KEGG   Delphinapterus leucas (beluga whale): 111166258
Entry
111166258         CDS       T05885                                 

Gene name
BRCA1
Definition
(RefSeq) breast cancer type 1 susceptibility protein isoform X1
  KO
K10605  breast cancer type 1 susceptibility protein [EC:2.3.2.27]
Organism
dle  Delphinapterus leucas (beluga whale)
Pathway
dle01524  Platinum drug resistance
dle03440  Homologous recombination
dle03460  Fanconi anemia pathway
dle04120  Ubiquitin mediated proteolysis
dle04151  PI3K-Akt signaling pathway
dle05206  MicroRNAs in cancer
dle05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:dle00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    111166258 (BRCA1)
  09124 Replication and repair
   03440 Homologous recombination
    111166258 (BRCA1)
   03460 Fanconi anemia pathway
    111166258 (BRCA1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    111166258 (BRCA1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    111166258 (BRCA1)
  09162 Cancer: specific types
   05224 Breast cancer
    111166258 (BRCA1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    111166258 (BRCA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:dle01009]
    111166258 (BRCA1)
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:dle04121]
    111166258 (BRCA1)
   03036 Chromosome and associated proteins [BR:dle03036]
    111166258 (BRCA1)
   03400 DNA repair and recombination proteins [BR:dle03400]
    111166258 (BRCA1)
Enzymes [BR:dle01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     111166258 (BRCA1)
Protein phosphatases and associated proteins [BR:dle01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     111166258 (BRCA1)
Ubiquitin system [BR:dle04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    111166258 (BRCA1)
  Multi subunit Ring-finger type E3
   BRCC complex
    111166258 (BRCA1)
Chromosome and associated proteins [BR:dle03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     111166258 (BRCA1)
DNA repair and recombination proteins [BR:dle03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-core complex
     111166258 (BRCA1)
    BRCA1-A complex
     111166258 (BRCA1)
    BRCA1-B complex
     111166258 (BRCA1)
    BRCA1-C complex
     111166258 (BRCA1)
    BRCA complex
     111166258 (BRCA1)
   FA (Fanconi anemia) pathway
    Downstream FA components
     111166258 (BRCA1)
SSDB
Motif
Pfam: BRCT_assoc BRCT zf-C3HC4 zf-C3HC4_2 zf-C3HC4_4 zf-C3HC4_3 zf-RING_2 zf-RING_UBOX zf-RING_5 BRCT_2 zf-Nse zf-RING_6 zf-ANAPC11 Prok-RING_4 zf-RING_10 zf-rbx1
Other DBs
NCBI-GeneID: 111166258
