 | | DRUG: Lamotrigine | |
| Entry |
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| Name |
Lamotrigine (JAN/USP/INN);
Lamictal (TN) |
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| Product |
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| Generic |
LAMOTRIGINE (Cadila Healthcare Limited), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (Actavis Pharma), LAMOTRIGINE (Advagen Pharma Limited), LAMOTRIGINE (Ajanta Pharma USA), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE (American Health Packaging), LAMOTRIGINE (Amneal Pharmaceuticals LLC), LAMOTRIGINE (Amneal Pharmaceuticals of New York LLC), LAMOTRIGINE (Amneal Pharmaceuticals of New York LLC), LAMOTRIGINE (Amring Pharmaceuticals), LAMOTRIGINE (Ascend Laboratories), LAMOTRIGINE (Asclemed USA), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (AvKARE), LAMOTRIGINE (AvKARE), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Cadila Healthcare Limited), LAMOTRIGINE (Cardinal Health), LAMOTRIGINE (Cardinal Health 107), LAMOTRIGINE (Cipla USA), LAMOTRIGINE (Clinical Solutions Wholesale), LAMOTRIGINE (Clinical Solutions Wholesale), LAMOTRIGINE (DIRECT RX), LAMOTRIGINE (DIRECT RX), LAMOTRIGINE (Denton Pharma), LAMOTRIGINE (DirectRX), LAMOTRIGINE (Dr. Reddy's Laboratories), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Glenmark Pharmaceuticals), LAMOTRIGINE (Golden State Medical Supply), LAMOTRIGINE (JUBILANT CADISTA PHARMACEUTICALS), LAMOTRIGINE (Lake Erie Medical DBA Quality Care Products LLC), LAMOTRIGINE (Lake Erie Medical DBA Quality Care Products LLC), LAMOTRIGINE (Major Pharmaceuticals), LAMOTRIGINE (NCS HealthCare of KY), LAMOTRIGINE (NorthStar Rx LLC), LAMOTRIGINE (NorthStar Rx LLC), LAMOTRIGINE (Northstar Rx LLC.), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (NuCare Pharmaceuticals), LAMOTRIGINE (OWP Pharmaceuticals), SUBVENITE (OWP Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (Par Pharmaceutical), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), SUBVENITE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (RPK Pharmaceuticals), LAMOTRIGINE (RPK Pharmaceuticals), LAMOTRIGINE (RPK Pharmaceuticals), LAMOTRIGINE (Rising Pharma Holdings), LAMOTRIGINE (ScieGen Pharmaceuticals), LAMOTRIGINE (St. Mary's Medical Park Pharmacy), LAMOTRIGINE (St. Mary's Medical Park Pharmacy), LAMOTRIGINE (St. Mary's Medical Park Pharmacy), LAMOTRIGINE (Taro Pharmaceuticals U.S.A.), LAMOTRIGINE (Taro Pharmaceuticals U.S.A.), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Unichem Pharmaceuticals (USA)), LAMOTRIGINE (Wockhardt USA LLC.), LAMOTRIGINE (Zydus Pharmaceuticals (USA)), LAMOTRIGINE (Zydus Pharmaceuticals USA), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE EXTENDED RELEASE (Bryant Ranch Prepack), LAMOTRIGINE EXTENDED RELEASE (Par Pharmaceutical), LAMOTRIGINE EXTENDED RELEASE (TruPharma), LAMOTRIGINE (Yiling Pharmaceutical) |
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| Formula |
C9H7Cl2N5
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| Exact mass |
255.0079
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| Mol weight |
256.0914
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| Structure |
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| Class |
Metabolizing enzyme substrate
DG02924 UGT substrate
DG03182 UGT1A4 substrate
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| Remark |
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| Efficacy |
Anti-bipolar disorder, Anticonvulsant, Antiepileptic |
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| Disease |
Lennox-Gastaut syndrome [DS: H01813] Bipolar disorder [DS: H01653] |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: UGT1A4 [HSA: 54657]
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AX Other antiepileptics
N03AX09 Lamotrigine
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Anticonvulsants
Anticonvulsants, Other
Lamotrigine
D00354 Lamotrigine (JAN/USP/INN)
Bipolar Agents
Mood Stabilizers
Lamotrigine
D00354 Lamotrigine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
113 Antiepileptics
1139 Others
D00354 Lamotrigine (JAN/USP/INN)
117 Psychotropics
1179 Others
D00354 Lamotrigine (JAN/USP/INN)
Drug groups [BR:br08330]
Metabolizing enzyme substrate
DG02924 UGT substrate
DG03182 UGT1A4 substrate
D00354 Lamotrigine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN2A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN3A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN4A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN5A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN8A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN9A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN10A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN11A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00354
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00354
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 16
1 C8y C 21.7344 -17.9428
2 C8y C 20.5227 -17.2321
3 C8y C 21.7285 -19.3408
4 N5x N 22.9459 -17.2378
5 C8y C 20.5286 -15.8341
6 C8x C 19.3053 -17.9311
7 N5x N 22.9343 -20.0398
8 N1a N 20.5111 -20.0281
9 N5x N 24.1576 -17.9485
10 C8y C 19.3169 -15.1350
11 X Cl 21.7461 -15.1467
12 C8x C 18.0995 -17.2262
13 C8y C 24.1517 -19.3465
14 C8x C 18.0995 -15.8281
15 X Cl 19.3228 -13.7313
16 N1a N 25.3633 -20.0513
BOND 17
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 3 8 1
8 4 9 2
9 5 10 1
10 5 11 1
11 6 12 2
12 7 13 2
13 10 14 2
14 10 15 1
15 13 16 1
16 9 13 1
17 12 14 1
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