KEGG   PATHWAY: cqu04214
Entry
cqu04214                    Pathway                                

Name
Apoptosis - fly - Culex quinquefasciatus (southern house mosquito)
Description
Apoptosis, or programmed cell death, is a critical factor in homeostasis in all multicellular organisms, playing a crucial role in removing excess unwanted cells without stimulation of an immune response. Caspases are the central components of the apoptotic response. In Drosophila, Dark promotes activation of the initiator caspase Dronc. Drosophila inhibitor of apoptosis protein 1 (DIAP1) inhibits Dronc and the effector caspases Drice and Dcp-1. RHG family proteins such as Rpr, Hid, Grim, Sickle, and Jafrac-2 promote cell death, in part by disrupting DIAP1's ability to inhibit caspase activity. Proapoptotic proteins such as caspases and RHG proteins are regulated through multiple pathways. The Drosophila steroid hormone ecdysone mediates cell death by controling the up-regulation of a number of proapoptotic genes. Cytotoxic stress such as DNA damage can activate P53, which in turn induces the expression of RHG genes. Eiger can initiate cell death through an IAP-sensitive cell death pathway via JNK signaling. Hid, a member of the RHG family, is negatively regulated by the epidermal growth factor (EGF) receptor-dependent survival signaling and positively regulated by the tumor suppressors Hippo, Salvador, and Warts.
Class
Cellular Processes; Cell growth and death
Pathway map
cqu04214  Apoptosis - fly
cqu04214

Organism
Culex quinquefasciatus (southern house mosquito) [GN:cqu]
Gene
CpipJ_CPIJ002963  ecdysone receptor [KO:K14034]
CpipJ_CPIJ016024  retinoid x receptor [KO:K14030]
CpipJ_CPIJ002923  caspase-1 [KO:K20009] [EC:3.4.22.-]
CpipJ_CPIJ003068  conserved hypothetical protein [KO:K09428]
CpipJ_CPIJ003269  broad complex Z4 [KO:K02174]
CpipJ_CPIJ012997  Eip93F [KO:K20015]
CpipJ_CPIJ000671  caspase [KO:K04397] [EC:3.4.22.60]
CpipJ_CPIJ008252  caspase [KO:K04397] [EC:3.4.22.60]
CpipJ_CPIJ008253  caspase-1 [KO:K04397] [EC:3.4.22.60]
CpipJ_CPIJ009056  caspase-3 [KO:K04397] [EC:3.4.22.60]
CpipJ_CPIJ009057  caspase-3 [KO:K04397] [EC:3.4.22.60]
CpipJ_CPIJ002803  conserved hypothetical protein [KO:K02084]
CpipJ_CPIJ012580  Caspase-3 [KO:K20010] [EC:3.4.22.-]
CpipJ_CPIJ002200  Bcl-2 associated protein [KO:K02561]
CpipJ_CPIJ002201  buffy [KO:K20017]
CpipJ_CPIJ012794  dynamin [KO:K17065] [EC:3.6.5.5]
CpipJ_CPIJ013828  conserved hypothetical protein [KO:K06030] [EC:3.6.5.-]
CpipJ_CPIJ018960  conserved hypothetical protein [KO:K06030] [EC:3.6.5.-]
CpipJ_CPIJ019024  cytochrome c [KO:K08738]
CpipJ_CPIJ010388  cytochrome c-2 [KO:K08738]
CpipJ_CPIJ010872  translocator protein [KO:K05770]
CpipJ_CPIJ009683  translocator protein [KO:K05770]
CpipJ_CPIJ004804  translocator protein [KO:K05770]
CpipJ_CPIJ009681  translocator protein [KO:K05770]
CpipJ_CPIJ009682  translocator protein [KO:K05770]
CpipJ_CPIJ018964  translocator protein [KO:K05770]
CpipJ_CPIJ020106  translocator protein [KO:K05770]
CpipJ_CPIJ002642  apoptosis-inducing factor 1, mitochondrial [KO:K04727] [EC:1.-.-.-]
CpipJ_CPIJ000514  conserved hypothetical protein [KO:K07870] [EC:3.6.5.-]
CpipJ_CPIJ002689  survivin [KO:K10586] [EC:2.3.2.23]
CpipJ_CPIJ011413  peroxiredoxin-4 [KO:K03386] [EC:1.11.1.24]
