KEGG   Capra hircus (goat): 102181262
Entry
102181262         CDS       T02910                                 

Gene name
CHUK
Definition
(RefSeq) conserved helix-loop-helix ubiquitous kinase
  KO
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
Organism
chx  Capra hircus (goat)
Pathway
chx01523  Antifolate resistance
chx04010  MAPK signaling pathway
chx04014  Ras signaling pathway
chx04062  Chemokine signaling pathway
chx04064  NF-kappa B signaling pathway
chx04068  FoxO signaling pathway
chx04150  mTOR signaling pathway
chx04151  PI3K-Akt signaling pathway
chx04210  Apoptosis
chx04380  Osteoclast differentiation
chx04620  Toll-like receptor signaling pathway
chx04621  NOD-like receptor signaling pathway
chx04622  RIG-I-like receptor signaling pathway
chx04623  Cytosolic DNA-sensing pathway
chx04625  C-type lectin receptor signaling pathway
chx04657  IL-17 signaling pathway
chx04658  Th1 and Th2 cell differentiation
chx04659  Th17 cell differentiation
chx04660  T cell receptor signaling pathway
chx04662  B cell receptor signaling pathway
chx04668  TNF signaling pathway
chx04920  Adipocytokine signaling pathway
chx05010  Alzheimer disease
chx05132  Salmonella infection
chx05135  Yersinia infection
chx05142  Chagas disease
chx05145  Toxoplasmosis
chx05160  Hepatitis C
chx05161  Hepatitis B
chx05162  Measles
chx05163  Human cytomegalovirus infection
chx05164  Influenza A
chx05165  Human papillomavirus infection
chx05166  Human T-cell leukemia virus 1 infection
chx05167  Kaposi sarcoma-associated herpesvirus infection
chx05168  Herpes simplex virus 1 infection
chx05169  Epstein-Barr virus infection
chx05170  Human immunodeficiency virus 1 infection
chx05171  Coronavirus disease - COVID-19
chx05200  Pathways in cancer
chx05212  Pancreatic cancer
chx05215  Prostate cancer
chx05220  Chronic myeloid leukemia
chx05221  Acute myeloid leukemia
chx05222  Small cell lung cancer
chx05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
chx05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:chx00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102181262 (CHUK)
   04014 Ras signaling pathway
    102181262 (CHUK)
   04064 NF-kappa B signaling pathway
    102181262 (CHUK)
   04668 TNF signaling pathway
    102181262 (CHUK)
   04068 FoxO signaling pathway
    102181262 (CHUK)
   04151 PI3K-Akt signaling pathway
    102181262 (CHUK)
   04150 mTOR signaling pathway
    102181262 (CHUK)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    102181262 (CHUK)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    102181262 (CHUK)
   04621 NOD-like receptor signaling pathway
    102181262 (CHUK)
   04622 RIG-I-like receptor signaling pathway
    102181262 (CHUK)
   04623 Cytosolic DNA-sensing pathway
    102181262 (CHUK)
   04625 C-type lectin receptor signaling pathway
    102181262 (CHUK)
   04660 T cell receptor signaling pathway
    102181262 (CHUK)
   04658 Th1 and Th2 cell differentiation
    102181262 (CHUK)
   04659 Th17 cell differentiation
    102181262 (CHUK)
   04657 IL-17 signaling pathway
    102181262 (CHUK)
   04662 B cell receptor signaling pathway
    102181262 (CHUK)
   04062 Chemokine signaling pathway
    102181262 (CHUK)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    102181262 (CHUK)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102181262 (CHUK)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102181262 (CHUK)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102181262 (CHUK)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    102181262 (CHUK)
   05221 Acute myeloid leukemia
    102181262 (CHUK)
   05220 Chronic myeloid leukemia
    102181262 (CHUK)
   05215 Prostate cancer
    102181262 (CHUK)
   05222 Small cell lung cancer
    102181262 (CHUK)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102181262 (CHUK)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    102181262 (CHUK)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102181262 (CHUK)
   05135 Yersinia infection
    102181262 (CHUK)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102181262 (CHUK)
   05170 Human immunodeficiency virus 1 infection
