KEGG   DRUG: Gemfibrozil
Entry
D00334                      Drug                                   

Name
Gemfibrozil (JAN/USP/INN);
Lopid (TN)
Product
  Generic
GEMFIBROZIL (A-S Medication Solutions), GEMFIBROZIL (American Health Packaging), GEMFIBROZIL (Aphena Pharma Solutions - Tennessee), GEMFIBROZIL (Aphena Pharma Solutions - Tennessee), GEMFIBROZIL (Aurobindo Pharma Limited), GEMFIBROZIL (AvPAK), GEMFIBROZIL (Bryant Ranch Prepack), GEMFIBROZIL (Bryant Ranch Prepack), GEMFIBROZIL (Bryant Ranch Prepack), GEMFIBROZIL (Bryant Ranch Prepack), GEMFIBROZIL (Cadila Healthcare Limited), GEMFIBROZIL (Cadila Pharmaceuticals Limited), GEMFIBROZIL (Cipla USA), GEMFIBROZIL (Contract Pharmacy Services-PA), GEMFIBROZIL (Denton Pharma), GEMFIBROZIL (Denton Pharma), GEMFIBROZIL (DirectRX), GEMFIBROZIL (Direct_Rx), GEMFIBROZIL (Epic Pharma), GEMFIBROZIL (Exelan Pharmaceuticals), GEMFIBROZIL (Lake Erie Medical DBA Quality Care Products LLC), GEMFIBROZIL (Nivagen Pharmaceuticals), GEMFIBROZIL (Northstar RxLLC), GEMFIBROZIL (Northwind Pharmaceuticals), GEMFIBROZIL (NuCare Pharmaceuticals), GEMFIBROZIL (NuCare Pharmaceuticals), GEMFIBROZIL (NuCare Pharmaceuticals), GEMFIBROZIL (PD-Rx Pharmaceuticals), GEMFIBROZIL (PD-Rx Pharmaceuticals), GEMFIBROZIL (Preferred Pharmaceuticals), GEMFIBROZIL (Proficient Rx LP), GEMFIBROZIL (Proficient Rx LP), GEMFIBROZIL (Proficient Rx LP), GEMFIBROZIL (PuraCap Laboratories LLC dba Blu Pharmaceuticals), GEMFIBROZIL (REMEDYREPACK), GEMFIBROZIL (Rising Health), GEMFIBROZIL (St. Mary's Medical Park Pharmacy), GEMFIBROZIL (Viona Pharmaceuticals), GEMFIBROZIL (Zydus Pharmaceuticals (USA))
Formula
C15H22O3
Exact mass
250.1569
Mol weight
250.3334
Structure
Simcomp
Class
Cardiovascular agent
 DG01946  Hypolipidemic agent
  DG01547  Fibrates
Other
 DG01733  PPAR agonist
  DG01547  Fibrates
Metabolizing enzyme inhibitor
 DG01641  CYP2C8 inhibitor
Transporter inhibitor
 DG02865  SLCO1B1 (OATP1B1) inhibitor
Remark
Same as: C07020
ATC code: C10AB04
Product: D00334<US>
Efficacy
Antihyperlipidemic, Triglyceride synthesis inhibitor, Peroxisome proliferator-activated receptor (PPAR) alpha agonist
  Disease
Types IV and V hyperlipidemia [DS:H01635]
Comment
Clofibrate derivative
Target
NR1C1 (PPARA) [HSA:5465] [KO:K07294]
  Pathway
hsa03320  PPAR signaling pathway
hsa04920  Adipocytokine signaling pathway
Interaction
CYP inhibition: CYP2C8 [HSA:1558]
Transporter inhibition: SLCO1B1 [HSA:10599]
Structure map
map07222  Peroxisome proliferator-activated receptor (PPAR) agonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AB Fibrates
     C10AB04 Gemfibrozil
      D00334  Gemfibrozil (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, Fibric Acid Derivatives
   Gemfibrozil
    D00334  Gemfibrozil (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    NR1C1 (PPARA)
     D00334  Gemfibrozil (JAN/USP/INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00334
 Drug transporters
  D00334
Other DBs
CAS: 25812-30-0
PubChem: 7847400
ChEBI: 5296
ChEMBL: CHEMBL457
DrugBank: DB01241
PDB-CCD: 4TX[PDBj]
LigandBox: D00334
NIKKAJI: J40.721F
LinkDB
KCF data

ATOM        18
            1   C8x C     9.4500  -21.2100
            2   C8x C     9.4500  -22.6100
            3   C8y C    10.6624  -23.3100
            4   C8y C    11.8749  -22.6100
            5   C8x C    11.8749  -21.2100
            6   C8y C    10.6624  -20.5100
            7   C1a C    10.6624  -19.1102
            8   C1a C    10.6624  -24.7098
            9   O2a O    13.1060  -23.3210
            10  C1b C    14.3112  -22.6253
            11  C1b C    15.4935  -23.3081
            12  C1b C    16.6875  -22.6188
            13  C1d C    17.8754  -23.3048
            14  C6a C    19.0665  -22.6171
            15  O6a O    20.2559  -23.3039
            16  O6a O    19.0667  -21.2103
            17  C1a C    17.1178  -24.5033
            18  C1a C    18.5957  -24.4949
BOND        18
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     3   8 1
            9     4   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   14  16 2
            17   13  17 1
            18   13  18 1

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