KEGG   DRUG: Clonazepam
Entry
D00280                      Drug                                   

Name
Clonazepam (JP17/USP/INN);
Klonopin (TN)
Product
  Generic
CLONAZEPAM (A-S Medication Solutions), CLONAZEPAM (A-S Medication Solutions), CLONAZEPAM (A-S Medication Solutions), CLONAZEPAM (A-S Medication Solutions), CLONAZEPAM (ATLANTIC BIOLOGICALS CORP.), CLONAZEPAM (ATLANTIC BIOLOGICALS CORP.), CLONAZEPAM (Accord Healthcare), CLONAZEPAM (Actavis Pharma), CLONAZEPAM (Alembic Pharmaceuticals), CLONAZEPAM (Alembic Pharmaceuticals Limited), CLONAZEPAM (American Health Packaging), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Cardinal Health), CLONAZEPAM (Clinical Solutions Wholesale), CLONAZEPAM (Contract Pharmacy Services-PA), CLONAZEPAM (Contract Pharmacy Services-PA), CLONAZEPAM (Contract Pharmacy Services-PA), CLONAZEPAM (DIRECT RX), CLONAZEPAM (DIRECT RX), CLONAZEPAM (DIRECT RX), CLONAZEPAM (Direct_Rx), CLONAZEPAM (Direct_Rx), CLONAZEPAM (Eon Labs), CLONAZEPAM (Golden State Medical Supply), CLONAZEPAM (Golden State Medical Supply), CLONAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), CLONAZEPAM (Medsource Pharmaceuticals), CLONAZEPAM (NCS HealthCare of KY), CLONAZEPAM (Northstar RxLLC), CLONAZEPAM (Nu Care Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (Par Pharmaceutical), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Quality Care Products), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (RPK Pharmaceuticals), CLONAZEPAM (Sandoz), CLONAZEPAM (Solco Healthcare LLC), CLONAZEPAM (St Marys Medical Park Pharmacy), CLONAZEPAM (Sun Pharmaceutical Industries), CLONAZEPAM (Teva Pharmaceuticals USA), CLONAZEPAM (Teva Pharmaceuticals USA), KLONOPIN (Advanced Rx Pharmacy of Tennessee)
Formula
C15H10ClN3O3
Exact mass
315.0411
Mol weight
315.7112
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG02036  Antiepileptics, benzodiazepine derivatives
Remark
Therapeutic category: 1139
ATC code: N03AE01
Product: D00280<JP/US>
Efficacy
Anticonvulsant, Antiepileptic
  Disease
Lennox-Gastaut syndrome [DS:H01813]
Panic disorder [DS:H01664]
Comment
Benzodiazepine derivative
Cytochrome P-450 including CYP3A, may play an important role in clonazepam reduction and oxidation.
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Structure map
map07033  Anticonvulsants
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AE Benzodiazepine derivatives
     N03AE01 Clonazepam
      D00280  Clonazepam (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Benzodiazepines
    Clonazepam
     D00280  Clonazepam (JP17/USP/INN)
 Anxiolytics
  Benzodiazepines
   Clonazepam
    D00280  Clonazepam (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00280  Clonazepam (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00280  Clonazepam (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00280  Clonazepam
  D00280  Clonazepam tablets
  D00280  Clonazepam fine granules
Other DBs
CAS: 1622-61-3
PubChem: 7847346
ChEBI: 3756
ChEMBL: CHEMBL452
DrugBank: DB01068
LigandBox: D00280
NIKKAJI: J5.233G
LinkDB
KCF data

ATOM        22
            1   C2y C    18.3334  -14.2894
            2   C8y C    17.4913  -13.1798
            3   C8y C    17.8265  -11.8230
            4   N1x N    19.0875  -11.2449
            5   N2x N    19.7392  -14.3146
            6   C5x C    20.3411  -11.8672
            7   C1x C    20.6276  -13.2359
            8   C8x C    16.8194  -10.8546
            9   C8x C    15.4774  -11.2427
            10  C8y C    15.1422  -12.5995
            11  C8x C    16.1493  -13.5676
            12  N2b N    13.7774  -12.9939 #+
            13  C8y C    17.6989  -15.5391
            14  C8x C    16.2973  -15.5391
            15  O5x O    21.4503  -11.0095
            16  C8x C    15.5973  -16.7516
            17  C8x C    16.2973  -17.9640
            18  C8x C    17.6989  -17.9640
            19  C8y C    18.3989  -16.7516
            20  X   Cl   19.8098  -16.7517
            21  O3a O    12.6477  -11.9025 #-
            22  O3a O    13.4361  -14.3745
BOND        24
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13   10  12 1
            14    1  13 1
            15   13  14 1
            16    6  15 2
            17   14  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   13  19 2
            22   19  20 1
            23   12  21 1
            24   12  22 2

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