KEGG   DRUG: Noradrenaline
Entry
D00076                      Drug                                   

Name
Noradrenaline (JP17);
Norepinephrine (INN);
Nor adrenalin (TN)
Formula
C8H11NO3
Exact mass
169.0739
Mol weight
169.1778
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01451  beta1-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
   DG01453  beta3-Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
Remark
Same as: C00547
Therapeutic category: 2451
ATC code: C01CA03
Chemical structure group: DG00212
Product (DG00212): D00076<JP> D05206<US>
Efficacy
Antihypotensive, Vasoconstrictor, Adrenergic receptor agonist
Comment
Catecholamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
Interaction
Structure map
map07215  alpha-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA03 Norepinephrine
      D00076  Noradrenaline (JP17) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2451  Epinephrines
     D00076  Noradrenaline (JP17); Norepinephrine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00076  Noradrenaline (JP17) <JP>
    ADRA2
     D00076  Noradrenaline (JP17) <JP>
    ADRB
     D00076  Noradrenaline (JP17) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00076  Noradrenaline
  D00076  Noradrenaline injection
Other DBs
CAS: 51-41-2
PubChem: 7847144
ChEBI: 18357
ChEMBL: CHEMBL1437
DrugBank: DB00368
PDB-CCD: E5E[PDBj] LNR[PDBj]
LigandBox: D00076
NIKKAJI: J9.223A
LinkDB
KCF data

ATOM        12
            1   C8y C    25.1107  -17.0137
            2   C8x C    25.1107  -18.4285
            3   C8x C    23.8950  -16.3188
            4   C1c C    26.3149  -16.3188
            5   C8x C    23.8950  -19.1423
            6   C8y C    22.6850  -17.0137
            7   C1b C    27.5246  -17.0080
            8   O1a O    26.3149  -14.9217
            9   C8y C    22.6850  -18.4285
            10  N1a N    28.7227  -16.3130
            11  O1a O    21.4681  -19.1189
            12  O1a O    21.4728  -16.3208
BOND        12
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 1 #Up
            8     5   9 2
            9     7  10 1
            10    9  11 1
            11    6   9 1
            12    6  12 1

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