KEGG   Bos mutus (wild yak): 102286241
Entry
102286241         CDS       T02919                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor bound protein 2
  KO
K04364  growth factor receptor-bound protein 2
Organism
bom  Bos mutus (wild yak)
Pathway
bom01521  EGFR tyrosine kinase inhibitor resistance
bom01522  Endocrine resistance
bom04010  MAPK signaling pathway
bom04012  ErbB signaling pathway
bom04014  Ras signaling pathway
bom04062  Chemokine signaling pathway
bom04068  FoxO signaling pathway
bom04072  Phospholipase D signaling pathway
bom04150  mTOR signaling pathway
bom04151  PI3K-Akt signaling pathway
bom04380  Osteoclast differentiation
bom04510  Focal adhesion
bom04540  Gap junction
bom04550  Signaling pathways regulating pluripotency of stem cells
bom04630  JAK-STAT signaling pathway
bom04650  Natural killer cell mediated cytotoxicity
bom04660  T cell receptor signaling pathway
bom04662  B cell receptor signaling pathway
bom04664  Fc epsilon RI signaling pathway
bom04714  Thermogenesis
bom04722  Neurotrophin signaling pathway
bom04910  Insulin signaling pathway
bom04912  GnRH signaling pathway
bom04915  Estrogen signaling pathway
bom04917  Prolactin signaling pathway
bom04926  Relaxin signaling pathway
bom04935  Growth hormone synthesis, secretion and action
bom05034  Alcoholism
bom05160  Hepatitis C
bom05161  Hepatitis B
bom05163  Human cytomegalovirus infection
bom05165  Human papillomavirus infection
bom05200  Pathways in cancer
bom05203  Viral carcinogenesis
bom05205  Proteoglycans in cancer
bom05206  MicroRNAs in cancer
bom05210  Colorectal cancer
bom05211  Renal cell carcinoma
bom05213  Endometrial cancer
bom05214  Glioma
bom05215  Prostate cancer
bom05220  Chronic myeloid leukemia
bom05221  Acute myeloid leukemia
bom05223  Non-small cell lung cancer
bom05224  Breast cancer
bom05225  Hepatocellular carcinoma
bom05226  Gastric cancer
bom05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:bom00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102286241 (GRB2)
   04012 ErbB signaling pathway
    102286241 (GRB2)
   04014 Ras signaling pathway
    102286241 (GRB2)
   04630 JAK-STAT signaling pathway
    102286241 (GRB2)
   04068 FoxO signaling pathway
    102286241 (GRB2)
   04072 Phospholipase D signaling pathway
    102286241 (GRB2)
   04151 PI3K-Akt signaling pathway
    102286241 (GRB2)
   04150 mTOR signaling pathway
    102286241 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102286241 (GRB2)
   04540 Gap junction
    102286241 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    102286241 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    102286241 (GRB2)
   04660 T cell receptor signaling pathway
    102286241 (GRB2)
   04662 B cell receptor signaling pathway
    102286241 (GRB2)
   04664 Fc epsilon RI signaling pathway
    102286241 (GRB2)
   04062 Chemokine signaling pathway
    102286241 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102286241 (GRB2)
   04912 GnRH signaling pathway
    102286241 (GRB2)
   04915 Estrogen signaling pathway
    102286241 (GRB2)
   04917 Prolactin signaling pathway
    102286241 (GRB2)
   04926 Relaxin signaling pathway
    102286241 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    102286241 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    102286241 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102286241 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    102286241 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102286241 (GRB2)
   05206 MicroRNAs in cancer
    102286241 (GRB2)
   05205 Proteoglycans in cancer
    102286241 (GRB2)
   05203 Viral carcinogenesis
    102286241 (GRB2)
   05231 Choline metabolism in cancer
    102286241 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102286241 (GRB2)
   05225 Hepatocellular carcinoma
    102286241 (GRB2)
   05226 Gastric cancer
    102286241 (GRB2)
   05214 Glioma
    102286241 (GRB2)
   05221 Acute myeloid leukemia
    102286241 (GRB2)
   05220 Chronic myeloid leukemia
    102286241 (GRB2)
   05211 Renal cell carcinoma
    102286241 (GRB2)
   05215 Prostate cancer
    102286241 (GRB2)
   05213 Endometrial cancer
    102286241 (GRB2)
   05224 Breast cancer
    102286241 (GRB2)
   05223 Non-small cell lung cancer
    102286241 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    102286241 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    102286241 (GRB2)
   05160 Hepatitis C
    102286241 (GRB2)
   05163 Human cytomegalovirus infection
    102286241 (GRB2)
   05165 Human papillomavirus infection
    102286241 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102286241 (GRB2)
   01522 Endocrine resistance
    102286241 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:bom04131]
    102286241 (GRB2)
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified [BR:bom04990]
    102286241 (GRB2)
Membrane trafficking [BR:bom04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    102286241 (GRB2)
Domain-containing proteins not elsewhere classified [BR:bom04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   102286241 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 102286241
NCBI-ProteinID: XP_005908006
UniProt: L8HUE2
LinkDB
Position
Un
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagccaccgcagacgacgagctgagcttcaaa
agaggggacatcctcaaggttttgaatgaggaatgtgatcagaactggtacaaggcagag
ctcaatgggaaagacggcttcatccccaagaactacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgctcagcaaacagcggcatgac
ggggcctttcttatccgagagagcgagagtgctcctggggatttctccctctccgtcaag
tttggaaatgatgtacagcacttcaaggtgctccgagatggggctggaaagtatttcctc
tgggtggtcaagttcaactctttgaatgagctggtagattatcacagatctacatccgtc
tccagaaaccagcagatatttctccgggacatagagcaggtgccacagcagccaacatac
gtccaagccctctttgactttgacccccaagaggatggagagctgggattccgtcgggga
gactttatccacgtcatggataactcagaccccaactggtggaaaggggcttgccacggg
cagaccggcatgttcccacgcaattacgtcacccccgtgaaccggaacgtctaa

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