KEGG   Bos taurus (cow): 100337204
Entry
100337204         CDS       T01008                                 

Gene name
CACNA1S
Definition
(RefSeq) voltage-dependent L-type calcium channel subunit alpha-1S isoform X1
  KO
K04857  voltage-dependent calcium channel L type alpha-1S
Organism
bta  Bos taurus (cow)
Pathway
bta04010  MAPK signaling pathway
bta04020  Calcium signaling pathway
bta04022  cGMP-PKG signaling pathway
bta04024  cAMP signaling pathway
bta04260  Cardiac muscle contraction
bta04261  Adrenergic signaling in cardiomyocytes
bta04270  Vascular smooth muscle contraction
bta04723  Retrograde endocannabinoid signaling
bta04725  Cholinergic synapse
bta04726  Serotonergic synapse
bta04727  GABAergic synapse
bta04911  Insulin secretion
bta04912  GnRH signaling pathway
bta04921  Oxytocin signaling pathway
bta04924  Renin secretion
bta04925  Aldosterone synthesis and secretion
bta04927  Cortisol synthesis and secretion
bta04929  GnRH secretion
bta04934  Cushing syndrome
bta04935  Growth hormone synthesis, secretion and action
bta05010  Alzheimer disease
bta05020  Prion disease
bta05022  Pathways of neurodegeneration - multiple diseases
bta05410  Hypertrophic cardiomyopathy
bta05412  Arrhythmogenic right ventricular cardiomyopathy
bta05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:bta00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100337204 (CACNA1S)
   04020 Calcium signaling pathway
    100337204 (CACNA1S)
   04024 cAMP signaling pathway
    100337204 (CACNA1S)
   04022 cGMP-PKG signaling pathway
    100337204 (CACNA1S)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    100337204 (CACNA1S)
   04929 GnRH secretion
    100337204 (CACNA1S)
   04912 GnRH signaling pathway
    100337204 (CACNA1S)
   04921 Oxytocin signaling pathway
    100337204 (CACNA1S)
   04935 Growth hormone synthesis, secretion and action
    100337204 (CACNA1S)
   04924 Renin secretion
    100337204 (CACNA1S)
   04925 Aldosterone synthesis and secretion
    100337204 (CACNA1S)
   04927 Cortisol synthesis and secretion
    100337204 (CACNA1S)
  09153 Circulatory system
   04260 Cardiac muscle contraction
    100337204 (CACNA1S)
   04261 Adrenergic signaling in cardiomyocytes
    100337204 (CACNA1S)
   04270 Vascular smooth muscle contraction
    100337204 (CACNA1S)
  09156 Nervous system
   04727 GABAergic synapse
    100337204 (CACNA1S)
   04725 Cholinergic synapse
    100337204 (CACNA1S)
   04726 Serotonergic synapse
    100337204 (CACNA1S)
   04723 Retrograde endocannabinoid signaling
    100337204 (CACNA1S)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100337204 (CACNA1S)
   05020 Prion disease
    100337204 (CACNA1S)
   05022 Pathways of neurodegeneration - multiple diseases
    100337204 (CACNA1S)