    102181262 (CHUK)
   05161 Hepatitis B
    102181262 (CHUK)
   05160 Hepatitis C
    102181262 (CHUK)
   05171 Coronavirus disease - COVID-19
    102181262 (CHUK)
   05164 Influenza A
    102181262 (CHUK)
   05162 Measles
    102181262 (CHUK)
   05168 Herpes simplex virus 1 infection
    102181262 (CHUK)
   05163 Human cytomegalovirus infection
    102181262 (CHUK)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102181262 (CHUK)
   05169 Epstein-Barr virus infection
    102181262 (CHUK)
   05165 Human papillomavirus infection
    102181262 (CHUK)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    102181262 (CHUK)
   05142 Chagas disease
    102181262 (CHUK)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    102181262 (CHUK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:chx01001]
    102181262 (CHUK)
Enzymes [BR:chx01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     102181262 (CHUK)
Protein kinases [BR:chx01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   102181262 (CHUK)
SSDB
Motif
Pfam: IKBKB_SDD Pkinase PK_Tyr_Ser-Thr IKKbetaNEMObind Pkinase_fungal Kdo TBK1_ULD
Other DBs
NCBI-GeneID: 102181262
NCBI-ProteinID: XP_017896836
UniProt: A0A452EYD5
LinkDB
Position
26
AA seq 740 aa
MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH
EIQIMKKLNHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIMHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMTGEVRFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSEMGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNTNLTKMKNTLISASQQLKAKL
EFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHTE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEMALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGSSLEGVTPQLPPTSAEREHPLSCVVTPQDGETLAQMIEENLNCLGHLSTIIH
EANEKQGDSMMSLDWSWLTE
NT seq 2223 nt   +upstreamnt  +downstreamnt
atggagcggcccccggggctgcggccgggcgcgggcgggccctgggagatgcgggagcgg
ctgggcaccggtggcttcgggaacgtctgcctgtatcaacatcgggaacttgatctcaaa
atagcaattaagtcttgtcgcctagagctaagtaccaaaaacagagaacggtggtgccat
gaaatccagatcatgaagaagttgaaccacgccaatgttgtaaaggcctgtgacgttcct
gaggaattgaattttttgattaacgatgtgcctcttctagcaatggaatattgttctgga
ggagatctccggaagctactcaacaaaccagaaaattgctgtggacttaaagaaagccag
atactttctttactgagtgatataggatctgggatccgatatttgcatgaaaacaaaatt
atacatcgtgatctaaaacctgaaaacatagttcttcaggatgttggcggaaagattatg
cataaaataattgatttgggatatgccaaagatgttgatcaaggaagtctttgtacatct
tttgtgggaactttgcagtatctggccccagagctctttgagaataagccttatacagcc
actgttgattattggagctttgggaccatggtgtttgaatgtattgctggatataggcct
tttttgcatcatctgcagccatttacttggcatgagaagattaagaagaaggatccaaag
tgtatatttgcatgtgaagaaatgacaggagaagttcggtttagtagccatttacctcaa
ccaaatagcctttgtagtttaatagtagaacccatggaaaactggctgcagttgatgcta
aactgggatcctcagcagagaggaggacctgttgatcttactttgaagcagccaagatgt
tttgtattaatggatcacattctgaatttgaagatagtacatatcctaaatatgacttct
gcaaagataatttcttttctgttaccacctgatgaaagtcttcattcactacagtctcgt
attgagcgggaaactggaataaatactggttctcaagagcttctttcagagatgggaatt
tctctggatcctcggaaaccagcctctcagtgtgttctggatggagttaggggctgtgat
agctatatggtttatttgtttgataaaagtaagactgtatatgaaggaccatttgcttcc
agaagtttatctgactgtgtaaattatattgtacaggacagcaaaatacagcttccaatt
atccagttgcgtaaagtttgggctgaagcagtacactatgtgtctgggctgaaagaagac
tacagcaggctctttcagggacagagagcagccatgttaagccttcttagatacaatact
aacttgacaaaaatgaaaaacactttgatctcagcatctcagcaactgaaagctaaattg
gagttttttcacaaaagcattcagcttgacttggaaagatatagtgagcagatgacgtac
gggatatcctcagaaaaaatgttaaaagcttggaaagaaatggaagaaaaggctatccac
tatgctgaggtgggtgtcattggatacctggaggatcaaatcatgtccctgcacactgaa
atcatggagctacagaagagcccctatggacgacgtcagggagacttgatggaatctctg
gaacagcgtgcaattgatctatataagcagttaaagcacagaccttcagatcactcctac
agcgacagcacggagatggtgaaaatcattgtgcatactgtgcagagtcaggaccgggtt
ctcaaggagctgtttggtcatctgagcaagttgttgggctgtaagcagaagattattgat
ctactgcccaaggtggaaatggccctcagtaacatcaaagaagctgacaatactgtcatg
tttatgcagggaaagaggcagaaagaaatatggcatctccttaaaattgcctgtacacag
agttctgctcggtcccttgtaggatccagtctagaaggtgtaacccctcagctgccccca
acttcagcagaacgtgaacatcctctgtcatgcgtggtaactcctcaagatggggagact
ttagcacaaatgatagaagaaaatttgaactgtcttggccatttaagcactattattcat
gaagcaaatgaaaaacagggcgacagtatgatgagtcttgattggagttggttaacagaa
tga

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