KEGG   PATHWAY: clv04115
Entry
clv04115                    Pathway                                

Name
p53 signaling pathway - Columba livia (rock pigeon)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
clv04115  p53 signaling pathway
clv04115

Organism
Columba livia (rock pigeon) [GN:clv]
Gene
102086207  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
102090751  CHEK2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
102085982  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
102094428  CHEK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
102083894  GORAB; RAB6-interacting golgin [KO:K19748]
102085264  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
102092604  MDM4; protein Mdm4 [KO:K10127]
102096820  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102086245  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102093196  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
102090134  CCND3; LOW QUALITY PROTEIN: G1/S-specific cyclin-D3 [KO:K10152]
102091430  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102094830  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
102091343  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
102097806  SFN; 14-3-3 protein sigma [KO:K06644]
102098298  CCNB1; LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1 [KO:K05868]
102084928  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
102083762  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
102090065  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102087532  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102092757  GTSE1; G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
102087399  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
102092914  PIDD1; p53-induced death domain-containing protein 1 isoform X3 [KO:K10130]
102095613  uncharacterized protein LOC102095613 [KO:K04722]
102094994  tumor necrosis factor receptor superfamily member 10A [KO:K04722]
102084608  caspase-8 [KO:K04398] [EC:3.4.22.61]
102084797  caspase-8 [KO:K04398] [EC:3.4.22.61]
102093655  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
102097231  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
102097802  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102092853  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
102098853  TP53I3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
102094606  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
102098246  SHISA5; protein shisa-5 [KO:K10135]
102097536  p53 apoptosis effector related to PMP-22 [KO:K10136]
102097711  p53 apoptosis effector related to PMP-22 [KO:K10136]
102083979  ZMAT3; zinc finger matrin-type protein 3 [KO:K10137]
102089742  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
102085712  cytochrome c [KO:K08738]
102095228  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
102093506  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
102089427  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102093622  AIFM2; apoptosis-inducing factor 2 [KO:K22745]
102098854  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
102092089  IGF1; insulin-like growth factor I [KO:K05459]
110365053  ADGRB1; brain-specific angiogenesis inhibitor 1 [KO:K04596]
102085372  CD82; CD82 antigen [KO:K06509]
102091738  THBS1; LOW QUALITY PROTEIN: thrombospondin-1 [KO:K16857]
102093220  SERPINB5; serpin B5 [KO:K10139]
102087151  DDB2; DNA damage-binding protein 2 isoform X2 [KO:K10140]
102089725  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
102098900  RRM2; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
102096978  SESN3; sestrin-3 isoform X1 [KO:K10141]
102093092  SESN1; sestrin-1 isoform X3 [KO:K10141]
102095012  sestrin-3-like [KO:K10141]
102095747  SESN2; LOW QUALITY PROTEIN: sestrin-2 [KO:K20394]
102094724  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102098310  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
102095030  STEAP3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
102094521  RFWD2; E3 ubiquitin-protein ligase RFWD2 isoform X2 [KO:K10143] [EC:2.3.2.27]
102090104  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
102084345  CCNG1; cyclin-G1 [KO:K10145]
102091922  CCNG2; cyclin-G2 [KO:K10146]
102098653  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
102090439  TP73; tumor protein p73 isoform X2 [KO:K10148]
Reference
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Related
pathway
clv04110  Cell cycle
clv04210  Apoptosis
clv04218  Cellular senescence
KO pathway
ko04115   
LinkDB

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