KEGG   DRUG: Pramipexole dihydrochloride
Entry
D00559                      Drug                                   

Name
Pramipexole dihydrochloride (USP);
Pramipexole hydrochloride hydrate (JAN);
Pramipexole dihydrochloride monohydrate;
Mirapex (TN)
Product
  Generic
PRAMIPEXOLE (Camber Pharmaceuticals), PRAMIPEXOLE DIHYDROCHLORIDE (Par Pharmaceutical), PRAMIPEXOLE DIHYDROCHLORIDE (A-S Medication Solutions), PRAMIPEXOLE DIHYDROCHLORIDE (A-S Medication Solutions), PRAMIPEXOLE DIHYDROCHLORIDE (A-S Medication Solutions), PRAMIPEXOLE DIHYDROCHLORIDE (Alembic Pharmaceuticals), PRAMIPEXOLE DIHYDROCHLORIDE (Alembic Pharmaceuticals), PRAMIPEXOLE DIHYDROCHLORIDE (Alembic Pharmaceuticals Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Alembic Pharmaceuticals Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Alembic Pharmaceuticals Limited), PRAMIPEXOLE DIHYDROCHLORIDE (American Health Packaging), PRAMIPEXOLE DIHYDROCHLORIDE (Aurobindo Pharma Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Cadila Healthcare Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Cadila Healthcare Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Denton Pharma), PRAMIPEXOLE DIHYDROCHLORIDE (Dr. Reddy's Laboratories Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Glenmark Pharmaceuticals), PRAMIPEXOLE DIHYDROCHLORIDE (Golden State Medical Supply), PRAMIPEXOLE DIHYDROCHLORIDE (Graviti Pharmaceuticals Private Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Macleods Pharmaceuticals Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Major Pharmaceuticals), PRAMIPEXOLE DIHYDROCHLORIDE (NorthStar RxLLC), PRAMIPEXOLE DIHYDROCHLORIDE (Rising Health), PRAMIPEXOLE DIHYDROCHLORIDE (ScieGen Pharmaceuticals), PRAMIPEXOLE DIHYDROCHLORIDE (Strides Pharma Science Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Torrent Pharmaceuticals Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Unichem Pharmaceuticals (USA)), PRAMIPEXOLE DIHYDROCHLORIDE (Zydus Pharmaceuticals (USA)), PRAMIPEXOLE DIHYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C10H17N3S. 2HCl. H2O
Exact mass
301.0782
Mol weight
302.2642
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01472  Dopamine agonist
  DG01468  Dopamine D2-receptor agonist
  DG01469  Dopamine D3-receptor agonist
  DG01470  Dopamine D4-receptor agonist
 DG01967  Antiparkinson agent
Remark
Therapeutic category: 1169 1190
ATC code: N04BC05
Chemical structure group: DG00863
Product (DG00863): D00559<JP/US>
Efficacy
Antidepressant, Antiparkinsonian, Dopamine receptor agonist
  Disease
Parkinson disease [DS:H00057]
Restless legs syndrome [DS:H01597]
Target
DRD2 [HSA:1813] [KO:K04145]
DRD3 [HSA:1814] [KO:K04146]
DRD4 [HSA:1815] [KO:K04147]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
hsa05012  Parkinson disease
Interaction
Structure map
map07057  Antiparkinsonian agents
map07213  Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BC Dopamine agonists
     N04BC05 Pramipexole
      D00559  Pramipexole dihydrochloride (USP) <JP/US>
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Dopamine Agonists
   Pramipexole
    D00559  Pramipexole dihydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D00559  Pramipexole dihydrochloride (USP); Pramipexole hydrochloride hydrate (JAN)
   119  Miscellaneous
    1190  Miscellaneous
     D00559  Pramipexole dihydrochloride (USP); Pramipexole hydrochloride hydrate (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00559  Pramipexole dihydrochloride (USP) <JP/US>
    DRD3
     D00559  Pramipexole dihydrochloride (USP) <JP/US>
    DRD4
     D00559  Pramipexole dihydrochloride (USP) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00559
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00559
Other DBs
CAS: 191217-81-9
PubChem: 7847625
ChEBI: 51147 8356
ChEMBL: CHEMBL3182733
DrugBank: DB00413
LigandBox: D00559
NIKKAJI: J1.992.469F
LinkDB
KCF data

ATOM        17
            1   C8y C    21.1335  -18.9431
            2   C8y C    21.1744  -17.5455
            3   N5x N    22.5777  -19.3681
            4   C1x C    20.0330  -19.6475
            5   C1x C    20.0274  -16.8467
            6   S2x S    22.5720  -17.1086
            7   C8y C    23.3987  -18.2384
            8   C1x C    18.8276  -18.9548
            9   C1y C    18.8219  -17.5513
            10  N1a N    24.8023  -18.2793
            11  N1b N    17.6048  -16.8524
            12  C1b C    16.3936  -17.5572
            13  C1b C    15.1884  -16.8583
            14  C1a C    13.9771  -17.5629
            15  X   Cl   29.1282  -17.3329
            16  O0  O    29.1804  -19.7534
            17  X   Cl   29.1282  -17.3329
BOND        15
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1 #Down
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    6   7 1
            15    8   9 1
BRACKET     1    27.5100  -18.2000   27.5100  -16.5200
            1    30.0300  -16.5200   30.0300  -18.2000
            1  2
 ORIGINAL  1   15
 REPEAT    1   17

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