KEGG   Cricetulus griseus (Chinese hamster): 100769018
Entry
100769018         CDS       T02813                                 

Gene name
Raf1
Definition
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
cge  Cricetulus griseus (Chinese hamster)
Pathway
cge01521  EGFR tyrosine kinase inhibitor resistance
cge01522  Endocrine resistance
cge04010  MAPK signaling pathway
cge04012  ErbB signaling pathway
cge04014  Ras signaling pathway
cge04015  Rap1 signaling pathway
cge04022  cGMP-PKG signaling pathway
cge04024  cAMP signaling pathway
cge04062  Chemokine signaling pathway
cge04068  FoxO signaling pathway
cge04071  Sphingolipid signaling pathway
cge04072  Phospholipase D signaling pathway
cge04140  Autophagy - animal
cge04150  mTOR signaling pathway
cge04151  PI3K-Akt signaling pathway
cge04210  Apoptosis
cge04218  Cellular senescence
cge04270  Vascular smooth muscle contraction
cge04360  Axon guidance
cge04370  VEGF signaling pathway
cge04371  Apelin signaling pathway
cge04510  Focal adhesion
cge04540  Gap junction
cge04550  Signaling pathways regulating pluripotency of stem cells
cge04625  C-type lectin receptor signaling pathway
cge04630  JAK-STAT signaling pathway
cge04650  Natural killer cell mediated cytotoxicity
cge04660  T cell receptor signaling pathway
cge04662  B cell receptor signaling pathway
cge04664  Fc epsilon RI signaling pathway
cge04666  Fc gamma R-mediated phagocytosis
cge04720  Long-term potentiation
cge04722  Neurotrophin signaling pathway
cge04726  Serotonergic synapse
cge04730  Long-term depression
cge04810  Regulation of actin cytoskeleton
cge04910  Insulin signaling pathway
cge04912  GnRH signaling pathway
cge04914  Progesterone-mediated oocyte maturation
cge04915  Estrogen signaling pathway
cge04916  Melanogenesis
cge04917  Prolactin signaling pathway
cge04919  Thyroid hormone signaling pathway
cge04921  Oxytocin signaling pathway
cge04926  Relaxin signaling pathway
cge04928  Parathyroid hormone synthesis, secretion and action
cge04929  GnRH secretion
cge04935  Growth hormone synthesis, secretion and action
cge05010  Alzheimer disease
cge05022  Pathways of neurodegeneration - multiple diseases
cge05034  Alcoholism
cge05132  Salmonella infection
cge05152  Tuberculosis
cge05160  Hepatitis C
cge05161  Hepatitis B
cge05163  Human cytomegalovirus infection
cge05164  Influenza A
cge05165  Human papillomavirus infection
cge05167  Kaposi sarcoma-associated herpesvirus infection
cge05170  Human immunodeficiency virus 1 infection
cge05200  Pathways in cancer
cge05205  Proteoglycans in cancer
cge05206  MicroRNAs in cancer
cge05210  Colorectal cancer
cge05211  Renal cell carcinoma
cge05212  Pancreatic cancer
cge05213  Endometrial cancer
cge05214  Glioma
cge05215  Prostate cancer
cge05218  Melanoma
cge05219  Bladder cancer
cge05220  Chronic myeloid leukemia
cge05221  Acute myeloid leukemia
cge05223  Non-small cell lung cancer
cge05224  Breast cancer
cge05225  Hepatocellular carcinoma
cge05226  Gastric cancer
cge05230  Central carbon metabolism in cancer
cge05231  Choline metabolism in cancer
cge05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:cge00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100769018 (Raf1)
   04012 ErbB signaling pathway
    100769018 (Raf1)
   04014 Ras signaling pathway
    100769018 (Raf1)
   04015 Rap1 signaling pathway
    100769018 (Raf1)
   04370 VEGF signaling pathway
    100769018 (Raf1)
   04371 Apelin signaling pathway
    100769018 (Raf1)
