KEGG   Cricetulus griseus (Chinese hamster): 100771734
Entry
100771734         CDS       T02813                                 
Symbol
Mapk8
Name
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
cge  Cricetulus griseus (Chinese hamster)
Pathway
cge01522  Endocrine resistance
cge04010  MAPK signaling pathway
cge04012  ErbB signaling pathway
cge04014  Ras signaling pathway
cge04024  cAMP signaling pathway
cge04068  FoxO signaling pathway
cge04071  Sphingolipid signaling pathway
cge04137  Mitophagy - animal
cge04140  Autophagy - animal
cge04141  Protein processing in endoplasmic reticulum
cge04210  Apoptosis
cge04215  Apoptosis - multiple species
cge04217  Necroptosis
cge04310  Wnt signaling pathway
cge04380  Osteoclast differentiation
cge04510  Focal adhesion
cge04530  Tight junction
cge04620  Toll-like receptor signaling pathway
cge04621  NOD-like receptor signaling pathway
cge04622  RIG-I-like receptor signaling pathway
cge04625  C-type lectin receptor signaling pathway
cge04657  IL-17 signaling pathway
cge04658  Th1 and Th2 cell differentiation
cge04659  Th17 cell differentiation
cge04660  T cell receptor signaling pathway
cge04664  Fc epsilon RI signaling pathway
cge04668  TNF signaling pathway
cge04722  Neurotrophin signaling pathway
cge04723  Retrograde endocannabinoid signaling
cge04728  Dopaminergic synapse
cge04750  Inflammatory mediator regulation of TRP channels
cge04910  Insulin signaling pathway
cge04912  GnRH signaling pathway
cge04914  Progesterone-mediated oocyte maturation
cge04917  Prolactin signaling pathway
cge04920  Adipocytokine signaling pathway
cge04926  Relaxin signaling pathway
cge04930  Type II diabetes mellitus
cge04931  Insulin resistance
cge04932  Non-alcoholic fatty liver disease
cge04933  AGE-RAGE signaling pathway in diabetic complications
cge04935  Growth hormone synthesis, secretion and action
cge04936  Alcoholic liver disease
cge05010  Alzheimer disease
cge05012  Parkinson disease
cge05016  Huntington disease
cge05017  Spinocerebellar ataxia
cge05020  Prion disease
cge05022  Pathways of neurodegeneration - multiple diseases
cge05132  Salmonella infection
cge05133  Pertussis
cge05135  Yersinia infection
cge05142  Chagas disease
cge05145  Toxoplasmosis
cge05152  Tuberculosis
cge05161  Hepatitis B
cge05162  Measles
cge05166  Human T-cell leukemia virus 1 infection
cge05167  Kaposi sarcoma-associated herpesvirus infection
cge05169  Epstein-Barr virus infection
cge05170  Human immunodeficiency virus 1 infection
cge05171  Coronavirus disease - COVID-19
cge05200  Pathways in cancer
cge05208  Chemical carcinogenesis - reactive oxygen species
cge05210  Colorectal cancer
cge05212  Pancreatic cancer
cge05231  Choline metabolism in cancer
cge05415  Diabetic cardiomyopathy
cge05417  Lipid and atherosclerosis
cge05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cge00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    100771734 (Mapk8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100771734 (Mapk8)
   04012 ErbB signaling pathway
    100771734 (Mapk8)
   04014 Ras signaling pathway
    100771734 (Mapk8)
   04310 Wnt signaling pathway
    100771734 (Mapk8)
   04668 TNF signaling pathway
    100771734 (Mapk8)
   04068 FoxO signaling pathway
    100771734 (Mapk8)
   04071 Sphingolipid signaling pathway
    100771734 (Mapk8)
   04024 cAMP signaling pathway
    100771734 (Mapk8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100771734 (Mapk8)
   04137 Mitophagy - animal
    100771734 (Mapk8)
  09143 Cell growth and death
   04210 Apoptosis
    100771734 (Mapk8)
   04215 Apoptosis - multiple species
    100771734 (Mapk8)
   04217 Necroptosis
    100771734 (Mapk8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100771734 (Mapk8)
   04530 Tight junction
    100771734 (Mapk8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    100771734 (Mapk8)
   04621 NOD-like receptor signaling pathway
    100771734 (Mapk8)
   04622 RIG-I-like receptor signaling pathway
    100771734 (Mapk8)
   04625 C-type lectin receptor signaling pathway
    100771734 (Mapk8)
   04660 T cell receptor signaling pathway
    100771734 (Mapk8)
   04658 Th1 and Th2 cell differentiation
    100771734 (Mapk8)
   04659 Th17 cell differentiation
    100771734 (Mapk8)
   04657 IL-17 signaling pathway
    100771734 (Mapk8)
   04664 Fc epsilon RI signaling pathway
    100771734 (Mapk8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100771734 (Mapk8)
   04920 Adipocytokine signaling pathway
