Delphinapterus leucas (beluga whale): 111171885 Help Entry 111171885         CDS       T05885                                  Gene name IRS1 Definition (RefSeq) insulin receptor substrate 1   KO K16172   insulin receptor substrate 1 Organism dle  Delphinapterus leucas (beluga whale) Pathway dle04022   cGMP-PKG signaling pathway dle04068   FoxO signaling pathway dle04140   Autophagy - animal dle04150   mTOR signaling pathway dle04151   PI3K-Akt signaling pathway dle04152   AMPK signaling pathway dle04211   Longevity regulating pathway dle04213   Longevity regulating pathway - multiple species dle04722   Neurotrophin signaling pathway dle04910   Insulin signaling pathway dle04920   Adipocytokine signaling pathway dle04923   Regulation of lipolysis in adipocytes dle04930   Type II diabetes mellitus dle04931   Insulin resistance dle04932   Non-alcoholic fatty liver disease dle04935   Growth hormone synthesis, secretion and action dle04960   Aldosterone-regulated sodium reabsorption dle05010   Alzheimer disease dle05206   MicroRNAs in cancer Brite KEGG Orthology (KO) [BR:dle00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     111171885 (IRS1)    04022 cGMP-PKG signaling pathway     111171885 (IRS1)    04151 PI3K-Akt signaling pathway     111171885 (IRS1)    04152 AMPK signaling pathway     111171885 (IRS1)    04150 mTOR signaling pathway     111171885 (IRS1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     111171885 (IRS1)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     111171885 (IRS1)    04923 Regulation of lipolysis in adipocytes     111171885 (IRS1)    04920 Adipocytokine signaling pathway     111171885 (IRS1)    04935 Growth hormone synthesis, secretion and action     111171885 (IRS1)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     111171885 (IRS1)   09156 Nervous system    04722 Neurotrophin signaling pathway     111171885 (IRS1)   09149 Aging    04211 Longevity regulating pathway     111171885 (IRS1)    04213 Longevity regulating pathway - multiple species     111171885 (IRS1)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     111171885 (IRS1)   09164 Neurodegenerative disease    05010 Alzheimer disease     111171885 (IRS1)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     111171885 (IRS1)    04932 Non-alcoholic fatty liver disease     111171885 (IRS1)    04931 Insulin resistance     111171885 (IRS1)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04990 Domain-containing proteins not elsewhere classified [BR:dle04990]     111171885 (IRS1) Domain-containing proteins not elsewhere classified [BR:dle04990]  Phosphotyrosine binding (PTB) domain-containing proteins   IRS related family proteins    111171885 (IRS1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  IRS PH PH_11 Motif Other DBs NCBI-GeneID:  111171885 NCBI-ProteinID:  XP_022423539 UniProt:  A0A2Y9MMM9 LinkDB All DBs Position Unknown AA seq 1248 aa AA seqDB search MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI GIYRLCLTSRTISFVKLNAEAAAVVLQLMNVRRCGHSENFFFIEVGRSAVTGPGEFWMQV DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT RRSRTESITATSPASLVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPN GHYILPRSGNGPRYIPAAGLGTSPALTGDEAASAADLDNRFRKRTHSAGTSPTISHQKTP SQSSVASIEEYTEMMPAYPPGGGSGGRVPSYRHSAFVPTHSYPEEGLEMHPLERRVGHHR PDTSNLHTDDGYMPMSPGVAPVPGSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPN GYMMMSPSGSCSPDIGGGPSSGGSSGAAPSGSSYGKLWTNGVGGHHSHALPHPKLPVESS SGKLLSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELE EGARHQHLRLSSSSGRLLYAAAAEDSSSSTSSDSLGGGYCAARPEPGLPHLHHQVLQPHL PRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQPQPQPQPPPPLLPPPEPKSPGEYV NIEFGSDQPGYLSGPGASHSSPSVRCPSQLQPAPREEETGAEEYMNMDLGPGRRAAWRES AGVQPGSMGPAPPGDASVCRPTRAVPSSRGDYMTMQMGCPRQSYVDTSPVAPISYADMRT GGGGLVEEASLPGAAAATPSSSSKASASPAAPQGAEELAARSSLLGGPQGPGGSSAFTRV NLSPNCNQSAKVIRADPQGCRRRHSSETFSSTPSATRAGNTVPFGGAAAAGGGGGGGSSS TEDVKRHSSASFENVWLRPGELGGAPKELAQVCGAAGGLENGLNYIDLDLVKDFNQSPQE