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    100337204 (CACNA1S)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    100337204 (CACNA1S)
   05414 Dilated cardiomyopathy
    100337204 (CACNA1S)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100337204 (CACNA1S)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:bta04040]
    100337204 (CACNA1S)
Ion channels [BR:bta04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   100337204 (CACNA1S)
SSDB
Motif
Pfam: Ion_trans GPHH Ca_chan_IQ PKD_channel CAC1F_C
Other DBs
NCBI-GeneID: 100337204
NCBI-ProteinID: XP_024832342
LinkDB
Position
16
AA seq 1872 aa
MEPAPAQDEGLRRKQAKKPVPEVLPRPPRALFCLTLQNPVRKACISIVEWKPFETIILLT
IFANCVALAVYLPMPEDDNNRLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRS
GWNVLDFIIVFLGVFTVILEQVNLIQSNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVP
SLQVVLNSIFKAMLPLFHIALLVLFMVVIYAIIGLELFKGKMHKTCYFIGTDIVATVENE
KPSPCARTGSGRPCTISGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITMEGWTDVLYW
VNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLE
EDLRGYLSWITQGEVMDVDDLREGKLALDEGGSDTESLYEIAGLNKVIQFIRHWRQWNRV
FRWKCHDVVKSRVFYWLVILIVALNTLSIASEHHHQPLWLTHLQDVANRVLLALFTVEML
MKMYGLGLRQYFMSIFNRFDCFVVCSGLLEILLVESGAMSPLGISVLRCIRLLRIFKITK
YWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFEDTEVRRSNFDSF
PQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIA
VDNLAEAESLTSAQKAKAEERRRRKMSKGLPDKSEEEKVTVAKKLEQKPKGEGIPTTAKL
KIDEFESNVNEVKDPYPSADFPGDDEEDEPEVPISPRPRPLAELQLKEKAVPIPEASAFF
IFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPLRAESVRNQILGYFDIGFT
SVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLVVVAVSLISMGLESSTISVVKILRVLR
VLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFFSCNDL
SKMTEEECRGYYYVYKDGDPTQIEVRPRQWVHNAFHFDNVLSAMMSLFTVSTFEGWPELL
YKAIDSHEEDKGPVYNHRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCE
LDKNQRQCVQYALKARPLRCYIPKNPYQYRVWYIVTSSYFEYLMFALIMLNTICLGMQHY
NQSEQMNHISDILNVAFTIIFTLEMVLKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILS
EIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTF
IKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLFRCA
TGEAWQEILLACSYGQLCDPESDYAPGEEYTCGTDFAYYYFLSFYMLCAFLIINLFVAVI
MDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEATGRIKHLDVVTLLRRIQPPLGFGKFCP
HRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGNFEQANEELRAIIKKVWKR
TSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMRRQEEYYGYRPKKDTVQIQAGLR
TIEEEAAPEIRRTISGDLMAEEELERAMVEAAMEEGIFRRTGGLFGQVDSFLERTNSLAP
HMANQRPLQFTEIEMEEMESPVFLEDFPQRPSAHPLARANTNNANANVASGNGNHGNSPA
FPSVHYEGELAGETETPATRGGLFGQPRGALGPHSKSRVEWPQGQLPRRRTPRAQAPAAS
CQHAGAESQVPEERSPTPGSLPGEAPPGSRTEDGTPGGPAPAMALLIREALVRGGLDSLA
ADANFIMATGQALAEACRMEPREVEVAAAELLQGREALEGVPGARGCPGLGSSLGSLDLR
EGSQETLIPRRP
NT seq 5619 nt   +upstreamnt  +downstreamnt
atggagccggccccggcacaggacgagggcctgcggaggaagcaggccaagaagcccgtc
ccggaggtcctgcccaggccaccccgggccttgttctgcttgaccctccagaaccccgtg
