KEGG   PATHWAY: cfr04350
Entry
cfr04350                    Pathway                                
Name
TGF-beta signaling pathway - Camelus ferus (Wild Bactrian camel)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
cfr04350  TGF-beta signaling pathway
cfr04350

Other DBs
GO: 0007179
Organism
Camelus ferus (Wild Bactrian camel) [GN:cfr]
Gene
102508690  CHRD; chordin isoform X1 [KO:K04657]
102507068  NOG; noggin [KO:K04658]
102507891  NBL1; neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
102504474  GREM1; gremlin-1 [KO:K23318]
102516790  GREM2; gremlin-2 [KO:K23318]
102519986  THBS1; thrombospondin-1 [KO:K16857]
102518914  DCN; decorin [KO:K04660]
102514364  FMOD; fibromodulin [KO:K08121]
102510705  left-right determination factor 2 isoform X1 [KO:K04668]
106730063  left-right determination factor 2 [KO:K04668]
102523674  FST; follistatin isoform X1 [KO:K04661]
102514653  BMP2; bone morphogenetic protein 2 [KO:K21283]
102509507  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
102506218  BMP6; bone morphogenetic protein 6 [KO:K16620]
102510183  INHBB; inhibin beta B chain [KO:K22687]
102515755  TF; serotransferrin [KO:K14736]
102515239  inhibitor of carbonic anhydrase-like [KO:K14736]
102517202  BMP5; LOW QUALITY PROTEIN: bone morphogenetic protein 5 [KO:K04663]
102518616  BMP7; bone morphogenetic protein 7 isoform X2 [KO:K16621]
102510777  BMP8B; bone morphogenetic protein 8B isoform X1 [KO:K16622]
116656645  BMP8A; bone morphogenetic protein 8A isoform X1 [KO:K16622]
102511577  GDF5; growth/differentiation factor 5 [KO:K04664]
102518971  GDF6; growth/differentiation factor 6 [KO:K20012]
102521145  GDF7; growth/differentiation factor 7 [KO:K20013]
102522839  AMH; muellerian-inhibiting factor isoform X1 [KO:K04665]
102504614  IFNG; interferon gamma [KO:K04687]
102510424  TNF; tumor necrosis factor [KO:K03156]
102521653  THSD4; LOW QUALITY PROTEIN: thrombospondin type-1 domain-containing protein 4 [KO:K23377]
102519605  FBN1; fibrillin-1 [KO:K06825]
102504170  LTBP1; LOW QUALITY PROTEIN: latent-transforming growth factor beta-binding protein 1 [KO:K19559]
102509937  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
102505811  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
102517948  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102508772  INHBA; inhibin beta A chain [KO:K04667]
102516448  INHBC; inhibin beta C chain [KO:K22688]
102517116  INHBE; LOW QUALITY PROTEIN: inhibin beta E chain [KO:K22689]
102519072  NODAL; nodal homolog [KO:K04666]
102503742  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
102511519  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
102512007  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
102504117  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
102518044  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
102522930  HJV; hemojuvelin [KO:K23100]
102524431  NEO1; neogenin isoform X4 [KO:K06766]
102504403  HFE; hereditary hemochromatosis protein isoform X1 [KO:K26535]
102504782  TFR2; transferrin receptor protein 2 isoform X1 [KO:K23910]
102506651  TFRC; transferrin receptor protein 1 [KO:K06503]
102508593  RGMA; repulsive guidance molecule A [KO:K23096]
102519422  RGMB; RGM domain family member B isoform X1 [KO:K06847]
102520441  AMHR2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
102522485  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
102509744  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102519388  EMP3; epithelial membrane protein 3 [KO:K26257]
102506253  LRRC32; transforming growth factor beta activator LRRC32 [KO:K26316]
102513731  NRROS; transforming growth factor beta activator LRRC33 [KO:K26317]
102510501  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
102514517  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
102511434  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
102519467  IGSF1; immunoglobulin superfamily member 1 [KO:K26168]
102514322  SMAD1; mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676]
102518120  SMAD5; mothers against decapentaplegic homolog 5 [KO:K16790]
102516449  SMAD9; mothers against decapentaplegic homolog 9 [KO:K16791]
102508588  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
102523073  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
102507868  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
102522816  SMAD6; mothers against decapentaplegic homolog 6 isoform X1 [KO:K04677]
102509632  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
102514579  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
102507049  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
102511870  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
102503924  ZFYVE16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
102515877  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
102517054  CUL1; cullin-1 [KO:K03347]
102519293  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
102517586  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102521659  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102507993  RHOA; transforming protein RhoA [KO:K04513]
102520724  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
102505057  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
102509649  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
106728419  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
102509650  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
102518322  RPS6KB2; LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
102511731  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102523251  HAMP; hepcidin [KO:K23106]
116657996  ID1; DNA-binding protein inhibitor ID-1 isoform X1 [KO:K04680]
102507656  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
102517768  DNA-binding protein inhibitor ID-3 [KO:K17694]
116668295  ID3; DNA-binding protein inhibitor ID-3 [KO:K17694]
116658220  ID4; DNA-binding protein inhibitor ID-4 [KO:K17695]
102509030  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
102517931  E2F4; transcription factor E2F4 [KO:K04682]
102507844  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
102519988  TFDP1; transcription factor Dp-1 [KO:K04683]
102515619  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
102505509  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
102520683  SP1; transcription factor Sp1 [KO:K04684]
102522755  SKIL; LOW QUALITY PROTEIN: ski-like protein [KO:K18499]
102510338  SKI; ski oncogene isoform X2 [KO:K26503]
102520681  SIN3A; LOW QUALITY PROTEIN: paired amphipathic helix protein Sin3a [KO:K11644]
102508320  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
102504100  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
102518187  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
102516591  TGIF1; homeobox protein TGIF1 isoform X2 [KO:K19383]
102517644  TGIF2; homeobox protein TGIF2 isoform X1 [KO:K19553]
102511086  MYC; myc proto-oncogene protein [KO:K04377]
116663067  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
102509618  PITX2; pituitary homeobox 2 isoform X2 [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
cfr04010  MAPK signaling pathway
cfr04110  Cell cycle
cfr04120  Ubiquitin mediated proteolysis
cfr04210  Apoptosis
KO pathway
ko04350   
LinkDB

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