CpipJ_CPIJ010022  activating transcription factor [KO:K04374]
CpipJ_CPIJ005160  serine protease htra2 [KO:K08669] [EC:3.4.21.108]
CpipJ_CPIJ019291  serine protease htra2 [KO:K08669] [EC:3.4.21.108]
CpipJ_CPIJ014995  caspase-8 [KO:K04398] [EC:3.4.22.61]
CpipJ_CPIJ004906  transcription factor BTF3 [KO:K01527]
CpipJ_CPIJ017403  transcription factor btf3 [KO:K01527]
CpipJ_CPIJ000689  eukaryotic translation initiation factor 5 [KO:K03262]
CpipJ_CPIJ010129  lamin [KO:K07611]
CpipJ_CPIJ012304  poly [KO:K24070] [EC:2.4.2.30]
CpipJ_CPIJ009203  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
CpipJ_CPIJ006054  ras [KO:K07827]
CpipJ_CPIJ004499  raf [KO:K04365] [EC:2.7.11.1]
CpipJ_CPIJ005303  shaggy-like protein kinase [KO:K04371] [EC:2.7.11.24]
CpipJ_CPIJ000288  serine/threonine-protein kinase 3 [KO:K04412]
CpipJ_CPIJ006349  scaffold protein salvador [KO:K16686]
CpipJ_CPIJ014837  serine/threonine protein kinase lats [KO:K08791] [EC:2.7.11.1]
CpipJ_CPIJ005312  tnf receptor associated factor [KO:K09848]
CpipJ_CPIJ008487  mitogen activated protein kinase kinase kinase 5, mapkkk5, mekk5 [KO:K04426] [EC:2.7.11.25]
CpipJ_CPIJ011491  conserved hypothetical protein [KO:K16678]
CpipJ_CPIJ017286  conserved hypothetical protein [KO:K16679]
CpipJ_CPIJ006370  tak1 [KO:K04427] [EC:2.7.11.25]
CpipJ_CPIJ000820  conserved hypothetical protein [KO:K04404]
CpipJ_CPIJ008931  dual specificity mitogen-activated protein kinase kinase hemipterous [KO:K04431] [EC:2.7.12.2]
CpipJ_CPIJ001158  jnk [KO:K04440] [EC:2.7.11.24]
CpipJ_CPIJ001156  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
CpipJ_CPIJ001157  jnk [KO:K04440] [EC:2.7.11.24]
CpipJ_CPIJ017823  stress-activated protein kinase JNK [KO:K04440] [EC:2.7.11.24]
CpipJ_CPIJ000084  jun [KO:K04448]
CpipJ_CPIJ003767  conserved hypothetical protein [KO:K09031]
CpipJ_CPIJ008018  dual specificity protein phosphatase [KO:K20216] [EC:3.1.3.16 3.1.3.48]
CpipJ_CPIJ001772  ataxia telangiectasia mutated [KO:K04728] [EC:2.7.11.1]
CpipJ_CPIJ001777  ataxia telangiectasia mutated [KO:K04728] [EC:2.7.11.1]
CpipJ_CPIJ002521  esr1 protein [KO:K06640] [EC:2.7.11.1]
CpipJ_CPIJ002758  cellular tumor antigen p53 [KO:K10149]
Compound
C00477  Ecdysone
Reference
  Authors
Hay BA, Guo M
  Title
Caspase-dependent cell death in Drosophila.
  Journal
Annu Rev Cell Dev Biol 22:623-50 (2006)
DOI:10.1146/annurev.cellbio.21.012804.093845
Reference
  Authors
Hay BA, Huh JR, Guo M
  Title
The genetics of cell death: approaches, insights and opportunities in Drosophila.
  Journal
Nat Rev Genet 5:911-22 (2004)
DOI:10.1038/nrg1491
Reference
  Authors
Kumar S, Cakouros D
  Title
Transcriptional control of the core cell-death machinery.
  Journal
Trends Biochem Sci 29:193-9 (2004)
DOI:10.1016/j.tibs.2004.02.001
Reference
  Authors
Fuchs Y, Steller H
  Title
Live to die another way: modes of programmed cell death and the signals emanating from dying cells.
  Journal
Nat Rev Mol Cell Biol 16:329-44 (2015)
DOI:10.1038/nrm3999
Reference
  Authors
Arya R, White K
  Title
Cell death in development: Signaling pathways and core mechanisms.
  Journal
Semin Cell Dev Biol 39:12-9 (2015)
DOI:10.1016/j.semcdb.2015.02.001
Reference
  Authors
Danial NN, Korsmeyer SJ
  Title
Cell death: critical control points.
