Cricetulus griseus (Chinese hamster): 100769018
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Entry
100769018 CDS
T02813
Gene name
Raf1
Definition
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase
KO
K04366
RAF proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
cge
Cricetulus griseus (Chinese hamster)
Pathway
cge01521
EGFR tyrosine kinase inhibitor resistance
cge01522
Endocrine resistance
cge04010
MAPK signaling pathway
cge04012
ErbB signaling pathway
cge04014
Ras signaling pathway
cge04015
Rap1 signaling pathway
cge04022
cGMP-PKG signaling pathway
cge04024
cAMP signaling pathway
cge04062
Chemokine signaling pathway
cge04068
FoxO signaling pathway
cge04071
Sphingolipid signaling pathway
cge04072
Phospholipase D signaling pathway
cge04140
Autophagy - animal
cge04150
mTOR signaling pathway
cge04151
PI3K-Akt signaling pathway
cge04210
Apoptosis
cge04218
Cellular senescence
cge04270
Vascular smooth muscle contraction
cge04360
Axon guidance
cge04370
VEGF signaling pathway
cge04371
Apelin signaling pathway
cge04510
Focal adhesion
cge04540
Gap junction
cge04550
Signaling pathways regulating pluripotency of stem cells
cge04625
C-type lectin receptor signaling pathway
cge04630
JAK-STAT signaling pathway
cge04650
Natural killer cell mediated cytotoxicity
cge04660
T cell receptor signaling pathway
cge04662
B cell receptor signaling pathway
cge04664
Fc epsilon RI signaling pathway
cge04666
Fc gamma R-mediated phagocytosis
cge04720
Long-term potentiation
cge04722
Neurotrophin signaling pathway
cge04726
Serotonergic synapse
cge04730
Long-term depression
cge04810
Regulation of actin cytoskeleton
cge04910
Insulin signaling pathway
cge04912
GnRH signaling pathway
cge04914
Progesterone-mediated oocyte maturation
cge04915
Estrogen signaling pathway
cge04916
Melanogenesis
cge04917
Prolactin signaling pathway
cge04919
Thyroid hormone signaling pathway
cge04921
Oxytocin signaling pathway
cge04926
Relaxin signaling pathway
cge04928
Parathyroid hormone synthesis, secretion and action
cge04929
GnRH secretion
cge04935
Growth hormone synthesis, secretion and action
cge05010
Alzheimer disease
cge05022
Pathways of neurodegeneration - multiple diseases
cge05034
Alcoholism
cge05132
Salmonella infection
cge05152
Tuberculosis
cge05160
Hepatitis C
cge05161
Hepatitis B
cge05163
Human cytomegalovirus infection
cge05164
Influenza A
cge05165
Human papillomavirus infection
cge05167
Kaposi sarcoma-associated herpesvirus infection
cge05170
Human immunodeficiency virus 1 infection
cge05200
Pathways in cancer
cge05205
Proteoglycans in cancer
cge05206
MicroRNAs in cancer
cge05210
Colorectal cancer
cge05211
Renal cell carcinoma
cge05212
Pancreatic cancer
cge05213
Endometrial cancer
cge05214
Glioma
cge05215
Prostate cancer
cge05218
Melanoma
cge05219
Bladder cancer
cge05220
Chronic myeloid leukemia
cge05221
Acute myeloid leukemia
cge05223
Non-small cell lung cancer
cge05224
Breast cancer
cge05225
Hepatocellular carcinoma
cge05226
Gastric cancer
cge05230
Central carbon metabolism in cancer
cge05231
Choline metabolism in cancer
cge05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
cge00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
100769018 (Raf1)
04012 ErbB signaling pathway
100769018 (Raf1)
04014 Ras signaling pathway
100769018 (Raf1)
04015 Rap1 signaling pathway
100769018 (Raf1)
04370 VEGF signaling pathway
100769018 (Raf1)
04371 Apelin signaling pathway
