattactgcgtgcgcgaggatggggac agtcctgtgttctggtatgccccggagtgcctgaaggagtgtaagttctactatgcatca gacgtctggtcctttggggtcctcatgtatgagctgctgacctactgtgactccagccag agccctccctcgaaattcatcgagctcataggcctcacccaagggcagatgactgtgctg aggctcacagagctgctggaacgaggggagaggctgccgcaaccagagaaatgcccctct gagatctattgcctcatgaaggactgctggaaggcagaggcctcattccgcccgaccttc cagaacctcgtacccatcctcagatcataccacgagaaataccaaggccaggccccctcg gtgttcagtgtctgctga

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