KEGG   DRUG: Prochlorperazine
Entry
D00493                      Drug                                   
Name
Prochlorperazine (JAN/USP/INN);
Compro (TN)
Product
  Generic
Formula
C20H24ClN3S
Exact mass
373.1379
Mol weight
373.9427
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG03200  Antipsychotic agent
  DG01905  Phenothiazine antipsychotics
Remark
Same as: C07403
ATC code: N05AB04
Chemical structure group: DG00876
Product (DG00876): D00493<US> D00479<JP/US> D02022<JP> D02609<US>
Efficacy
Antipsychotic, Anti-emetic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07029  Antipsychotics - phenothiazines
map07048  Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AB Phenothiazines with piperazine structure
     N05AB04 Prochlorperazine
      D00493  Prochlorperazine (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Prochlorperazine
    D00493  Prochlorperazine (JAN/USP/INN)
 Antipsychotics
  1st Generation/Typical
   Prochlorperazine
    D00493  Prochlorperazine (JAN/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00876  Prochlorperazine
     D00493  Prochlorperazine
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00876  Prochlorperazine
     D00493  Prochlorperazine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00493  Prochlorperazine (JAN/USP/INN) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00876  Prochlorperazine
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00876  Prochlorperazine
Other DBs
CAS: 58-38-8
PubChem: 7847559
ChEBI: 8435
PDB-CCD: P77[PDBj]
LigandBox: D00493
NIKKAJI: J1.386B
LinkDB
KCF data

ATOM        25
            1   C8x C     9.8700  -14.4200
            2   C8x C     9.8700  -15.8200
            3   C8x C    11.0824  -16.5200
            4   C8y C    12.2949  -15.8200
            5   C8y C    12.2949  -14.4200
            6   C8x C    11.0824  -13.7200
            7   S2x S    13.5073  -16.5200
            8   C8y C    14.7197  -15.8200
            9   C8y C    14.7197  -14.4200
            10  N4y N    13.5073  -13.7200
            11  C8x C    15.9322  -16.5200
            12  C8x C    17.1446  -15.8200
            13  C8y C    17.1446  -14.4200
            14  C8x C    15.9322  -13.7200
            15  C1b C    13.5073  -12.3200
            16  X   Cl   18.3611  -13.7177
            17  C1b C    14.7218  -11.6188
            18  C1b C    15.9183  -12.3098
            19  N1y N    17.1051  -11.6246
            20  C1x C    18.2966  -12.3128
            21  C1x C    19.5091  -11.6129
            22  N1y N    19.5093  -10.2129
            23  C1x C    18.3178   -9.5248
            24  C1x C    17.1053  -10.2246
            25  C1a C    20.7341   -9.5058
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   10  15 1
            18   13  16 1
            19   15  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   19  24 1
            28   22  25 1

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