DRUG: Propranolol hydrochloride
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Entry
D00483 Drug
Name
Propranolol hydrochloride (JP17/USP);
Inderal (TN);
Innopran XL (TN)
Product
INDERAL (ANI Pharmaceuticals)
,
INDERAL XL (ANI Pharmaceuticals)
,
INNOPRAN XL (ANI Pharmaceuticals)
,
HEMANGEOL (Pierre Fabre Pharmaceuticals)
Generic
PROPRANOLOL HCL ER (Direct Rx)
,
PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions)
,
PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions)
,
PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions)
,
PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions)
,
PROPRANOLOL HYDROCHLORIDE (AMICI PHARMACEUTICALS LLC)
,
PROPRANOLOL HYDROCHLORIDE (ANI Pharmaceuticals)
,
PROPRANOLOL HYDROCHLORIDE (Actavis Pharma)
,
PROPRANOLOL HYDROCHLORIDE (Actavis Pharma)
,
PROPRANOLOL HYDROCHLORIDE (American Health Packaging)
,
PROPRANOLOL HYDROCHLORIDE (American Health Packaging)
,
PROPRANOLOL HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC)
,
PROPRANOLOL HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC)
,
PROPRANOLOL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee)
,
PROPRANOLOL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee)
,
PROPRANOLOL HYDROCHLORIDE (AvKARE)
,
PROPRANOLOL HYDROCHLORIDE (AvPAK)
,
PROPRANOLOL HYDROCHLORIDE (Breckenridge Pharmaceutical)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack)
,
PROPRANOLOL HYDROCHLORIDE (Cadila Healthcare Limited)
,
PROPRANOLOL HYDROCHLORIDE (DIRECT RX)
,
PROPRANOLOL HYDROCHLORIDE (DIRECT RX)
,
PROPRANOLOL HYDROCHLORIDE (DOH CENTRAL PHARMACY)
,
PROPRANOLOL HYDROCHLORIDE (Denton Pharma)
,
PROPRANOLOL HYDROCHLORIDE (Direct_Rx)
,
PROPRANOLOL (Fresenius Kabi USA)
,
PROPRANOLOL HYDROCHLORIDE (General Injectables and Vaccines)
,
PROPRANOLOL HYDROCHLORIDE (Golden State Medical Supply)
,
PROPRANOLOL HYDROCHLORIDE (Golden State Medical Supply)
,
PROPRANOLOL HYDROCHLORIDE (HF Acquisition Co LLC)
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PROPRANOLOL HYDROCHLORIDE (Lannett Company)
,
PROPRANOLOL HYDROCHLORIDE (Major Pharmaceuticals)
,
PROPRANOLOL HYDROCHLORIDE (Medical Purchasing Solutions)
,
PROPRANOLOL (Medical Purchasing Solutions)
,
PROPRANOLOL HYDROCHLORIDE (Mylan Pharmaceuticals)
,
PROPRANOLOL HYDROCHLORIDE (NCS HealthCare of KY)
,
PROPRANOLOL HYDROCHLORIDE (NCS HealthCare of KY)
,
PROPRANOLOL HYDROCHLORIDE (Northwind Pharmaceuticals)
,
PROPRANOLOL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
PROPRANOLOL HYDROCHLORIDE (NuCare Pharmaceuticals)
,
PROPRANOLOL HYDROCHLORIDE (NuCare Pharmaceuticals)
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PROPRANOLOL HYDROCHLORIDE (PD-Rx Pharmaceuticals)
,
PROPRANOLOL HYDROCHLORIDE (PD-Rx Pharmaceuticals)
,
PROPRANOLOL HYDROCHLORIDE (Par Pharmaceutical)
,
PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals)
,
PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals)
,
PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals)
,
PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals)
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PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals)
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PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals)
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PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP)
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PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP)
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PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP)
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PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP)
,
PROPRANOLOL HYDROCHLORIDE (Quality Care Products)
,
PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK)
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PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK)
,
PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK)
,
PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK)
,
PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK)
,
PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK)
,
PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK)
,
PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK)
,
PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK)
,
PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK)
,
PROPRANOLOL HYDROCHLORIDE (RPK Pharmaceuticals)
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PROPRANOLOL HYDROCHLORIDE (RPK Pharmaceuticals)
,
PROPRANOLOL HYDROCHLORIDE (RPK Pharmaceuticals)
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PROPRANOLOL HYDROCHLORIDE (RedPharm Drug)
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PROPRANOLOL HYDROCHLORIDE (RedPharm Drug)
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PROPRANOLOL HYDROCHLORIDE (RedPharm Drug)
,
PROPRANOLOL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy)
,
PROPRANOLOL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy)
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PROPRANOLOL HYDROCHLORIDE (West Ward Pharmaceuticals Corp.)
