KEGG   PATHWAY: cjc04630
cjc04630                    Pathway                                

JAK-STAT signaling pathway - Callithrix jacchus (white-tufted-ear marmoset)
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Environmental Information Processing; Signal transduction
Pathway map
cjc04630  JAK-STAT signaling pathway

Other DBs
GO: 0007259
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
100386848  IL2; interleukin 2 [KO:K05429]
100410529  IL3; interleukin 3 [KO:K04736]
100406536  IL4; interleukin 4 [KO:K05430]
100407630  IL5; interleukin 5 [KO:K05428]
100393440  IL6; interleukin 6 [KO:K05405]
100387798  IL7; interleukin 7 [KO:K05431]
100396248  IL9; interleukin 9 [KO:K05432]
100386149  IL10; interleukin 10 [KO:K05443]
100390490  IL11; interleukin 11 [KO:K05417]
100406669  IL12A; interleukin 12A [KO:K05406]
100395403  IL12B; interleukin 12B [KO:K05425]
100406899  IL13; interleukin 13 [KO:K05435]
100409575  IL15; interleukin 15 [KO:K05433]
100412953  IL17D; interleukin 17D [KO:K05492]
100386502  IL19; interleukin 19 [KO:K05444]
100386858  IL20; interleukin 20 [KO:K22667]
100386141  IL21; interleukin 21 [KO:K05434]
100391124  IL22; interleukin 22 [KO:K05445]
100414179  IL23A; interleukin 23 subunit alpha [KO:K05426]
100394339  IL24; interleukin 24 [KO:K22668]
100413432  interferon alpha-5-like [KO:K05414]
100414516  interferon alpha-1/13-like [KO:K05414]
100390201  interferon alpha-5-like [KO:K05414]
100406098  interferon alpha-5-like [KO:K05414]
100406466  IFNa; interferon alpha-14-like [KO:K05414]
100390925  interferon alpha-14-like [KO:K05414]
100387372  interferon alpha-8-like [KO:K05414]
103793369  interferon alpha-5-like [KO:K05414]
103793373  interferon alpha-5-like [KO:K05414]
100388391  IFNB1; interferon beta 1 [KO:K05415]
100388952  IFNG; interferon gamma [KO:K04687]
100392730  IFNE; interferon epsilon [KO:K05442]
100404940  IFNK; interferon kappa [KO:K05441]
100395801  IFNL1; interferon lambda 1 [KO:K05447]
100395444  IL28B; interleukin 28B (interferon, lambda 3) [KO:K22669]
100388753  IFNW1; interferon omega 1 [KO:K05440]
100387903  OSM; oncostatin M [KO:K05418]
100387550  LIF; leukemia inhibitory factor [KO:K05419]
100401829  TSLP; thymic stromal lymphopoietin [KO:K05436]
100393348  CTF1; cardiotrophin 1 [KO:K05422]
100393705  cardiotrophin-2 [KO:K24382]
100410164  CSF2; colony stimulating factor 2 [KO:K05427]
103796320  CNTF; ciliary neurotrophic factor [KO:K05420]
100411779  granulocyte colony-stimulating factor-like [KO:K05423]
100407554  granulocyte colony-stimulating factor-like [KO:K05423]
100394313  EPO; erythropoietin [KO:K05437]
100392546  GH1; growth hormone 1 [KO:K05438]
100412471  GH1P6; somatotropin-like [KO:K05438]
100412128  GH1P5; somatotropin-like [KO:K05438]
100407456  LEP; leptin [KO:K05424]
100399619  THPO; thrombopoietin [KO:K06854]
100413643  PRL; prolactin [KO:K05439]
100388651  EGF; epidermal growth factor [KO:K04357]
100412906  PDGFA; platelet derived growth factor subunit A [KO:K04359]
100388628  PDGFB; platelet derived growth factor subunit B [KO:K17386]
100412016  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
100394910  IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
100388189  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
100405472  IL3RA; interleukin 3 receptor subunit alpha [KO:K04737]
100412639  IL4R; interleukin 4 receptor [KO:K05071]
100414222  IL5RA; interleukin 5 receptor subunit alpha [KO:K05067]
100385661  IL6R; interleukin 6 receptor [KO:K05055]
100397720  IL7R; interleukin 7 receptor [KO:K05072]
100408034  IL9R; interleukin 9 receptor [KO:K05073]
100396693  IL10RA; interleukin 10 receptor subunit alpha [KO:K05134]
100409946  IL10RB; interleukin 10 receptor subunit beta [KO:K05135]
100894787  IL11RA; interleukin 11 receptor subunit alpha [KO:K05056]
