KEGG   DRUG: Mitomycin
Entry
D00208                      Drug                                   
Name
Mitomycin (USP/INN);
Mitomycin C (JP18);
MMC;
Jelmyto (TN);
Mitomycin (TN);
Muamycin (TN)
Product
JELMYTO (UroGen Pharma), MITOSOL (Mobius Therapeutics LLC)
  Generic
MITOMYCIN (Accord Healthcare), MITOMYCIN (Archis Pharma LLC), MITOMYCIN (Archis Pharma LLC), MITOMYCIN (BluePoint Laboratories), MITOMYCIN (BluePoint Laboratories), MITOMYCIN (Bryant Ranch Prepack), MITOMYCIN (Eugia US LLC), MITOMYCIN (Fresenius Kabi USA), MITOMYCIN (Fresenius Kabi USA), MITOMYCIN (Gland Pharma Limited), MITOMYCIN (Gland Pharma Limited), MITOMYCIN (Hikma Pharmaceuticals USA), MITOMYCIN (Hikma Pharmaceuticals USA), MITOMYCIN (Meitheal Pharmaceuticals), MITOMYCIN (Meitheal Pharmaceuticals), MITOMYCIN (Sagent Pharmaceuticals), MITOMYCIN (Sagent Pharmaceuticals), MUTAMYCIN (Accord BioPharma)
Formula
C15H18N4O5
Exact mass
334.1277
Mol weight
334.33
Structure
Simcomp
Source
Streptomyces caespitosus [TAX:53502]
Remark
Same as: C06681
Therapeutic category: 1317 4231
ATC code: L01DC03
Product: D00208<JP/US>
Efficacy
Antineoplastic
  Disease
Glaucoma [DS:H00612]
Upper tract urothelial cancer [DS:H00022]
Adenocarcinoma of the stomach or pancreas [DS:H00018 H00019]
Comment
DNA synthesis inhibitor
Target
DNA
Interaction
Structure map
map07040  Antineoplastics - alkylating agents
map07042  Antineoplastics - agents from natural products
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
    L01DC Other cytotoxic antibiotics
     L01DC03 Mitomycin
      D00208  Mitomycin (USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antineoplastics, Other
   Antineoplastics, Miscellaneous
    Mitomycin
     D00208  Mitomycin (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1317  Ophthalmic antibiotics
     D00208  Mitomycin (USP/INN); Mitomycin C (JP18)
 4  Agents affecting cellular function
  42  Antineoplastics
   423  Antibiotics
    4231  Mytomycin C
     D00208  Mitomycin (USP/INN); Mitomycin C (JP18)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00208  Mitomycin C
  D00208  Mitomycin C for injection
Other DBs
CAS: 50-07-7
PubChem: 7847275
ChEBI: 27504
LigandBox: D00208
NIKKAJI: J64.512E
LinkDB
KCF data

ATOM        24
            1   C1z C    26.7153  -18.5085
            2   N1y N    25.8935  -19.6917
            3   C1y C    28.0734  -18.9398
            4   C1y C    25.8935  -17.3777
            5   C2y C    24.5646  -19.2603
            6   C1x C    26.7445  -20.7467
            7   C1y C    28.0967  -20.3444
            8   N1x N    29.3090  -19.6509
            9   C2y C    24.5646  -17.8557
            10  C1b C    26.3074  -16.0547
            11  C5x C    23.3581  -19.9714
            12  C5x C    23.3581  -17.1213
            13  O7a O    25.3573  -15.0289
            14  C2y C    22.1049  -19.2953
            15  O5x O    23.3581  -21.3645
            16  C2y C    22.0875  -17.8674
            17  O5x O    23.3990  -15.7574
            18  C7a C    25.7537  -13.6360
            19  C1a C    20.8694  -20.0006
            20  N1a N    20.8694  -17.1796
            21  N1a N    27.1700  -13.3270
            22  O6a O    24.8443  -12.5926
            23  O2a O    27.4153  -17.2960
            24  C1a C    28.8400  -16.6662
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 1 #Up
            10    5  11 1
            11    9  12 1
            12   10  13 1
            13   11  14 1
            14   11  15 2
            15   12  16 1
            16   12  17 2
            17   13  18 1
            18   14  19 1
            19   16  20 1
            20   18  21 1
            21   18  22 2
            22    5   9 2
            23    6   7 1
            24    7   8 1
            25   14  16 2
            26    1  23 1 #Down
            27   23  24 1

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