KEGG   PATHWAY: dle05213
Entry
dle05213                    Pathway                                

Name
Endometrial cancer - Delphinapterus leucas (beluga whale)
Description
Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.
Class
Human Diseases; Cancer: specific types
Pathway map
dle05213  Endometrial cancer
dle05213

Organism
Delphinapterus leucas (beluga whale) [GN:dle]
Gene
111186135  EGF; pro-epidermal growth factor [KO:K04357]
111184548  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111173839  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111179235  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111187262  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111166652  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111185984  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111175760  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111172530  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111185202  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
111169176  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
111177559  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111176008  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111180855  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111187099  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
111183810  BAD; bcl2-associated agonist of cell death [KO:K02158]
111164348  FOXO3; forkhead box protein O3 [KO:K09408]
111182833  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
111174855  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
111173177  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
111170340  HRAS; GTPase HRas isoform X1 [KO:K02833]
111176851  KRAS; GTPase KRas [KO:K07827]
111179996  NRAS; GTPase NRas [KO:K07828]
111165554  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
111177653  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111168973  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111177745  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111165994  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
111163022  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
111182181  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111165564  ELK1; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1 [KO:K04375]
111164258  MLH1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
111179595  CDH1; cadherin-1 [KO:K05689]
111169438  CTNNB1; catenin beta-1 [KO:K02105]
111165399  CTNNA2; catenin alpha-2 [KO:K05691]
111178986  LOW QUALITY PROTEIN: catenin alpha-1-like [KO:K05691]
111183426  CTNNA3; catenin alpha-3 isoform X1 [KO:K05691]
111182500  CTNNA1; catenin alpha-1 [KO:K05691]
111185093  AXIN1; axin-1 isoform X1 [KO:K02157]
111182912  AXIN2; axin-2 isoform X1 [KO:K04385]
111183639  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
111170519  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
111168040  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111182442  TCF7; transcription factor 7 isoform X1 [KO:K02620]
111165393  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
111172300  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
111171490  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
111164391  MYC; myc proto-oncogene protein [KO:K04377]
111183632  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
111185755  TP53; cellular tumor antigen p53 [KO:K04451]
111178743  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
111170922  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
111178438  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
111167640  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
111180640  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
111178690  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
111183968  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
111185272  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
111166300  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Ryan AJ, Susil B, Jobling TW, Oehler MK.
  Title
Endometrial cancer.
  Journal
Cell Tissue Res 322:53-61 (2005)
DOI:10.1007/s00441-005-1109-5
Reference
  Authors
Lax SF.
  Title
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
  Journal
Virchows Arch 444:213-23 (2004)
DOI:10.1007/s00428-003-0947-3
Reference
  Authors
Shiozawa T, Konishi I.
  Title
Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment.
  Journal
Int J Clin Oncol 11:13-21 (2006)
DOI:10.1007/s10147-005-0546-1
Reference
  Authors
Hecht JL, Mutter GL.
  Title
Molecular and pathologic aspects of endometrial carcinogenesis.
  Journal
J Clin Oncol 24:4783-91 (2006)
DOI:10.1200/JCO.2006.06.7173
Reference
  Authors
Matias-Guiu X, Catasus L, Bussaglia E, Lagarda H, Garcia A, Pons C, Munoz J, Arguelles R, Machin P, Prat J.
  Title
Molecular pathology of endometrial hyperplasia and carcinoma.
  Journal
Hum Pathol 32:569-77 (2001)
DOI:10.1053/hupa.2001.25929
Reference
  Authors
Slomovitz BM, Broaddus RR, Burke TW, Sneige N, Soliman PT, Wu W, Sun CC, Munsell MF, Gershenson DM, Lu KH.
  Title
Her-2/neu overexpression and amplification in uterine papillary serous carcinoma.
  Journal
J Clin Oncol 22:3126-32 (2004)
DOI:10.1200/JCO.2004.11.154
Reference
PMID:7585656
  Authors
Saffari B, Jones LA, el-Naggar A, Felix JC, George J, Press MF.
  Title
Amplification and overexpression of HER-2/neu (c-erbB2) in endometrial cancers: correlation with overall survival.
  Journal
Cancer Res 55:5693-8 (1995)
Reference
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Related
pathway
dle04010  MAPK signaling pathway
dle04012  ErbB signaling pathway
dle04060  Cytokine-cytokine receptor interaction
dle04110  Cell cycle
dle04115  p53 signaling pathway
dle04151  PI3K-Akt signaling pathway
dle04310  Wnt signaling pathway
dle04520  Adherens junction
KO pathway
ko05213   
LinkDB

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