RPAQPQPSPPPPPHQPLGRSESGSSSRSSEDLSAYASISFQKPPEDLQ NT seq 3747 nt NT seq  +upstreamnt  +downstreamnt atggcgagccctcccgagaccgacggcttctccgacgtgcgcaaggtgggctacctgcgc aagcccaagagcatgcacaagcgattcttcgtgctgcgggcggccagcgaggctgggggc ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc aaacgctcgatccccctcgagagctgcttcaacatcaacaagcgggccgactccaagaac aagcacctggtggccctctatacccgggacgagcactttgccatcgcggcggacagcgag gccgagcaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac cacgacggggccgcggcccccggggcgggaggcggcgggggcagctgcagtggcagctcc ggccttggcgaggctggggaggacttgagctacggggacgtgcccccaggacccgccttc aaggaagtctggcaggtgatcctgaaacccaagggcctgggtcagaccaagaacctgatt ggcatctaccgcctctgcctgaccagcaggaccatcagcttcgtgaagctgaacgcggag gccgccgcagtggtgctgcagctgatgaacgtcaggcgctgcggccactcagagaacttc ttcttcatcgaagtgggccgttccgccgtgacgggacccggggagttctggatgcaggtg gatgactctgtggtggcccagaacatgcacgagacgatcctggaagccatgcgggccatg agcgatgagttccgccctcgaagcaagagccagtcctcctccaactgctccaaccccatc agtgtccccctgcgcaggcatcacctcaacaaccctccacccagccaggtggggctgacc cgccgctcgcgcacagagagcatcactgccacctccccggccagcttggtgggcgggaag cagggctccttccgggtccgcgcctctagtgatggcgaaggcaccatgtctcgccctgcc tctgtggacggcagtcctgtgagtcccagcaccaacaggacccatgcccaccggcatcgc ggcagttcccggctgcacccgcctctcaaccacagccgctccatccccatgccttcttct cgctgctcgccttccgccaccagcccggtcagtctatcgtccagtagcaccagtggccac ggctccacctcggactgtctcttcccgcggcggtctagtgcttccgtgtccggttccccc agtgatggcggtttcatctcctctgatgagtatggctccagtccctgcgacttccgaagt tccttccgcagtgtcaccccggattccctgggccacaccccgccggcccgcggtgaggag gagctgagcaactacatctgcatgggaggcaagggggcctccaccctcacggcccccaat ggtcactacattttgcctcggagtggcaacggtccccgctacatcccggcagccggcttg ggcacgagcccagccctgacaggggatgaagcagccagtgctgcagatctggacaatcgg ttccgaaagcggactcactctgctggcacgtcacctaccatttcccaccagaagacccca tcccagtcctctgtggcctccattgaggaatataccgagatgatgcctgcctacccacca ggaggtggcagtggaggccgagtgcccagctaccggcactccgccttcgtgcccacccac tcctacccagaggagggtctggaaatgcaccccttggagcggcgtgtgggccaccaccgc ccagacacctccaacctccacaccgatgatggctacatgcccatgtccccaggggtggcc ccagtgcccgggagccgaaagggcagtggggactacatgcccatgagccccaagagcgtg tctgcccctcagcagatcatcaaccccatcagacgccatccccagagagtggaccccaat ggctacatgatgatgtccccaagcggcagctgctctcctgacattggaggcgggcccagc agcggcggcagcagcggtgccgccccttctgggagcagctatggcaagctctggacgaat ggggtagggggccaccactctcacgcgctgccacaccccaaactccctgtggagagcagt agcggcaagctgttgtcttgtacgggtgactacatgaacatgtcgccagtgggggactcc aacaccagcagcccttccgactgctactatggccctgaggacccccagcacaagccagtc ctctcctactactcattgccaaggtcctttaagcacacccagcgccccggggagctggag gagggcgcccggcaccagcacctccgcctttcctccagctcgggtcgactcctctatgct gcggcggcggaagattcctcctcgtccaccagcagcgacagcctgggcgggggatactgc gcggctaggcccgagcccggcctcccgcatctccaccatcaggtcctgcagccccatctg cctcgaaaggtggacacagctgcccagaccaacagccgcctggcccggcccacgaggctg tccctgggggatcccaaggccagcaccttaccccgggcccgagagcagccgcagccccag ccgcagccgccgccgcccctgctgccccctccggaacccaagagcccaggggaatatgtg aatattgaatttgggagcgatcagccgggctacttatcaggcccgggggcttcccacagc tcgccttctgtccggtgtccatcccagctccagccggctcccagagaggaggagacgggc gcggaagagtacatgaacatggacctggggccgggccggagggccgcctggcgggagagc gctggggtccagccgggcagcatgggcccggcaccccctggagatgctagcgtgtgcagg cccaccagggcagtgcccagcagccggggtgactacatgaccatgcagatgggctgtccc cggcagagctacgtggacacctcgccagtcgcccccatcagctatgcggacatgcggacc ggcggcggcggcctcgtggaggaggccagcctgcctggggccgccgcggccacgccctcc tcatcctcgaaggcctctgcttcccccgccgcgcctcaaggagcagaggagctggcggcc cgctcttccctgctggggggcccgcagggacccgggggctcgagtgccttcacgcgggtg aacctcagtcccaactgcaaccagagtgccaaagtgatccgtgccgacccgcaagggtgc aggaggcggcacagctccgagaccttctcctcgacgcccagtgccaccagggcaggcaac acggtgcccttcggaggggcggctgcagccgggggcggcggtggtggcggcagcagcagc acggaggacgtgaaacgccacagctctgcttcctttgagaacgtgtggctgcggcctggg gagctcgggggagcccccaaggagctggcccaagtgtgcggggccgccgggggtttggag aatgggcttaactacatagacctggatttggtcaaggacttcaaccagagccctcaagag cgtcccgctcagccgcagccttctcctcccccaccccctcatcagcctctgggacgcagc gagagcggctccagcagccgctccagcgaggatttaagcgcctatgccagcatcagtttc cagaagccgccagaggacctccagtag

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