KEGG   PATHWAY: cdk00590
Entry
cdk00590                    Pathway                                

Name
Arachidonic acid metabolism - Camelus dromedarius (Arabian camel)
Class
Metabolism; Lipid metabolism
Pathway map
cdk00590  Arachidonic acid metabolism
cdk00590

Other DBs
GO: 0019369
Organism
Camelus dromedarius (Arabian camel) [GN:cdk]
Gene
105088845  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
105088846  PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105088847  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105088848  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105088887  PLA2G2F; LOW QUALITY PROTEIN: group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105103971  PLA2G2E; group IIE secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
105099428  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105092473  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
105101999  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105089899  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105091384  group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
105096850  cytosolic phospholipase A2 beta isoform X2 [KO:K16342] [EC:3.1.1.4]
105099290  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
105101745  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
105101759  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
105101760  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
105091954  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
105098563  PLB1; phospholipase B1, membrane-associated isoform X2 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
105101524  PLAAT3; phospholipase A and acyltransferase 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
105104317  PTGS1; prostaglandin G/H synthase 1 [KO:K00509] [EC:1.14.99.1]
105099289  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105092543  PTGES; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
105092587  PTGES2; prostaglandin E synthase 2 isoform X1 [KO:K05309] [EC:5.3.99.3]
105086350  PTGES3; prostaglandin E synthase 3 isoform X1 [KO:K15730] [EC:5.3.99.3]
105089844  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
105102236  LOW QUALITY PROTEIN: carbonyl reductase [NADPH] 2-like [KO:K00081] [EC:1.1.1.184]
105089845  CBR3; carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
105106649  PRXL2B; prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
105091642  TBXAS1; thromboxane-A synthase [KO:K01832] [EC:5.3.99.5]
105106194  PTGDS; prostaglandin-H2 D-isomerase [KO:K01830] [EC:5.3.99.2]
105089526  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
105105880  dihydrodiol dehydrogenase 3-like isoform X1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
105104488  LOW QUALITY PROTEIN: prostaglandin F synthase 1-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
105104489  dihydrodiol dehydrogenase 3-like isoform X2 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
105087868  PTGIS; prostacyclin synthase isoform X1 [KO:K01831] [EC:5.3.99.4]
105093424  ALOX5; arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
105097432  LTA4H; leukotriene A-4 hydrolase isoform X1 [KO:K01254] [EC:3.3.2.6]
105105133  cytochrome P450 4F3 [KO:K17726] [EC:1.14.14.78 1.14.14.79 1.14.14.94]
116148476  LTC4S; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
105095196  GGT1; glutathione hydrolase 1 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
105095198  GGT5; glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
105087146  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
105088187  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
105084546  GPX6; glutathione peroxidase 6 isoform X2 [KO:K00432] [EC:1.11.1.9]
105084547  GPX5; epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
105086185  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
105092970  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
105098466  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
105096474  cytochrome P450 2E1 [KO:K07415] [EC:1.14.13.-]
105096288  cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105096275  cytochrome P450 2J2-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105092849  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105105287  cytochrome P450 2U1 [KO:K07422]
105092933  cytochrome P450 4A6 [KO:K07425] [EC:1.14.14.80]
105103060  ALOX12; arachidonate 12-lipoxygenase, 12S-type [KO:K00458] [EC:1.13.11.31]
105103063  ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
105102997  ALOX15B; LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase B [KO:K08022] [EC:1.13.11.33 1.13.11.-]
116157868  LOW QUALITY PROTEIN: arachidonate 8S-lipoxygenase-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
105093362  LOW QUALITY PROTEIN: cytochrome P450 2B4 [KO:K07412] [EC:1.14.14.1]
105093363  cytochrome P450 2B4 [KO:K07412] [EC:1.14.14.1]
105084254  cytochrome P450 2C21 [KO:K07413] [EC:1.14.14.1]
105084313  cytochrome P450 2C23 isoform X1 [KO:K07413] [EC:1.14.14.1]
105102229  EPHX2; bifunctional epoxide hydrolase 2 isoform X2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
105106001  arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
cdk00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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