KEGG   Capra hircus (goat): 102180119Help
Entry
102180119         CDS       T02910                                 

Gene name
DOT1L
Definition
(RefSeq) DOT1 like histone lysine methyltransferase
  KO
K11427  histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
Organism
chx  Capra hircus (goat)
Pathway
chx00310  Lysine degradation
chx05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:chx00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    102180119 (DOT1L)
 09160 Human Diseases
  09161 Cancers
   05202 Transcriptional misregulation in cancers
    102180119 (DOT1L)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:chx03036]
    102180119 (DOT1L)
Enzymes [BR:chx01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     102180119 (DOT1L)
Chromosome and associated proteins [BR:chx03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     102180119 (DOT1L)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: DOT1 HALZ
Motif
Other DBs
NCBI-GeneID: 102180119
NCBI-ProteinID: XP_017906244
LinkDB All DBs
Position
7
AA seq 1714 aa AA seqDB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVVFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKAAVPADTPVDSGAEEEKAGTAAVKKPSPSKARKKKLNKKGRKMVGRKRGRPKKMSAT
NPERKPKKTQSALDLLHAQTVSRAASPLPQDVHRPPHSPFYQLPPSVQRPTPEQLLLAPT
PPALHRLLESFRIQYLQFLAYTKTPQYKATLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EESKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKGNRELRSQSLRLL
KARCEELKLDWSTLSLENLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDEALALQLRGKPEAEPGRLHLELDCARFSLPPFSSLSPELSMNGHAAGYELCSAL
GRPSPKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSSLALPDYTRLSPAKLVLRRHLS
QDHAASGKAAASELHPRAEHAKENGLPYQSPGITNGIKLSPQDPRPSSPTALQMGEKGPE
KGVKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKARSTPSPGPPA
RESSSTLEKQVAANTHGAGGNAAGSKSLALAPTGFAYSGSVAISGALAGSPAPLGPGAEP
PALDESSSSGSLFATVGSRSSTPQHPPLLTQPRTCGSASPAPQLCASPRLGALGPLPDSG
KGDLPCDASFSDPESEAKRRIVFTISAGASSAKQSPSSKHSPLPSAARGDGGQGHGPDSR
KRGRRKRASAGTPSLSSSVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAIS
SPESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEPGSEDEPGSARIERKI
ATISLESKSPPKTLENAGGSLAGRKAPLASEPVNSSKWKSTFSPISDLGLAKAADSPLQA
ASALSHNSLFAFRPGLEEPSTADGKLATHSRKSFPGTLPGAGGLSPNSLPASGFALGGGL
AADLSLHSFSDGASLSHKAPEAAGLGAPMSFPGPRGKEGGAAESGPFVNKRQLDGLGPKG
EGGLPTCGPPDKASTAHSKAGKGREREPDVKNGHNLFMAAAAAPPAGLLSGPGLAPAASS
AGGTAPSVQTHRPFLGAFAPGPQFALGPMSLQANLGPSVLQSLFSSVPAAGLVHVSTAAT
RLTNSHAMGSFSSGVAGGAVGGVFNHAVPPASAHPFGASFGSGAACRSTTLSLTPLQAVA
STPASSFQAPSSAEPRPPQPPPHLGRPPPGQPALHAPPHPNATLPPPPALLPANSEPVLL
QNLASLPANQAFLPAASAASLPPANASLSIKLASLPHKVSRPALTVHHQPLPGLALAQAA
PVNPQASSTGPPAVWVSLGMPPPYAARLAGVKPR
NT seq 5145 nt NT seq  +upstreamnt  +downstreamnt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtttacgacaaacaccacgatgctgctcatgaaatcatcgagacc
atcagatgggtctgtgaggaaatcccggatctcaagctcgctatggagaattacgtttta
attgactacgataccaaaagctttgagagtatgcagaggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggcaccacacagcccatgaagctgaacaca
cggccgtccactgggctcctgcggcacatcctgcagcaggtctacaaccactcggtgact
gaccctgagaagctcaacaactatgagcccttctccccagaggtgtatggggagacctcc
ttcgacctggtcgcccagatgatcgatgagatcaagatgaccgaagatgacctgttcgtg
gacctgggcagtggggtgggccaggtcgtgctgcaggttgccgcagccaccaactgcaaa
catcattatggtgtagagaaagctgacatcccagccaagtacgcggagacgatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagagg
ggggacttcctctcggaggagtggagagaacggattgctaatacaagtgttgtatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcaaacatg
aaggaaggtggcagaatcgtgtcctcgaagccctttgcgcctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgtcgtggagctgtcgccgctaaaa
ggctcggtgtcatggacggggaagccagtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctaaaaaatccaaaactcagggaggaacaagaggca
gctcggcgccggcagcagcgggagaacaagagcaacacaaccacacccaccaaggtgccc
gagagcaaggcagctgtgccggcagacacccccgtggactccggtgctgaggaggagaaa
gccgggacggccgctgtcaagaagccatctccctccaaggcccggaagaagaagctgaac
aagaagggccggaagatggtgggtcggaagcgtgggcgccccaagaagatgagtgccacc
aaccccgagcgcaagcccaagaagacccagagcgcactggacctgctgcacgcccagacc
