KEGG   DRUG: Capsaicin
Entry
D00250                      Drug                                   

Name
Capsaicin (JAN/USP);
Zostrix (TN)
Product
Formula
C18H27NO3
Exact mass
305.1991
Mol weight
305.4119
Structure
Simcomp
Class
Neuropsychiatric agent
 DG02030  Anesthetics
  DG01675  Local anesthetic
 DG01675  Local anesthetic
Remark
Same as: C06866
ATC code: M02AB01 N01BX04
Product: D00250<US>
Efficacy
Analgesic (topical), Transient receptor potential (TRP) channel agonist
Comment
Antineuralgic, specific pain syndromes, topical
Target
TRPV1 [HSA:7442] [KO:K05222]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AB Capsaicin and similar agents
     M02AB01 Capsaicin
      D00250  Capsaicin (JAN/USP) <US>
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BX Other local anesthetics
     N01BX04 Capsaicin
      D00250  Capsaicin (JAN/USP) <US>
Risk category of Japanese OTC drugs [BR:br08312]
 Third-class OTC drugs
  Inorganic and organic chemicals
   Capsaicin
    D00250  Capsaicin (JAN/USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Transient receptor potential channels
    TRPV1
     D00250  Capsaicin (JAN/USP) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D00250
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00250
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00250
Other DBs
CAS: 404-86-4
PubChem: 7847316
ChEBI: 3374
ChEMBL: CHEMBL294199
PDB-CCD: 4DY[PDBj]
LigandBox: D00250
NIKKAJI: J1.529F
LinkDB
KCF data

ATOM        22
            1   C8y C    14.3789  -14.5250
            2   C8x C    13.1676  -15.2238
            3   C8x C    14.3789  -13.1272
            4   C1b C    15.5904  -15.2238
            5   C8y C    11.9504  -14.5250
            6   C8x C    13.1676  -12.4226
            7   N1b N    16.8017  -14.5250
            8   C8y C    11.9504  -13.1272
            9   O2a O    10.7391  -15.2238
            10  C5a C    18.0189  -15.2179
            11  O1a O    10.7391  -12.4226
            12  C1a C     9.5219  -14.5307
            13  C1b C    19.2244  -14.5250
            14  O5a O    18.0189  -16.6216
            15  C1b C    20.4357  -15.2179
            16  C1b C    21.6529  -14.5190
            17  C1b C    22.8644  -15.2179
            18  C2b C    24.0816  -14.5190
            19  C2b C    25.2929  -15.2179
            20  C1c C    26.5042  -14.5190
            21  C1a C    27.7214  -15.2122
            22  C1a C    26.5042  -13.1156
BOND        22
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     7  10 1
            10    8  11 1
            11    9  12 1
            12   10  13 1
            13   10  14 2
            14   13  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 2
            19   19  20 1
            20   20  21 1
            21   20  22 1
            22    6   8 1

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