Bos mutus (wild yak): 102281443
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Entry
102281443 CDS
T02919
Gene name
IKBKB
Definition
(RefSeq) inhibitor of nuclear factor kappa B kinase subunit beta
KO
K07209
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:
2.7.11.10
]
Organism
bom
Bos mutus (wild yak)
Pathway
bom01523
Antifolate resistance
bom04010
MAPK signaling pathway
bom04014
Ras signaling pathway
bom04062
Chemokine signaling pathway
bom04064
NF-kappa B signaling pathway
bom04068
FoxO signaling pathway
bom04150
mTOR signaling pathway
bom04151
PI3K-Akt signaling pathway
bom04210
Apoptosis
bom04380
Osteoclast differentiation
bom04620
Toll-like receptor signaling pathway
bom04621
NOD-like receptor signaling pathway
bom04622
RIG-I-like receptor signaling pathway
bom04623
Cytosolic DNA-sensing pathway
bom04625
C-type lectin receptor signaling pathway
bom04657
IL-17 signaling pathway
bom04658
Th1 and Th2 cell differentiation
bom04659
Th17 cell differentiation
bom04660
T cell receptor signaling pathway
bom04662
B cell receptor signaling pathway
bom04668
TNF signaling pathway
bom04722
Neurotrophin signaling pathway
bom04910
Insulin signaling pathway
bom04920
Adipocytokine signaling pathway
bom04930
Type II diabetes mellitus
bom04931
Insulin resistance
bom04932
Non-alcoholic fatty liver disease
bom05010
Alzheimer disease
bom05132
Salmonella infection
bom05135
Yersinia infection
bom05142
Chagas disease
bom05145
Toxoplasmosis
bom05160
Hepatitis C
bom05161
Hepatitis B
bom05162
Measles
bom05163
Human cytomegalovirus infection
bom05164
Influenza A
bom05165
Human papillomavirus infection
bom05166
Human T-cell leukemia virus 1 infection
bom05167
Kaposi sarcoma-associated herpesvirus infection
bom05168
Herpes simplex virus 1 infection
bom05169
Epstein-Barr virus infection
bom05170
Human immunodeficiency virus 1 infection
bom05171
Coronavirus disease - COVID-19
bom05200
Pathways in cancer
bom05206
MicroRNAs in cancer
bom05212
Pancreatic cancer
bom05215
Prostate cancer
bom05220
Chronic myeloid leukemia
bom05221
Acute myeloid leukemia
bom05222
Small cell lung cancer
bom05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
bom05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
bom00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
102281443 (IKBKB)
04014 Ras signaling pathway
102281443 (IKBKB)
04064 NF-kappa B signaling pathway
102281443 (IKBKB)
04668 TNF signaling pathway
102281443 (IKBKB)
04068 FoxO signaling pathway
102281443 (IKBKB)
04151 PI3K-Akt signaling pathway
102281443 (IKBKB)
04150 mTOR signaling pathway
102281443 (IKBKB)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
102281443 (IKBKB)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
102281443 (IKBKB)
04621 NOD-like receptor signaling pathway
102281443 (IKBKB)
04622 RIG-I-like receptor signaling pathway
102281443 (IKBKB)
04623 Cytosolic DNA-sensing pathway
102281443 (IKBKB)
04625 C-type lectin receptor signaling pathway
102281443 (IKBKB)
04660 T cell receptor signaling pathway
102281443 (IKBKB)
04658 Th1 and Th2 cell differentiation
102281443 (IKBKB)
04659 Th17 cell differentiation
102281443 (IKBKB)
04657 IL-17 signaling pathway
102281443 (IKBKB)
04662 B cell receptor signaling pathway
102281443 (IKBKB)
04062 Chemokine signaling pathway
102281443 (IKBKB)
09152 Endocrine system
04910 Insulin signaling pathway
102281443 (IKBKB)
04920 Adipocytokine signaling pathway
102281443 (IKBKB)
09156 Nervous system
04722 Neurotrophin signaling pathway
102281443 (IKBKB)
09158 Development and regeneration
04380 Osteoclast differentiation
102281443 (IKBKB)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
102281443 (IKBKB)
05206 MicroRNAs in cancer
102281443 (IKBKB)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
102281443 (IKBKB)
09162 Cancer: specific types
05212 Pancreatic cancer
102281443 (IKBKB)
05221 Acute myeloid leukemia
102281443 (IKBKB)
05220 Chronic myeloid leukemia
102281443 (IKBKB)
05215 Prostate cancer
102281443 (IKBKB)
05222 Small cell lung cancer
102281443 (IKBKB)
09164 Neurodegenerative disease
05010 Alzheimer disease
102281443 (IKBKB)
09166 Cardiovascular disease
05418 Fluid shear stress and atherosclerosis
102281443 (IKBKB)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
102281443 (IKBKB)
04932 Non-alcoholic fatty liver disease
102281443 (IKBKB)
04931 Insulin resistance
102281443 (IKBKB)
09171 Infectious disease: bacterial
05132 Salmonella infection
102281443 (IKBKB)
05135 Yersinia infection
