KEGG   DRUG: Dichlorphenamide
Entry
D00518                      Drug                                   
Name
Dichlorphenamide (USP);
Diclofenamide (JAN/INN);
Daranide (TN);
Keveyis (TN)
Product
KEVEYIS (Strongbridge US), KEVEYIS (Xeris Pharmaceuticals)
  Generic
DICHLORPHENAMIDE (Torrent pharmaceuticals limited), ORMALVI (Cycle Pharmaceuticals)
Formula
C6H6Cl2N2O4S2
Exact mass
303.9146
Mol weight
305.16
Structure
Simcomp
Class
Cardiovascular agent
 DG01534  Carbonic anhydrase inhibitor
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Remark
Same as: C07459
ATC code: S01EC02
Product: D00518<US>
Efficacy
Antiglaucoma, Antiepileptic, Carbonic anhydrase inhibitor
  Disease
Hyperkalemic periodic paralysis [DS:H00215 H00745]
Hypokalemic periodic paralysis [DS:H00215 H00746]
Comment
Sulfonamide derivative
Target
CA [HSA:759 760 761 762 763 11238 765 766 767 768 771 377677 23632] [KO:K01672 K18245 K18246]
  Pathway
hsa04964  Proximal tubule bicarbonate reclamation
Interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07055  Sulfonamide derivatives - overview
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EC Carbonic anhydrase inhibitors
     S01EC02 Diclofenamide
      D00518  Dichlorphenamide (USP) <US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Dichlorphenamide
   D00518  Dichlorphenamide (USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01534  Carbonic anhydrase inhibitor
   D00518  Dichlorphenamide
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D00518  Dichlorphenamide
Drug classes [BR:br08332]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D00518  Dichlorphenamide
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Aldehyde-lyases
    CA
     D00518  Dichlorphenamide (USP) <US>
Other DBs
CAS: 120-97-8
PubChem: 7847584
ChEBI: 101085
PDB-CCD: I7A[PDBj]
LigandBox: D00518
NIKKAJI: J8.589H
LinkDB
KCF data

ATOM        16
            1   C8y C     8.9600  -15.7500
            2   C8x C     8.9600  -17.1500
            3   C8y C    10.1724  -17.8500
            4   C8y C    11.3849  -17.1500
            5   C8y C    11.3849  -15.7500
            6   C8x C    10.1724  -15.0500
            7   S4a S     7.7476  -15.0500
            8   S4a S    12.6160  -15.0390
            9   N1a N     6.5351  -14.3500
            10  O3c O     8.4630  -13.8335
            11  O3c O     7.0437  -16.2469
            12  N1a N    13.8284  -14.3390
            13  O3c O    11.9167  -13.8281
            14  O3c O    13.3168  -16.2526
            15  X   Cl   10.1724  -19.2498
            16  X   Cl   12.6160  -17.8610
BOND        16
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     5   8 1
            9     7   9 1
            10    7  10 2
            11    7  11 2
            12    8  12 1
            13    8  13 2
            14    8  14 2
            15    3  15 1
            16    4  16 1

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