KEGG   DRUG: Losartan potassium
Entry
D00357                      Drug                                   

Name
Losartan potassium (JP18/USP);
Cozaar (TN)
Product
  Generic
LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (A-S Medication Solutions), LOSARTAN POTASSIUM (Alembic Pharmaceuticals), LOSARTAN POTASSIUM (Alembic Pharmaceuticals Limited), LOSARTAN POTASSIUM (American Health Packaging), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aphena Pharma Solutions - Tennessee), LOSARTAN POTASSIUM (Aurobindo Pharma Limited), LOSARTAN POTASSIUM (Aurolife Pharma), LOSARTAN POTASSIUM (AvKARE), LOSORTAN POTASSIUM (AvPAK), LOSARTAN POTASSIUM TABLETS, 100 MG (Bryant Ranch Prepack), LOSARTAN POTASSIUM TABLETS, 50 MG (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSORTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSORTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Bryant Ranch Prepack), LOSARTAN POTASSIUM TABLETS, 25 MG (Bryant Ranch Prepack), LOSARTAN POTASSIUM (Cadila Healthcare Limited), LOSARTAN POTASSIUM (Camber Pharmaceuticals), LOSARTAN POTASSIUM (Cardinal Health), LOSARTAN POTASSIUM (Cardinal Health), LOSARTAN POTASSIUM (Cardinal Health), LOSARTAN POTASSIUM (Contract Pharmacy Services-PA), LOSARTAN POTASSIUM (DIRECT RX), LOSARTAN POTASSIUM (DIRECT RX), LOSARTAN POTASSIUM (Denton Pharma), LOSARTAN POTASSIUM (Denton Pharma), LOSARTAN POTASSIUM (Denton Pharma), LOSARTAN POTASSIUM (Denton Pharma), LOSARTAN POTASSIUM (Denton Pharma), LOSARTAN POTASSIUM (Denton Pharma), LOSARTAN POTASSIUM (Denton Pharma), LOSARTAN POTASSIUM (Direct Rx), LOSARTAN POTASSIUM (Direct Rx), LOSARTAN POTASSIUM (Direct_Rx), LOSARTAN POTASSIUM (Direct_Rx), LOSARTAN POTASSIUM (H.J. Harkins Company), LOSARTAN POTASSIUM TABLETS, 25 MG (Jubilant Cadista Pharmaceuticals), LOSARTAN POTASSIUM (Lake Erie Medical DBA Quality Care Products LLC), LOSARTAN POTASSIUM (Legacy Pharmaceutical Packaging), LOSORTAN POTASSIUM (Legacy Pharmaceutical Packaging), LOSARTAN POTASSIUM (Lupin Pharmaceuticals), LOSARTAN POTASSIUM (Macleods Pharmaceuticals Limited), LOSARTAN POTASSIUM (Major Pharmaceuticals), LOSARTAN POTASSIUM (Major Pharmaceuticals), LOSARTAN POTASSIUM (McKesson Corporation dba SKY Packaging), LOSARTAN POTASSIUM (Mckesson Corporation DBA SKY Packaginng), LOSARTAN POTASSIUM (Micro Labs Limited), LOSARTAN POTASSIUM (NCS HealthCare of KY), LOSARTAN POTASSIUM (Northwind Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmaceuticals), LOSARTAN POTASSIUM (NuCare Pharmceuticals), LOSARTAN POTASSIUM (NuCarePharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSORTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (PD-Rx Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSORTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Preferred Pharmaceuticals), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSORTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (Proficient Rx LP), LOSARTAN POTASSIUM (QPharma), LOSARTAN POTASSIUM (QPharma), LOSARTAN POTASSIUM (QPharma), LOSARTAN POTASSIUM (Quality Care Products), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (REMEDYREPACK), LOSARTAN POTASSIUM (RPK Pharmaceuticals), LOSARTAN POTASSIUM (RPK Pharmaceuticals), LOSARTAN POTASSIUM (RPK Pharmaceuticals), LOSARTAN POTASSIUM (RPK Pharmaceuticals), LOSARTAN POTASSIUM (RPK Pharmaceuticals), LOSARTAN POTASSIUM (RPK Pharmaceuticals), LOSARTAN POTASSIUM (RPK Pharmaceuticals), LOSARTAN POTASSIUM (RPK Pharmaceuticals), LOSARTAN POTASSIUM (RPK Pharmaceuticals), LOSARTAN POTASSIUM (Rising Health), LOSARTAN POTASSIUM (Sandoz), LOSARTAN POTASSIUM (Solco Healthcare US), LOSARTAN POTASSIUM (St Marys Medical Park Pharmacy), LOSARTAN POTASSIUM (St. Mary's Medical Park Pharmacy), LOSARTAN POTASSIUM (St. Mary's Medical Park Pharmacy), LOSARTAN POTASSIUM (St. Mary's Medical Park Pharmacy), LOSARTAN POTASSIUM (Strides Pharma Science Limited), LOSARTAN POTASSIUM (Torrent Pharmaceuticals Limited), LOSARTAN POTASSIUM (Unichem Pharmaceuticals (USA)), LOSARTAN POTASSIUM (West-Ward Pharmaceuticals Corp.), LOSARTAN POTASSIUM (XLCare Pharmaceuticals), LOSORTAN POTASSIUM (Zydus Pharmaceuticals (USA)), LOSARTAN POTASSIUM (medsource pharmaceuticals), LOSARTAN POTASSIUM (Direct RX)
Formula
C22H22ClN6O. K
Exact mass
460.1181
Mol weight
461.001
Structure
Simcomp
Class
Cardiovascular agent
 DG01495  Angiotensin II receptor antagonist
 DG01925  Renin-angiotensin system inhibitor
  DG01495  Angiotensin II receptor antagonist
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
Remark
Therapeutic category: 2149
ATC code: C09CA01
Chemical structure group: DG00348
Product (DG00348): D00357<JP/US>
Product (mixture): D07895<JP/US>
Efficacy
Antihypertensive, Angiotensin II receptor antagonist
  Disease
Hypertension [DS:H01633]
Nephropathy in type 2 diabetic [DS:H01456]
Target
AGTR1 [HSA:185] [KO:K04166]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Structure map
map07229  Angiotensin receptor and endothelin receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN
    C09CA Angiotensin II receptor blockers, plain
     C09CA01 Losartan
      D00357  Losartan potassium (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Losartan
    D00357  Losartan potassium (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2149  Others
     D00357  Losartan potassium (JP18/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    AGTR1
     D00357  Losartan potassium (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00357  Losartan potassium
  D00357  Losartan potassium tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00357
Other DBs
CAS: 124750-99-8
PubChem: 7847423
ChEMBL: CHEMBL995
DrugBank: DB00678
LigandBox: D00357
NIKKAJI: J277.880G
LinkDB
KCF data