102281443 (IKBKB)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
102281443 (IKBKB)
05170 Human immunodeficiency virus 1 infection
102281443 (IKBKB)
05161 Hepatitis B
102281443 (IKBKB)
05160 Hepatitis C
102281443 (IKBKB)
05171 Coronavirus disease - COVID-19
102281443 (IKBKB)
05164 Influenza A
102281443 (IKBKB)
05162 Measles
102281443 (IKBKB)
05168 Herpes simplex virus 1 infection
102281443 (IKBKB)
05163 Human cytomegalovirus infection
102281443 (IKBKB)
05167 Kaposi sarcoma-associated herpesvirus infection
102281443 (IKBKB)
05169 Epstein-Barr virus infection
102281443 (IKBKB)
05165 Human papillomavirus infection
102281443 (IKBKB)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
102281443 (IKBKB)
05142 Chagas disease
102281443 (IKBKB)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
102281443 (IKBKB)
Enzymes [BR:
bom01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.10 IkappaB kinase
102281443 (IKBKB)
Protein kinases [BR:
bom01001
]
Serine/threonine kinases: Other
IKK family [OT]
102281443 (IKBKB)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
IKBKB_SDD
Pkinase
PK_Tyr_Ser-Thr
IKKbetaNEMObind
Pkinase_fungal
Kdo
APH
ubiquitin
YrbL-PhoP_reg
Med20
GTSE1_N
Glyco_hydro_65m
Motif
Other DBs
NCBI-GeneID:
102281443
NCBI-ProteinID:
XP_005901827
UniProt:
L8I6C2
LinkDB
All DBs
Position
Un
AA seq
756 aa
AA seq
DB search
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLNHPNVVAARDVPEGMQSLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
MDIVVSEDLNGAVKFSSSLPHPNNLNSVLAQRLEKWLQLMLMWHPRQRGTDPVYGPNGCF
KALDDILNLKLLHVLNMVTGTLHTYPVTEDESLQSLKARIRQDTGILEEDQELLQEAGLA
LIPDKPAAQCLSDGKLNEGRTLDMDLVFLFDNSRVTYESQVSPQPQPESVSCILQEPKRN
LPFFQLRKVWGQVWHSIQALKEDCSRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYREQTEFGITSDKLLLAWREMEQAVELCGRENEVKHLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTDGDSQEMVRLLLQAIQG
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMSEDEKMVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSHPCQLMSQPCTAPDSLPEAAEKSEDLVAEAHTLCTQLE
NALQDTMKEQDQSLRSLDWSWLQSEEEEQQSLERAS
NT seq
2271 nt
NT seq
+upstream
nt +downstream
nt
atgagctggtcaccttccctgccaacccagacatgtggggcctgggaaatgaaagagcgt
cttgggacagggggatttgggaacgtcatccgatggcacaatcaggagacgggcgagcag
attgccatcaagcagtgccggcaagagctcagtccccggaaccgcgagcgctggtgcctg
gagatccagatcatgaggaggctgaaccaccccaatgtggtggccgcccgggacgtccct
gaaggcatgcagagcctggctcccaacgacctgcccctgctggccatggagtactgccag
ggcggggacctgcgcaagtacctgaaccagtttgagaactgctgcggcctgcgggaagga
gccatcctcaccttgctgagcgacattgcctctgcacttcgataccttcatgagaacaga
atcatccatcgggatctgaagccagaaaacattgtcctgcagcaaggggagcagagatta
atacacaaaattattgacctgggatatgccaaggagctggaccagggcagcctctgcacg
tccttcgtggggaccctgcagtacctggcccccgagctgctggagcagcagaagtacacg
gtgaccgtggactactggagcttcggcaccttggccttcgagtgcatcaccggcttccgg
cctttcctgcccaactggcagccggtgcagtggcactccaaagtccggcagaagagcgag
atggacatcgtggtgagcgaggacctgaacggggccgtgaagttctccagctcgctgccg
caccccaacaacctcaacagcgtcctggcccagcggctggagaagtggctgcagctgatg
ctgatgtggcacccgcgccagaggggcaccgaccctgtctacgggcccaacggctgcttc
aaggccctggacgacatcttgaacttgaagctgcttcatgtcctgaacatggtcacgggc
accctgcacacctaccccgtgaccgaggacgagagcctgcagagcctgaaggcccgcatc
cgccaggacacaggcatcctcgaggaggaccaggagctgctgcaggaggcagggctggcc
ctgatccccgacaagcctgccgcccagtgcctctcggacggcaagctgaacgagggccgc
acgctggacatggacctcgttttcctctttgacaacagcagggtcacctatgaaagccag
gtctccccacagccccagcctgaaagcgtcagctgcatcttgcaagagcccaagaggaac
ctcccgttcttccagctgcggaaggtgtggggccaagtctggcacagcatccaggccctg
aaggaagactgcagccgcctgcagcagggccagcgcgcggccatgatgaatctgctgcgg
aacaacagctgtctgtccaagatgaagaactccatggcctccatgtctcagcagctcaag
gccaagctggacttctttaagaccagtatccagattgacctggagaagtacagggagcag
acggagtttgggatcacgtcagacaagctgctgctagcctggagggagatggagcaggcc
gtggagctctgcggacgggagaacgaggtgaagcacttggtggagcggatgatggccctg
cagacggacatcgtggacctgcagcgcagccccatgggccggaagcagggcgggacgctg
gatgatctggaagagcaggcgcgggagctttaccgcaggctgagggagaagcccagagac
cagcggactgatggtgacagtcaggaaatggtgcggctgctcctccaggcaatccaaggc
tttgagaagaaagtgcgagtgatttatacgcagctcagtaagaccgtggtctgcaagcag
aaggccctggagctgctgcccaaggtggaggaggtggtcagcctgatgagcgaggacgag
aagatggtggtgcggctgcaggagaagcggcagaaggagctctggaacctcctgaagatt
gcgtgtagcaaggtccggggtcccgtcagcggaagcccggacagtatgaacgcctcccgc
ctgagtcacccctgccagctgatgtcacagccctgcacggctcccgacagcttgcccgag
gccgccgagaagagtgaggacctggtggctgaagctcacaccctgtgcacccagctggag
aacgccctgcaggacaccatgaaggagcaggaccagagtttgaggtctctagactggagc
tggttgcagtcggaggaggaggaacagcagagcctggagcgggcctcgtga
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