cggaaagcctgcatcagcatcgtcgagtggaaacccttcgagaccatcatcttactcacc
atctttgccaactgcgtggccctggccgtgtacctgcccatgccggaggacgacaacaac
agactgaacctcggcctggagaagctggaatacttcttcctcatcgtcttctccatcgag
gccgccatgaagatcatcgcctacggcttcctgttccaccaggatgcctacctgcgcagc
ggctggaacgtgctggatttcatcatcgtcttcctgggggtcttcaccgtgatcctggag
caggtcaacctcatccagagcaacacggccccgatgagcagcaaaggcgcgggcctggac
gtcaaggcactgcgggccttccgcgtgctccgtccgctccggctggtgtccggggtgccc
agcctgcaggtggtcctcaactccatcttcaaggccatgctgccgctcttccacatcgcc
ctgctggtgctcttcatggtcgtcatctacgccatcatcggcctcgagctcttcaagggc
aagatgcacaagacctgctacttcatcggcacagacatcgtggccacggtggagaacgag
aagccgtccccctgcgcccggacgggctccggccggccctgcaccatcagcggcagcgag
tgccgtggcgggtggcccggccccaaccacggcatcacgcacttcgacaacttcggcttc
tccatgctcaccgtctaccagtgcatcaccatggagggctggaccgacgtcctctactgg
gtgaatgatgctatcgggaacgagtggccctggatctactttgtcaccctcatcctgctg
ggctccttcttcatcctcaacctggtgctgggcgtcctgagcggggaattcaccaaggag
cgggagaaggccaagtccagggggaccttccagaagctgcgggagaagcagcagctggag
gaggacctccggggctacctgagctggatcacgcagggcgaggtcatggacgtggatgac
ttgagagaagggaagctggctctggatgaaggcggctccgacacggagagcctgtacgaa
atcgcgggcctgaacaaagttatccagttcatccgacactggaggcagtggaaccgtgtc
ttccgctggaagtgccacgatgtggtgaagtccagggtgttctactggctggtcatcctg
atcgtcgctctcaacacactgtcgatcgcctcagagcaccaccaccagcctctctggttg
acccacctgcaagacgtggccaaccgggtgctgctggccctgttcaccgtggagatgctg
atgaagatgtacgggctgggcctgcgccagtacttcatgtccatcttcaaccgcttcgac
tgcttcgtggtgtgcagcggcctcctggagatcctgctggtggagtcgggtgccatgtcg
cccctgggcatctcggtgctgcgctgcatccgtctgctgcggatcttcaagatcaccaag
tactggacgtcgctgagcaacctggtggcgtcgctgctcaactccatccgctccatcgcc
tcgctgctgctgctgctcttcctgttcatcgtcatcttcgccctgctgggcatgcagctc
ttcgggggcaggtacgacttcgaggacaccgaggtgcggcgtagcaacttcgacagcttc
ccacaggccctcatcagcgtcttccaggtgctgacaggagaggactggaactccgtgatg
tacaacgggatcatggcctacggcggcccatcctaccccggggtgctcgtctgcatttac
ttcatcatcctgtttgtttgcggcaactacatcctgctcaacgtcttcctggccatcgct
gtggacaacctggcagaggccgagagcctgacttctgcccagaaggccaaggctgaagag
cggagacgcaggaagatgtccaagggtctcccggacaagtcagaggaggagaaggtgacg
gtggccaagaagctggagcagaaacccaagggggaaggcatccccaccaccgccaagctg
aagatcgacgagtttgaatccaacgtcaacgaggtgaaggacccctacccctcagccgac
ttcccaggggacgacgaggaagacgagcccgaggtcccaataagcccccggccccgtccg
ctggctgagctgcagctgaaggagaaggcggtgcccattccagaagccagtgccttcttc
atcttcagccccaccaacaagatccgcgtcctgtgccaccgcattgtcaatgccacctgg
ttcactaacttcatcctgctcttcatcctgctcagcagtgccgccttggccgccgaggac
cccctccgggctgagtccgtgaggaaccagatcctcgggtattttgacatcgggttcacc
tctgtcttcactgtggagattgtcctcaagatgaccacctacggggccttcctgcacaag
ggctccttctgccgcaactacttcaacatcctggacctggtggtggtggccgtgtccctc
atctccatgggactcgagtccagcaccatctccgtggtgaagatcctgagggtcctgagg
gtgctccgaccgctccgggccatcaacagagccaaaggcctgaagcacgtggtacagtgt
gtgttcgtggccatccgcaccatcgggaacatcgtcctggtcaccaccctcctgcagttc
atgttcgcttgcatcggcgtccagctcttcaaggggaagttcttcagctgcaatgacttg
