KEGG   DRUG: Lamotrigine
Entry
D00354                      Drug                                   

Name
Lamotrigine (JAN/USP/INN);
Lamictal (TN)
Product
  Generic
LAMOTRIGINE (Cadila Healthcare Limited), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (A-S Medication Solutions), LAMOTRIGINE (Actavis Pharma), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE (American Health Packaging), LAMOTRIGINE (Amneal Pharmaceuticals LLC), LAMOTRIGINE (Amneal Pharmaceuticals of New York LLC), LAMOTRIGINE (Ascend Laboratories), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (Aurobindo Pharma Limited), LAMOTRIGINE (AvKARE), LAMOTRIGINE (AvKARE), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Bryant Ranch Prepack), LAMOTRIGINE (Cadila Healthcare Limited), LAMOTRIGINE (Cardinal Health), LAMOTRIGINE (Cardinal Health), LAMOTRIGINE (Cipla USA), LAMOTRIGINE (Clinical Solutions Wholesale), LAMOTRIGINE (Clinical Solutions Wholesale), LAMOTRIGINE (DIRECT RX), LAMOTRIGINE (DIRECT RX), LAMOTRIGINE (DirectRX), LAMOTRIGINE (Dr. Reddy's Laboratories), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Dr.Reddy's Laboratories Limited), LAMOTRIGINE (Glenmark Pharmaceuticals), LAMOTRIGINE (Golden State Medical Supply), LAMOTRIGINE (H. J. Harkins Company), LAMOTRIGINE (Hikma Pharmaceutical), LAMOTRIGINE (Hikma Pharmaceuticals USA), LAMOTRIGINE (JUBILANT CADISTA PHARMACEUTICALS), LAMOTRIGINE (Jubilant Cadista Pharmaceuticals), LAMOTRIGINE (Lake Erie Medical DBA Quality Care Products LLC), LAMOTRIGINE (Lake Erie Medical DBA Quality Care Products LLC), LAMOTRIGINE (Major Pharmaceuticals), LAMOTRIGINE (McKesson Corporation dba RX Pak), LAMOTRIGINE (McKesson Corporation dba SKY Packaging), LAMOTRIGINE (McKesson Corporation dba SKY Packaging), LAMOTRIGINE (NCS HealthCare of KY), LAMOTRIGINE (NorthStar Rx LLC), LAMOTRIGINE (NorthStar Rx LLC), LAMOTRIGINE (OWP Pharmaceuticals), SUBVENITE (OWP Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (PD-Rx Pharmaceuticals), LAMOTRIGINE (Par Pharmaceutical), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Preferred Pharmaceuticals), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (Proficient Rx LP), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), SUBVENITE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (REMEDYREPACK), LAMOTRIGINE (Rising Pharmaceuticals), LAMOTRIGINE (ScieGen Pharmaceuticals), LAMOTRIGINE (St. Mary's Medical Park Pharmacy), LAMOTRIGINE (St. Mary's Medical Park Pharmacy), LAMOTRIGINE (Taro Pharmaceuticals U.S.A.), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Torrent Pharmaceuticals Limited), LAMOTRIGINE (Unichem Pharmaceuticals (USA)), LAMOTRIGINE (Unit Dose Services), LAMOTRIGINE (Wockhardt USA LLC.), LAMOTRIGINE (Zydus Pharmaceuticals (USA)), LAMOTRIGINE (Zydus Pharmaceuticals (USA)), LAMOTRIGINE (Alembic Pharmaceuticals), LAMOTRIGINE (Alembic Pharmaceuticals Limited), LAMOTRIGINE EXTENDED RELEASE (Par Pharmaceutical), LAMOTRIGINE EXTENDED RELEASE (TruPharma)
Formula
C9H7Cl2N5
Exact mass
255.0079
Mol weight
256.0914
Structure
Class
Metabolizing enzyme substrate
 DG02924  UGT substrate
Remark
Therapeutic category: 1139 1179
ATC code: N03AX09
Product: D00354<JP/US>
Efficacy
Anti-bipolar disorder, Anticonvulsant, Antiepileptic
  Disease
Lennox-Gastaut syndrome [DS:H01813]
Bipolar disorder [DS:H01653]
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: UGT1A4 [HSA:54657]
Interaction
Structure map
map07033  Anticonvulsants
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX09 Lamotrigine
      D00354  Lamotrigine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Anticonvulsants, Other
   Multiple MOA
    Lamotrigine
     D00354  Lamotrigine (JAN/USP/INN)
 Bipolar Agents
  Mood Stabilizers
   Lamotrigine
    D00354  Lamotrigine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00354  Lamotrigine (JAN/USP/INN)
   117  Psychotropics
    1179  Others
     D00354  Lamotrigine (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN2A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN3A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN4A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN5A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN8A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN9A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN10A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
    SCN11A
     D00354  Lamotrigine (JAN/USP/INN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00354
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00354
Other DBs
CAS: 84057-84-1
PubChem: 7847420
ChEBI: 6367
ChEMBL: CHEMBL741
DrugBank: DB00555
LigandBox: D00354
NIKKAJI: J25.814H
LinkDB
KCF data

ATOM        16
            1   C8y C    21.7344  -17.9428
            2   C8y C    20.5227  -17.2321
            3   C8y C    21.7285  -19.3408
            4   N5x N    22.9459  -17.2378
            5   C8y C    20.5286  -15.8341
            6   C8x C    19.3053  -17.9311
            7   N5x N    22.9343  -20.0398
            8   N1a N    20.5111  -20.0281
            9   N5x N    24.1576  -17.9485
            10  C8y C    19.3169  -15.1350
            11  X   Cl   21.7461  -15.1467
            12  C8x C    18.0995  -17.2262
            13  C8y C    24.1517  -19.3465
            14  C8x C    18.0995  -15.8281
            15  X   Cl   19.3228  -13.7313
            16  N1a N    25.3633  -20.0513
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 2
            13   10  14 2
            14   10  15 1
            15   13  16 1
            16    9  13 1
            17   12  14 1

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