gtgtcacgagcggcctcccccttgccgcaggacgtgcacaggccacctcacagcccattc
taccagctacctcccagcgtgcagcggcctacccctgagcagctgctgctggcacccacc
ccgcccgcgctgcacaggctgctagagtccttcaggattcagtatctacagttcctggca
tacacgaagacccctcagtacaaggccaccctgcagcagctgctggaccaggagaaggag
aagaatgcccggttgctaggcgcagcgcagcagctgtttggccactgccaagctcagaag
gaggaaagcaagaggctcttccagcagaaactggacgagctgggagtgaaggcgctgacc
tacaacgacctgatccaagcgcagaaggagatctcggctcacaaccaacagttgagggaa
cagacggagcagctagagaagggcaaccgggagctgaggagccagagcctgcggctgctc
aaggcacggtgtgaggagctgaagctggactggtccacgctgtccctggagaatctgctg
aaggagaagcaggccctgaagagccagatctcagagaagcagaggcactgcctggaactg
cagatcagcattgtggagctggagaagagccagcggcagcaggagttgctccagctcaag
tcctgcgtgccgcctgatgaggcactggccctgcagcttcgtgggaagccagaggccgag
cctggccggcttcacttggagctggactgcgcccgcttctccctgccacctttcagcagc
ttgagccccgagctctccatgaatggccatgcggccggctatgagctctgcagcgcactg
ggtcggccctcacccaagcagaacaccccccagtacctggcctctccgctagaccaggag
gtcgtgccctgcacccctagccacagcggccggccacggctggagaagctatccagcctg
gccctgcctgactataccaggctatcccctgccaagctggtgctgcggcgccacctgagc
caggaccacgcggccagtggcaaggcagctgccagcgagctgcacccacgagccgagcat
gccaaggagaacgggctcccttaccagagccctggcatcaccaacggcatcaagctgagc
ccacaagacccccgaccttcatcccccacagctttacagatgggagagaagggccctgag
aagggtgtgaaggagcgtgcctacgccagcagtggggaggccatcaccagcctgcctgtc
agcatcccgctgagcaccgtgcagcccagcaagctgcccgtcagcatccccctggccagc
gtggtgctgcccagccgcgccgagaaggcgagaagcacacccagccctgggccaccggcc
cgagagtcctcgtctacgctggagaagcaggtggctgctaacacccatggtgccgggggc
aacgctgctgggagcaagagcctcgccctggctcccacaggctttgcatacagcggctcg
gtggccatcagtggggccctggcaggcagcccagcaccccttggccctggagctgagccc
ccggccctagacgagtcctccagctctggaagcctctttgccactgtggggtcccgcagc
tccaccccgcagcacccacccctgctgacgcagccacgtacctgcggctcagcctcgccg
gccccccagctctgcgccagcccccggctaggcgccctgggcccgctccccgactctggc
aaaggggacctgccctgcgacgccagcttctcagaccctgagagcgaagccaaaaggagg
atcgtcttcaccatctcggcgggtgccagcagcgccaagcagtcaccttccagcaaacac
agccctctgccctcggctgcccgcggggacggtggccagggccatgggccagacagccgc
aagcggggccggaggaagcgggcatcagcggggacccccagcctgagctcgagtgtgtcc
cccaagcgccgggccttgccatctgtcgctgggcttttcacgcagtcttcagggtccccc
ctgaatctcaactccatggtcagcaacatcaaccagcccctggagatcacggccatctcg
tcccctgagagctccctaaagagctcacccgtcccctaccaggacaatgaccaaccacct
gtgctcaagaaggagaagcccctgagccagaccaatggtgcccactactccccactgacc
tcggacgaggagccaggctctgaggatgagcccggcagtgccagaattgagagaaaaatt
gcaacaatctccttagaaagcaagtctccaccaaaaaccttggaaaatgcaggtggcagc
ctagcaggaaggaaggcaccgctggccagcgagccggtcaacagcagcaagtggaagtcc
accttctcacccatctccgacctgggcctggccaaggcagctgacagcccgctgcaggct
gcctccgctctgagccacaactccctgttcgctttccggcctggcctggaggagcccagt
acagccgatggcaagctggccacccactccaggaagagcttcccaggcaccctgccgggg
gcgggcgggctgagccccaatagccttcctgccagtggcttcgccctgggcgggggccta
gcagctgacctcagtttacacagcttcagtgatggtgcttctctctcccacaaggccccc
gaggcagctggcctgggtgcccccatgagcttccctggcccacggggcaaggagggtggc
gctgcagagtctggccccttcgtgaacaagcggcagctggacggactgggcccaaaaggc
gaggggggccttcccacatgcggacccccggacaaggcctctacagcgcatagcaaggca
ggcaagggccgtgagcgcgagcccgacgtcaagaatggccacaacctgttcatggctgct
gccgccgcgccccctgcaggcctcctcagtggcccaggtcttgccccagcggcatcctcg
gcaggtggcacagccccgtccgtgcagacccaccgccccttcctgggcgccttcgcccct
gggccacagttcgcgctgggccccatgtcgctacaggccaacctgggcccgtctgtgctg
cagtccctgttcagttctgtgcccgccgccggcctggttcacgtctcgaccgccgccacc
agattgaccaactcgcacgccatgggcagcttctcctccggggtggccggcggcgcagtt
ggaggtgtctttaaccacgcggtgcctcccgcctccgcccatccgtttggagccagtttc
ggcagtggggctgcatgtcgcagcaccacgctgagcttaaccccgctgcaggcggtggcc
agcaccccggcctcttcctttcaggccccgtcctctgcggagccgaggccaccccaaccc
cctccgcacctgggccggccccctccggggcagcctgccctccatgcacccccccatcct
aacgccaccttgcctcctccccctgcgctgctcccagctaactctgagcccgtgcttctg
cagaacctcgcatccctccctgctaaccaagctttcttgcccgccgcctctgccgcctct
ctgccgcctgctaacgcctctctgtccatcaagctcgcctccctcccgcacaaggtgtcc
cggcccgccttgacggtgcaccaccagcccctgcctgggttggccctggcccaggccgcg
cccgtgaacccacaggccagctccacggggccgcccgccgtgtgggtttcccttggcatg
ccgcctccgtatgccgcgcgccttgcgggggttaagccgcgataa

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