NCBI-ProteinID: XP_022413471
UniProt: A0A2Y9LXF5
LinkDB
Position
Unknown
AA seq 1866 aa
MDFSANHVEEVQNVLNAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQ
CPLCKNDITRRSLQESTRFSQLVEELLKIIHAFELDTGLQIANSYNFSKKENNSPEHLKE
EVSIIQSMGYRNRTKRLQQSEPENPTLQETSLSVQLSNLGIVRSLRTEQQIQPQNKSVYI
ELGSDSSEDTVNKASYFSVEDHELLEITPQGAKAEASLNRAKNAACEFSEKDITKAEHHQ
FSNKDLTTTEKHETEKHPEKYQGIFVSNLHVEPCGTDTHASSLQHENSSLLLTKDRMNVE
KAEFCNKSKQLVLGKSQQSRWAESKDTCNDRQTPSTEKKVVLNADPLYGRKELNKQKPAS
SDSPRDSQEFPWITLNSSIQKVNEWFSRSDEMLTSYDSRDGGFESNTEVARAVEVPKEVD
GYLGSSEKIDLMASDPHGALIRERVHAKPVESNIEDKIFGKTYQRKASLPNLSRIAEDLI
IGASTVEPQITQERPLTKKLKRKRRSTSGLHPEDFIKKVDLAVLPKTPENIIEGTDQTEQ
NGHGMNITSNGHETEMKGGYVQKEKNANRTESLEKESAFRTKAEPISSSISNMELELNIH
SSKAPKNRLRRKSSTRNIHALELVVSRNPSPPNHTELQIDSCSSSEEMKKKHSSQMPVRH
GKKLQFMGDKEPTTGAKKSDKPHEQITKRLASDTYPELNLTNIPVFFTHCSSSNKLQEFV
NPSLQREESLGTIQVSNNTKDPQDLTLSGGKGLQIERCVESTNISLVPDTDYGTQDSISL
LEADTLGKAKTAPNQHVSLCAAIESPKELIPGCSKDIRNDTEDFQDPLGHDVNHIQKASI
EMEESELDTQYLQNMFKVSKRQTFALFSNPENPEKECATVCAHSGSLREQSPRVPLECRQ
KEENQGKSESKIKHVRAINTTVDFPVAGQKDKKPSDHAKRSPERVTRLCQSSQFRGNKTE
LIIANKHGISHSPYLIPSLSPIRSSIKTMCKKNLSEEKFEEPVMSPERAVENESIVQSTV
RTISQNNSRESTFKEVSSSSINEVGSSTNEVGSSINEVGSSGENIQAKLDRNRGPKLSAL
LRLGLMQPEVYKQSLPVSNCQLPEIKRQGENEGTLQAVNEDFSPCLNSDNLEQPMGRSHA
SQVCSETPDELLNDDKIKESSNFAESDIKERSAVFSKSVQKGEFRRSPGPLAHHTSLVQG
HERGAESSEENVSSEDEELPCFQHLFGKVTNTLSPSTRRNAVATEGLSKETEENLISLKN
SLNDCSDHVTSAKASQEHHLHEEARCSDSLFSSRCSAVEDLTANTNTQDPFLMFDPLSKQ
VGHQSENQEVLSGKELVSDDDEREAGWEEDNRQDEQSVDSDLGEAASEYESETSLSEDCL
GLSSQSDILTTQQRDTMQDNLLKIQQEMAELEAVLEQHGSQPSHSSPSLIADSCASEDLL
NLEQNTSEKAVLTSEKSSEYPISRNPESLSADKFQVSPDTSTSKNKEPGMERSSPSKSQL
SDNSWYMHSHSRSLQNRNCPPQKELEVVDVEEQQLTESEAQDLMEQSSLPRQDLEGTPYL
ESGISLFSDDPESDPSEDRAPEPAHVCSMPPSASALKLPQFQVVESARSPAAAHATNTAG
YNVREESVSREKPELISSTQRGNKRISMVASGLTPKEFVLVHKFARKHHITLTNLITEET
THVIMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLDEHDFEVRGDVVNGR
NHQGPKRARESQDRKIFKGLEICCYGPFTNMPTDQLEWMVHLCGASVVKEPSSFTLSQGT
QPIVVVQPDAWTEGGGFRVIGQMCEAPVVTREWVLDSVALYQCQELDTYLISQVPRAAAD
SSLPCI
NT seq 5601 nt   +upstreamnt  +downstreamnt
atggatttttctgcgaatcacgttgaagaagtacaaaatgtccttaatgctatgcagaaa
atcttagagtgtccaatctgtctggagttgatcaaagagcctgtttccacaaagtgtgat
cacatattttgcaaattttgtatgctgaaacttctcaaccagaagaaagggccttcacag
tgtcctttgtgtaagaatgatataaccagaagaagcctgcaagaaagtacaagatttagt
cagcttgttgaagagctattgaagatcattcatgcttttgagcttgacacaggattgcag
attgcaaacagttataacttttcaaaaaaggaaaataactctcctgagcatctaaaggag
gaagtttctatcattcaaagtatgggctaccgaaaccggaccaaaagacttcaacagagt
gaacctgaaaatcctaccttgcaggaaaccagtcttagtgtccagctctctaaccttgga
attgtgagatctctgaggacagagcagcagatacaacctcaaaataagtccgtctacatt