100769018 (Raf1)
04630 JAK-STAT signaling pathway
100769018 (Raf1)
04068 FoxO signaling pathway
100769018 (Raf1)
04072 Phospholipase D signaling pathway
100769018 (Raf1)
04071 Sphingolipid signaling pathway
100769018 (Raf1)
04024 cAMP signaling pathway
100769018 (Raf1)
04022 cGMP-PKG signaling pathway
100769018 (Raf1)
04151 PI3K-Akt signaling pathway
100769018 (Raf1)
04150 mTOR signaling pathway
100769018 (Raf1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100769018 (Raf1)
09143 Cell growth and death
04210 Apoptosis
100769018 (Raf1)
04218 Cellular senescence
100769018 (Raf1)
09144 Cellular community - eukaryotes
04510 Focal adhesion
100769018 (Raf1)
04540 Gap junction
100769018 (Raf1)
04550 Signaling pathways regulating pluripotency of stem cells
100769018 (Raf1)
09142 Cell motility
04810 Regulation of actin cytoskeleton
100769018 (Raf1)
09150 Organismal Systems
09151 Immune system
04625 C-type lectin receptor signaling pathway
100769018 (Raf1)
04650 Natural killer cell mediated cytotoxicity
100769018 (Raf1)
04660 T cell receptor signaling pathway
100769018 (Raf1)
04662 B cell receptor signaling pathway
100769018 (Raf1)
04664 Fc epsilon RI signaling pathway
100769018 (Raf1)
04666 Fc gamma R-mediated phagocytosis
100769018 (Raf1)
04062 Chemokine signaling pathway
100769018 (Raf1)
09152 Endocrine system
04910 Insulin signaling pathway
100769018 (Raf1)
04929 GnRH secretion
100769018 (Raf1)
04912 GnRH signaling pathway
100769018 (Raf1)
04915 Estrogen signaling pathway
100769018 (Raf1)
04914 Progesterone-mediated oocyte maturation
100769018 (Raf1)
04917 Prolactin signaling pathway
100769018 (Raf1)
04921 Oxytocin signaling pathway
100769018 (Raf1)
04926 Relaxin signaling pathway
100769018 (Raf1)
04935 Growth hormone synthesis, secretion and action
100769018 (Raf1)
04919 Thyroid hormone signaling pathway
100769018 (Raf1)
04928 Parathyroid hormone synthesis, secretion and action
100769018 (Raf1)
04916 Melanogenesis
100769018 (Raf1)
09153 Circulatory system
04270 Vascular smooth muscle contraction
100769018 (Raf1)
09156 Nervous system
04726 Serotonergic synapse
100769018 (Raf1)
04720 Long-term potentiation
100769018 (Raf1)
04730 Long-term depression
100769018 (Raf1)
04722 Neurotrophin signaling pathway
100769018 (Raf1)
09158 Development and regeneration
04360 Axon guidance
100769018 (Raf1)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100769018 (Raf1)
05206 MicroRNAs in cancer
100769018 (Raf1)
05205 Proteoglycans in cancer
100769018 (Raf1)
05230 Central carbon metabolism in cancer
100769018 (Raf1)
05231 Choline metabolism in cancer
100769018 (Raf1)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100769018 (Raf1)
09162 Cancer: specific types
05210 Colorectal cancer
100769018 (Raf1)
05212 Pancreatic cancer
100769018 (Raf1)
05225 Hepatocellular carcinoma
100769018 (Raf1)
05226 Gastric cancer
100769018 (Raf1)
05214 Glioma
100769018 (Raf1)
05221 Acute myeloid leukemia
100769018 (Raf1)
05220 Chronic myeloid leukemia
100769018 (Raf1)
05218 Melanoma
100769018 (Raf1)
05211 Renal cell carcinoma
100769018 (Raf1)
05219 Bladder cancer
100769018 (Raf1)
05215 Prostate cancer
100769018 (Raf1)
05213 Endometrial cancer
100769018 (Raf1)
05224 Breast cancer
100769018 (Raf1)
05223 Non-small cell lung cancer
100769018 (Raf1)
09164 Neurodegenerative disease
05010 Alzheimer disease
100769018 (Raf1)
05022 Pathways of neurodegeneration - multiple diseases
