KEGG   DRUG: Pindolol
Entry
D00513                      Drug                                   

Name
Pindolol (JP17/USP/INN);
Blocklin-L (TN);
Carvisken (TN);
Visken (TN)
Product
  Generic
Formula
C14H20N2O2
Exact mass
248.1525
Mol weight
248.3208
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Transporter substrate
 DG02854  SLC22A2 (OCT2) substrate
Remark
Same as: C07445
Therapeutic category: 2123 2149
ATC code: C07AA03
Product: D00513<JP/US>
Efficacy
Antiarrhythmic, Antihypertensive, Vasodilator, beta-Adrenergic receptor antagonist
  Disease
Hypertension [DS:H01633]
Comment
Propranolol derivative
Target
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Transporter: SLC22A2 [HSA:6582]
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07214  beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA03 Pindolol
      D00513  Pindolol (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Beta-adrenergic Blocking Agents, Other
    Pindolol
     D00513  Pindolol (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D00513  Pindolol (JP17/USP/INN)
   214  Antihypertensives
    2149  Others
     D00513  Pindolol (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB
     D00513  Pindolol (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00513  Pindolol
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00513
 Drug transporters
  D00513
Other DBs
CAS: 13523-86-9
PubChem: 7847579
ChEBI: 8214
ChEMBL: CHEMBL500
DrugBank: DB00960
LigandBox: D00513
NIKKAJI: J3.439H
LinkDB
KCF data

ATOM        18
            1   C8y C    18.9000  -17.2200
            2   C8y C    18.9000  -18.6200
            3   C8y C    20.1600  -16.5200
            4   C8x C    17.5700  -16.8000
            5   N4x N    17.5700  -19.1100
            6   C8x C    20.1600  -19.3200
            7   C8x C    21.3500  -17.2200
            8   O2a O    20.1600  -15.1200
            9   C8x C    16.8000  -17.9200
            10  C8x C    21.3500  -18.6200
            11  C1b C    21.3500  -14.4200
            12  C1c C    22.5400  -15.1200
            13  C1b C    23.8000  -14.4200
            14  O1a O    22.5400  -16.5200
            15  N1b N    24.9900  -15.1200
            16  C1c C    26.1800  -14.4200
            17  C1a C    27.4400  -15.1200
            18  C1a C    26.1800  -13.0200
BOND        19
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     6  10 2
            10    8  11 1
            11   11  12 1
            12   12  13 1
            13   12  14 1
            14   13  15 1
            15   15  16 1
            16   16  17 1
            17   16  18 1
            18    5   9 1
            19    7  10 1

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