gaattgggatctgattcttctgaagatacagttaataaggccagttatttcagtgtagaa
gaccatgaattgttagaaatcacccctcaaggagccaaggctgaagccagtttgaatcgt
gcaaaaaacgctgcttgtgagttttctgagaaggacataacaaaggctgaacatcatcag
ttcagtaacaaagatttgaccaccactgagaagcatgaaactgagaagcatccagaaaag
tatcagggtatttttgtttcaaacttgcatgtggagccatgtggcacagatactcatgcc
agctcattacagcatgaaaacagcagtttattactcactaaagacagaatgaatgtagaa
aaggctgaattctgtaataaaagcaaacagcttgtcttaggaaagagccaacagagcaga
tgggctgaaagtaaggacacatgtaatgataggcagactcccagtacagagaaaaaggta
gttctgaatgctgatcccctatatgggagaaaagaactgaataagcagaaacctgcgtcc
tctgacagtcctagagattcccaagagtttccttggataacactgaatagtagcatacag
aaagttaatgaatggttttccagaagtgatgaaatgttaacttcttacgactcacgtgat
gggggatttgaatcaaacactgaagtagctcgtgcagtggaagttccaaaggaagttgat
ggatatttgggttcttcagagaaaatagacttaatggccagtgatcctcacggtgcttta
atacgtgaaagagtccacgccaaaccagtagagagtaatattgaagataaaatatttggg
aaaacctatcagaggaaggcaagcctccctaacttgagccgcatagctgaagatctaatt
ataggagcatctactgtagaacctcagataacacaagagcgccccctcacaaaaaaacta
aagcgtaaaaggagaagtacatcaggccttcatcctgaggattttatcaagaaagtcgat
ttggcagttcttccaaagactccagaaaacataattgagggaactgaccaaacagagcag
aatggtcatgggatgaatattactagtaatggtcatgagactgaaatgaaaggtggttat
gttcagaaagagaaaaatgctaaccgaacagaatcattggaaaaagaatctgctttcaga
actaaggctgaacctataagcagcagtataagcaatatggaactagaattgaatatccat
agttcaaaagcacctaaaaataggctgaggaggaagtcctctaccaggaacattcatgca
cttgaactagtagtcagtagaaacccaagcccacctaatcatactgaactacaaattgat
agttgttctagcagtgaagagatgaagaaaaaacattccagccaaatgccagtcaggcac
ggcaaaaagcttcaattcatgggagataaagaacctacaactggagccaagaagagtgac
aagccacacgaacaaataactaagagacttgccagtgacacttacccagaactaaatttg
acaaacatacctgttttttttactcactgttccagttctaataaacttcaagagtttgtt
aatcctagccttcaaagagaggagagcctaggaacaattcaagtgtcgaataataccaaa
gacccccaagatctgacattaagtggaggaaaaggtttgcaaattgaaagatgtgtagag
agtaccaatatttccttggtacctgatactgattatggcactcaggatagtatttcatta
ctggaagctgacaccctagggaaggcaaagacagcaccaaatcaacatgtgagtctgtgt
gcagcaattgaaagccccaaggaacttatccctggttgttctaaagatattagaaacgac
acagaggactttcaggatccactgggacatgacgttaaccacattcagaaggcgagcata
gaaatggaagagagtgaacttgatacacagtatttgcagaatatgttcaaggtttcaaag
cgtcagacgtttgctctgttttcaaatccagaaaatccagaaaaggaatgtgcaacagtc
tgtgcccactctgggtccttaagggaacaaagtccaagagtccctcttgaatgcagacaa
aaagaagaaaatcagggaaagagtgagtctaaaatcaagcatgtgcgggcaattaataca
actgtggacttccctgtcgctggtcaaaaagataagaagccgagcgatcatgccaaacgt
agcccagaaagagtaactaggctttgtcagtcatcacagttcagaggcaacaaaactgag
ctcattattgcaaataaacatgggatttcacacagcccatatcttataccatcactttct
cccatcaggtcatctattaaaactatgtgtaagaaaaacctgtcagaggaaaagtttgag
gaacctgtaatgtcacctgaaagagcagtggaaaacgagagcatcgttcaaagtacagtg
cgcacaattagccaaaataacagtcgagaaagcacttttaaagaagtcagctcaagcagt