100769018 (Raf1)
09165 Substance dependence
05034 Alcoholism
100769018 (Raf1)
09171 Infectious disease: bacterial
05132 Salmonella infection
100769018 (Raf1)
05152 Tuberculosis
100769018 (Raf1)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
100769018 (Raf1)
05161 Hepatitis B
100769018 (Raf1)
05160 Hepatitis C
100769018 (Raf1)
05164 Influenza A
100769018 (Raf1)
05163 Human cytomegalovirus infection
100769018 (Raf1)
05167 Kaposi sarcoma-associated herpesvirus infection
100769018 (Raf1)
05165 Human papillomavirus infection
100769018 (Raf1)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100769018 (Raf1)
01522 Endocrine resistance
100769018 (Raf1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
cge01001
]
100769018 (Raf1)
Enzymes [BR:
cge01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100769018 (Raf1)
Protein kinases [BR:
cge01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100769018 (Raf1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
Pkinase_fungal
C1_2
Motif
Other DBs
NCBI-GeneID:
100769018
NCBI-ProteinID:
XP_027284970
UniProt:
G3HVN3
LinkDB
All DBs
Position
8
AA seq
648 aa
AA seq
DB search
MEHIQGAWKSISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDSGVPALPSLTMRRMRESVSRMPASSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq
1947 nt
NT seq
+upstream
nt +downstream
nt
atggagcacatacagggagcttggaagtcgatcagcaatggctttggactcaaagatgcg
gtatttgatggctccagctgcatctctccaacaattgttcagcagtttggctatcagcgc
cgggcgtcagatgatggcaaactcacggattcatctaagacaagcaacactattcgagtt
ttcttgccgaataagcaaaggacagtggtcaatgtgcggaatggaatgagcttgcacgac
tgccttatgaaagctctcaaggtgaggggtctgcagccagagtgttgtgcagtgttcaga
cttctccaggaacacaaaggtaagaaagcacgcttagactggaacaccgacgctgcctct
ctgattggagaagaactgcaagtggatttcttggatcatgttccactcacaactcacaac
tttgctcggaaaacgttcctgaagcttgcattctgtgacatctgtcaaaagttcctgcta
aatggatttcggtgtcagacttgtggctacaagtttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacagctcttgctgtttccaaattccact
gttggtgatagcggagtcccagcactaccttctttgacaatgcgtcggatgcgagagtct
gtttcccggatgcctgctagttcccagcacagatactccacacctcatgccttcactttc
aacacctccagcccttcctctgaaggttccctctcccagaggcagaggtcaacgtccact
cccaatgttcacatggtcagcaccaccttgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagtgaatcagcctcaccttcagccctgtccagcagccccaacaacctg
agcccaacaggatggtcgcagcctaaaacccctgtgccagcacaaagagaacgggcacca
ggatctgggacccaggaaaaaaacaaaattaggcctcgtgggcagagagattcaagctat
tactgggaaatagaagccagtgaggtgatgctgtccactcggattggatcgggctccttt
ggcactgtgtacaagggcaagtggcacggagatgttgcagtaaagatcctaaaagtggtt
gacccaaccccagagcagcttcaggccttcaggaacgaggtggctgtcttgcgcaaaaca
cggcatgttaatatcctgctgttcatgggctatatgacaaaggacaacctggccattgtg
acccagtggtgtgaaggcagcagtctctataaacacctacatgtccaggagaccaaattc
cagatgttccagctaattgacattgcccgacagacagctcagggaatggactatttgcat
gcgaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctc
acggtgaaaattggagattttggtttggcaacagtgaagtcacgctggagtggttctcag
caggttgaacagcccaccggctctgtgctatggatggccccagaagtaatccgaatgcag
gataacaacccgtttagcttccagtctgacgtctactcctatggcattgtgctgtatgag
ctgatgacgggggagcttccctactcgcacatcaacaatcgagaccagatcatcttcatg
gtgggccgtggatatgcttccccagatcttagcaggctctacaagaactgccccaaggca
atgaagagattggtggccgactgtgtgaagaaagtaaaggaagagaggcctctgtttccc
cagatcctgtcttccatcgagctgcttcagcactctctgccgaaaatcaacaggagcgcc
tctgagccctctctgcatcgggcggcccacactgaggacatcaatgcttgcactctgacc
acatccccgaggctacctgtcttctag
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