   04630 JAK-STAT signaling pathway
    100769018 (Raf1)
   04068 FoxO signaling pathway
    100769018 (Raf1)
   04072 Phospholipase D signaling pathway
    100769018 (Raf1)
   04071 Sphingolipid signaling pathway
    100769018 (Raf1)
   04024 cAMP signaling pathway
    100769018 (Raf1)
   04022 cGMP-PKG signaling pathway
    100769018 (Raf1)
   04151 PI3K-Akt signaling pathway
    100769018 (Raf1)
   04150 mTOR signaling pathway
    100769018 (Raf1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100769018 (Raf1)
  09143 Cell growth and death
   04210 Apoptosis
    100769018 (Raf1)
   04218 Cellular senescence
    100769018 (Raf1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100769018 (Raf1)
   04540 Gap junction
    100769018 (Raf1)
   04550 Signaling pathways regulating pluripotency of stem cells
    100769018 (Raf1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    100769018 (Raf1)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    100769018 (Raf1)
   04650 Natural killer cell mediated cytotoxicity
    100769018 (Raf1)
   04660 T cell receptor signaling pathway
    100769018 (Raf1)
   04662 B cell receptor signaling pathway
    100769018 (Raf1)
   04664 Fc epsilon RI signaling pathway
    100769018 (Raf1)
   04666 Fc gamma R-mediated phagocytosis
    100769018 (Raf1)
   04062 Chemokine signaling pathway
    100769018 (Raf1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100769018 (Raf1)
   04929 GnRH secretion
    100769018 (Raf1)
   04912 GnRH signaling pathway
    100769018 (Raf1)
   04915 Estrogen signaling pathway
    100769018 (Raf1)
   04914 Progesterone-mediated oocyte maturation
    100769018 (Raf1)
   04917 Prolactin signaling pathway
    100769018 (Raf1)
   04921 Oxytocin signaling pathway
    100769018 (Raf1)
   04926 Relaxin signaling pathway
    100769018 (Raf1)
   04935 Growth hormone synthesis, secretion and action
    100769018 (Raf1)
   04919 Thyroid hormone signaling pathway
    100769018 (Raf1)
   04928 Parathyroid hormone synthesis, secretion and action
    100769018 (Raf1)
   04916 Melanogenesis
    100769018 (Raf1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    100769018 (Raf1)
  09156 Nervous system
   04726 Serotonergic synapse
    100769018 (Raf1)
   04720 Long-term potentiation
    100769018 (Raf1)
   04730 Long-term depression
    100769018 (Raf1)
   04722 Neurotrophin signaling pathway
    100769018 (Raf1)
  09158 Development and regeneration
   04360 Axon guidance
    100769018 (Raf1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100769018 (Raf1)
   05206 MicroRNAs in cancer
    100769018 (Raf1)
   05205 Proteoglycans in cancer
    100769018 (Raf1)
   05230 Central carbon metabolism in cancer
    100769018 (Raf1)
   05231 Choline metabolism in cancer
    100769018 (Raf1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100769018 (Raf1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100769018 (Raf1)
   05212 Pancreatic cancer
    100769018 (Raf1)
   05225 Hepatocellular carcinoma
    100769018 (Raf1)
   05226 Gastric cancer
    100769018 (Raf1)
   05214 Glioma
    100769018 (Raf1)
   05221 Acute myeloid leukemia
    100769018 (Raf1)
   05220 Chronic myeloid leukemia
    100769018 (Raf1)
   05218 Melanoma
    100769018 (Raf1)
   05211 Renal cell carcinoma
    100769018 (Raf1)
   05219 Bladder cancer
    100769018 (Raf1)
   05215 Prostate cancer
    100769018 (Raf1)
   05213 Endometrial cancer
    100769018 (Raf1)
   05224 Breast cancer
    100769018 (Raf1)
