KEGG T02910: 102175285

KEGG Orthology (KO) [BR:chx00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102175285 (MAP2K2)
   04012 ErbB signaling pathway
    102175285 (MAP2K2)
   04014 Ras signaling pathway
    102175285 (MAP2K2)
   04015 Rap1 signaling pathway
    102175285 (MAP2K2)
   04370 VEGF signaling pathway
    102175285 (MAP2K2)
   04371 Apelin signaling pathway
    102175285 (MAP2K2)
   04066 HIF-1 signaling pathway
    102175285 (MAP2K2)
   04068 FoxO signaling pathway
    102175285 (MAP2K2)
   04072 Phospholipase D signaling pathway
    102175285 (MAP2K2)
   04071 Sphingolipid signaling pathway
    102175285 (MAP2K2)
   04024 cAMP signaling pathway
    102175285 (MAP2K2)
   04022 cGMP-PKG signaling pathway
    102175285 (MAP2K2)
   04151 PI3K-Akt signaling pathway
    102175285 (MAP2K2)
   04150 mTOR signaling pathway
    102175285 (MAP2K2)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102175285 (MAP2K2)
  09143 Cell growth and death
   04210 Apoptosis
    102175285 (MAP2K2)
   04218 Cellular senescence
    102175285 (MAP2K2)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    102175285 (MAP2K2)
   04550 Signaling pathways regulating pluripotency of stem cells
    102175285 (MAP2K2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102175285 (MAP2K2)
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102175285 (MAP2K2)
   04620 Toll-like receptor signaling pathway
    102175285 (MAP2K2)
   04650 Natural killer cell mediated cytotoxicity
    102175285 (MAP2K2)
   04660 T cell receptor signaling pathway
    102175285 (MAP2K2)
   04662 B cell receptor signaling pathway
    102175285 (MAP2K2)
   04664 Fc epsilon RI signaling pathway
    102175285 (MAP2K2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102175285 (MAP2K2)
   04929 GnRH secretion
    102175285 (MAP2K2)
   04912 GnRH signaling pathway
    102175285 (MAP2K2)
   04915 Estrogen signaling pathway
    102175285 (MAP2K2)
   04917 Prolactin signaling pathway
    102175285 (MAP2K2)
   04921 Oxytocin signaling pathway
    102175285 (MAP2K2)
   04926 Relaxin signaling pathway
    102175285 (MAP2K2)
   04935 Growth hormone synthesis, secretion and action
    102175285 (MAP2K2)
   04919 Thyroid hormone signaling pathway
    102175285 (MAP2K2)
   04916 Melanogenesis
    102175285 (MAP2K2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102175285 (MAP2K2)
  09156 Nervous system
   04720 Long-term potentiation
    102175285 (MAP2K2)
   04730 Long-term depression
    102175285 (MAP2K2)
   04722 Neurotrophin signaling pathway
    102175285 (MAP2K2)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102175285 (MAP2K2)
   05206 MicroRNAs in cancer
    102175285 (MAP2K2)
   05205 Proteoglycans in cancer
    102175285 (MAP2K2)
   05230 Central carbon metabolism in cancer
    102175285 (MAP2K2)
   05231 Choline metabolism in cancer
    102175285 (MAP2K2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102175285 (MAP2K2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102175285 (MAP2K2)
   05225 Hepatocellular carcinoma
    102175285 (MAP2K2)
   05226 Gastric cancer
    102175285 (MAP2K2)
   05214 Glioma
    102175285 (MAP2K2)
   05216 Thyroid cancer
    102175285 (MAP2K2)
   05221 Acute myeloid leukemia
    102175285 (MAP2K2)
   05220 Chronic myeloid leukemia
    102175285 (MAP2K2)
   05218 Melanoma
    102175285 (MAP2K2)
   05211 Renal cell carcinoma
    102175285 (MAP2K2)
   05219 Bladder cancer
    102175285 (MAP2K2)
   05215 Prostate cancer
    102175285 (MAP2K2)
   05213 Endometrial cancer
    102175285 (MAP2K2)
   05224 Breast cancer
    102175285 (MAP2K2)
   05223 Non-small cell lung cancer
    102175285 (MAP2K2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102175285 (MAP2K2)
   05022 Pathways of neurodegeneration - multiple diseases
    102175285 (MAP2K2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102175285 (MAP2K2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102175285 (MAP2K2)
   05135 Yersinia infection
    102175285 (MAP2K2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102175285 (MAP2K2)
   05170 Human immunodeficiency virus 1 infection
    102175285 (MAP2K2)
   05161 Hepatitis B
    102175285 (MAP2K2)
   05160 Hepatitis C
    102175285 (MAP2K2)
   05164 Influenza A
    102175285 (MAP2K2)
   05163 Human cytomegalovirus infection
    102175285 (MAP2K2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102175285 (MAP2K2)
   05165 Human papillomavirus infection
    102175285 (MAP2K2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102175285 (MAP2K2)
   01522 Endocrine resistance
    102175285 (MAP2K2)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:chx01001]
    102175285 (MAP2K2)
Enzymes [BR:chx01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     102175285 (MAP2K2)
Protein kinases [BR:chx01001]
Serine/threonine kinases: STE group
  STE7 family
   102175285 (MAP2K2)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Pkinase_fungal Kinase-like APH Seadorna_VP7 Kdo