    100771734 (Mapk8)
   04912 GnRH signaling pathway
    100771734 (Mapk8)
   04914 Progesterone-mediated oocyte maturation
    100771734 (Mapk8)
   04917 Prolactin signaling pathway
    100771734 (Mapk8)
   04926 Relaxin signaling pathway
    100771734 (Mapk8)
   04935 Growth hormone synthesis, secretion and action
    100771734 (Mapk8)
  09156 Nervous system
   04728 Dopaminergic synapse
    100771734 (Mapk8)
   04723 Retrograde endocannabinoid signaling
    100771734 (Mapk8)
   04722 Neurotrophin signaling pathway
    100771734 (Mapk8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    100771734 (Mapk8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100771734 (Mapk8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100771734 (Mapk8)
   05208 Chemical carcinogenesis - reactive oxygen species
    100771734 (Mapk8)
   05231 Choline metabolism in cancer
    100771734 (Mapk8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100771734 (Mapk8)
   05212 Pancreatic cancer
    100771734 (Mapk8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    100771734 (Mapk8)
   05170 Human immunodeficiency virus 1 infection
    100771734 (Mapk8)
   05161 Hepatitis B
    100771734 (Mapk8)
   05171 Coronavirus disease - COVID-19
    100771734 (Mapk8)
   05162 Measles
    100771734 (Mapk8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    100771734 (Mapk8)
   05169 Epstein-Barr virus infection
    100771734 (Mapk8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100771734 (Mapk8)
   05135 Yersinia infection
    100771734 (Mapk8)
   05133 Pertussis
    100771734 (Mapk8)
   05152 Tuberculosis
    100771734 (Mapk8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    100771734 (Mapk8)
   05142 Chagas disease
    100771734 (Mapk8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100771734 (Mapk8)
   05012 Parkinson disease
    100771734 (Mapk8)
   05016 Huntington disease
    100771734 (Mapk8)
   05017 Spinocerebellar ataxia
    100771734 (Mapk8)
   05020 Prion disease
    100771734 (Mapk8)
   05022 Pathways of neurodegeneration - multiple diseases
    100771734 (Mapk8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100771734 (Mapk8)
   05418 Fluid shear stress and atherosclerosis
    100771734 (Mapk8)
   05415 Diabetic cardiomyopathy
    100771734 (Mapk8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    100771734 (Mapk8)
   04936 Alcoholic liver disease
    100771734 (Mapk8)
   04932 Non-alcoholic fatty liver disease
    100771734 (Mapk8)
   04931 Insulin resistance
    100771734 (Mapk8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    100771734 (Mapk8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    100771734 (Mapk8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cge01001]
    100771734 (Mapk8)
Enzymes [BR:cge01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     100771734 (Mapk8)
Protein kinases [BR:cge01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   100771734 (Mapk8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH DUF530
Other DBs
NCBI-GeneID: 100771734
NCBI-ProteinID: XP_027245268
UniProt: A0A9J7F1H4
LinkDB
Position
1
AA seq 427 aa
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSPSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaagcgggacaacaatttttatagtgtagagattggagattctacattc
acagtcctaaaacggtatcagaatttaaaacctataggttcaggagctcaaggaatagtg
tgtgcagcttatgatgctattcttgaaagaaatgttgcaatcaagaagctcagccggcca
tttcagaatcagactcatgctaagcgagcctaccgagaactagttcttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggagttagatcatgaaagaatgtcctaccttctctatcaaatgctgtgtggaatcaag
caccttcactctgctggaattattcaccgggacttaaagcctagtaatatagtagtcaaa
tcagactgcactttgaagattcttgattttggactggcgaggactgcaggaacaagtttc
atgatgacgccttatgtagtgactcgctactacagagcaccagaggtcatcctcggcatg
ggctacaaggagaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgaacag
cttggaacaccctgtcctgaattcatgaagaaactacaaccaacagtaaggacttatgtc
gaaaacagacctaaatatgctggatatagctttgagaaactgttccctgatgtgcttttc
ccagctgactctgagcataacaaacttaaagccagtcaggcaagggatttgttatccaaa
atgctagtaatagatgcatccaaaaggatctcagtagatgaagctctccagcacccatac
atcaacgtctggtatgacccttcagaagcagaagctccaccaccaaagatccctgacaag
cagttagatgaaagggagcacacaatagaagagtggaaagaactgatatataaagaggta
atggacttggaggagcgaaccaagaatggagtcataagagggcaaccatctcctttaggt
gcagcagtgatcaatggctctcaacacccatcgtcttcaccgtctgtcaatgatgtgtct
tcaatgtccacagatccgactttggcctcggatacagacagcagtctagaagcatcagcc
ggacctctaggctgctgtagatga

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