   05223 Non-small cell lung cancer
    100769018 (Raf1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100769018 (Raf1)
   05022 Pathways of neurodegeneration - multiple diseases
    100769018 (Raf1)
  09165 Substance dependence
   05034 Alcoholism
    100769018 (Raf1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100769018 (Raf1)
   05152 Tuberculosis
    100769018 (Raf1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100769018 (Raf1)
   05161 Hepatitis B
    100769018 (Raf1)
   05160 Hepatitis C
    100769018 (Raf1)
   05164 Influenza A
    100769018 (Raf1)
   05163 Human cytomegalovirus infection
    100769018 (Raf1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100769018 (Raf1)
   05165 Human papillomavirus infection
    100769018 (Raf1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100769018 (Raf1)
   01522 Endocrine resistance
    100769018 (Raf1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cge01001]
    100769018 (Raf1)
Enzymes [BR:cge01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100769018 (Raf1)
Protein kinases [BR:cge01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100769018 (Raf1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 100769018
NCBI-ProteinID: XP_027284970
UniProt: G3HVN3
LinkDB
Position
8
AA seq 648 aa
MEHIQGAWKSISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDSGVPALPSLTMRRMRESVSRMPASSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacagggagcttggaagtcgatcagcaatggctttggactcaaagatgcg
gtatttgatggctccagctgcatctctccaacaattgttcagcagtttggctatcagcgc
cgggcgtcagatgatggcaaactcacggattcatctaagacaagcaacactattcgagtt
ttcttgccgaataagcaaaggacagtggtcaatgtgcggaatggaatgagcttgcacgac
tgccttatgaaagctctcaaggtgaggggtctgcagccagagtgttgtgcagtgttcaga
cttctccaggaacacaaaggtaagaaagcacgcttagactggaacaccgacgctgcctct
ctgattggagaagaactgcaagtggatttcttggatcatgttccactcacaactcacaac
tttgctcggaaaacgttcctgaagcttgcattctgtgacatctgtcaaaagttcctgcta
aatggatttcggtgtcagacttgtggctacaagtttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacagctcttgctgtttccaaattccact
gttggtgatagcggagtcccagcactaccttctttgacaatgcgtcggatgcgagagtct
gtttcccggatgcctgctagttcccagcacagatactccacacctcatgccttcactttc
aacacctccagcccttcctctgaaggttccctctcccagaggcagaggtcaacgtccact
cccaatgttcacatggtcagcaccaccttgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagtgaatcagcctcaccttcagccctgtccagcagccccaacaacctg
agcccaacaggatggtcgcagcctaaaacccctgtgccagcacaaagagaacgggcacca
ggatctgggacccaggaaaaaaacaaaattaggcctcgtgggcagagagattcaagctat
tactgggaaatagaagccagtgaggtgatgctgtccactcggattggatcgggctccttt
ggcactgtgtacaagggcaagtggcacggagatgttgcagtaaagatcctaaaagtggtt
gacccaaccccagagcagcttcaggccttcaggaacgaggtggctgtcttgcgcaaaaca
cggcatgttaatatcctgctgttcatgggctatatgacaaaggacaacctggccattgtg
acccagtggtgtgaaggcagcagtctctataaacacctacatgtccaggagaccaaattc
cagatgttccagctaattgacattgcccgacagacagctcagggaatggactatttgcat
gcgaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctc
acggtgaaaattggagattttggtttggcaacagtgaagtcacgctggagtggttctcag
caggttgaacagcccaccggctctgtgctatggatggccccagaagtaatccgaatgcag
gataacaacccgtttagcttccagtctgacgtctactcctatggcattgtgctgtatgag
ctgatgacgggggagcttccctactcgcacatcaacaatcgagaccagatcatcttcatg
gtgggccgtggatatgcttccccagatcttagcaggctctacaagaactgccccaaggca
atgaagagattggtggccgactgtgtgaagaaagtaaaggaagagaggcctctgtttccc
cagatcctgtcttccatcgagctgcttcagcactctctgccgaaaatcaacaggagcgcc
tctgagccctctctgcatcgggcggcccacactgaggacatcaatgcttgcactctgacc
acatccccgaggctacctgtcttctag

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