ATOM        31
            1   N4y N    22.4920  -11.1792
            2   C8y C    22.9128  -12.4884
            3   C8y C    23.6142  -10.3376
            4   C1b C    21.2763  -10.4778
            5   N5x N    24.3155  -12.4884
            6   C1b C    22.0712  -13.6573
            7   C8y C    24.7363  -11.1792
            8   C1b C    23.6142   -8.9349
            9   C8y C    20.0607  -11.2260
            10  C1b C    22.6790  -14.9197
            11  X   Cl   26.0922  -10.7584
            12  O1a O    24.8298   -8.2335
            13  C8x C    20.0607  -12.6286
            14  C8x C    18.8451  -10.5246
            15  C1b C    21.8374  -16.0418
            16  C8x C    18.8917  -13.3300
            17  C8x C    17.6761  -11.3194
            18  C1a C    22.3984  -17.3509
            19  C8y C    17.6761  -12.6754
            20  C8y C    16.4605  -13.3768
            21  C8y C    15.2448  -12.6754
            22  C8x C    16.4605  -14.7794
            23  C8y C    15.2448  -11.2727
            24  C8x C    14.0292  -13.4235
            25  C8x C    15.2916  -15.4808
            26  N4x N    14.1226  -10.4778 #-
            27  N5x N    16.3669  -10.4311
            28  C8x C    14.0292  -14.8729
            29  N5x N    14.5435   -9.1219
            30  N5x N    15.8994   -9.1219
            31  Z   K    11.0368  -10.5714 #+
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    7  11 1
            11    8  12 1
            12    9  13 2
            13    9  14 1
            14   10  15 1
            15   13  16 1
            16   14  17 2
            17   15  18 1
            18   16  19 2
            19   19  20 1
            20   20  21 1
            21   20  22 2
            22   21  23 1
            23   21  24 2
            24   22  25 1
            25   23  26 1
            26   23  27 2
            27   24  28 1
            28   26  29 1
            29   27  30 1
            30    5   7 1
            31   17  19 1
            32   25  28 2
            33   29  30 2

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