KEGG   PATHWAY: cjc04150
Entry
cjc04150                    Pathway                                
Name
mTOR signaling pathway - Callithrix jacchus (white-tufted-ear marmoset)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
cjc04150  mTOR signaling pathway
cjc04150

Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100414003  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
100395002  SLC3A2; 4F2 cell-surface antigen heavy chain isoform X1 [KO:K06519]
100397834  SLC38A9; neutral amino acid transporter 9 isoform X1 [KO:K14995]
100411357  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100400819  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform isoform X1 [KO:K02147]
100405540  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100402895  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X10 [KO:K02148]
100395645  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
100399709  ATP6V1D; V-type proton ATPase subunit D isoform X4 [KO:K02149]
100402779  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
100396342  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
100397160  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
100415557  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
100396510  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X2 [KO:K02152]
103795015  V-type proton ATPase subunit G 1-like [KO:K02152]
100408708  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
100386055  ragulator complex protein LAMTOR1 [KO:K20397]
118142867  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
100398197  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
100388524  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
100386831  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
100386780  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
100395467  FLCN; folliculin isoform X1 [KO:K09594]
100387800  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
100398081  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
100404468  RRAGA; ras-related GTP-binding protein A [KO:K16185]
100385876  ras-related GTP-binding protein A-like [KO:K16185]
100389765  ras-related GTP-binding protein A-like [KO:K16185]
100387963  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
100399288  RRAGD; ras-related GTP-binding protein D isoform X1 [KO:K16186]
100395593  RRAGC; ras-related GTP-binding protein C [KO:K16186]
100397149  SESN2; sestrin-2 isoform X1 [KO:K20394]
103796530  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
100394442  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
100405382  MIOS; GATOR complex protein MIOS isoform X1 [KO:K20407]
100895681  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
100402756  WDR24; GATOR complex protein WDR24 isoform X1 [KO:K20408]
100389026  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
100410639  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
100401690  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
100408834  NPRL2; GATOR complex protein NPRL2 isoform X2 [KO:K20405]
100388494  NPRL3; GATOR complex protein NPRL3 isoform X2 [KO:K20406]
100393248  SKP2; S-phase kinase-associated protein 2 isoform X2 [KO:K03875]
100386106  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
100413313  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
100385926  AKT1S1; proline-rich AKT1 substrate 1 [KO:K16184]
100406608  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100396252  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
100388495  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
100386338  TELO2; telomere length regulation protein TEL2 homolog isoform X2 [KO:K11137]
100388906  TTI1; TELO2-interacting protein 1 homolog isoform X1 [KO:K20403]
100403827  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
100402854  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
100400101  LPIN1; phosphatidate phosphatase LPIN1 isoform X3 [KO:K15728] [EC:3.1.3.4]
100414205  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
100398224  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
100403342  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
100386171  ULK2; serine/threonine-protein kinase ULK2 isoform X6 [KO:K08269] [EC:2.7.11.1]
100386453  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
100395777  EIF4E; eukaryotic translation initiation factor 4E isoform X5 [KO:K03259]
100415426  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
100401386  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
100397180  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100409247  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X3 [KO:K04688] [EC:2.7.11.1]
100401147  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
100412650  RPS6; 40S ribosomal protein S6 [KO:K02991]
100395673  40S ribosomal protein S6-like [KO:K02991]
100398705  40S ribosomal protein S6-like [KO:K02991]
100393608  40S ribosomal protein S6-like [KO:K02991]
103791583  40S ribosomal protein S6-like [KO:K02991]
108589548  40S ribosomal protein S6-like [KO:K02991]
118155347  40S ribosomal protein S6 [KO:K02991]
118155393  40S ribosomal protein S6 [KO:K02991]
100391088  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
100396910  STRADB; STE20-related kinase adapter protein beta [KO:K17532]
100390825  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
100404935  CAB39L; calcium-binding protein 39-like isoform X1 [KO:K08272]
100391713  CAB39; calcium-binding protein 39 [KO:K08272]
