KEGG   DRUG: Levodopa
Entry
D00059                      Drug                                   
Name
Levodopa (JP18/USP/INN);
Dopar (TN)
Product
INBRIJA (Merz Pharmaceuticals)
Formula
C9H11NO4
Exact mass
197.0688
Mol weight
197.19
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01472  Dopamine agonist
 DG01967  Antiparkinson agent
Remark
Same as: C00355
Therapeutic category: 1164
ATC code: N04BA01
Product: D00059<JP/US>
Product (mixture): D00253<JP/US> D02135<JP> D10293<JP/US>
Efficacy
Antiparkinsonian
  Disease
Parkinson disease [DS:H00057]
Parkinsonism [DS:H01600]
Comment
Dopamine precursor
Active form of prodrug: Dopamine [DR:D07870]
Target
DRD [HSA:1812 1813 1814 1815 1816] [KO:K04144 K04145 K04146 K04147 K05840]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
hsa05012  Parkinson disease
Interaction
Structure map
map07057  Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BA Dopa and dopa derivatives
     N04BA01 Levodopa
      D00059  Levodopa (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Dopamine Precursors and/or L-Amino Acid Decarboxylase Inhibitors
   Levodopa
    D00059  Levodopa (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1164  Levodopas
     D00059  Levodopa (JP18/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01472  Dopamine agonist
   D00059  Levodopa
  DG01967  Antiparkinson agent
   D00059  Levodopa
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01967  Antiparkinson agent
   D00059  Levodopa
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD
     D00059  Levodopa (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00059  Levodopa
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00059
Prodrugs [br08324.html]
 D00059
Other DBs
CAS: 59-92-7
PubChem: 7847127
ChEBI: 15765
PDB-CCD: DAH[PDBj]
LigandBox: D00059
NIKKAJI: J9.225H
LinkDB
KCF data

ATOM        14
            1   C8y C    22.9600  -19.2500
            2   C8y C    22.9600  -20.6500
            3   C8x C    24.1500  -18.5500
            4   O1a O    21.7000  -18.5500
            5   C8x C    24.1500  -21.3500
            6   O1a O    21.7000  -21.3500
            7   C8y C    25.3400  -19.2500
            8   C8x C    25.3400  -20.6500
            9   C1b C    26.6000  -18.6200
            10  C1c C    27.7900  -19.2500
            11  C6a C    28.9800  -18.6200
            12  N1a N    27.7900  -20.6500
            13  O6a O    30.2400  -19.2500
            14  O6a O    28.9800  -17.2200
BOND        14
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     5   8 1
            8     7   9 1
            9     9  10 1
            10   10  11 1
            11   10  12 1 #Up
            12   11  13 1
            13   11  14 2
            14    7   8 2

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