100399291  IL12RB1; interleukin 12 receptor subunit beta 1 [KO:K05063]
100393796  IL12RB2; interleukin 12 receptor subunit beta 2 [KO:K05064]
100385087  IL13RA1; interleukin 13 receptor subunit alpha 1 [KO:K05076]
100387833  IL13RA2; interleukin 13 receptor subunit alpha 2 [KO:K05077]
100413804  IL15RA; interleukin 15 receptor subunit alpha [KO:K05074]
100392660  IL20RA; interleukin 20 receptor subunit alpha [KO:K05136]
100394922  IL20RB; interleukin 20 receptor subunit beta [KO:K05137]
100401171  IL21R; interleukin 21 receptor [KO:K05075]
100394149  IL22RA1; interleukin 22 receptor subunit alpha 1 [KO:K05138]
100386163  IL22RA2; interleukin 22 receptor subunit alpha 2 [KO:K05139]
100393072  IL23R; interleukin 23 receptor [KO:K05065]
100394581  IL27RA; interleukin 27 receptor subunit alpha [KO:K19598]
100396729  IL6ST; interleukin 6 signal transducer [KO:K05060]
100410306  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
100386516  IFNGR1; interferon gamma receptor 1 [KO:K05132]
100389763  IFNGR2; interferon gamma receptor 2 [KO:K05133]
100394504  IFNLR1; interferon lambda receptor 1 [KO:K05140]
100388286  OSMR; oncostatin M receptor [KO:K05057]
100413035  LIFR; leukemia inhibitory factor receptor alpha [KO:K05058]
100394434  CNTFR; ciliary neurotrophic factor receptor [KO:K05059]
100894193  uncharacterized LOC100894193 [KO:K05066]
100413917  CSF2RA; colony stimulating factor 2 receptor alpha subunit [KO:K05066]
100393477  CSF2RB; colony stimulating factor 2 receptor beta common subunit [KO:K04738]
100393434  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
100389634  EPOR; erythropoietin receptor [KO:K05079]
100399027  GHR; growth hormone receptor [KO:K05080]
100408177  LEPR; leptin receptor [KO:K05062]
100409031  MPL; MPL proto-oncogene, thrombopoietin receptor [KO:K05082]
100401704  PRLR; prolactin receptor [KO:K05081]
100412158  EGFR; epidermal growth factor receptor [KO:K04361] [EC:]
100412331  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:]
100389852  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:]
100385835  JAK1; Janus kinase 1 [KO:K11217] [EC:]
100413251  JAK2; Janus kinase 2 [KO:K04447] [EC:]
100397491  JAK3; Janus kinase 3 [KO:K11218] [EC:]
100405583  TYK2; tyrosine kinase 2 [KO:K11219] [EC:]
100401630  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
100393190  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
100389282  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100402355  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
100388917  STAT5A; signal transducer and activator of transcription 5A [KO:K11223]
100388552  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
100390285  STAT6; signal transducer and activator of transcription 6 [KO:K11225]
100411002  CISH; cytokine inducible SH2 containing protein [KO:K04701]
100402275  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
100396208  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
100398838  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
100386210  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
100393834  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
100386814  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
100896284  SOCS7; suppressor of cytokine signaling 7 [KO:K04699]
100408947  BCL2; BCL2, apoptosis regulator [KO:K02161]
100406790  MCL1; BCL2 family apoptosis regulator [KO:K02539]
100401978  BCL2L1; BCL2 like 1 [KO:K04570]
100391311  PIM1; Pim-1 proto-oncogene, serine/threonine kinase [KO:K04702] [EC:]
100407754  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
100399312  G1/S-specific cyclin-D1-like [KO:K04503]
100390172  CCND2; cyclin D2 [KO:K10151]
100408249  CCND3; cyclin D3 [KO:K10152]
100894215  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