118148429  calcium-binding protein 39-like [KO:K08272]
100396565  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
100385413  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
100407741  TSC1; hamartin isoform X2 [KO:K07206]
100390664  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
100413529  TBC1D7; TBC1 domain family member 7 isoform X1 [KO:K20396]
100410955  RHEB; GTP-binding protein Rheb isoform X2 [KO:K07208]
100397684  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
100389319  WNT1; proto-oncogene Wnt-1 [KO:K03209]
100395234  WNT2B; protein Wnt-2b [KO:K00182]
100411308  WNT2; protein Wnt-2 [KO:K00182]
100385309  WNT3A; protein Wnt-3a [KO:K00312]
100398579  WNT3; proto-oncogene Wnt-3 [KO:K00312]
100387135  WNT4; protein Wnt-4 [KO:K00408]
100401066  WNT5A; protein Wnt-5a isoform X2 [KO:K00444]
100405273  WNT5B; protein Wnt-5b [KO:K00444]
100394855  WNT6; protein Wnt-6 [KO:K00445]
100414221  WNT7B; protein Wnt-7b isoform X2 [KO:K00572]
100387909  WNT7A; protein Wnt-7a [KO:K00572]
100414921  WNT8B; protein Wnt-8b [KO:K00714]
100402422  WNT8A; protein Wnt-8a [KO:K00714]
100397032  WNT9A; protein Wnt-9a isoform X2 [KO:K01064]
100393646  WNT9B; protein Wnt-9b [KO:K01064]
100395222  WNT10A; protein Wnt-10a [KO:K01357]
100388949  WNT10B; protein Wnt-10b [KO:K01357]
100398625  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
100387388  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
100401631  FZD7; frizzled-7 [KO:K02432]
100404550  FZD1; frizzled-1 [KO:K02432]
100409481  FZD2; frizzled-2 [KO:K02235]
100396334  FZD3; frizzled-3 isoform X1 [KO:K02329]
100403228  FZD4; frizzled-4 isoform X1 [KO:K02354]
100410939  FZD5; frizzled-5 [KO:K02375]
100398598  FZD8; frizzled-8 [KO:K02375]
100387077  FZD6; frizzled-6 [KO:K02376]
100403975  FZD9; frizzled-9 [KO:K02842]
100398976  FZD10; frizzled-10 [KO:K02842]
100406268  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
100389922  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
100390081  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
100398229  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
100388569  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X3 [KO:K02353]
118154524  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
100387683  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100397484  TNF; tumor necrosis factor [KO:K03156]
100397418  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
100393096  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
100393089  INS; insulin [KO:K04526]
100394985  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
100403400  INSR; insulin receptor isoform X4 [KO:K04527] [EC:2.7.10.1]
100408399  IGF1R; insulin-like growth factor 1 receptor isoform X3 [KO:K05087] [EC:2.7.10.1]
100395682  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100414931  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
100410124  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100406017  HRAS; GTPase HRas [KO:K02833]
118144179  KRAS; GTPase KRas isoform X2 [KO:K07827]
100414782  NRAS; GTPase NRas isoform X2 [KO:K07828]
108591807  GTPase NRas-like [KO:K07828]
100403091  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100415300  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100387394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100393991  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100393148  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
100407933  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
100407189  RPS6KA6; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
100403409  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
100387742  IRS1; insulin receptor substrate 1 [KO:K16172]
100406689  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100392639  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100414659  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100403494  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100391655  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100398849  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100393460  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100389944  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X4 [KO:K06276] [EC:2.7.11.1]
100404447  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100399039  AKT3; RAC-gamma serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
100388080  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100390680  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X2 [KO:K20410]
100412090  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
100412072  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
100394639  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
100393236  RHOA; transforming protein RhoA [KO:K04513]
100404129  transforming protein RhoA-like [KO:K04513]
100391814  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100410136  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100404028  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100389266  SGK1; serine/threonine-protein kinase Sgk1 isoform X3 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
cjc00561  Glycerolipid metabolism
cjc04010  MAPK signaling pathway
cjc04140  Autophagy - animal
cjc04151  PI3K-Akt signaling pathway
cjc04152  AMPK signaling pathway
cjc04810  Regulation of actin cytoskeleton
cjc04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

DBGET integrated database retrieval system