DRUG: Lamotrigine
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Entry
D00354 Drug
Name
Lamotrigine (JAN/USP/INN);
Lamictal (TN)
Product
LAMICTAL (GlaxoSmithKline LLC)
,
LAMICTAL (GlaxoSmithKline LLC)
,
LAMICTAL (PD-Rx Pharmaceuticals)
Generic
LAMOTRIGINE (Cadila Healthcare Limited)
,
LAMOTRIGINE (A-S Medication Solutions)
,
LAMOTRIGINE (A-S Medication Solutions)
,
LAMOTRIGINE (A-S Medication Solutions)
,
LAMOTRIGINE (A-S Medication Solutions)
,
LAMOTRIGINE (Actavis Pharma)
,
LAMOTRIGINE (Ajanta Pharma Limited)
,
LAMOTRIGINE (Alembic Pharmaceuticals)
,
LAMOTRIGINE (Alembic Pharmaceuticals)
,
LAMOTRIGINE (Alembic Pharmaceuticals Limited)
,
LAMOTRIGINE (American Health Packaging)
,
LAMOTRIGINE (Amneal Pharmaceuticals LLC)
,
LAMOTRIGINE (Amneal Pharmaceuticals of New York LLC)
,
LAMOTRIGINE (Ascend Laboratories)
,
LAMOTRIGINE (Asclemed USA)
,
LAMOTRIGINE (Aurobindo Pharma Limited)
,
LAMOTRIGINE (Aurobindo Pharma Limited)
,
LAMOTRIGINE (AvKARE)
,
LAMOTRIGINE (AvKARE)
,
LAMOTRIGINE (Bryant Ranch Prepack)
,
LAMOTRIGINE (Bryant Ranch Prepack)
,
LAMOTRIGINE (Bryant Ranch Prepack)
,
LAMOTRIGINE (Bryant Ranch Prepack)
,
LAMOTRIGINE (Bryant Ranch Prepack)
,
LAMOTRIGINE (Cadila Healthcare Limited)
,
LAMOTRIGINE (Cardinal Health)
,
LAMOTRIGINE (Cardinal Health)
,
LAMOTRIGINE (Cipla USA)
,
LAMOTRIGINE (Clinical Solutions Wholesale)
,
LAMOTRIGINE (Clinical Solutions Wholesale)
,
LAMOTRIGINE (DIRECT RX)
,
LAMOTRIGINE (DIRECT RX)
,
LAMOTRIGINE (DirectRX)
,
LAMOTRIGINE (Dr. Reddy's Laboratories)
,
LAMOTRIGINE (Dr.Reddy's Laboratories Limited)
,
LAMOTRIGINE (Dr.Reddy's Laboratories Limited)
,
LAMOTRIGINE (Dr.Reddy's Laboratories Limited)
,
LAMOTRIGINE (Glenmark Pharmaceuticals)
,
LAMOTRIGINE (Golden State Medical Supply)
,
LAMOTRIGINE (H. J. Harkins Company)
,
LAMOTRIGINE (JUBILANT CADISTA PHARMACEUTICALS)
,
LAMOTRIGINE (Jubilant Cadista Pharmaceuticals)
,
LAMOTRIGINE (Lake Erie Medical DBA Quality Care Products LLC)
,
LAMOTRIGINE (Lake Erie Medical DBA Quality Care Products LLC)
,
LAMOTRIGINE (Major Pharmaceuticals)
,
LAMOTRIGINE (McKesson Corporation dba RX Pak)
,
LAMOTRIGINE (McKesson Corporation dba SKY Packaging)
,
LAMOTRIGINE (NCS HealthCare of KY)
,
LAMOTRIGINE (NorthStar Rx LLC)
,
LAMOTRIGINE (NorthStar Rx LLC)
,
LAMOTRIGINE (OWP Pharmaceuticals)
,
SUBVENITE (OWP Pharmaceuticals)
,
LAMOTRIGINE (PD-Rx Pharmaceuticals)
,
LAMOTRIGINE (PD-Rx Pharmaceuticals)
,
LAMOTRIGINE (PD-Rx Pharmaceuticals)
,
LAMOTRIGINE (PD-Rx Pharmaceuticals)
,
LAMOTRIGINE (Par Pharmaceutical)
,
LAMOTRIGINE (Preferred Pharmaceuticals)
,
LAMOTRIGINE (Preferred Pharmaceuticals)
,
LAMOTRIGINE (Preferred Pharmaceuticals)
,
LAMOTRIGINE (Preferred Pharmaceuticals)
,
LAMOTRIGINE (Preferred Pharmaceuticals)
,
LAMOTRIGINE (Preferred Pharmaceuticals)
,
LAMOTRIGINE (Preferred Pharmaceuticals)
,
LAMOTRIGINE (Preferred Pharmaceuticals)
,
LAMOTRIGINE (Proficient Rx LP)
,
LAMOTRIGINE (Proficient Rx LP)
,
LAMOTRIGINE (Proficient Rx LP)
,
LAMOTRIGINE (REMEDYREPACK)
,
LAMOTRIGINE (REMEDYREPACK)
,
LAMOTRIGINE (REMEDYREPACK)
,
LAMOTRIGINE (REMEDYREPACK)
,
LAMOTRIGINE (REMEDYREPACK)
,
LAMOTRIGINE (REMEDYREPACK)
,
LAMOTRIGINE (REMEDYREPACK)
,
LAMOTRIGINE (REMEDYREPACK)
,
LAMOTRIGINE (REMEDYREPACK)
,
LAMOTRIGINE (REMEDYREPACK)
,
SUBVENITE (REMEDYREPACK)
,
LAMOTRIGINE (REMEDYREPACK)
,
LAMOTRIGINE (REMEDYREPACK)
,
LAMOTRIGINE (REMEDYREPACK)
,
LAMOTRIGINE (REMEDYREPACK)
,
LAMOTRIGINE (RPK Pharmaceuticals)
,
LAMOTRIGINE (RPK Pharmaceuticals)
,
LAMOTRIGINE (RPK Pharmaceuticals)
,
LAMOTRIGINE (Rising Pharmaceuticals)
,
LAMOTRIGINE (ScieGen Pharmaceuticals)
,
LAMOTRIGINE (St. Mary's Medical Park Pharmacy)
,
LAMOTRIGINE (St. Mary's Medical Park Pharmacy)
,
LAMOTRIGINE (Torrent Pharmaceuticals Limited)
,
LAMOTRIGINE (Torrent Pharmaceuticals Limited)
,
LAMOTRIGINE (Unichem Pharmaceuticals (USA))
,
LAMOTRIGINE (Wockhardt USA LLC.)