Other DBs

NCBI-GeneID:

102175285

NCBI-ProteinID:

XP_017906345

UniProt:

A0A452ENE3

LinkDB

Position

AA seq 400 aa
MLARRKPVLPALTINPAIAEGPSPTSEGASEAHLVDLQKKLEELELDEQQKKRLEAFLTQ
KAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQ
VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRG
LAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQ
GTHYSVQSDIWSMGLSLVELSIGRYPIPPPDAKELEAIFGRPMVDGAEGEPPSISPRPRP
PGRPISGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTQDFQEFVNKCLIKNPAERADL
KMLMNHTFIKRSEVEEVDFAGWLCKTLRLNQPSTPTRTAV

NT seq 1203 nt +upstreamnt +downstreamnt
atgctggcccggaggaagccggtgctgccggcgctcaccatcaaccccgccatcgccgag
ggtccgtcccccaccagcgagggcgcctccgaagcacacctggtggacctccagaagaag
ctggaggagctagagcttgacgagcagcagaagaagcggctggaagccttccttacccag
aaggccaaggttggcgagctcaaggacgatgacttcgaacggatctccgagctgggagcc
ggcaatggtggagtggtcaccaaggtccagcacagaccttcgggcctcatcatggccaga
aagctgatccacctggagatcaagccggccatccggaaccagatcatccgagagctgcag
gtgctgcatgagtgcaactccccgtacattgtgggcttctacggggccttctacagcgac
ggcgagatcagcatctgcatggagcacatggatggcggctccctggaccaggtgttgaaa
gaagccaagagaatccccgaagagatcctgggcaaggtcagcatcgcggttctgcggggc
ctggcatacctccgggagaaacaccagatcatgcaccgagacgtgaagccgtccaacatc
ctcgtcaactcccggggggagatcaagctgtgtgactttggggtgagcggccagctcatc
gactccatggccaactccttcgtgggcacgcggtcctacatgtctccggagcgactacaa
ggcacccactactcagtgcagtcagacatctggagcatgggcctgtccctggtggaactg
tccatcggaaggtaccccatccccccgccagacgccaaggagctggaggccatattcggc
cggcccatggttgatggcgcggaaggagaacctcccagcatctcaccacggccgaggccc
cccggacgccccatcagcggtcatgggatggacagccggccggccatggcgatctttgag
ctgctggactacattgtgaacgagcctcctcccaagctgcccaatggcgtgttcacccag
gacttccaggagtttgtaaataaatgcctaattaagaacccagctgagcgagcagacctg
aagatgctcatgaaccacaccttcatcaagcggtccgaggtggaagaagtggattttgct
ggctggttgtgtaaaacactgcggctaaaccagcccagcacgcccacacgcaccgccgtg
tga

Capra hircus (goat): 102190520

Entry

102190520 CDS T02910

Gene name

MAP2K1

Definition

(RefSeq) mitogen-activated protein kinase kinase 1

K04368

mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]

Organism

chx Capra hircus (goat)