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PROPRANOLOL HYDROCHLORIDE (West-Ward Pharmaceuticals Corp)
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PROPRANOLOL HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C16H21NO2. HCl
Exact mass
295.1339
Mol weight
295.8044
Structure
Mol file
KCF file
DB search
Simcomp
Neighbor
Class
Cardiovascular agent
DG01653
Antiarrhythmics
DG01806
Class II antiarrhythmic agent
DG01466
Adrenergic receptor antagonist
DG01464
beta-Adrenergic receptor antagonist
DG01461
beta1-Adrenergic receptor antagonist
DG01462
beta2-Adrenergic receptor antagonist
DG01463
beta3-Adrenergic receptor antagonist
Metabolizing enzyme substrate
DG01892
CYP1A2 substrate
DG01639
CYP2C19 substrate
DG01644
CYP2D6 substrate
Remark
Therapeutic category:
2123 2149 2900
ATC code:
C07AA05
Chemical structure group:
DG00305
Product (DG00305):
D00483<
JP
/US>
Product (mixture):
D10274<
US
>
Efficacy
Antiarrhythmic, Antihypertensive, Vasodilator, beta-Adrenergic receptor antagonist
Disease
Hypertension [DS:
H01633
]
Angina pectoris due to coronary atherosclerosis [DS:
H01632
]
Atrial fibrillation [DS:
H00731
]
Myocardial infarction [DS:
H01730
]
Essential tremor [DS:
H01577
]
Infantile hemangioma [DS:
H01482
]
Comment
Class II antiarrhythmic agent
Propranolol derivative
Target
ADRB [HSA:
153
154
155
] [KO:
K04141
K04142
K04143
]
Pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04261
Adrenergic signaling in cardiomyocytes
Metabolism
Enzyme: CYP2D6 [HSA:
1565
], CYP1A2 [HSA:
1544
], CYP2C19 [HSA:
1557
]
Interaction
DDI search
Structure map
map07037
Antiarrhythmic drugs
map07048
Antimigraines
map07114
Naphthalene family
map07214
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:
br08303
]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AA Beta blocking agents, non-selective
C07AA05 Propranolol
D00483 Propranolol hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:
br08302
]
Cardiovascular Agents
Antiarrhythmics
Vaughn Williams-Class II
Propranolol
D00483 Propranolol hydrochloride (JP17/USP)
Beta-adrenergic Blocking Agents
Non-Selective
Propranolol
D00483 Propranolol hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:
br08301
]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2123 Beta blockers
D00483 Propranolol hydrochloride (JP17/USP)
214 Antihypertensives
2149 Others
D00483 Propranolol hydrochloride (JP17/USP)
29 Other agents affecting individual organs
290 Other agents affecting individual organs
2900 Other agents affecting individual organs
D00483 Propranolol hydrochloride (JP17/USP)
Target-based classification of drugs [BR:
br08310
]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB
D00483 Propranolol hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:
br08311
]
Chemicals
D00483 Propranolol hydrochloride
D00483 Propranolol hydrochloride tablets
New drug approvals in Europe [
br08329.html
]
European public assessment reports (EPAR) authorised medicine
D00483
Drug metabolizing enzymes and transporters [
br08309.html
]
Drug metabolizing enzymes
D00483
Pharmacogenomic biomarkers [
br08341.html
]
Polymorphisms and mutations affecting drug response
D00483
BRITE hierarchy
Other DBs
CAS:
318-98-9
PubChem:
7847549
ChEBI:
8500
ChEMBL:
CHEMBL1671
DrugBank:
DB00571
LigandBox:
D00483
NIKKAJI:
J262.867H
LinkDB
All DBs
KCF data
Show
ATOM 20
1 C8x C 7.6300 -12.9500
2 C8x C 7.6300 -14.3500
3 C8x C 8.8424 -15.0500
4 C8y C 10.0549 -14.3500
5 C8y C 10.0549 -12.9500
6 C8x C 8.8424 -12.2500
7 C8x C 11.2673 -15.0500
8 C8x C 12.4797 -14.3500
9 C8x C 12.4797 -12.9500
10 C8y C 11.2673 -12.2500
11 O2a O 11.2673 -10.8500
12 C1b C 12.4818 -10.1488
13 C1c C 13.6783 -10.8398
14 C1b C 14.8651 -10.1546
15 O1a O 13.6784 -12.2497
16 N1b N 16.0566 -10.8428
17 C1c C 17.2460 -10.1561
18 C1a C 18.4362 -10.8435
19 C1a C 17.2462 -8.7502
20 X Cl 18.7600 -14.2800
BOND 20
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 5 10 1
12 10 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 13 15 1
17 14 16 1
18 16 17 1
19 17 18 1
20 17 19 1
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