KEGG   PATHWAY: cjc05217
Entry
cjc05217                    Pathway                                

Name
Basal cell carcinoma - Callithrix jacchus (white-tufted-ear marmoset)
Description
Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC.
Class
Human Diseases; Cancer: specific types
Pathway map
cjc05217  Basal cell carcinoma
cjc05217

Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100415710  TP53; tumor protein p53 [KO:K04451]
100894215  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
100412572  GADD45B; growth arrest and DNA damage inducible beta [KO:K04402]
100405303  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
100394399  GADD45A; growth arrest and DNA damage inducible alpha [KO:K04402]
100391322  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
100387945  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
100390419  DDB2; damage specific DNA binding protein 2 [KO:K10140]
100403269  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
100395600  SHH; sonic hedgehog [KO:K11988]
100410387  PTCH1; patched 1 [KO:K06225]
100394403  SMO; smoothened, frizzled class receptor [KO:K06226]
100407677  KIF7; kinesin family member 7 [KO:K18806]
100398505  SUFU; SUFU negative regulator of hedgehog signaling [KO:K06229]
100401526  GLI1; GLI family zinc finger 1 [KO:K16797]
100413916  GLI2; GLI family zinc finger 2 [KO:K16798]
100400779  GLI3; GLI family zinc finger 3 [KO:K06230]
100408260  BMP2; bone morphogenetic protein 2 [KO:K21283]
100398270  BMP4; bone morphogenetic protein 4 [KO:K04662]
100404963  HHIP; hedgehog interacting protein [KO:K06231]
100394151  PTCH2; patched 2 [KO:K11101]
100389319  WNT1; Wnt family member 1 [KO:K03209]
100395234  WNT2B; Wnt family member 2B [KO:K00182]
100411308  WNT2; Wnt family member 2 [KO:K00182]
100385309  WNT3A; Wnt family member 3A [KO:K00312]
100398579  WNT3; Wnt family member 3 [KO:K00312]
100387135  WNT4; Wnt family member 4 [KO:K00408]
100401066  WNT5A; Wnt family member 5A [KO:K00444]
100405273  WNT5B; Wnt family member 5B [KO:K00444]
100394855  WNT6; Wnt family member 6 [KO:K00445]
100414221  WNT7B; Wnt family member 7B [KO:K00572]
100387909  WNT7A; Wnt family member 7A [KO:K00572]
100414921  WNT8B; Wnt family member 8B [KO:K00714]
100402422  WNT8A; Wnt family member 8A [KO:K00714]
100397032  WNT9A; Wnt family member 9A [KO:K01064]
100393646  WNT9B; Wnt family member 9B [KO:K01064]
100395222  WNT10A; Wnt family member 10A [KO:K01357]
100388949  WNT10B; Wnt family member 10B [KO:K01357]
100398625  WNT11; Wnt family member 11 [KO:K01384]
100387388  WNT16; Wnt family member 16 [KO:K01558]
100401631  FZD7; frizzled class receptor 7 [KO:K02432]
100404550  FZD1; frizzled class receptor 1 [KO:K02432]
100409481  FZD2; frizzled class receptor 2 [KO:K02235]
100396334  FZD3; frizzled class receptor 3 [KO:K02329]
100403228  FZD4; frizzled class receptor 4 [KO:K02354]
100410939  FZD5; frizzled class receptor 5 [KO:K02375]
100398598  FZD8; frizzled class receptor 8 [KO:K02375]
100387077  FZD6; frizzled class receptor 6 [KO:K02376]
100403975  FZD9; frizzled class receptor 9 [KO:K02842]
100398976  FZD10; frizzled class receptor 10 [KO:K02842]
100390081  DVL3; dishevelled segment polarity protein 3 [KO:K02353]
100398229  DVL2; dishevelled segment polarity protein 2 [KO:K02353]
100388569  DVL1; dishevelled segment polarity protein 1 [KO:K02353]