100394388  AOX2; aldehyde oxidase 2 [KO:K00157] [EC:]
100393665  AOX1; aldehyde oxidase 1 [KO:K00157] [EC:]
100393644  GFAP; glial fibrillary acidic protein [KO:K05640]
100389794  STAM2; signal transducing adaptor molecule 2 [KO:K04705]
100409144  STAM; signal transducing adaptor molecule [KO:K04705]
100412533  PTPN2; protein tyrosine phosphatase, non-receptor type 2 [KO:K18026] [EC:]
100410231  PTPN6; protein tyrosine phosphatase, non-receptor type 6 [KO:K05697] [EC:]
100408433  IRF9; interferon regulatory factor 9 [KO:K04693]
100395278  EP300; E1A binding protein p300 [KO:K04498] [EC:]
100405037  CREBBP; CREB binding protein [KO:K04498] [EC:]
100399947  PIAS1; protein inhibitor of activated STAT 1 [KO:K04706] [EC:2.3.2.-]
100391152  PIAS2; protein inhibitor of activated STAT 2 [KO:K16063] [EC:2.3.2.-]
100401461  PIAS3; protein inhibitor of activated STAT 3 [KO:K16064] [EC:2.3.2.-]
100393272  PIAS4; protein inhibitor of activated STAT 4 [KO:K16065] [EC:]
100387250  FHL1; four and a half LIM domains 1 [KO:K14365]
100414905  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:]
100395682  GRB2; growth factor receptor bound protein 2 [KO:K04364]
100414931  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
100410124  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
100406017  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
100415300  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:]
100403494  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:]
100391655  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:]
100398849  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:]
100406689  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
100392639  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100414659  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
100404447  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:]
100399039  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:]
100388080  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:]
100406608  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:]
Harrison DA
The Jak/STAT pathway.
Cold Spring Harb Perspect Biol 4:a011205 (2012)
Kiu H, Nicholson SE
Biology and significance of the JAK/STAT signalling pathways.
Growth Factors 30:88-106 (2012)
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Direct effects of type I interferons on cells of the immune system.
Clin Cancer Res 17:2619-27 (2011)
Fish EN, Platanias LC
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Mol Cancer Res 12:1691-703 (2014)
Ivanenkov YA, Balakin KV, Lavrovsky Y
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Mini Rev Med Chem 11:55-78 (2011)
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Annu Rev Med 66:311-28 (2015)
Zoranovic T, Grmai L, Bach EA
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
JAKSTAT 2:e25408 (2013)
Ungureanu D, Silvennoinen O
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Sci STKE 2005:pe49 (2005)
Richard AJ, Stephens JM
The role of JAK-STAT signaling in adipose tissue function.
Biochim Biophys Acta 1842:431-9 (2014)
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Neuropathol Appl Neurobiol 41:347-70 (2015)
Hirano T, Ishihara K, Hibi M
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Oncogene 19:2548-56 (2000)
Rane SG, Reddy EP
Janus kinases: components of multiple signaling pathways.
Oncogene 19:5662-79 (2000)
Heim MH
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Eur J Clin Invest 26:1-12 (1996)
cjc04010  MAPK signaling pathway
cjc04060  Cytokine-cytokine receptor interaction
cjc04110  Cell cycle
cjc04120  Ubiquitin mediated proteolysis
cjc04151  PI3K-Akt signaling pathway
cjc04210  Apoptosis
KO pathway

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