Pathway

chx01521

EGFR tyrosine kinase inhibitor resistance

chx01522

Endocrine resistance

chx04010

MAPK signaling pathway

chx04012

ErbB signaling pathway

chx04014

Ras signaling pathway

chx04015

Rap1 signaling pathway

chx04022

cGMP-PKG signaling pathway

chx04024

cAMP signaling pathway

chx04062

Chemokine signaling pathway

chx04066

HIF-1 signaling pathway

chx04068

FoxO signaling pathway

chx04071

Sphingolipid signaling pathway

chx04072

Phospholipase D signaling pathway

chx04114

Oocyte meiosis

chx04140

Autophagy - animal

chx04150

mTOR signaling pathway

chx04151

PI3K-Akt signaling pathway

chx04210

Apoptosis

chx04218

Cellular senescence

chx04270

Vascular smooth muscle contraction

chx04370

VEGF signaling pathway

chx04371

Apelin signaling pathway

chx04380

Osteoclast differentiation

chx04510

Focal adhesion

chx04540

Gap junction

chx04550

Signaling pathways regulating pluripotency of stem cells

chx04613

Neutrophil extracellular trap formation

chx04620

Toll-like receptor signaling pathway

chx04650

Natural killer cell mediated cytotoxicity

chx04660

T cell receptor signaling pathway

chx04662

B cell receptor signaling pathway

chx04664

Fc epsilon RI signaling pathway

chx04666

Fc gamma R-mediated phagocytosis

chx04668

TNF signaling pathway

chx04720

Long-term potentiation

chx04722

Neurotrophin signaling pathway

chx04725

Cholinergic synapse

chx04726

Serotonergic synapse

chx04730

Long-term depression

chx04810

Regulation of actin cytoskeleton

chx04910

Insulin signaling pathway

chx04912

GnRH signaling pathway

chx04914

Progesterone-mediated oocyte maturation

chx04915

Estrogen signaling pathway

chx04916

Melanogenesis

chx04917

Prolactin signaling pathway

chx04919

Thyroid hormone signaling pathway

chx04921

Oxytocin signaling pathway

chx04926

Relaxin signaling pathway

chx04928

Parathyroid hormone synthesis, secretion and action

chx04929

GnRH secretion

chx04934

Cushing syndrome

chx04935

Growth hormone synthesis, secretion and action

chx05010

Alzheimer disease

chx05022

Pathways of neurodegeneration - multiple diseases

chx05034

Alcoholism

chx05132

Salmonella infection

chx05135

Yersinia infection

chx05160

Hepatitis C

chx05161

Hepatitis B

chx05163

Human cytomegalovirus infection

chx05164

Influenza A

chx05165

Human papillomavirus infection

chx05166

Human T-cell leukemia virus 1 infection

chx05167

Kaposi sarcoma-associated herpesvirus infection

chx05170

Human immunodeficiency virus 1 infection

chx05200

Pathways in cancer

chx05205

Proteoglycans in cancer

chx05206

MicroRNAs in cancer

chx05210

Colorectal cancer

chx05211

Renal cell carcinoma

chx05212

Pancreatic cancer

chx05213

Endometrial cancer

chx05214

Glioma

chx05215

Prostate cancer

chx05216

Thyroid cancer

chx05218

Melanoma

chx05219

Bladder cancer

chx05220

Chronic myeloid leukemia

chx05221

Acute myeloid leukemia

chx05223

Non-small cell lung cancer

chx05224

Breast cancer

chx05225

Hepatocellular carcinoma

chx05226

Gastric cancer

chx05230

Central carbon metabolism in cancer

chx05231

Choline metabolism in cancer

chx05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Brite

KEGG Orthology (KO) [BR:chx00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102190520 (MAP2K1)
   04012 ErbB signaling pathway
    102190520 (MAP2K1)
   04014 Ras signaling pathway
    102190520 (MAP2K1)
   04015 Rap1 signaling pathway
    102190520 (MAP2K1)
   04370 VEGF signaling pathway
    102190520 (MAP2K1)
   04371 Apelin signaling pathway
    102190520 (MAP2K1)
   04668 TNF signaling pathway
    102190520 (MAP2K1)
   04066 HIF-1 signaling pathway
    102190520 (MAP2K1)
   04068 FoxO signaling pathway
    102190520 (MAP2K1)
   04072 Phospholipase D signaling pathway
    102190520 (MAP2K1)
   04071 Sphingolipid signaling pathway
    102190520 (MAP2K1)
   04024 cAMP signaling pathway
    102190520 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    102190520 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    102190520 (MAP2K1)
   04150 mTOR signaling pathway
    102190520 (MAP2K1)
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102190520 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    102190520 (MAP2K1)
   04210 Apoptosis
    102190520 (MAP2K1)
   04218 Cellular senescence
    102190520 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102190520 (MAP2K1)
   04540 Gap junction
    102190520 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    102190520 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102190520 (MAP2K1)
09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102190520 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    102190520 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    102190520 (MAP2K1)
   04660 T cell receptor signaling pathway
    102190520 (MAP2K1)
   04662 B cell receptor signaling pathway
    102190520 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    102190520 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    102190520 (MAP2K1)
   04062 Chemokine signaling pathway
    102190520 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102190520 (MAP2K1)
   04929 GnRH secretion
    102190520 (MAP2K1)
   04912 GnRH signaling pathway