attaatgaagtaggttccagtactaatgaagtaggctctagtattaatgaagtaggttcc
agtggtgaaaacattcaagcaaaactagatagaaacagaggacctaaattaagtgctttg
ctcagattaggtcttatgcaacccgaagtctataagcaaagtcttcctgtaagtaactgt
caacttcctgaaataaaaaggcaaggagaaaatgaaggcacacttcaggctgttaatgaa
gatttctccccatgtctaaattcagataacctagaacaacctatgggaagaagccacgct
tctcaggtttgttctgagacacctgatgagttgttaaatgatgacaaaataaaggaaagt
agcaactttgctgaaagtgacattaaggaaagatctgctgtttttagcaaaagtgtccaa
aaaggagaattcagaaggagccctggccctttagcccatcatacatctttggttcagggt
cacgaaagaggggctgagtcctcagaagagaatgtttctagtgaggatgaagagcttccc
tgcttccaacacttatttggtaaagtaaccaatacactgtctccatctaccagacgtaat
gctgttgccacggagggtctatctaaggaaacagaggagaatctaatatcattgaagaat
agtttaaatgactgcagtgaccacgtaacatcggcaaaggcatcccaggaacatcacctt
catgaggaagcgagatgttctgatagcttattttcttcacggtgcagtgcagtggaagac
ttgaccgctaatacaaacacccaggatcctttcttgatgtttgatcctctttccaaacaa
gtggggcatcagtctgaaaaccaggaagttctgagtggcaaggaattggtttcagatgat
gatgaaagggaagctggctgggaagaggataatcgccaagacgagcagagtgtggattca
gacttaggtgaagcagcatccgagtatgagagtgaaacaagcctctctgaagactgtttg
gggctgtcctctcagagcgatatcttaaccactcagcagagggataccatgcaagataac
ctgctaaagatccagcaggaaatggccgaactggaagctgtgttagagcagcacgggagc
cagccttctcacagctccccttccctcatagccgattcttgtgcctctgaggacctgcta
aatctggaacaaaacacatcagaaaaagcagtattaacttcagagaaaagtagtgaatat
cctataagccggaatccagaaagcctttctgctgacaagtttcaagtatctccggatact
tccaccagtaaaaataaagaaccaggaatggaaaggtcttccccttctaaatcacagttg
tcagataatagttggtatatgcacagccactcaaggagtcttcagaacagaaactgccca
cctcaaaaggagcttgaggttgttgatgtggaggagcaacagctgacggagtctgaggcc
caggatttaatggagcagtcttctttgccaagacaagatctagagggaaccccttaccta
gaatctggaatcagcctcttctctgatgaccctgagtctgatccctctgaagacagagcc
ccagagccagctcatgtctgcagcatgccaccctcagcctctgcactgaaattaccccaa
tttcaagtagtagaatctgccaggagtccggctgcagctcatgctactaatactgcaggg
tataatgtgcgggaagaaagtgtgagcagggagaagccagagttgatatcttcaacacaa
agaggcaacaaaagaatttctatggtggcatcaggcttgaccccaaaagaatttgtgctt
gtgcacaagtttgccagaaaacatcacatcactttaactaatctaattactgaagagact
actcatgtcattatgaaaacagatgccgagtttgtgtgtgaacggacactgaaatatttc
ctggggatcgcaggaggaaaatgggtagttagctatttctgggtgacccagtctattaaa
gaaagaaagatgctggatgagcatgattttgaagtcagaggcgatgttgtcaatggaaga
aaccatcaaggcccaaagcgagcaagagaatcccaggacaggaagatcttcaagggctta
gaaatctgttgctatggaccgtttaccaatatgcccacagatcaactagagtggatggtg
catctgtgtggggcttctgtggtgaaggagccctcatcattcaccctcagccagggtact
caaccaattgtggtcgtgcagccagatgcctggacagagggcggtggcttccgtgtcatc
gggcagatgtgtgaagcacctgtggtgacccgagagtgggtattggacagcgtagccctc
taccagtgccaggagctggacacctacctgatatcccaggtccccagagctgctgctgat
tccagcctgccatgtatatag

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