KEGG   Caenorhabditis elegans (nematode): CELE_PAR2.3
Entry
CELE_PAR2.3       CDS       T00019                                 

Gene name
aak-1
Definition
(RefSeq) 5'-AMP-activated protein kinase catalytic subunit alpha-1
  KO
K07198  5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
Organism
cel  Caenorhabditis elegans (nematode)
Pathway
cel04068  FoxO signaling pathway
cel04140  Autophagy - animal
cel04150  mTOR signaling pathway
cel04213  Longevity regulating pathway - multiple species
cel04361  Axon regeneration
Brite
KEGG Orthology (KO) [BR:cel00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    CELE_PAR2.3 (aak-1)
   04150 mTOR signaling pathway
    CELE_PAR2.3 (aak-1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    CELE_PAR2.3 (aak-1)
 09150 Organismal Systems
  09158 Development and regeneration
   04361 Axon regeneration
    CELE_PAR2.3 (aak-1)
  09149 Aging
   04213 Longevity regulating pathway - multiple species
    CELE_PAR2.3 (aak-1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cel01001]
    CELE_PAR2.3 (aak-1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cel04131]
    CELE_PAR2.3 (aak-1)
   03029 Mitochondrial biogenesis [BR:cel03029]
    CELE_PAR2.3 (aak-1)
Enzymes [BR:cel01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.11  cAMP-dependent protein kinase
     CELE_PAR2.3 (aak-1)
Protein kinases [BR:cel01001]
 Serine/threonine kinases: CAMK group
  CAMKL family
   CELE_PAR2.3 (aak-1)
Membrane trafficking [BR:cel04131]
 Autophagy
  Other autophagy associated proteins
   Others
    CELE_PAR2.3 (aak-1)
Mitochondrial biogenesis [BR:cel03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    CELE_PAR2.3 (aak-1)
  Mitophagy factors
   Other mitophagy factors
    CELE_PAR2.3 (aak-1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like AdenylateSensor RIO1 Choline_kinase APH Kdo
Other DBs
NCBI-GeneID: 176230
NCBI-ProteinID: NP_741254
WormBase: WBGene00019801
UniProt: P45894
LinkDB
Position
III:complement(join(8757236..8757361,8757419..8757507,8757983..8758117,8758465..8758764,8758813..8759017,8759445..8759653,8759702..8759963,8760243..8760568,8760931..8761048))
AA seq 589 aa
MPPSGRFDRTIALAGTGHLKIGNFVIKETIGKGAFGAVKRGTHIQTGYDVAIKILNRGRM
KGLGTVNKTRNEIDNLQKLTHPHITRLFRVISTPSDIFLVMELVSGGELFSYITRKGALP
IRESRRYFQQIISGVSYCHNHMIVHRDLKPENLLLDANKNIKIADFGLSNYMTDGDLLST
ACGSPNYAAPELISNKLYVGPEVDLWSCGVILYAMLCGTLPFDDQNVPTLFAKIKSGRYT
VPYSMEKQAADLISTMLQVDPVKRADVKRIVNHSWFRIDLPYYLFPECENESSIVDIDVV
QSVAEKFDVKEEDVTGALLAEDHHHFLCIAYRLEVNHKRNADESSQKAMEDFWEIGKTMK
MGSTSLPVGATTKTNVGRKILEGLKKEQKKLTWNLGIRACLDPVETMKHVFLSLKSVDME
WKVLSMYHIIVRSKPTPINPDPVKVSLQLFALDKKENNKGYLLDFKGLTEDEEAVPPSRC
RSRAASVSVTLAKSKSDLNGNSSKVPMSPLSPMSPISPSVNIPKVRVDDADASLKSSLNS
SIYMADIENSMESLDEVSTQSSEPEAPIRSQTMEFFATCHIIMQALLAE
NT seq 1770 nt   +upstreamnt  +downstreamnt
atgcctccaagtggacgtttcgatagaacaatcgccttggctggcactggacatttgaaa
attggaaactttgtcatcaaagagacaattggaaaaggagcatttggagctgttaaaaga
ggaacacatattcaaaccggatacgacgtcgccattaaaattctgaatcgtggaagaatg
aaaggactcggaacagttaacaaaactcgaaatgagattgataatcttcagaaactcaca
catccacatatcacacgtctcttccgtgttatcagtactccttcggacatatttttggtc
atggaactagtttctggtggagaacttttcagttatataactagaaaaggtgctcttcca