  Journal
Cell 116:205-19 (2004)
DOI:10.1016/S0092-8674(04)00046-7
Reference
  Authors
Gorski S, Marra M
  Title
Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila.
  Journal
Physiol Genomics 9:59-69 (2002)
DOI:10.1152/physiolgenomics.00114.2001
Reference
  Authors
Richardson H, Kumar S
  Title
Death to flies: Drosophila as a model system to study programmed cell death.
  Journal
J Immunol Methods 265:21-38 (2002)
DOI:10.1016/S0022-1759(02)00068-6
Reference
  Authors
Kuranaga E
  Title
Caspase signaling in animal development.
  Journal
Dev Growth Differ 53:137-48 (2011)
DOI:10.1111/j.1440-169X.2010.01237.x
Reference
  Authors
Bergmann A, Steller H
  Title
Apoptosis, stem cells, and tissue regeneration.
  Journal
Sci Signal 3:re8 (2010)
DOI:10.1126/scisignal.3145re8
Reference
  Authors
Riedl SJ, Shi Y
  Title
Molecular mechanisms of caspase regulation during apoptosis.
  Journal
Nat Rev Mol Cell Biol 5:897-907 (2004)
DOI:10.1038/nrm1496
Reference
  Authors
Igaki T, Miura M
  Title
Role of Bcl-2 family members in invertebrates.
  Journal
Biochim Biophys Acta 1644:73-81 (2004)
DOI:10.1016/j.bbamcr.2003.09.007
Reference
  Authors
Clavier A, Rincheval-Arnold A, Colin J, Mignotte B, Guenal I
  Title
Apoptosis in Drosophila: which role for mitochondria?
  Journal
Apoptosis 21:239-51 (2016)
DOI:10.1007/s10495-015-1209-y
Reference
  Authors
Abdelwahid E, Rolland S, Teng X, Conradt B, Hardwick JM, White K
  Title
Mitochondrial involvement in cell death of non-mammalian eukaryotes.
  Journal
Biochim Biophys Acta 1813:597-607 (2011)
DOI:10.1016/j.bbamcr.2010.10.008
Reference
  Authors
Demay Y, Perochon J, Szuplewski S, Mignotte B, Gaumer S
  Title
The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model.
  Journal
Cell Death Dis 5:e1452 (2014)
DOI:10.1038/cddis.2014.403
Reference
  Authors
Kilpatrick ZE, Cakouros D, Kumar S
  Title
Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells.
  Journal
J Biol Chem 280:11981-6 (2005)
DOI:10.1074/jbc.M413971200
Reference
  Authors
Yu SY, Yoo SJ, Yang L, Zapata C, Srinivasan A, Hay BA, Baker NE
  Title
A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye.
  Journal
Development 129:3269-78 (2002)
Reference
  Authors
McNeill H, Downward J
  Title
Apoptosis: Ras to the rescue in the fly eye.
  Journal
Curr Biol 9:R176-9 (1999)
DOI:10.1016/S0960-9822(99)80107-9
Reference
  Authors
Narasimamurthy R, Geuking P, Ingold K, Willen L, Schneider P, Basler K
  Title
Structure-function analysis of Eiger, the Drosophila TNF homolog.
  Journal
Cell Res 19:392-4 (2009)
DOI:10.1038/cr.2009.16
Reference
  Authors
Liu B, Behura SK, Clem RJ, Schneemann A, Becnel J, Severson DW, Zhou L
  Title
P53-mediated rapid induction of apoptosis conveys resistance to viral infection in Drosophila melanogaster.
  Journal
PLoS Pathog 9:e1003137 (2013)
DOI:10.1371/journal.ppat.1003137
Reference
  Authors
Kuranaga E, Kanuka H, Igaki T, Sawamoto K, Ichijo H, Okano H, Miura M
  Title
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.
  Journal
Nat Cell Biol 4:705-10 (2002)
DOI:10.1038/ncb842
Reference
  Authors
Creagh EM, Brumatti G, Sheridan C, Duriez PJ, Taylor RC, Cullen SP, Adrain C, Martin SJ
  Title
Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival.
  Journal
PLoS One 4:e5055 (2009)
DOI:10.1371/journal.pone.0005055
Reference
  Authors
Bilak A, Su TT
  Title
Regulation of Drosophila melanogaster pro-apoptotic gene hid.
  Journal
Apoptosis 14:943-9 (2009)
DOI:10.1007/s10495-009-0374-2
Related
pathway
cqu04391  Hippo signaling pathway - fly
KO pathway
ko04214   
LinkDB

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