tccaagatgacggaggaggagtgcaggggctactactatgtgtacaaagatggagacccc
acacagatagaggtgcgtccccgccagtgggtgcacaacgccttccacttcgacaacgtg
ctttcggccatgatgtccctcttcaccgtgtccaccttcgagggatggcctgagctgctg
tacaaggccattgactctcatgaggaggacaagggccccgtgtacaaccaccgcgtggag
atggccattttcttcatcatctacatcatccttatcgccttcttcatgatgaacatcttc
gtgggctttgtcatcgtcaccttccaggagcagggggagactgagtacaagaactgtgag
ctggacaagaaccagcgccagtgcgtgcagtacgccctgaaggcccggcccctgaggtgc
tacatccccaagaacccctaccagtaccgggtgtggtacatcgtcacctcctcctacttc
gagtacctgatgttcgccctcatcatgctcaacaccatctgcctgggcatgcagcactac
aaccagtcggagcaaatgaaccacatctctgacatcctcaacgtagccttcaccatcatc
ttcacactggagatggtcctcaagctcatggcgttcaaggccaggggctattttggggac
ccctggaacgtgtttgactttctgattgtcatcggcagcatcatcgacgtcatcctcagt
gagatcgacactttcctggcctccagcgggggactgtattgcctgggtggcggctgcggg
aacgttgacccggacgagagcgcccgcatctccagcgccttcttccgcctgttccgtgtc
atgaggctgatcaagctgctgagccgcgcggagggcgtgcgcacgctgctctggactttc
atcaagtccttccaggccctgccctacgtggctctgctcatcgtcatgctcttcttcatc
tacgcggtcatcggcatgcagatgttcgggaagatcgccttggtggacgggacccagatc
aaccggaacaacaacttccagaccttcccccaggcggtgctgctgctcttcaggtgcgcc
acgggggaggcgtggcaggagatcctgctggcctgcagctacggccagctgtgtgacccc
gagtcggactacgcccccggggaggagtacacctgtggcacggacttcgcctactactac
ttcctcagcttctacatgctgtgcgccttcctgatcatcaacctctttgtggccgtcatc
atggacaactttgactacctgacacgggactggtccatcctgggccctcatcacctggat
gagttcaaggccatctgggcggagtacgacccggaggctacgggcaggatcaagcacctg
gacgtggtgaccctgctgaggaggatccagcccccgctgggcttcgggaagttctgcccc
caccgggtagcgtgtaagcggctggtgggcatgaacatgcccctcaacagtgacggcacg
gtcaccttcaacgccacgctcttcgccctggtgcgcacagctctgaagatcaagacggaa
ggtaacttcgagcaggccaacgaggagctgcgagccatcatcaagaaggtctggaagagg
accagcatgaagctcctggaccaggtcatccctcccataggagatgacgaggtgacggtg
gggaagttctacgccacgttcctcatccaggagcacttccggaagttcatgaggcgccag
gaggagtattatgggtaccggcccaagaaggacaccgtgcagatccaggctggactgagg
accatcgaggaagaggcagcccctgagatccgccgcaccatctcgggagacctgatggcc
gaagaggagctggagagagccatggtggaggccgcgatggaggaagggatcttccggagg
accggcggcctgtttggccaggtggacagcttcctggaaaggaccaactcgttggccccg
cacatggccaaccagagacccctccagtttactgaaattgagatggaggagatggaatcg
cccgtcttcctggaggacttccctcaacgtccgagtgcccacccccttgctcgtgccaac
accaacaacgccaacgccaacgtcgccagtggcaacggcaaccatggcaacagcccagca
tttcccagtgtccactacgaaggggagctcgcaggggagacagagacgcctgccaccaga
ggaggactcttcggccagccccggggggccctggggccccacagcaagtcccgagtagag
tggccgcagggacagctgccccggagaaggacgcccagggcccaggcccccgctgcctcc
tgccagcacgcgggagcagagtcccaggtgcccgaggagaggagccccaccccagggtcc
ctgcccggggaggcgccgcccggcagtaggacagaggacggaacccctgggggtccagct
ccagccatggccctgctgatccgcgaggctctggttcgagggggcctggacagcttggcg
gcggatgctaacttcatcatggccacgggccaggcgctggcagaggcctgccggatggaa
ccgcgggaagtggaggtggcagccgcagagcttctgcagggacgcgaggccctggagggc
gtgcctggtgcccgagggtgcccaggcctcgggtcctccctgggcagcctcgacctgcgt
gagggctcccaggagaccctgattccccgcaggccatga

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