atcagagaaagtcgacgatactttcaacaaattatttctggagtcagttattgtcataat
catatgattgtgcatagagacttgaagcccgaaaatcttcttctggacgcgaacaagaac
attaaaatcgctgatttcggtctctcgaactacatgacagatggtgatcttctctcgacg
gcatgtggatctccaaactacgcggcacccgaactaatatcaaataaactttatgtgggc
cctgaagttgatctatggtcatgtggagttatactttatgcgatgctttgtggaactttg
ccatttgatgatcagaatgttccaacgttgtttgcaaaaattaaaagtggccgatacaca
gttccatattccatggaaaaacaagcagccgatctaatttctacgatgcttcaagttgat
cctgtgaagagagctgatgtaaaacgaattgttaatcacagttggttccgtatcgatctt
ccatattatttgttcccagaatgtgaaaatgaatcatcgattgttgatattgatgtggtt
cagagtgttgcagagaaatttgatgtgaaagaagaagatgtaactggagctctacttgct
gaagatcatcatcattttctctgtattgcatatcgtcttgaagtaaatcataaaagaaat
gccgatgaatcttctcaaaaagcaatggaagatttttgggagattggaaaaacaatgaaa
atgggaagcacttcgttgccagtcggtgccaccacgaaaacaaatgttggtcgaaaaatc
ttggaaggactgaaaaaagagcaaaagaaattgacatggaatcttggaattcgtgcatgt
cttgatccagttgagaccatgaaacatgtttttttgagtttaaaatctgttgatatggaa
tggaaagtactcagtatgtatcatattattgttcgtagcaaaccgactccaattaatccg
gatcctgtgaaagtatctcttcaattatttgctctcgataaaaaagagaataacaaagga
tatttactcgatttcaaaggactcactgaagacgaagaagctgttccaccgagtcgttgt
cgttcccgtgctgcgtccgtatcagtaactctcgccaaatcgaaaagtgatttaaatgga
aatagctcgaaagttccaatgtctccactatctccaatgtctccaatttctccgtctgtc
aacattccaaaagttcgcgttgatgacgcggacgcctcgctgaaatcatcgttgaacagc
agtatctacatggctgatattgagaactcaatggaaagtcttgatgaagtttcaactcaa
tcttcggaacccgaagctccaattcgttctcagacgatggaattctttgcaacttgccac
atcatcatgcaggctttgttagctgaataa

KEGG   Caenorhabditis elegans (nematode): CELE_T01C8.1
Entry
CELE_T01C8.1      CDS       T00019                                 

Gene name
aak-2
Definition
(RefSeq) 5'-AMP-activated protein kinase catalytic subunit alpha-2
  KO
K07198  5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
Organism
cel  Caenorhabditis elegans (nematode)
Pathway
cel04068  FoxO signaling pathway
cel04140  Autophagy - animal
cel04150  mTOR signaling pathway
cel04213  Longevity regulating pathway - multiple species
cel04361  Axon regeneration
Brite
KEGG Orthology (KO) [BR:cel00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    CELE_T01C8.1 (aak-2)
   04150 mTOR signaling pathway
    CELE_T01C8.1 (aak-2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    CELE_T01C8.1 (aak-2)
 09150 Organismal Systems
  09158 Development and regeneration
   04361 Axon regeneration
    CELE_T01C8.1 (aak-2)
  09149 Aging
   04213 Longevity regulating pathway - multiple species
    CELE_T01C8.1 (aak-2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cel01001]
    CELE_T01C8.1 (aak-2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cel04131]
    CELE_T01C8.1 (aak-2)
   03029 Mitochondrial biogenesis [BR:cel03029]
    CELE_T01C8.1 (aak-2)
Enzymes [BR:cel01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.11  cAMP-dependent protein kinase
     CELE_T01C8.1 (aak-2)
Protein kinases [BR:cel01001]
 Serine/threonine kinases: CAMK group
  CAMKL family
   CELE_T01C8.1 (aak-2)
Membrane trafficking [BR:cel04131]
 Autophagy
  Other autophagy associated proteins
   Others
    CELE_T01C8.1 (aak-2)
Mitochondrial biogenesis [BR:cel03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    CELE_T01C8.1 (aak-2)