,
LAMOTRIGINE (Zydus Pharmaceuticals (USA))
,
LAMOTRIGINE (Zydus Pharmaceuticals (USA))
,
LAMOTRIGINE (Alembic Pharmaceuticals Limited)
,
LAMOTRIGINE EXTENDED RELEASE (Bryant Ranch Prepack)
,
LAMOTRIGINE EXTENDED RELEASE (Par Pharmaceutical)
,
LAMOTRIGINE EXTENDED RELEASE (TruPharma)
Formula
C9H7Cl2N5
Exact mass
255.0079
Mol weight
256.0914
Structure
Mol file
KCF file
DB search
Class
Metabolizing enzyme substrate
DG02924
UGT substrate
Remark
Therapeutic category:
1139 1179
ATC code:
N03AX09
Product:
D00354<
JP
/US>
Efficacy
Anti-bipolar disorder, Anticonvulsant, Antiepileptic
Disease
Lennox-Gastaut syndrome [DS:
H01813
]
Bipolar disorder [DS:
H01653
]
Target
SCN1A [HSA:
6323
] [KO:
K04833
]
SCN2A [HSA:
6326
] [KO:
K04834
]
SCN3A [HSA:
6328
] [KO:
K04836
]
SCN4A [HSA:
6329
] [KO:
K04837
]
SCN5A [HSA:
6331
] [KO:
K04838
]
SCN8A [HSA:
6334
] [KO:
K04840
]
SCN9A [HSA:
6335
] [KO:
K04841
]
SCN10A [HSA:
6336
] [KO:
K04842
]
SCN11A [HSA:
11280
] [KO:
K04843
]
Pathway
hsa04728
Dopaminergic synapse
Metabolism
Enzyme: UGT1A4 [HSA:
54657
]
Interaction
DDI search
Structure map
map07033
Anticonvulsants
map07231
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:
br08303
]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AX Other antiepileptics
N03AX09 Lamotrigine
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
USP drug classification [BR:
br08302
]
Anticonvulsants
Anticonvulsants, Other
Multiple MOA
Lamotrigine
D00354 Lamotrigine (JAN/USP/INN)
Bipolar Agents
Mood Stabilizers
Lamotrigine
D00354 Lamotrigine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:
br08301
]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
113 Antiepileptics
1139 Others
D00354 Lamotrigine (JAN/USP/INN)
117 Psychotropics
1179 Others
D00354 Lamotrigine (JAN/USP/INN)
Target-based classification of drugs [BR:
br08310
]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN2A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN3A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN4A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN5A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN8A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN9A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN10A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
SCN11A
D00354 Lamotrigine (JAN/USP/INN) <JP/US>
New drug approvals in Japan [
br08318.html
]
Drugs with new active ingredients
D00354
Drug metabolizing enzymes and transporters [
br08309.html
]
Drug metabolizing enzymes
D00354
BRITE hierarchy
Other DBs
CAS:
84057-84-1
PubChem:
7847420
ChEBI:
6367
ChEMBL:
CHEMBL741
DrugBank:
DB00555
LigandBox:
D00354
NIKKAJI:
J25.814H
LinkDB
All DBs
KCF data
Show
ATOM 16
1 C8y C 21.7344 -17.9428
2 C8y C 20.5227 -17.2321
3 C8y C 21.7285 -19.3408
4 N5x N 22.9459 -17.2378
5 C8y C 20.5286 -15.8341
6 C8x C 19.3053 -17.9311
7 N5x N 22.9343 -20.0398
8 N1a N 20.5111 -20.0281
9 N5x N 24.1576 -17.9485
10 C8y C 19.3169 -15.1350
11 X Cl 21.7461 -15.1467
12 C8x C 18.0995 -17.2262
13 C8y C 24.1517 -19.3465
14 C8x C 18.0995 -15.8281
15 X Cl 19.3228 -13.7313
16 N1a N 25.3633 -20.0513
BOND 17
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 3 8 1
8 4 9 2
9 5 10 1
10 5 11 1
11 6 12 2
12 7 13 2
13 10 14 2
14 10 15 1
15 13 16 1
16 9 13 1
17 12 14 1
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