100387683  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
100392475  AXIN1; axin 1 [KO:K02157]
100400518  AXIN2; axin 2 [KO:K04385]
100397972  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
100385653  APC; APC, WNT signaling pathway regulator [KO:K02085]
100395047  CTNNB1; catenin beta 1 [KO:K02105]
100399154  TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
100385633  transcription factor 7-like 1 [KO:K04490]
100406757  TCF7L2; transcription factor 7 like 2 [KO:K04491]
100399759  LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
Compound
C00187  Cholesterol
Reference
  Authors
Tilli CM, Van Steensel MA, Krekels GA, Neumann HA, Ramaekers FC.
  Title
Molecular aetiology and pathogenesis of basal cell carcinoma.
  Journal
Br J Dermatol 152:1108-24 (2005)
DOI:10.1111/j.1365-2133.2005.06587.x
Reference
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
  Authors
Daya-Grosjean L, Couve-Privat S.
  Title
Sonic hedgehog signaling in basal cell carcinomas.
  Journal
Cancer Lett 225:181-92 (2005)
DOI:10.1016/j.canlet.2004.10.003
Reference
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
  Authors
Athar M, Tang X, Lee JL, Kopelovich L, Kim AL.
  Title
Hedgehog signalling in skin development and cancer.
  Journal
Exp Dermatol 15:667-77 (2006)
DOI:10.1111/j.1600-0625.2006.00473.x
Reference
  Authors
Rubin AI, Chen EH, Ratner D.
  Title
Basal-cell carcinoma.
  Journal
N Engl J Med 353:2262-9 (2005)
DOI:10.1056/NEJMra044151
Reference
  Authors
Saldanha G.
  Title
The Hedgehog signalling pathway and cancer.
  Journal
Reference
  Authors
Saldanha G, Ghura V, Potter L, Fletcher A.
  Title
Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation.
  Journal
Br J Dermatol 151:157-64 (2004)
DOI:10.1111/j.1365-2133.2004.06048.x
Reference
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
  Authors
Reifenberger J, Wolter M, Knobbe CB, Kohler B, Schonicke A, Scharwachter C, Kumar K, Blaschke B, Ruzicka T, Reifenberger G.
  Title
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
  Journal
Br J Dermatol 152:43-51 (2005)
DOI:10.1111/j.1365-2133.2005.06353.x
Reference
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
  Authors
Yamazaki F, Aragane Y, Kawada A, Tezuka T.
  Title
Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.
  Journal
Br J Dermatol 145:771-7 (2001)
DOI:10.1046/j.1365-2133.2001.04468.x
Reference
  Authors
Erb P, Ji J, Wernli M, Kump E, Glaser A, Buchner SA.
  Title
Role of apoptosis in basal cell and squamous cell carcinoma formation.
  Journal
Immunol Lett 100:68-72 (2005)
DOI:10.1016/j.imlet.2005.06.008
Reference
  Authors
Toftgard R.
  Title
Hedgehog signalling in cancer.
  Journal
Cell Mol Life Sci 57:1720-31 (2000)
DOI:10.1007/PL00000654
Reference
  Authors
Wu F, Zhang Y, Sun B, McMahon AP, Wang Y
  Title
Hedgehog Signaling: From Basic Biology to Cancer Therapy.
  Journal
Cell Chem Biol 24:252-280 (2017)
DOI:10.1016/j.chembiol.2017.02.010
Reference
  Authors
Otsuka A, Levesque MP, Dummer R, Kabashima K
  Title
Hedgehog signaling in basal cell carcinoma.
  Journal
J Dermatol Sci 78:95-100 (2015)
DOI:10.1016/j.jdermsci.2015.02.007
Related
pathway
cjc04110  Cell cycle
cjc04115  p53 signaling pathway
cjc04310  Wnt signaling pathway
cjc04340  Hedgehog signaling pathway
cjc04350  TGF-beta signaling pathway
KO pathway
ko05217   
LinkDB

DBGET integrated database retrieval system