  Mitophagy factors
   Other mitophagy factors
    CELE_T01C8.1 (aak-2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr AdenylateSensor Kinase-like RIO1 Kdo APH
Other DBs
NCBI-GeneID: 181727
NCBI-ProteinID: NP_510710
WormBase: WBGene00020142
UniProt: Q95ZQ4
LinkDB
Position
X:join(16796089..16796231,16799707..16799870,16800046..16800514,16800689..16800807,16801033..16801138,16801228..16801333,16801383..16801590,16801692..16802003,16802414..16802565,16802749..16802850)
AA seq 626 aa
MFSHQDRDRDRKEDGGGDGTEMKSKSRSQPSGLNRVKNLSRKLSAKSRKERKDRDSTDNS
SKMSSPGGETSTKQQQELKAQIKIGHYILKETLGVGTFGKVKVGIHETTQYKVAVKILNR
QKIKSLDVVGKIRREIQNLSLFRHPHIIRLYQVISTPSDIFMIMEHVSGGELFDYIVKHG
RLKTAEARRFFQQIISGVDYCHRHMVVHRDLKPENLLLDEQNNVKIADFGLSNIMTDGDF
LRTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDDEHVPSLFRKIKSG
VFPTPDFLERPIVNLLHHMLCVDPMKRATIKDVIAHEWFQKDLPNYLFPPINESEASIVD
IEAVREVTEFQRYHVAEEEVTSALLGDDPHHHLSIAYNLIVDNKRIADETAKLSIEEFYQ
VTPNKGPGPVHRHPERIAASVSSKITPTLDNTEASGANRNKRAKWHLGIRSQSRPEDIMF
EVFRAMKQLDMEWKVLNPYHVIVRRKPDAPAADPPKMSLQLYQVDQRSYLLDFKSLADEE
SGSASASSSRHASMSMPQKPAGIRGTRTSSMPQAMSMEASIEKMEVHDFSDMSCDVTPPP
SPGGAKLSQTMQFFEICAALIGTLAR
NT seq 1881 nt   +upstreamnt  +downstreamnt
atgttttctcatcaagatcgagaccgcgataggaaggaggacggtggtggagacggtact
gagatgaaatccaagagtcggagtcagccaagtggacttaatcgcgtgaaaaatctttca
agaaagctatcggcaaagtcaagaaaggaacgcaaggaccgcgatagcacagacaacagt
tcgaaaatgtcgtctccaggaggagaaacgtcgacgaagcagcaacaagagctcaaagct
caaatcaaaatcggacattacattctcaaggagacactcggagttggtacttttggtaaa
gtaaaagttggaatccatgagacaactcaatacaaagtggctgtcaagattctgaaccgt
cagaagatcaagtcactggatgtcgttggaaagattcgccgcgaaatccaaaacctctcg
ctcttccgccatccgcatatcatccgcctctaccaagtcatcagtacaccttctgacatt
ttcatgattatggagcacgtttccggcggggagctctttgactacattgttaagcacgga
cggctgaagaccgcagaagctcgtcgcttctttcaacaaatcatttccggcgttgactac
tgtcatcgtcatatggttgtccatagagatttgaagccagagaatttgttgctcgatgag
cagaacaatgtgaagattgcggactttggactttcaaatattatgacggatggtgacttc
ttacgcaccagctgcggatcgccaaattatgctgcccctgaggttattagcggaaagttg
tacgcaggtcccgaagttgatgtatggtcgtgtggagtcattttgtatgcacttctttgt
ggaaccctgccatttgatgatgagcacgtgccaagtcttttcagaaaaattaaatctggc
gtattcccaactccagactttctggagcgcccaattgtaaatctgcttcaccatatgctc
tgcgtagacccgatgaagagggccaccatcaaggacgtcattgctcacgagtggttccag
aaggatttgccgaactacttgttcccaccaatcaacgagagtgaggcttccattgttgat
attgaggctgtccgagaggtcactgagtttcagcgctatcatgtcgccgaagaggaagtc
acctcagcattgctgggagatgatccacatcaccatttgtcgattgcatataacttgatt
gttgataacaagagaattgccgatgagactgccaagttgtcaattgaggagttttatcaa
gtgacgccgaataagggacctggaccagttcatcgccatccagagcgcattgcagcgtca
gtcagcagcaagatcacaccaactctcgacaacacggaagccagtggcgcgaaccgcaac
aaacgtgccaagtggcatctgggtatccgatcccaaagtcgtccggaagacatcatgttc
gaggtgttccgtgcgatgaagcagctggacatggagtggaaggtgctcaacccatatcat
gtgattgttcgtcgcaagcctgatgcacccgctgccgacccgccaaagatgtcgttgcag
ttgtaccaagtggatcagagaagttacttgttggatttcaagagtttggccgacgaggag
tctggatccgccagtgcatcttcatcccgacacgcatcaatgtctatgccgcagaagccg
gccggaattcgtggaactagaacgtcaagcatgccacaggcgatgagtatggaggcgagt
attgagaaaatggaagtgcatgatttttcggacatgtcgtgcgatgtgacaccaccacca
tctcctggaggagctaagctttcccagactatgcaattctttgagatttgcgccgcattg
attggaacactggctcgttaa

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