    102190520 (MAP2K1)
   04915 Estrogen signaling pathway
    102190520 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    102190520 (MAP2K1)
   04917 Prolactin signaling pathway
    102190520 (MAP2K1)
   04921 Oxytocin signaling pathway
    102190520 (MAP2K1)
   04926 Relaxin signaling pathway
    102190520 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    102190520 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    102190520 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    102190520 (MAP2K1)
   04916 Melanogenesis
    102190520 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102190520 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    102190520 (MAP2K1)
   04726 Serotonergic synapse
    102190520 (MAP2K1)
   04720 Long-term potentiation
    102190520 (MAP2K1)
   04730 Long-term depression
    102190520 (MAP2K1)
   04722 Neurotrophin signaling pathway
    102190520 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102190520 (MAP2K1)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102190520 (MAP2K1)
   05206 MicroRNAs in cancer
    102190520 (MAP2K1)
   05205 Proteoglycans in cancer
    102190520 (MAP2K1)
   05230 Central carbon metabolism in cancer
    102190520 (MAP2K1)
   05231 Choline metabolism in cancer
    102190520 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102190520 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102190520 (MAP2K1)
   05212 Pancreatic cancer
    102190520 (MAP2K1)
   05225 Hepatocellular carcinoma
    102190520 (MAP2K1)
   05226 Gastric cancer
    102190520 (MAP2K1)
   05214 Glioma
    102190520 (MAP2K1)
   05216 Thyroid cancer
    102190520 (MAP2K1)
   05221 Acute myeloid leukemia
    102190520 (MAP2K1)
   05220 Chronic myeloid leukemia
    102190520 (MAP2K1)
   05218 Melanoma
    102190520 (MAP2K1)
   05211 Renal cell carcinoma
    102190520 (MAP2K1)
   05219 Bladder cancer
    102190520 (MAP2K1)
   05215 Prostate cancer
    102190520 (MAP2K1)
   05213 Endometrial cancer
    102190520 (MAP2K1)
   05224 Breast cancer
    102190520 (MAP2K1)
   05223 Non-small cell lung cancer
    102190520 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102190520 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    102190520 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    102190520 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102190520 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102190520 (MAP2K1)
   05135 Yersinia infection
    102190520 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102190520 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    102190520 (MAP2K1)
   05161 Hepatitis B
    102190520 (MAP2K1)
   05160 Hepatitis C
    102190520 (MAP2K1)
   05164 Influenza A
    102190520 (MAP2K1)
   05163 Human cytomegalovirus infection
    102190520 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102190520 (MAP2K1)
   05165 Human papillomavirus infection
    102190520 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102190520 (MAP2K1)
   01522 Endocrine resistance
    102190520 (MAP2K1)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:chx01001]
    102190520 (MAP2K1)
Enzymes [BR:chx01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     102190520 (MAP2K1)
Protein kinases [BR:chx01001]
Serine/threonine kinases: STE group
  STE7 family
   102190520 (MAP2K1)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Pkinase_fungal Kinase-like Seadorna_VP7 NAD_binding_6

Other DBs

NCBI-GeneID:

102190520

NCBI-ProteinID:

XP_005685187

LinkDB

Position

AA seq 391 aa
MCRGAATSSVCRMHSCRAPEMKLERTNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGE
LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECN
SPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE
KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV
QSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGM
DSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK
RSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV

NT seq 1176 nt +upstreamnt +downstreamnt
atgtgtagaggagcggcaactagttcagtgtgccggatgcatagctgcagggcgccggag
atgaagctggagaggaccaacctggaggccttgcagaagaagctggaggagctggagctc
gatgaacagcagcggaagcgcctcgaggcctttctgacccagaagcagaaggtgggggag
ctgaaggatgatgactttgagaagatcagtgagctgggtgccggcaatggaggtgtggtg
ttcaaggtctcccacaagccgtccggactcgttatggccagaaagctaattcacctggag
atcaaacctgccatccggaaccagatcataagggagctgcaggttctccatgagtgcaac
tcgccgtacatcgtgggcttctacggggccttctacagcgacggcgagatcagcatctgc
atggagcacatggatgggggttccttggatcaagttctgaagaaagctggaagaattcct
gaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatacctgagggag
aagcacaagattatgcatagagatgtcaagccgtccaacatcctagtgaacagccgtggg
gagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggccaactct
ttcgtgggcaccaggtcctacatgtcgccagagcgactccaggggacccattactccgtg
cagtcggacatctggagcatggggctctctctggttgagatggcggtcgggagatatccc
attcctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggagggagat
gcggcagagaccccgcccaggccaaggacccccgggaggcccctcagctcttatggaatg
gacagccgacctccaatggcaatttttgagttgttggattacatagtcaatgagcctcct
ccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaatgctta
ataaaaaaccccgcagagagagcagatctgaagcaactcatggttcatgcttttatcaag
agatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggccttaac
cagcccagcacacccacccatgcagctggcgtctaa

DBGET integrated database retrieval system